Published in Proc Natl Acad Sci U S A on May 09, 2011
Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation. Blood (2015) 1.48
von Willebrand factor, Jedi knight of the bloodstream. Blood (2014) 1.15
The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies. J Clin Invest (2011) 1.13
Platelet mimetic particles for targeting thrombi in flowing blood. Adv Mater (2012) 0.98
Structural basis of regulation of von Willebrand factor binding to glycoprotein Ib. J Biol Chem (2014) 0.97
GpIbα interacts exclusively with exosite II of thrombin. J Mol Biol (2013) 0.84
Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis. Thromb Haemost (2014) 0.80
Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2. Biochem Biophys Res Commun (2014) 0.77
Role of electrostatic interactions in binding of thrombin to the fibrinogen γ' chain. Biochemistry (2012) 0.76
Structural and energetic determinants of tyrosylprotein sulfotransferase sulfation specificity. Bioinformatics (2014) 0.75
Primary Raynaud's phenomenon in an infant: a case report and review of literature. Pediatr Rheumatol Online J (2011) 0.75
Echicetin coated polystyrene beads: a novel tool to investigate GPIb-specific platelet activation and aggregation. PLoS One (2014) 0.75
New Concepts and Mechanisms of Platelet Activation Signaling. Physiology (Bethesda) (2017) 0.75
Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function. PLoS One (2016) 0.75
Selection of single-stranded DNA molecules that bind and inhibit human thrombin. Nature (1992) 7.61
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science (2002) 4.15
Adhesion mechanisms in platelet function. Circ Res (2007) 3.34
The biology and enzymology of protein tyrosine O-sulfation. J Biol Chem (2003) 2.80
Oligonucleotide inhibitors of human thrombin that bind distinct epitopes. J Mol Biol (1997) 2.75
The structure of a complex of recombinant hirudin and human alpha-thrombin. Science (1990) 2.71
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer. J Biol Chem (1993) 2.39
Refined structure of the hirudin-thrombin complex. J Mol Biol (1991) 2.06
Structure of the hirugen and hirulog 1 complexes of alpha-thrombin. J Mol Biol (1991) 1.89
Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations. J Biol Chem (2004) 1.76
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha. Science (2003) 1.65
The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments. J Biol Chem (1986) 1.62
Platelet glycocalicin. Interaction with thrombin and role as thrombin receptor of the platelet surface. J Biol Chem (1978) 1.60
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation. Science (2003) 1.57
The vascular biology of the glycoprotein Ib-IX-V complex. Thromb Haemost (2001) 1.53
Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. J Biol Chem (1998) 1.45
Platelet adhesion under flow. Microcirculation (2009) 1.31
Signaling and regulation of the platelet glycoprotein Ib-IX-V complex. Curr Opin Hematol (2007) 1.24
Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding. J Biol Chem (1995) 1.08
Survey of the year 2006 commercial optical biosensor literature. J Mol Recognit (2007) 1.03
HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase. J Biol Chem (2006) 1.01
Von Willebrand factor. Curr Opin Hematol (2003) 1.01
Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha. J Biol Chem (1994) 1.01
Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin. J Biol Chem (1991) 0.98
Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin. J Biol Chem (2000) 0.96
Long range communication between exosites 1 and 2 modulates thrombin function. J Biol Chem (2009) 0.94
The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III. J Biol Chem (2000) 0.94
Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase. J Thromb Haemost (2008) 0.93
Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib. Biochemistry (2001) 0.92
Tyrosine sulfation of the glycoprotein Ib-IX complex: identification of sulfated residues and effect on ligand binding. Biochemistry (1994) 0.91
Effect of the hirudin carboxy-terminal peptide 54-65 on the interaction of thrombin with platelets. Thromb Haemost (1991) 0.90
Tyrosylprotein sulfotransferase-2 expression is required for sulfation of RNase 9 and Mfge8 in vivo. J Biol Chem (2008) 0.90
Thrombin interaction with platelet GpIB: role of the heparin binding domain. Thromb Haemost (1997) 0.85
Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II. Biochemistry (2009) 0.85
Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib. Thromb Haemost (2010) 0.84
Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor. Biochemistry (2002) 0.84
In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation. J Thromb Haemost (2008) 0.83
Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII. Biochem J (2003) 0.82
The GPIbalpha-thrombin interaction: far from crystal clear. Trends Mol Med (2004) 0.78
The genome of M. acetivorans reveals extensive metabolic and physiological diversity. Genome Res (2002) 4.58
Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Proc Natl Acad Sci U S A (2012) 3.50
Adhesion mechanisms in platelet function. Circ Res (2007) 3.34
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med (2007) 2.85
Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat Med (2005) 2.19
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Proc Natl Acad Sci U S A (2006) 2.09
Reasons for not vaccinating adolescents: National Immunization Survey of Teens, 2008-2010. Pediatrics (2013) 2.01
Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress. Blood (2006) 1.95
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha. Science (2003) 1.65
The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci U S A (2006) 1.62
Simvastatin suppresses lung inflammatory response in a rat cardiopulmonary bypass model. Ann Thorac Surg (2007) 1.57
Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow. Blood (2009) 1.57
The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood (2003) 1.56
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo. J Exp Med (2003) 1.56
Role for ADAP in shear flow-induced platelet mechanotransduction. Blood (2009) 1.55
Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors. Blood (2004) 1.55
Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition. Circ Cardiovasc Imaging (2012) 1.53
Functional self-association of von Willebrand factor during platelet adhesion under flow. Proc Natl Acad Sci U S A (2001) 1.51
Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets. Proc Natl Acad Sci U S A (2005) 1.51
Angiotensin-converting enzyme (ACE) inhibitor angioedema: the silent epidemic. Am J Cardiol (2012) 1.50
Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A (2008) 1.48
A flu-like illness. Clin Pediatr (Phila) (2007) 1.40
Adolescent Vaccination Performance in South Carolina Compared to the United States. J S C Med Assoc (2016) 1.39
Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding. Proc Natl Acad Sci U S A (2003) 1.38
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant. Blood (2009) 1.36
Predicting dose-volume histograms for organs-at-risk in IMRT planning. Med Phys (2012) 1.35
P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice. J Clin Invest (2011) 1.29
Size regulation of von Willebrand factor-mediated platelet thrombi by ADAMTS13 in flowing blood. Blood (2005) 1.28
Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ibalpha mechanoreceptor. Blood (2002) 1.24
Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage. Blood (2009) 1.22
HBV pathogenesis in animal models: recent advances on the role of platelets. J Hepatol (2007) 1.20
Reduced body weight and increased postimplantation fetal death in tyrosylprotein sulfotransferase-1-deficient mice. J Biol Chem (2002) 1.20
Interactions between the YycFG and PhoPR two-component systems in Bacillus subtilis: the PhoR kinase phosphorylates the non-cognate YycF response regulator upon phosphate limitation. Mol Microbiol (2006) 1.19
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. Blood (2005) 1.19
Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease. Am J Pathol (2008) 1.19
Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody. J Biol Chem (2006) 1.19
Cell damage evaluation of thermal inkjet printed Chinese hamster ovary cells. Biotechnol Bioeng (2010) 1.18
Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency. Gen Comp Endocrinol (2007) 1.16
DNA complexed structure of the key transcription factor initiating development in sporulating bacteria. Structure (2002) 1.16
Neutrophils release brakes of coagulation. Nat Med (2010) 1.16
Targeted disruption of tyrosylprotein sulfotransferase-2, an enzyme that catalyzes post-translational protein tyrosine O-sulfation, causes male infertility. J Biol Chem (2006) 1.15
Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1. J Biol Chem (2002) 1.14
Using nature and outdoor activity to improve children's health. Curr Probl Pediatr Adolesc Health Care (2010) 1.14
The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies. J Clin Invest (2011) 1.13
Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow. Blood (2004) 1.11
In-vitro and in-vivo consequences of mutations in the von Willebrand factor cleaving protease ADAMTS13 in thrombotic thrombocytopenic purpura. Thromb Haemost (2006) 1.09
Lack of protein-tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy. Eur J Neurosci (2010) 1.08
Palliative procedures for congenital heart defects. Arch Cardiovasc Dis (2009) 1.07
Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5'-diphosphate receptor stimulation and cyclic calcium signaling. J Am Coll Cardiol (2005) 1.06
Pesticide exposure in children. Pediatrics (2012) 1.06
Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3. J Biol Chem (2002) 1.05
Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus. Clin Vaccine Immunol (2007) 1.04
