The Ins2Akita mouse as a model of early retinal complications in diabetes.

PubWeight™: 2.83‹?› | Rank: Top 1%

🔗 View Article (PMID 15914643)

Published in Invest Ophthalmol Vis Sci on June 01, 2005

Authors

Alistair J Barber1, David A Antonetti, Timothy S Kern, Chad E N Reiter, Rohit S Soans, J Kyle Krady, Steven W Levison, Thomas W Gardner, Sarah K Bronson

Author Affiliations

1: Penn State Retina Research Group, The Ulerich Ophthalmology Research Laboratory, Penn State College of Medicine, Hershey, 17033, USA. abarber@psu.edu

Articles citing this

(truncated to the top 100)

Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. Exp Diabetes Res (2007) 3.67

Vascular endothelial growth factor in eye disease. Prog Retin Eye Res (2008) 2.73

Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials. Nat Rev Drug Discov (2009) 2.24

Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy. Invest Ophthalmol Vis Sci (2009) 2.17

Retinal ganglion cells in diabetes. J Physiol (2008) 2.13

The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy. Invest Ophthalmol Vis Sci (2011) 1.85

Mouse models of diabetic neuropathy. Neurobiol Dis (2007) 1.76

Decreased retinal ganglion cell layer thickness in patients with type 1 diabetes. Invest Ophthalmol Vis Sci (2010) 1.73

Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy. FEBS Lett (2009) 1.65

Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models. Am J Pathol (2009) 1.61

Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes (2008) 1.55

TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. Invest Ophthalmol Vis Sci (2011) 1.47

Endothelial dysfunction as a potential contributor in diabetic nephropathy. Nat Rev Nephrol (2010) 1.43

Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes. Diabetologia (2010) 1.42

Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem J (2010) 1.40

Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals. Dis Model Mech (2012) 1.38

The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient. Exp Diabetes Res (2007) 1.35

In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine. Invest Ophthalmol Vis Sci (2008) 1.33

TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis. Cell Signal (2012) 1.32

Retinal ion regulation in a mouse model of diabetic retinopathy: natural history and the effect of Cu/Zn superoxide dismutase overexpression. Invest Ophthalmol Vis Sci (2008) 1.27

Reduced ocular blood flow as an early indicator of diabetic retinopathy in a mouse model of diabetes. Invest Ophthalmol Vis Sci (2012) 1.26

FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats. Diabetes (2009) 1.25

Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells. Invest Ophthalmol Vis Sci (2006) 1.20

Diabetic eNOS-knockout mice develop accelerated retinopathy. Invest Ophthalmol Vis Sci (2010) 1.18

Angiogenic Factors and Cytokines in Diabetic Retinopathy. J Clin Cell Immunol (2013) 1.15

IGFBP-3 and TNF-α regulate retinal endothelial cell apoptosis. Invest Ophthalmol Vis Sci (2013) 1.14

Hyperglycemia impairs proteasome function by methylglyoxal. Diabetes (2009) 1.14

Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy. Diabetes (2006) 1.13

TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1. J Bone Miner Res (2010) 1.11

Animal models of diabetic retinopathy: summary and comparison. J Diabetes Res (2013) 1.09

An integrated approach to diabetic retinopathy research. Arch Ophthalmol (2011) 1.07

Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice. Mol Med (2012) 1.06

Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy. Vision Res (2010) 1.03

Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathy. Invest Ophthalmol Vis Sci (2013) 1.02

Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic ganglia. Exp Neurol (2008) 1.02

Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons. Invest Ophthalmol Vis Sci (2011) 1.02

Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products. Diabetologia (2010) 1.01

Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment. Ann N Y Acad Sci (2014) 1.01

The role of microglia in diabetic retinopathy. J Ophthalmol (2014) 1.00

Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. PLoS One (2011) 1.00

Noninvasive imaging of retinal morphology and microvasculature in obese mice using optical coherence tomography and optical microangiography. Invest Ophthalmol Vis Sci (2014) 1.00

Validation of structural and functional lesions of diabetic retinopathy in mice. Mol Vis (2010) 1.00

Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. Invest Ophthalmol Vis Sci (2006) 0.99

Decrease in retinal neuronal cells in streptozotocin-induced diabetic mice. Mol Vis (2012) 0.99

Differential expression of dicer, miRNAs, and inflammatory markers in diabetic Ins2+/- Akita hearts. Cell Biochem Biophys (2014) 0.98

Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc- in mouse retinal Müller glial cells. Cell Tissue Res (2009) 0.98

Diabetes and retinal vascular dysfunction. J Ophthalmic Vis Res (2015) 0.98

Overexpression of Bcl-2 in vascular endothelium inhibits the microvascular lesions of diabetic retinopathy. Am J Pathol (2010) 0.97

Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases. Mediators Inflamm (2015) 0.96

Oral minocycline for the treatment of diabetic macular edema (DME): results of a phase I/II clinical study. Invest Ophthalmol Vis Sci (2012) 0.96

High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications. Biochem Biophys Res Commun (2013) 0.95

Retinal blood flow abnormalities following six months of hyperglycemia in the Ins2(Akita) mouse. Exp Eye Res (2012) 0.94

Prediction of diabetic retinopathy: role of oxidative stress and relevance of apoptotic biomarkers. EPMA J (2010) 0.94

Differential roles of hyperglycemia and hypoinsulinemia in diabetes induced retinal cell death: evidence for retinal insulin resistance. PLoS One (2011) 0.94

Characterization of a mouse model of hyperglycemia and retinal neovascularization. Am J Pathol (2010) 0.94

Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. Cell Tissue Res (2014) 0.93

Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture. Diabetes (2010) 0.93

MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model. Invest Ophthalmol Vis Sci (2013) 0.92

The db/db mouse: a useful model for the study of diabetic retinal neurodegeneration. PLoS One (2014) 0.92

Antiangiogenic and antineuroinflammatory effects of kallistatin through interactions with the canonical Wnt pathway. Diabetes (2013) 0.92

Tyrosine nitration of prostacyclin synthase is associated with enhanced retinal cell apoptosis in diabetes. Am J Pathol (2011) 0.92

Diabetes changes the levels of ionotropic glutamate receptors in the rat retina. Mol Vis (2009) 0.91

12/15-Lipoxygenase-derived lipid metabolites induce retinal endothelial cell barrier dysfunction: contribution of NADPH oxidase. PLoS One (2013) 0.91

Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse. PLoS One (2014) 0.91

Oxidative stress and light-evoked responses of the posterior segment in a mouse model of diabetic retinopathy. Invest Ophthalmol Vis Sci (2015) 0.91

Neuroinflammatory responses in diabetic retinopathy. J Neuroinflammation (2015) 0.91

Pharmacological inhibition of myostatin/TGF-β receptor/pSmad3 signaling rescues muscle regenerative responses in mouse model of type 1 diabetes. Acta Pharmacol Sin (2013) 0.90

Modes of Retinal Cell Death in Diabetic Retinopathy. J Clin Exp Ophthalmol (2013) 0.90

Role of Acid Sphingomyelinase in Shifting the Balance Between Proinflammatory and Reparative Bone Marrow Cells in Diabetic Retinopathy. Stem Cells (2016) 0.89

Diabetes-induced impairment in visual function in mice: contributions of p38 MAPK, rage, leukocytes, and aldose reductase. Invest Ophthalmol Vis Sci (2014) 0.89

Spatial frequency threshold and contrast sensitivity of an optomotor behavior are impaired in the Ins2Akita mouse model of diabetes. Behav Brain Res (2011) 0.89

Transcriptomic comparison of the retina in two mouse models of diabetes. J Ocul Biol Dis Infor (2009) 0.88

Untreated type 1 diabetes increases sepsis-induced mortality without inducing a prelethal cytokine response. Shock (2010) 0.88

Retinal O-linked N-acetylglucosamine protein modifications: implications for postnatal retinal vascularization and the pathogenesis of diabetic retinopathy. Mol Vis (2013) 0.88

The role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy. Proteomics Clin Appl (2014) 0.88

Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation. World J Diabetes (2010) 0.88

Photoreceptors in diabetic retinopathy. J Diabetes Investig (2015) 0.87

Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes. J Biol Chem (2011) 0.86

Diabetes Accelerates Retinal Neuronal Cell Death In A Mouse Model of Endogenous Hyperhomocysteinemia. Ophthalmol Eye Dis (2009) 0.86

Spontaneously diabetic Ins2(+/Akita):apoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis. Am J Physiol Endocrinol Metab (2011) 0.86

Modified Lipoproteins in Diabetic Retinopathy: A Local Action in the Retina. J Clin Exp Ophthalmol (2013) 0.86

Multifocal ERG defects associated with insufficient long-term glycemic control in adolescents with type 1 diabetes. Invest Ophthalmol Vis Sci (2010) 0.86

Retinal microangiopathy in a mouse model of inducible mural cell loss. Am J Pathol (2014) 0.85

Neurodegeneration and neuroprotection in diabetic retinopathy. Int J Mol Sci (2013) 0.85

Thrombospondin-1 Deficiency Exacerbates the Pathogenesis of Diabetic Retinopathy. J Diabetes Metab (2013) 0.85

Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection. Mitochondrion (2013) 0.84

