Published in Mol Cell Biol on August 14, 2006
Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol Cell Biol (2010) 1.28
Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells. Proc Natl Acad Sci U S A (2008) 1.23
Role of CD14 in host protection against infections and in metabolism regulation. Front Cell Infect Microbiol (2013) 1.08
The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes. Hum Genet (2009) 1.06
Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. Mol Cell Biol (2008) 1.00
STIM proteins: integrators of signalling pathways in development, differentiation and disease. J Cell Mol Med (2010) 0.97
Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes. Cell Metab (2015) 0.89
Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes. Mol Biol Cell (2013) 0.88
Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes (2011) 0.86
Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion. J Mol Cell Cardiol (2013) 0.85
Nuclear factor of activated T cells (NFAT) signaling regulates PTEN expression and intestinal cell differentiation. Mol Biol Cell (2010) 0.85
Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D. Mol Cell Biol (2010) 0.84
Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases. J Biol Chem (2012) 0.82
Multi-breed and multi-trait co-association analysis of meat tenderness and other meat quality traits in three French beef cattle breeds. Genet Sel Evol (2016) 0.80
Phosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β) by dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A). J Biol Chem (2014) 0.78
HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus. PLoS One (2009) 0.77
Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein. Mol Cell Biol (2015) 0.76
Pharmacogenetics of posttransplant diabetes mellitus. Pharmacogenomics J (2017) 0.75
Role of extracellular signal-regulated kinase 5 in adipocyte signaling. J Biol Chem (2014) 0.75
The Construction of Regulatory Network for Insulin-Mediated Genes by Integrating Methods Based on Transcription Factor Binding Motifs and Gene Expression Variations. Genomics Inform (2015) 0.75
Prevalence and trends in obesity among US adults, 1999-2000. JAMA (2002) 33.23
The disease burden associated with overweight and obesity. JAMA (1999) 19.39
Obesity as a medical problem. Nature (2000) 15.12
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab (2005) 13.91
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell (1998) 13.56
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
Transcriptional regulation of adipogenesis. Genes Dev (2000) 8.52
NFAT signaling: choreographing the social lives of cells. Cell (2002) 8.17
CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J (2002) 6.83
NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol (2005) 6.25
PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem (2001) 5.85
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature (2006) 4.80
Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology (2003) 4.28
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 4.18
The transcription factor NF-ATc is essential for cardiac valve formation. Nature (1998) 4.14
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell (2004) 3.71
The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J Biol Chem (1998) 3.64
Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J Biol Chem (2001) 3.54
Nuclear factor of activated T cells contains Fos and Jun. Nature (1992) 3.43
AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest (2006) 3.39
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37
Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity (1995) 3.07
Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity (1996) 3.05
Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord (2003) 2.94
Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord (2003) 2.89
An enhanced immune response in mice lacking the transcription factor NFAT1. Science (1996) 2.55
Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab (2001) 2.54
Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell (2003) 2.54
NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity (2001) 2.38
Adipogenesis: forces that tip the scales. Trends Endocrinol Metab (2001) 2.30
Calcium, calcineurin, and the control of transcription. J Biol Chem (2000) 2.16
Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity (1998) 2.16
Transcriptional control of adipogenesis. Annu Rev Nutr (2000) 2.14
The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity (1998) 2.13
A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem (2001) 2.09
NFAT: ubiquitous regulator of cell differentiation and adaptation. J Cell Biol (2002) 2.04
The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis. J Exp Med (2000) 1.63
Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis. J Mol Endocrinol (2001) 1.63
Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J Clin Invest (2005) 1.55
NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells. Nat Immunol (2001) 1.51
Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Mol Cell Biol (2002) 1.50
ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter. J Biol Chem (2005) 1.48
Evolutionary relationships among Rel domains indicate functional diversification by recombination. Proc Natl Acad Sci U S A (2001) 1.45
NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circ Res (2003) 1.37
Isolation of rat liver hepatocytes. Methods Mol Biol (1997) 1.34
Mechanisms regulating adipocyte expression of resistin. J Biol Chem (2002) 1.24
Secretory, endocrine and autocrine/paracrine function of the adipocyte. J Nutr (2000) 1.18
The role of C/EBP in nutrient and hormonal regulation of gene expression. Annu Rev Nutr (2001) 1.15
Transcription cooperation by NFAT.C/EBP composite enhancer complex. J Biol Chem (2003) 1.12
A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis. Proc Natl Acad Sci U S A (1998) 1.05
NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes. Diabetes (2006) 1.02
NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1. Diabetes (2002) 1.01
NF-ATp plays a prominent role in the transcriptional induction of Th2-type lymphokines. Immunol Lett (1997) 1.01
Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complex. Mol Cell Biol (2005) 1.01
Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity. Eur J Med Res (1997) 0.94
Serum- and glucocorticoid-inducible kinase 1 mediates salt sensitivity of glucose tolerance. Diabetes (2006) 0.93
Fat cells: afferent and efferent messages define new approaches to treat obesity. Annu Rev Pharmacol Toxicol (2005) 0.92
