Published in Biochim Biophys Acta on May 01, 2011
Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics. Future Med Chem (2012) 0.86
Iron chelation and multiple sclerosis. ASN Neuro (2014) 0.84
Coordination of hypoxia adaptation and iron homeostasis in human pathogenic fungi. Front Microbiol (2012) 0.81
Effects of carbon monoxide (CO) delivery by a CO donor or hemoglobin on vascular hypoxia inducible factor 1α and mitochondrial respiration. FEBS Open Bio (2012) 0.77
Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD1. Cell Signal (2016) 0.76
Competitive HIF Prolyl Hydroxylase Inhibitors Show Protection against Oxidative Stress by a Mechanism Partially Dependent on Glycolysis. ISRN Neurosci (2013) 0.76
Iron Deficiency Impairs Intra-Hepatic Lymphocyte Mediated Immune Response. PLoS One (2015) 0.75
Identification of an intestinal heme transporter. Cell (2005) 3.05
The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci (2005) 2.83
Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation (2003) 2.68
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci U S A (2002) 2.35
Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. J Clin Invest (2012) 2.19
Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood (2012) 2.10
The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment. Chem Biol (2007) 2.05
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood (2013) 2.05
CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin. Blood (2005) 1.86
Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. J Clin Invest (2009) 1.77
Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems. Transfusion (2004) 1.54
Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization. Haematologica (2009) 1.51
Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification. Blood (2009) 1.46
Release of redox-active iron by muscle crush trauma: no liberation into the circulation. Shock (2010) 1.44
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy. Br J Pharmacol (2005) 1.32
Iron chelators can protect against oxidative stress through ferryl heme reduction. Free Radic Biol Med (2007) 1.31
Metals ions and neurodegeneration. Biometals (2007) 1.24
Design of clinically useful iron(III)-selective chelators. Med Res Rev (2002) 1.21
Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway. J Biol Chem (2006) 1.20
Tyrosine as a redox-active center in electron transfer to ferryl heme in globins. Free Radic Biol Med (2007) 1.19
Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies. Cold Spring Harb Perspect Med (2013) 1.18
Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera. J Biol Inorg Chem (2007) 1.18
Results of an international round robin for the quantification of serum non-transferrin-bound iron: Need for defining standardization and a clinically relevant isoform. Anal Biochem (2005) 1.16
Design, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors. J Med Chem (2004) 1.14
Monitoring long-term efficacy of iron chelation therapy by deferiprone and desferrioxamine in patients with beta-thalassaemia major: application of SQUID biomagnetic liver susceptometry. Br J Haematol (2003) 1.13
First-generation blood substitutes: what have we learned? Biochemical and physiological perspectives. Expert Opin Biol Ther (2007) 1.13
Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig. J Pharmacol Exp Ther (2007) 1.11
Feruloyl-CoA 6'-Hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis. Plant Physiol (2013) 1.10
Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor. Antioxid Redox Signal (2007) 1.09
Iron(III) citrate speciation in aqueous solution. Dalton Trans (2009) 1.09
All hemoglobin-based oxygen carriers are not created equally. Biochim Biophys Acta (2008) 1.08
The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways. Free Radic Biol Med (2008) 1.08
Current status of the measurement of blood hepcidin levels in chronic kidney disease. Clin J Am Soc Nephrol (2010) 1.08
Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145. Antioxid Redox Signal (2012) 1.08
Quantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin. J Proteome Res (2010) 1.07
Clearance and control mechanisms of hemoglobin from cradle to grave. Antioxid Redox Signal (2010) 1.07
Design of iron chelators with therapeutic application. Dalton Trans (2012) 1.06
Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions. Anal Chem (2005) 1.04
Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1). Br J Nutr (2008) 1.04
Aceruloplasminemia: new clinical, pathophysiological and therapeutic insights. J Hepatol (2002) 1.04
Serum iron curves can be used to estimate dietary iron bioavailability in humans. J Nutr (2006) 1.03
Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity. Antioxid Redox Signal (2013) 1.01
Influence of non-enzymatic post-translation modifications on the ability of human serum albumin to bind iron. Implications for non-transferrin-bound iron speciation. Biochim Biophys Acta (2009) 1.01
Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza. Planta Med (2004) 1.00
Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. J Biol Chem (2003) 1.00
Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo. Biochem J (2006) 1.00
Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions. Free Radic Biol Med (2012) 0.99
Hemoglobin can attenuate hydrogen peroxide-induced oxidative stress by acting as an antioxidative peroxidase. Antioxid Redox Signal (2010) 0.99
Quantification of hepcidin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom (2009) 0.98
Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with (89)Zr(4+): comparison with desferrioxamine-B. Dalton Trans (2015) 0.97
Site-specific cross-linking of human and bovine hemoglobins differentially alters oxygen binding and redox side reactions producing rhombic heme and heme degradation. Biochemistry (2002) 0.96
Genetic epidemiology of induced CYP3A4 activity. Pharmacogenet Genomics (2011) 0.95
Differential induction of renal heme oxygenase and ferritin in ascorbate and nonascorbate producing species transfused with modified cell-free hemoglobin. Antioxid Redox Signal (2010) 0.95
Quantitation of hepcidin in serum using ultra-high-pressure liquid chromatography and a linear ion trap mass spectrometer. Rapid Commun Mass Spectrom (2010) 0.94
Differential roles of hyperglycemia and hypoinsulinemia in diabetes induced retinal cell death: evidence for retinal insulin resistance. PLoS One (2011) 0.94
Quantitation of hepcidin in human urine by liquid chromatography-mass spectrometry. Anal Biochem (2008) 0.93
The heme pocket geometry of Lucina pectinata hemoglobin II restricts nitric oxide and peroxide entry: model of ligand control for the design of a stable oxygen carrier. Biochemistry (2007) 0.93
Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands. Chem Commun (Camb) (2011) 0.93
Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry. Anal Chem (2012) 0.93
Iron binding dendrimers: a novel approach for the treatment of haemochromatosis. J Med Chem (2006) 0.93
Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium. Microbes Infect (2010) 0.93
Iron requirements based upon iron absorption tests are poorly predicted by haematological indices in patients with inactive inflammatory bowel disease. Br J Nutr (2011) 0.93
Functional comparison of hemoglobin purified by different methods and their biophysical implications. Biotechnol Bioeng (2010) 0.92
Molecular controls of the oxygenation and redox reactions of hemoglobin. Antioxid Redox Signal (2013) 0.92
Common presence of non-transferrin-bound iron among patients with type 2 diabetes. Diabetes Care (2006) 0.92
Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin. Am J Pathol (2011) 0.92
Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion. J Biol Chem (2008) 0.91
Peroxidase activity of hemoglobin towards ascorbate and urate: a synergistic protective strategy against toxicity of Hemoglobin-Based Oxygen Carriers (HBOC). Biochim Biophys Acta (2008) 0.91
Haptoglobin: the hemoglobin detoxifier in plasma. Trends Biotechnol (2012) 0.91
Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone. Transl Res (2010) 0.90
Iron mobilization from transferrin by therapeutic iron chelating agents. Biochim Biophys Acta (2011) 0.90
Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-α. J Nutr Biochem (2011) 0.90
Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways. Antioxid Redox Signal (2008) 0.89
Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells. J Neurochem (2008) 0.89
Blood aging, safety, and transfusion: capturing the "radical" menace. Antioxid Redox Signal (2011) 0.89
Targeting the lysosome: fluorescent iron(III) chelators to selectively monitor endosomal/lysosomal labile iron pools. J Med Chem (2008) 0.88
Charge states of deferasirox-ferric iron complexes. Am J Kidney Dis (2010) 0.88
α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide. J Biol Chem (2012) 0.87
Chelation and determination of labile iron in primary hepatocytes by pyridinone fluorescent probes. Biochem J (2006) 0.87
Comparison of oral absorption and bioavailablity of drugs between monkey and human. Pharm Res (2002) 0.87
Relevant activities of extracts and constituents of animals used in traditional Chinese medicine for central nervous system effects associated with Alzheimer's disease. J Pharm Pharmacol (2006) 0.86
Basic 3-hydroxypyridin-4-ones: potential antimalarial agents. Eur J Med Chem (2007) 0.86
Design, synthesis, and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: structure-activity investigation of metalloenzyme inhibition by iron chelators. J Med Chem (2002) 0.86
A role for the myoglobin redox cycle in the induction of endothelial cell apoptosis. Free Radic Biol Med (2002) 0.85
Oxygen binding and oxidation reactions of human hemoglobin conjugated to carboxylate dextran. Biochim Biophys Acta (2004) 0.85
O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: structural and functional consequences of beta93Cys modification. Proteins (2005) 0.85
An eye on insulin. J Clin Invest (2003) 0.85
Isolated Hb Providence β82Asn and β82Asp fractions are more stable than native HbA(0) under oxidative stress conditions. Biochemistry (2011) 0.85
Fenton chemistry and iron chelation under physiologically relevant conditions: Electrochemistry and kinetics. Chem Res Toxicol (2006) 0.84