Published in Science on May 13, 2011
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An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
Designing metallic glass matrix composites with high toughness and tensile ductility. Nature (2008) 5.95
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell (2012) 5.62
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BIPES, a cost-effective high-throughput method for assessing microbial diversity. ISME J (2010) 4.52
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet (2012) 4.07
A damage-tolerant glass. Nat Mater (2011) 3.91
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66
Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes. J Virol (2004) 3.17
Straightening Caenorhabditis elegans images. Bioinformatics (2007) 3.13
Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology (2012) 2.58
Development of tough, low-density titanium-based bulk metallic glass matrix composites with tensile ductility. Proc Natl Acad Sci U S A (2008) 2.22
Comprehensive comparison of three commercial human whole-exome capture platforms. Genome Biol (2011) 2.15
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Res (2013) 2.12
Anelastic to plastic transition in metallic glass-forming liquids. Phys Rev Lett (2007) 1.98
The Relationship Between Helicobacter pylori Infection and Open-Angle Glaucoma: A Meta-Analysis. Invest Ophthalmol Vis Sci (2015) 1.94
Local elastic properties of a metallic glass. Nat Mater (2011) 1.88
Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies. Gastroenterology (2013) 1.83
Cooperative shear model for the rheology of glass-forming metallic liquids. Phys Rev Lett (2006) 1.77
The Wilms tumor gene, Wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans. PLoS Genet (2013) 1.52
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Association between two polymorphisms of ABCB1 and breast cancer risk in the current studies: a meta-analysis. Breast Cancer Res Treat (2010) 1.46
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Solution to the problem of the poor cyclic fatigue resistance of bulk metallic glasses. Proc Natl Acad Sci U S A (2009) 1.18
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Functional comparisons of visual arrestins in rod photoreceptors of transgenic mice. Invest Ophthalmol Vis Sci (2007) 1.10
Simultaneous recognition and segmentation of cells: application in C.elegans. Bioinformatics (2011) 1.09
Functional identification of a hydroxyproline-o-galactosyltransferase specific for arabinogalactan protein biosynthesis in Arabidopsis. J Biol Chem (2013) 1.09
Quantitative imaging of energy expenditure in human brain. Neuroimage (2012) 1.09
CD40 ligation reverses T cell tolerance in acute myeloid leukemia. J Clin Invest (2013) 1.04
Experimental realization of a circuit-based broadband illusion-optics analogue. Phys Rev Lett (2010) 1.03
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Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression of Cyclins A and E. Gastroenterology (2012) 1.00
A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8). J Biol Chem (2008) 0.99
Unusual conservation of mitochondrial gene order in Crassostrea oysters: evidence for recent speciation in Asia. BMC Evol Biol (2010) 0.98
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Chemical influence on β-relaxations and the formation of molecule-like metallic glasses. Nat Commun (2013) 0.94
Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity. Clin Immunol (2010) 0.94
Distribution and translocation of selenium from soil to grain and its speciation in paddy rice (Oryza sativa L.). Environ Sci Technol (2010) 0.93
Expression of epidermal growth factor receptor is an independent prognostic factor for esophageal squamous cell carcinoma. World J Surg Oncol (2013) 0.92
Screening and analysis of the multiple absorbed bioactive components and metabolites of Baihe Zhimu Tang by the metabolic fingerprinting technique and liquid chromatography/diode array detection-electrospray ionization-mass spectrometry. Pharmacogn Mag (2011) 0.92
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Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock. Proc Natl Acad Sci U S A (2013) 0.91
Experimental study of detection of nodules showing ground-glass opacity and radiation dose by using anthropomorphic chest phantom: digital tomosynthesis and multidetector CT. J Comput Assist Tomogr (2012) 0.91
Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout. Arthritis Rheum (2011) 0.90
A sensitive liquid chromatography-mass spectrometry method for simultaneous determination of two active chromones from Saposhnikovia root in rat plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 0.90
TPX2 Level Correlates with Hepatocellular Carcinoma Cell Proliferation, Apoptosis, and EMT. Dig Dis Sci (2015) 0.90
Genetic aberrations in imatinib-resistant dermatofibrosarcoma protuberans revealed by whole genome sequencing. PLoS One (2013) 0.89