Insulin signaling in retinal neurons is regulated within cholesterol-enriched membrane microdomains. Am J Physiol Endocrinol Metab (2011) 0.84

Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice. Nutr Diabetes (2012) 0.84

Animal models of diabetic retinopathy: doors to investigate pathogenesis and potential therapeutics. J Biomed Sci (2013) 0.83

Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice. Diabetologia (2015) 0.83

Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina. ASN Neuro (2015) 0.81

Global transcriptional programs in peripheral nerve endoneurium and DRG are resistant to the onset of type 1 diabetic neuropathy in Ins2 mice. PLoS One (2010) 0.81

Involvement of Autophagic Pathway in the Progression of Retinal Degeneration in a Mouse Model of Diabetes. Front Cell Neurosci (2016) 0.81

Degeneration of retinal ganglion cells in diabetic dogs and mice: relationship to glycemic control and retinal capillary degeneration. Mol Vis (2013) 0.81

Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice. Stem Cell Res Ther (2016) 0.80

A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathy. Invest Ophthalmol Vis Sci (2013) 0.80

DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation. PLoS One (2014) 0.80

Retinal Neurodegeneration in db/db Mice at the Early Period of Diabetes. J Ophthalmol (2015) 0.80

Retinal vascular leakage occurring in GABA Rho-1 subunit deficient mice. Exp Eye Res (2010) 0.80

Spatial and temporal aspects and the interplay of Grb14 and protein tyrosine phosphatase-1B on the insulin receptor phosphorylation. Cell Commun Signal (2013) 0.80

Articles by these authors

Diabetic retinopathy. N Engl J Med (2012) 5.79

A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J (2004) 5.33

Retinopathy in diabetes. Diabetes Care (2004) 4.25

Retinal angiogenesis in development and disease. Nature (2005) 4.18

Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes (2006) 3.31

Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab (2007) 3.30

Inflammation in diabetic retinopathy. Prog Retin Eye Res (2011) 3.29

Diabetic retinopathy: more than meets the eye. Surv Ophthalmol (2002) 2.95

Regulation of tight junctions and loss of barrier function in pathophysiology. Int J Biochem Cell Biol (2004) 2.54

A diet-induced mouse model for glutaric aciduria type I. Brain (2006) 2.31

Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med (2009) 2.31

Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes (2005) 2.28

Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci (2007) 2.28

Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes. Diabetes (2002) 2.05

Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB. Diabetes (2004) 2.02

Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells. Diabetes (2007) 2.01

Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury. Ann Neurol (2007) 1.96

Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes. Invest Ophthalmol Vis Sci (2007) 1.90

VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability. Invest Ophthalmol Vis Sci (2006) 1.86

Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. J Neurosci (2009) 1.86

The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy. Invest Ophthalmol Vis Sci (2011) 1.85

Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes. Invest Ophthalmol Vis Sci (2005) 1.84

Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. J Biol Chem (2009) 1.81

Interleukin-1: a master regulator of neuroinflammation. J Neurosci Res (2004) 1.69

Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy. Diabetes (2007) 1.61

Diabetic retinopathy. Diabetes Care (2003) 1.61

TNF-α signals through PKCζ/NF-κB to alter the tight junction complex and increase retinal endothelial cell permeability. Diabetes (2010) 1.60

Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin. Diabetes (2006) 1.58

Diabetic retinopathy. Diabetes Care (2003) 1.52

5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy. Diabetes (2008) 1.48

Compound 49b prevents diabetes-induced apoptosis through increased IGFBP-3 levels. Invest Ophthalmol Vis Sci (2012) 1.46

Glucocorticoid induction of occludin expression and endothelial barrier requires transcription factor p54 NONO. Invest Ophthalmol Vis Sci (2013) 1.46

Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice. Invest Ophthalmol Vis Sci (2008) 1.45

Mapping the blood vessels with paracellular permeability in the retinas of diabetic rats. Invest Ophthalmol Vis Sci (2003) 1.45

Vascular permeability in ocular disease and the role of tight junctions. Angiogenesis (2007) 1.44

A comprehensive analysis of the expression of crystallins in mouse retina. Mol Vis (2003) 1.43

Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. Am J Physiol Renal Physiol (2005) 1.43

Neural stem/progenitor cells participate in the regenerative response to perinatal hypoxia/ischemia. J Neurosci (2006) 1.42

Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals. Dis Model Mech (2012) 1.38

Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci U S A (2013) 1.36

Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function. Invest Ophthalmol Vis Sci (2010) 1.31

Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes (2006) 1.31

Characterization of insulin signaling in rat retina in vivo and ex vivo. Am J Physiol Endocrinol Metab (2003) 1.29

Application of isoproterenol inhibits diabetic-like changes in the rat retina. Exp Eye Res (2010) 1.27

