Published in Blood on November 08, 2007
Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow. Blood (2009) 1.57
Platelet adhesion under flow. Microcirculation (2009) 1.31
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood (2009) 1.13
Loss of fibrinogen in zebrafish results in symptoms consistent with human hypofibrinogenemia. PLoS One (2013) 0.92
Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice. World J Exp Med (2012) 0.90
Modeling Disorders of Blood Coagulation in the Zebrafish. Curr Pathobiol Rep (2015) 0.80
Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice. Arterioscler Thromb Vasc Biol (2014) 0.79
Conditional knockout of integrin α2β1 in murine megakaryocytes leads to reduced mean platelet volume. PLoS One (2013) 0.78
α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis. PLoS One (2014) 0.76
Targeting GPVI as a novel antithrombotic strategy. J Blood Med (2014) 0.76
Normal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5). PLoS One (2015) 0.75
Aneurysm syndromes caused by mutations in the TGF-beta receptor. N Engl J Med (2006) 9.50
Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet (1999) 5.91
Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell (1998) 4.18
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A (2003) 3.93
Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression. J Biol Chem (2004) 2.94
Design and construction of a linear shear stress flow chamber. Ann Biomed Eng (1993) 2.57
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. EMBO J (2001) 2.44
Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J Biol Chem (1998) 2.15
Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2. J Cell Biol (2003) 1.84
Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain. J Biol Chem (2000) 1.82
Contribution of distinct adhesive interactions to platelet aggregation in flowing blood. Blood (1999) 1.81
Characterization of a mouse model for thrombomodulin deficiency. Arterioscler Thromb Vasc Biol (2001) 1.76
Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. J Exp Med (2001) 1.75
Platelet adhesion signalling and the regulation of thrombus formation. J Cell Sci (2004) 1.65
A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets. J Biol Chem (1997) 1.61
Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Blood (2000) 1.58
The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood (2003) 1.56
The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. J Biol Chem (1999) 1.55
A novel and highly conserved collagen (pro(alpha)1(XXVII)) with a unique expression pattern and unusual molecular characteristics establishes a new clade within the vertebrate fibrillar collagen family. J Biol Chem (2003) 1.47
GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. Blood (2005) 1.47
A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1. Blood (1997) 1.45
Vascular implications of the Krüppel-like family of transcription factors. Arterioscler Thromb Vasc Biol (2005) 1.45
Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest (2001) 1.41
Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency. Blood (2006) 1.37
Distinct antithrombotic consequences of platelet glycoprotein Ibalpha and VI deficiency in a mouse model of arterial thrombosis. J Thromb Haemost (2006) 1.28
Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts. Biochem Biophys Res Commun (2005) 1.19
In vivo effects of lipopolysaccharide and TLR4 on platelet production and activity: implications for thrombotic risk. J Appl Physiol (1985) (2006) 1.13
Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. J Biol Chem (2002) 1.08
Effects of tenascin-C on normal and diabetic retinal endothelial cells in culture. Invest Ophthalmol Vis Sci (2002) 1.00
Molecular and cellular characterization of SEL-OB/SVEP1 in osteogenic cells in vivo and in vitro. J Cell Physiol (2006) 0.95
Identifying novel genetic determinants of hemostatic balance. J Thromb Haemost (2005) 0.92
GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism. Thromb Res (2005) 0.92
Platelets of female mice are intrinsically more sensitive to agonists than are platelets of males. Arterioscler Thromb Vasc Biol (2003) 0.92
A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome. Blood (2005) 0.92
Cloning of the murine platelet glycoprotein Ibalpha gene highlighting species-specific platelet adhesion. Blood Cells Mol Dis (1997) 0.86
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat Genet (2005) 6.91
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol (2006) 5.83
Melanopsin is required for non-image-forming photic responses in blind mice. Science (2003) 4.22
Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science (2010) 4.22
Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol (2004) 4.08
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med (2012) 3.63
Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res (2008) 3.54
Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Proc Natl Acad Sci U S A (2012) 3.50
Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med (2007) 3.35
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med (2007) 2.85
Genetical genomics: spotlight on QTL hotspots. PLoS Genet (2008) 2.63
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. PLoS Genet (2008) 2.32
c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell (2005) 2.30
Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. Genome Res (2006) 2.26
Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat Med (2005) 2.19
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Proc Natl Acad Sci U S A (2006) 2.09
