Published in Lung on May 10, 2011
Updates on the COPD gene list. Int J Chron Obstruct Pulmon Dis (2012) 1.08
Vessel-associated transforming growth factor-beta1 (TGF-β1) is increased in the bronchial reticular basement membrane in COPD and normal smokers. PLoS One (2012) 0.93
Gene polymorphisms and chronic obstructive pulmonary disease. J Cell Mol Med (2013) 0.81
The International HapMap Project. Nature (2003) 73.65
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2007) 47.86
Role of transforming growth factor beta in human disease. N Engl J Med (2000) 10.17
Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature (1985) 10.13
Regulation of immune responses by TGF-beta. Annu Rev Immunol (1998) 8.01
Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest (1997) 5.77
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56
Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature (2003) 4.02
Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med (1997) 2.47
Characterization of the promoter region of the human transforming growth factor-beta 1 gene. J Biol Chem (1989) 2.40
Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation (1998) 2.29
The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet (2004) 2.19
Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research. Am J Respir Crit Care Med (2009) 2.04
Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.98
Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med (2001) 1.98
A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. Postgrad Med J (2009) 1.70
Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. Am J Physiol Lung Cell Mol Physiol (2004) 1.56
CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation. J Clin Invest (2000) 1.43
Transforming growth factor-beta1 genotype and susceptibility to chronic obstructive pulmonary disease. Thorax (2004) 1.39
The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Hum Mol Genet (2009) 1.35
Lung development and susceptibility to chronic obstructive pulmonary disease. Proc Am Thorac Soc (2006) 1.15
IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol (2007) 1.08
Transforming growth factor-beta1 gene polymorphisms associated with chronic obstructive pulmonary disease in Chinese population. Acta Pharmacol Sin (2005) 1.06
Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. Cancer Epidemiol Biomarkers Prev (2009) 1.02
Tumour necrosis factor gene polymorphisms are associated with COPD. Eur Respir J (2008) 1.02
Systemic inflammation in chronic obstructive pulmonary disease and asthma: Similarities and differences. Respirology (2008) 1.02
TGF-beta signaling in COPD: deciphering genetic and cellular susceptibilities for future therapeutic regimen. Swiss Med Wkly (2009) 1.02
Decreased macrophage release of TGF-beta and TIMP-1 in chronic obstructive pulmonary disease. Eur Respir J (2005) 1.02
Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema. Am J Respir Cell Mol Biol (2009) 0.98
Decorin and TGF-beta1 polymorphisms and development of COPD in a general population. Respir Res (2006) 0.98
Polymorphic variation in surfactant protein B is associated with COPD exacerbations. Eur Respir J (2008) 0.98
Functional SNPs in the SCGB3A2 promoter are associated with susceptibility to Graves' disease. Hum Mol Genet (2009) 0.96
Expression of transforming growth factor beta1 in bronchial biopsies in asthma and COPD. J Asthma (2003) 0.95
The association of transforming growth factor beta 1 gene polymorphisms with the emphysema phenotype of COPD in Japanese. Intern Med (2008) 0.94
Transforming growth factor-beta1 polymorphisms, airway responsiveness and lung function decline in smokers. Respir Med (2006) 0.92
Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. Chest (2008) 0.91
Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. Respir Med (2008) 0.88
Increased TGFbeta1 plasma level in patients with lung cancer: potential mechanisms. Eur J Clin Invest (2002) 0.87
Elevated plasma TGF-beta1 levels in patients with chronic obstructive pulmonary disease. Respir Med (2009) 0.85
Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate. Eur Respir J (2009) 0.83
Lack of association between COPD and transforming growth factor-beta1 (TGFB1) genetic polymorphisms in Koreans. Int J Tuberc Lung Dis (2006) 0.83
PTEN identified as important risk factor of chronic obstructive pulmonary disease. Respir Med (2009) 0.79
[TGF-beta1 gene polymorphism in chronic obstructive pulmonary disease]. Pneumonol Alergol Pol (2005) 0.78
Effects of single nucleotide polymorphisms 869 T/C and 915 G/C in the exon 1 locus of transforming growth factor-beta1 gene on chronic obstructive pulmonary disease susceptibility in Chinese. Chin Med J (Engl) (2010) 0.77
Association of cytokine gene polymorphisms with rate of decline in lung function. J Occup Environ Med (2008) 0.77
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature (2002) 8.28
The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus). Nature (2008) 5.54
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med (2006) 3.24
Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing. Nature (2013) 3.06
14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature (2007) 2.98
Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat Neurosci (2005) 2.31
MicroRNA profiling of human gastric cancer. Mol Med Rep (2011) 2.26
Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection. Ann N Y Acad Sci (2005) 2.03
ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res (2006) 1.80
Genomic and proteomic analyses of the fungus Arthrobotrys oligospora provide insights into nematode-trap formation. PLoS Pathog (2011) 1.72
Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. Nat Biotechnol (2004) 1.63
Analysis of trace metals (Cu, Cd, Pb, and Fe) in seawater using single batch nitrilotriacetate resin extraction and isotope dilution inductively coupled plasma mass spectrometry. Anal Chim Acta (2010) 1.59
Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats. Stroke (2007) 1.59
Efficacy of intrapleural instillation of fibrinolytics for treating pleural empyema and parapneumonic effusion: a meta-analysis of randomized control trials. Clin Respir J (2014) 1.58
Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits. Ann Neurol (2004) 1.56
Japanese encephalitis outbreak, Yuncheng, China, 2006. Emerg Infect Dis (2007) 1.56
Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia. J Neurosci (2003) 1.49
Emergence of genotype I of Japanese encephalitis virus as the dominant genotype in Asia. J Virol (2011) 1.46
Genome characterization of the oleaginous fungus Mortierella alpina. PLoS One (2011) 1.43
Human cerebrospinal fluid regulates proliferation and migration of stem cells through insulin-like growth factor-1. Stem Cells Dev (2015) 1.42
Draft genome sequence of the rubber tree Hevea brasiliensis. BMC Genomics (2013) 1.35
Interferon-γ-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway. Immunobiology (2011) 1.34
Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury. J Cereb Blood Flow Metab (2005) 1.30
Distribution of arboviruses and mosquitoes in northwestern Yunnan Province, China. Vector Borne Zoonotic Dis (2009) 1.29
Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection. J Immunol (2011) 1.26
Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor. J Neuroinflammation (2012) 1.22
PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection. Immunology (2010) 1.21
Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation. Eur J Neurosci (2007) 1.20
Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment. Diabetes (2005) 1.20
Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia. J Cereb Blood Flow Metab (2003) 1.14
Tahyna virus and human infection, China. Emerg Infect Dis (2009) 1.14
Adjuvant dexamethasone with bupivacaine prolongs the duration of interscalene block: a prospective randomized trial. J Anesth (2011) 1.14
Neurogenesis following brain ischemia. Brain Res Dev Brain Res (2002) 1.10
Early production of IL-17 protects against acute pulmonary Pseudomonas aeruginosa infection in mice. FEMS Immunol Med Microbiol (2011) 1.10
Temporal and parental-specific expression of imprinted genes in a newly derived Chinese human embryonic stem cell line and embryoid bodies. Hum Mol Genet (2005) 1.07
A comprehensive analysis of gait impairment after experimental stroke and the therapeutic effect of environmental enrichment in rats. J Cereb Blood Flow Metab (2008) 1.07
Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines. Cell Res (2007) 1.07
Identification and characterization of three members of the human metallocarboxypeptidase gene family. J Biol Chem (2002) 1.06
Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol (2013) 1.06
Microemboli composed of cholesterol crystals disrupt the blood-brain barrier and reduce cognition. Stroke (2008) 1.06
Distribution of mosquitoes and mosquito-borne arboviruses in Yunnan Province near the China-Myanmar-Laos border. Am J Trop Med Hyg (2011) 1.05
Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3. J Biol Chem (2013) 1.05
Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury. J Neurotrauma (2011) 1.04
Reduced hippocampal neurogenesis and skill reaching performance in adult Emx1 mutant mice. Exp Neurol (2007) 1.04
Obesity and diabetes in transgenic mice expressing proSAAS. J Endocrinol (2004) 1.04
Expression of thymidylate synthase predicts clinical outcomes of pemetrexed-containing chemotherapy for non-small-cell lung cancer: a systemic review and meta-analysis. Cancer Chemother Pharmacol (2013) 1.04
Role of transcription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol (2006) 1.02
Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures. Neurosurgery (2003) 1.01
Enriched environment and spatial learning enhance hippocampal neurogenesis and salvages ischemic penumbra after focal cerebral ischemia. Neurobiol Dis (2005) 1.01
Activity of deacetylase inhibitor panobinostat (LBH589) in cutaneous T-cell lymphoma models: Defining molecular mechanisms of resistance. Int J Cancer (2010) 1.01
AAV-mediated netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental stroke. Neurobiol Dis (2011) 1.00
Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats. J Cereb Blood Flow Metab (2009) 0.99
Non-contact detection of oxygen saturation based on visible light imaging device using ambient light. Opt Express (2013) 0.99
CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury. J Neurotrauma (2014) 0.99