Angiotensinogen, adipocyte differentiation and fat mass enlargement. Curr Opin Clin Nutr Metab Care (2002) 0.88
MR imaging of caveolin gene-specific alterations in right ventricular wall thickness. Magn Reson Imaging (2005) 0.87
Role of the CCAAT/enhancer-binding protein NFATc2 transcription factor cascade in the induction of secretory phospholipase A2. J Biol Chem (2006) 0.87
Insulin resistance and obesity: resistin, a hormone secreted by adipose tissue. Nutr Rev (2004) 0.81
Adipose tissue, inflammation, and cardiovascular disease. Circ Res (2005) 8.72
Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest (2007) 8.71
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature (2002) 8.28
Adipose tissue remodeling and obesity. J Clin Invest (2011) 6.12
Chromatin remodelling during development. Nature (2010) 5.86
MicroRNA-mediated conversion of human fibroblasts to neurons. Nature (2011) 5.59
The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus). Nature (2008) 5.54
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem (2003) 5.40
A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med (2007) 5.39
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc Natl Acad Sci U S A (2007) 5.36
An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron (2007) 5.35
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature (2012) 5.23
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med (2010) 4.96
ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res (2011) 4.91
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature (2012) 4.84
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature (2006) 4.80
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol (2008) 4.75
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab (2007) 4.74
Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med (2002) 4.69
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab (2002) 4.64
Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem (2002) 4.60
Hypothalamic K(ATP) channels control hepatic glucose production. Nature (2005) 4.56
Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem (2005) 4.32
Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology (2003) 4.28
Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes (2007) 4.28
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proc Natl Acad Sci U S A (2009) 4.07
Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol (2009) 3.96
Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med (2013) 3.86
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A (2009) 3.82
Dynamics and memory of heterochromatin in living cells. Cell (2012) 3.75
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell (2004) 3.71
Understanding the words of chromatin regulation. Cell (2009) 3.67
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature (2009) 3.66
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci (2002) 3.64
Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J Biol Chem (2001) 3.54
Regulation of fasted blood glucose by resistin. Science (2004) 3.54
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat Genet (2013) 3.51
Adiponectin acts in the brain to decrease body weight. Nat Med (2004) 3.47
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem (2004) 3.31
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci U S A (2002) 3.28
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med (2006) 3.24
Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med (2003) 3.21
Adipose tissue-derived factors: impact on health and disease. Endocr Rev (2006) 3.16
Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J Clin Invest (2003) 3.11
Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med (2011) 3.09
Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing. Nature (2013) 3.06
A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology (2003) 3.04
14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature (2007) 2.98
Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature (2006) 2.96
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest (2003) 2.95
Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat Med (2008) 2.91
Central administration of oleic acid inhibits glucose production and food intake. Diabetes (2002) 2.91
Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes (2002) 2.90
Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron (2007) 2.89
Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochim Biophys Acta (2009) 2.84
A brain-liver circuit regulates glucose homeostasis. Cell Metab (2005) 2.83
Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med (2005) 2.78
Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib. Mol Cancer Ther (2010) 2.78
Nuclear actin and actin-related proteins in chromatin remodeling. Annu Rev Biochem (2001) 2.74
Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology (2002) 2.72
JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology (2006) 2.70
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest (2011) 2.68
Hypothalamic sensing of fatty acids. Nat Neurosci (2005) 2.67
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med (2005) 2.66
An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab (2013) 2.62
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab (2010) 2.58
Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol Metab (2010) 2.58
Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity (2003) 2.56
Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell (2003) 2.54
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell Metab (2009) 2.52
O-GlcNAc modification is an endogenous inhibitor of the proteasome. Cell (2003) 2.51
From neural development to cognition: unexpected roles for chromatin. Nat Rev Genet (2013) 2.42
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature (2002) 2.41
Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes (2003) 2.40
Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock. Circ Res (2009) 2.38
Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. J Clin Invest (2005) 2.38
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J Biol Chem (2004) 2.37
Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J (2007) 2.30
esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat Cell Biol (2011) 2.29
Regulation of blood glucose by hypothalamic pyruvate metabolism. Science (2005) 2.28
Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol Cell Biol (2007) 2.27
Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene (2003) 2.27