The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Blood (2013) 1.03
Determination of the sites of tyrosine O-sulfation in peptides and proteins. Nat Methods (2007) 1.03
Children's Environmental Health Faculty Champions Initiative: a successful model for integrating environmental health into pediatric health care. Environ Health Perspect (2008) 1.02
New perspectives on von Willebrand factor functions in hemostasis and thrombosis. Semin Hematol (2005) 1.01
Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane. Blood (2011) 1.01
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function. Proc Natl Acad Sci U S A (2009) 1.01
Marfan's syndrome: an overview. Sao Paulo Med J (2010) 1.01
Analysis of drug resistance determinants in Klebsiella pneumoniae isolates from a tertiary-care hospital in Beijing, China. PLoS One (2012) 1.00
Osteopontin expression and its possible functions in the aortic disorders and coronary artery disease. Rev Bras Cir Cardiovasc (2011) 1.00
ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists. Blood (2006) 1.00
Metals in the sporulation phosphorelay: manganese binding by the response regulator Spo0F. Acta Crystallogr D Biol Crystallogr (2004) 0.98
Platelet mimetic particles for targeting thrombi in flowing blood. Adv Mater (2012) 0.98
The crystal structure of YycH involved in the regulation of the essential YycFG two-component system in Bacillus subtilis reveals a novel tertiary structure. Protein Sci (2006) 0.97
Cavity nonlinear optics at low photon numbers from collective atomic motion. Phys Rev Lett (2007) 0.96
Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine. Protein Sci (2009) 0.96
Induction of platelet thrombi by bacteria and antibodies. Blood (2002) 0.95
The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice. Blood (2007) 0.95
Recombinant human erythropoietin pretreatment attenuates myocardial infarct size: a possible mechanism involves heat shock Protein 70 and attenuation of nuclear factor-kappaB. Ann Clin Lab Sci (2005) 0.95
Protein tyrosine-O-sulfation in bovine ocular tissues. Adv Exp Med Biol (2012) 0.95
N-acetylcysteine to ameliorate acute renal injury in a rat cardiopulmonary bypass model. J Thorac Cardiovasc Surg (2007) 0.95
Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity. Arterioscler Thromb Vasc Biol (2009) 0.94
Cystic medial necrosis: pathological findings and clinical implications. Rev Bras Cir Cardiovasc (2011) 0.94
Excited Delirium Syndrome (ExDS): defining based on a review of the literature. J Emerg Med (2011) 0.93
The bicuspid aortic valve and related disorders. Sao Paulo Med J (2010) 0.93
Factor XI interacts with the leucine-rich repeats of glycoprotein Ibalpha on the activated platelet. J Biol Chem (2004) 0.93
Cystatin C as a reliable marker of renal function following heart valve replacement surgery with cardiopulmonary bypass. Clin Chim Acta (2006) 0.93
beta-Cryptoxanthin from supplements or carotenoid-enhanced maize maintains liver vitamin A in Mongolian gerbils ( Meriones unguiculatus) better than or equal to beta-carotene supplements. Br J Nutr (2008) 0.93
The implications of serum enzymes and coagulation activities in postinfarction myocardial rupture. Rev Bras Cir Cardiovasc (2011) 0.93
Brain natriuretic peptide limits myocardial infarct size dependent of nitric oxide synthase in rats. Clin Chim Acta (2006) 0.92
A sensitive ristocetin co-factor activity assay with recombinant glycoprotein Ibalpha for the diagnosis of patients with low von Willebrand factor levels. Haematologica (2004) 0.92
Pretreatment with recombined human erythropoietin attenuates ischemia-reperfusion-induced lung injury in rats. Eur J Cardiothorac Surg (2006) 0.92
Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm. J Biol Chem (2011) 0.91
Increased matrix metalloproteinase-9 activity and mRNA expression in lung injury following cardiopulmonary bypass. Lab Invest (2012) 0.91
A rat model of cardiopulmonary bypass with excellent survival. J Surg Res (2005) 0.91
Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2. J Am Soc Mass Spectrom (2008) 0.90
Platinum-induced space-group transformation in crystals of the platelet glycoprotein Ib alpha N-terminal domain. Acta Crystallogr D Biol Crystallogr (2004) 0.90
Platelet and von Willebrand factor interactions at the vessel wall. Hamostaseologie (2004) 0.90
Cardiac surgery and hypertension: a dangerous association that must be well known. Rev Bras Cir Cardiovasc (2011) 0.90
Cooperative activation of atrial naturetic peptide promoter by dHAND and MEF2C. J Cell Biochem (2004) 0.90
Tyrosylprotein sulfotransferase-2 expression is required for sulfation of RNase 9 and Mfge8 in vivo. J Biol Chem (2008) 0.90
Berberine acutely inhibits insulin secretion from beta-cells through 3',5'-cyclic adenosine 5'-monophosphate signaling pathway. Endocrinology (2008) 0.90
Parents' perceptions of the HPV vaccine: a key target for improving immunization rates. Expert Rev Clin Immunol (2013) 0.89