Filovirus RNA in Fruit Bats, China. Emerg Infect Dis (2015) 0.98
Etiologic diagnosis of lower respiratory tract bacterial infections using sputum samples and quantitative loop-mediated isothermal amplification. PLoS One (2012) 0.98
Impaired hepatitis B vaccine responses during chronic hepatitis C infection: involvement of the PD-1 pathway in regulating CD4(+) T cell responses. Vaccine (2011) 0.98
Development of a rabbit corneal equivalent using an acellular corneal matrix of a porcine substrate. Mol Vis (2008) 0.98
Development of a stepwise aeration control strategy for efficient docosahexaenoic acid production by Schizochytrium sp. Appl Microbiol Biotechnol (2010) 0.98
Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. J Med Chem (2013) 0.97
Abnormal B-cell activation associated with TALL-1 over-expression and SOCS-1 suppression during chronic hepatitis C virus infection. Immunology (2009) 0.96
The Drosophila SNR1 (SNF5/INI1) subunit directs essential developmental functions of the Brahma chromatin remodeling complex. Mol Cell Biol (2003) 0.96
MiR-222 modulates multidrug resistance in human colorectal carcinoma by down-regulating ADAM-17. Exp Cell Res (2012) 0.96
Human serum albumin and its N-terminal tetrapeptide (DAHK) block oxidant-induced neuronal death. Stroke (2004) 0.95
[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J Med Chem (2012) 0.95
Assessing gait impairment following experimental traumatic brain injury in mice. J Neurosci Methods (2008) 0.95
Role of HIF-1alpha in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2009) 0.94
PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expression. Cancer Lett (2010) 0.93
Processing of proSAAS in neuroendocrine cell lines. Biochem J (2002) 0.93
Differential regulation of T and B lymphocytes by PD-1 and SOCS-1 signaling in hepatitis C virus-associated non-Hodgkin's lymphoma. Immunol Invest (2011) 0.93
Construction of a sequence-tagged high-density genetic map of papaya for comparative structural and evolutionary genomics in brassicales. Genetics (2007) 0.93
Analogous nutrient limitations in unicellular diazotrophs and Prochlorococcus in the South Pacific Ocean. ISME J (2011) 0.92
Differential cerebral protein synthesis and heat shock protein 70 expression in the core and penumbra of rat brain after transient focal ischemia. Neurosurgery (2003) 0.92
Conditional ablation of neuroprogenitor cells in adult mice impedes recovery of poststroke cognitive function and reduces synaptic connectivity in the perforant pathway. J Neurosci (2013) 0.92
Programmed death-1 affects suppressor of cytokine signaling-1 expression in T cells during hepatitis C infection. Viral Immunol (2010) 0.91
MicroRNA-27b suppresses growth and invasion of NSCLC cells by targeting Sp1. Tumour Biol (2014) 0.91
Antitumor effects of ginkgolic acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis. Chemotherapy (2010) 0.89
Interaction of E2 glycoprotein with heparan sulfate is crucial for cellular infection of Sindbis virus. PLoS One (2010) 0.89
Hypoglycemia induces transient neurogenesis and subsequent progenitor cell loss in the rat hippocampus. Diabetes (2005) 0.89
Arthroderma vanbreuseghemii infection in three family members with kerion and tinea corporis. Med Mycol (2009) 0.88
Identification and distribution of mouse carboxypeptidase A-6. Brain Res Mol Brain Res (2005) 0.88
Inhibition of mTORC1 by RAD001 (everolimus) potentiates the effects of 1,25-dihydroxyvitamin D(3) to induce growth arrest and differentiation of AML cells in vitro and in vivo. Exp Hematol (2010) 0.88
Upregulation of REG Ialpha accelerates tumor progression in pancreatic cancer with diabetes. Int J Cancer (2010) 0.88
miR-297 modulates multidrug resistance in human colorectal carcinoma by down-regulating MRP-2. Biochem J (2012) 0.88
Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats. J Neuroinflammation (2012) 0.87
Angiotensin-(1-7) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K/Akt and MAPK signaling pathways. Oncol Rep (2011) 0.87
Efficient derivation of Chinese human embryonic stem cell lines from frozen embryos. In Vitro Cell Dev Biol Anim (2010) 0.87
Characterization of a novel G3P[3] rotavirus isolated from a lesser horseshoe bat: a distant relative of feline/canine rotaviruses. J Virol (2013) 0.87
Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice. Endocrinology (2004) 0.87
Mosquitoes of Western Yunnan Province, China: seasonal abundance, diversity, and arbovirus associations. PLoS One (2013) 0.87
Effects of small interfering RNAs targeting MAPK1 on gene expression profile in HeLa cells as revealed by microarray analysis. Cell Biol Int (2008) 0.87
Cytogenetic analysis of 531 Chinese women with premature ovarian failure. Hum Reprod (2012) 0.86
Post-transcriptional regulation of the tumor suppressor miR-139-5p and a network of miR-139-5p-mediated mRNA interactions in colorectal cancer. FEBS J (2014) 0.86
The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer. Oncol Rep (2010) 0.86
Pinopodes, leukemia inhibitory factor, integrin-β3, and mucin-1 expression in the peri-implantation endometrium of women with unexplained recurrent pregnancy loss. Fertil Steril (2012) 0.86