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Putative calcium channels CchA and MidA play the important roles in conidiation, hyphal polarity and cell wall components in Aspergillus nidulans. PLoS One (2012) 0.89
Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study. Proteomics (2012) 0.89
Full genomic analysis of human rotavirus strain TB-Chen isolated in China. Virology (2008) 0.89
Cloning, characterization and expression of two new polyphenol oxidase cDNAs from Agaricus bisporus. Biotechnol Lett (2010) 0.89
(4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl] quinoline) is a novel inhibitor of autophagy. Br J Pharmacol (2014) 0.88
3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy. Biochem Biophys Res Commun (2013) 0.88
Inferring direct regulatory targets from expression and genome location analyses: a comparison of transcription factor deletion and overexpression. BMC Genomics (2006) 0.88
Coordinated regulation of transcription factor Bcl11b activity in thymocytes by the mitogen-activated protein kinase (MAPK) pathways and protein sumoylation. J Biol Chem (2012) 0.87
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Enhanced fatigue endurance of metallic glasses through a staircase-like fracture mechanism. Proc Natl Acad Sci U S A (2013) 0.86
Exome capture from saliva produces high quality genomic and metagenomic data. BMC Genomics (2014) 0.86
A preliminary genetic linkage map of the Pacific abalone Haliotis discus hannai Ino. Mar Biotechnol (NY) (2006) 0.85
Molecular epidemiology of outbreak-associated pseudorabies virus (PRV) strains in central China. Virus Genes (2015) 0.85
Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia. J Hematol Oncol (2012) 0.85
Contact- and agonist-regulated microvesiculation of human platelets. Thromb Haemost (2013) 0.85
Facile synthesis and optical properties of polymer-laced ZnO-Au hybrid nanoparticles. Nanoscale Res Lett (2014) 0.85
Bone morphogenetic protein-4 contributes to the down-regulation of Kv4.3 K+ channels in pathological cardiac hypertrophy. Biochem Biophys Res Commun (2013) 0.84
Study on chemical fingerprinting of crude and processed Atractylodes macrocephala from different locations in Zhejiang province by reversed-phase high-performance liquid chromatography coupled with hierarchical cluster analysis. Pharmacogn Mag (2012) 0.84
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An integrated tool to study MHC region: accurate SNV detection and HLA genes typing in human MHC region using targeted high-throughput sequencing. PLoS One (2013) 0.84
Facile synthesis of amino-silane modified superparamagnetic Fe3O4 nanoparticles and application for lipase immobilization. J Biotechnol (2010) 0.84
The intracellular transport and secretion of calumenin-1/2 in living cells. PLoS One (2012) 0.84
Direct glycosylation of bioactive small molecules with glycosyl iodide and strained olefin as acid scavenger. J Org Chem (2014) 0.84
Increased expression of T cell immunoglobulin- and mucin domain-containing molecule-3 on natural killer cells in atherogenesis. Atherosclerosis (2012) 0.84
Kinetic roughening of laser deposited polymer films: crossover from single particle character to continuous growth. Phys Rev Lett (2004) 0.84
Brief report: Granulocyte-macrophage colony-stimulating factor drives monosodium urate monohydrate crystal-induced inflammatory macrophage differentiation and NLRP3 inflammasome up-regulation in an in vivo mouse model. Arthritis Rheumatol (2014) 0.84
Sequence variability of the 5' UTR in isolates of hepatitis C virus in China. Hepatobiliary Pancreat Dis Int (2002) 0.83
Cloning and expression analysis of a HSP70 gene from Pacific abalone (Haliotis discus hannai). Fish Shellfish Immunol (2006) 0.83
Effect of emodin on endoplasmic reticulum stress in rats with severe acute pancreatitis. Inflammation (2013) 0.83
Identification of short hairpin RNA targeting foot-and-mouth disease virus with transgenic bovine fetal epithelium cells. PLoS One (2012) 0.83
Expression of a GALACTINOL SYNTHASE gene is positively associated with desiccation tolerance of Brassica napus seeds during development. J Plant Physiol (2011) 0.83
Identification of antituberculosis agents that target ribosomal protein interactions using a yeast two-hybrid system. Proc Natl Acad Sci U S A (2012) 0.83
A consensus microsatellite-based linkage map for the hermaphroditic bay scallop (Argopecten irradians) and its application in size-related QTL analysis. PLoS One (2012) 0.82
Da-Huang-Fu-Zi-Tang attenuates liver injury in rats with severe acute pancreatitis. J Ethnopharmacol (2013) 0.82
Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: effect of changes in alkaloid composition. J Ethnopharmacol (2011) 0.81
Pharmacokinetics of brucine after intravenous and oral administration to rats. Fitoterapia (2011) 0.81
[Quick identification of sun-dried and sulfur-fumigated angelicae sinensis radix by Fourier transform infrared spectroscopy]. Zhongguo Zhong Yao Za Zhi (2012) 0.81