Genomewide association analysis in diverse inbred mice: power and population structure. Genetics (2007) 2.01
Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress. Blood (2006) 1.95
A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci (2007) 1.90
Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome. Blood (2002) 1.90
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75
Platelet glycoprotein Ib alpha supports experimental lung metastasis. Proc Natl Acad Sci U S A (2007) 1.68
A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A. J Cell Biol (2009) 1.67
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha. Science (2003) 1.65
The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci U S A (2006) 1.62
Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow. Blood (2009) 1.57
The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood (2003) 1.56
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo. J Exp Med (2003) 1.56
Role for ADAP in shear flow-induced platelet mechanotransduction. Blood (2009) 1.55
Comparative analysis of haplotype association mapping algorithms. BMC Bioinformatics (2006) 1.55
Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors. Blood (2004) 1.55
Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition. Circ Cardiovasc Imaging (2012) 1.53
Functional self-association of von Willebrand factor during platelet adhesion under flow. Proc Natl Acad Sci U S A (2001) 1.51
Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets. Proc Natl Acad Sci U S A (2005) 1.51
Platelet glycoprotein Ib-IX as a regulator of systemic inflammation. Arterioscler Thromb Vasc Biol (2014) 1.50
Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A (2008) 1.48
The low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding. Blood (2009) 1.46
GPIbα regulates platelet size by controlling the subcellular localization of filamin. Blood (2011) 1.45
A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior. PLoS One (2009) 1.44
A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells. Proc Natl Acad Sci U S A (2009) 1.39
Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding. Proc Natl Acad Sci U S A (2003) 1.38
Derivation of human embryonic stem cells from developing and arrested embryos. Stem Cells (2006) 1.37
Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans. Am J Hum Genet (2009) 1.37
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant. Blood (2009) 1.36
A prototypic platelet septin and its participation in secretion. Proc Natl Acad Sci U S A (2002) 1.36
c-Myb is required for progenitor cell homeostasis in colonic crypts. Proc Natl Acad Sci U S A (2007) 1.31
Response to desmopressin is influenced by the genotype and phenotype in type 1 von Willebrand disease (VWD): results from the European Study MCMDM-1VWD. Blood (2008) 1.30
Genetic architecture of voluntary exercise in an advanced intercross line of mice. Physiol Genomics (2010) 1.30
Platelets: linking hemostasis and cancer. Arterioscler Thromb Vasc Biol (2010) 1.29
P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice. J Clin Invest (2011) 1.29
Size regulation of von Willebrand factor-mediated platelet thrombi by ADAMTS13 in flowing blood. Blood (2005) 1.28
Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. Gastroenterology (2006) 1.27
Genetic dissection of a key reproductive barrier between nascent species of house mice. Genetics (2011) 1.25
Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ibalpha mechanoreceptor. Blood (2002) 1.24
Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest (2013) 1.24
Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage. Blood (2009) 1.22
Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity. Proc Natl Acad Sci U S A (2004) 1.20
HBV pathogenesis in animal models: recent advances on the role of platelets. J Hepatol (2007) 1.20
A novel approach to investigate tissue-specific trinucleotide repeat instability. BMC Syst Biol (2010) 1.20
Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells. J Exp Med (2008) 1.19
Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease. Am J Pathol (2008) 1.19
The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Mol Cell Biol (2002) 1.19
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. Blood (2005) 1.19
Cell damage evaluation of thermal inkjet printed Chinese hamster ovary cells. Biotechnol Bioeng (2010) 1.18
Quantitative trait loci that determine BMD in C57BL/6J and 129S1/SvImJ inbred mice. J Bone Miner Res (2005) 1.17
Mammalian septins nomenclature. Mol Biol Cell (2002) 1.16
Neutrophils release brakes of coagulation. Nat Med (2010) 1.16
The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies. J Clin Invest (2011) 1.13
Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model. Exp Hematol (2002) 1.13
Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease. Hum Mol Genet (2005) 1.13
Megakaryocyte proliferation and ploidy regulated by the cytoplasmic tail of glycoprotein Ibalpha. Blood (2004) 1.12
Prefrontal cortex and insight in schizophrenia: a volumetric MRI study. Schizophr Res (2006) 1.12
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role. Proc Natl Acad Sci U S A (2009) 1.12
Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow. Blood (2004) 1.11
Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol (2009) 1.11
In-vitro and in-vivo consequences of mutations in the von Willebrand factor cleaving protease ADAMTS13 in thrombotic thrombocytopenic purpura. Thromb Haemost (2006) 1.09
Clinically failed eggs as a source of normal human embryo stem cells. Stem Cell Res (2009) 1.09