Retinal ion regulation in a mouse model of diabetic retinopathy: natural history and the effect of Cu/Zn superoxide dismutase overexpression. Invest Ophthalmol Vis Sci (2008) 1.27

Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy. Front Biosci (Landmark Ed) (2009) 1.26

The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. J Neurosci (2002) 1.24

Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response. BMC Med Genomics (2008) 1.23

Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients. Diabetes (2002) 1.22

Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice. Diabetes (2012) 1.21

Circulating sphingolipid biomarkers in models of type 1 diabetes. J Lipid Res (2010) 1.21

Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production. J Biol Chem (2002) 1.20

The blood-retinal barrier: structure and functional significance. Methods Mol Biol (2011) 1.20

Roles of the mammalian subventricular zone in cell replacement after brain injury. Prog Neurobiol (2004) 1.19

Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Müller cells: model of diabetic retinopathy. J Biol Chem (2007) 1.19

Functions of insulin and insulin receptor signaling in retina: possible implications for diabetic retinopathy. Prog Retin Eye Res (2003) 1.18

Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury. J Cereb Blood Flow Metab (2005) 1.17

Platelet-derived growth factor mediates tight junction redistribution and increases permeability in MDCK cells. J Cell Physiol (2002) 1.16

Ciliary neurotrophic factor activates spinal cord astrocytes, stimulating their production and release of fibroblast growth factor-2, to increase motor neuron survival. Exp Neurol (2002) 1.16

Neonatal hypoxic/ischemic brain injury induces production of calretinin-expressing interneurons in the striatum. J Comp Neurol (2008) 1.16

Glucocorticoid regulation of endothelial cell tight junction gene expression: novel treatments for diabetic retinopathy. Curr Eye Res (2005) 1.15

IGFBP-3 and TNF-α regulate retinal endothelial cell apoptosis. Invest Ophthalmol Vis Sci (2013) 1.14

Protein kinase cβ phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo. Diabetes (2012) 1.13

Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy. Diabetes (2006) 1.13

Neural stem cells in the subventricular zone are resilient to hypoxia/ischemia whereas progenitors are vulnerable. J Cereb Blood Flow Metab (2004) 1.13

IGF-I and microglia/macrophage proliferation in the ischemic mouse brain. Glia (2002) 1.13

Increased basement membrane thickness, pericyte ghosts, and loss of retinal thickness and cells in dopamine beta hydroxylase knockout mice. Exp Eye Res (2009) 1.12

Alterations to the blood-retinal barrier in diabetes: cytokines and reactive oxygen species. Antioxid Redox Signal (2011) 1.11

Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection. Stroke (2005) 1.10

Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking. Diabetes (2005) 1.10

Mice with deficiency of G protein gamma3 are lean and have seizures. Mol Cell Biol (2004) 1.10

Increased tumor necrosis factor-α, cleaved caspase 3 levels and insulin receptor substrate-1 phosphorylation in the β₁-adrenergic receptor knockout mouse. Mol Vis (2011) 1.09

Roles of the mammalian subventricular zone in brain development. Prog Neurobiol (2003) 1.08

Minocycline prevents retinal inflammation and vascular permeability following ischemia-reperfusion injury. J Neuroinflammation (2013) 1.08

Low-intensity far-red light inhibits early lesions that contribute to diabetic retinopathy: in vivo and in vitro. Invest Ophthalmol Vis Sci (2013) 1.07

Ocular Anti-VEGF therapy for diabetic retinopathy: the role of VEGF in the pathogenesis of diabetic retinopathy. Diabetes Care (2014) 1.07

Tissue-specific expression of a BAC transgene targeted to the Hprt locus in mouse embryonic stem cells. Genomics (2004) 1.07

Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. Am J Physiol Endocrinol Metab (2007) 1.07

Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells. Neuropharmacology (2005) 1.07

Inner retinal visual dysfunction is a sensitive marker of non-proliferative diabetic retinopathy. Br J Ophthalmol (2011) 1.06

NRF2 plays a protective role in diabetic retinopathy in mice. Diabetologia (2013) 1.06

6-Fluoro-6-deoxy-D-glucose as a tracer of glucose transport. Am J Physiol Endocrinol Metab (2007) 1.06

CD40 mediates retinal inflammation and neurovascular degeneration. J Immunol (2008) 1.06

Identification and analysis of occludin phosphosites: a combined mass spectrometry and bioinformatics approach. J Proteome Res (2009) 1.05

Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. Am J Physiol Endocrinol Metab (2010) 1.05

Oxidation of fatty acids is the source of increased mitochondrial reactive oxygen species production in kidney cortical tubules in early diabetes. Diabetes (2012) 1.05