Resolution of quadruplex polymorphism by size-exclusion chromatography.

PubWeight™: 0.77‹?›

🔗 View Article (PMC 3963359)

Published in Curr Protoc Nucleic Acid Chem on June 01, 2011

Authors

M Clarke Miller1, John O Trent

Author Affiliations

1: James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA.

Articles cited by this

Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J (1992) 10.97

A survey of telomerase activity in human cancer. Eur J Cancer (1997) 10.84

Predicting new molecular targets for known drugs. Nature (2009) 9.71

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc Natl Acad Sci U S A (2002) 9.60

Prevalence of quadruplexes in the human genome. Nucleic Acids Res (2005) 7.79

G-quadruplexes in promoters throughout the human genome. Nucleic Acids Res (2006) 5.84

Inhibition of telomerase limits the growth of human cancer cells. Nat Med (1999) 4.96

DNA tetraplex formation in the control region of c-myc. Nucleic Acids Res (1998) 4.09

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res (2007) 3.49

Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev (1997) 3.42

Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization. Biochemistry (2005) 3.41

Telomere maintenance as a target for anticancer drug discovery. Nat Rev Drug Discov (2002) 3.32

Circular dichroism and conformational polymorphism of DNA. Nucleic Acids Res (2009) 3.20

Loop-length-dependent folding of G-quadruplexes. J Am Chem Soc (2004) 3.16

Hairpin and parallel quartet structures for telomeric sequences. Nucleic Acids Res (1992) 3.03

Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents. Nucleic Acids Res (2005) 3.01

An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution. J Am Chem Soc (2006) 2.91

Stability and kinetics of G-quadruplex structures. Nucleic Acids Res (2008) 2.75

Inhibition of human telomerase by a G-quadruplex-interactive compound. J Med Chem (1997) 2.66

A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry (2006) 2.62

Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal. Nucleic Acids Res (2005) 2.57

Biophysical and biological properties of quadruplex oligodeoxyribonucleotides. Nucleic Acids Res (2003) 2.34

Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter. Biochemistry (2005) 2.27

Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc (2007) 2.26

Targeting Stat3 in cancer therapy. Anticancer Drugs (2005) 2.13

Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation. Genome Res (2006) 2.12

Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution. Nucleic Acids Res (2007) 2.09

NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region. Nucleic Acids Res (2006) 2.03

Discovery and development of anticancer aptamers. Mol Cancer Ther (2006) 2.01

Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis. Cancer Res (2009) 1.98

Polymorphism of human telomeric quadruplex structures. Biochimie (2008) 1.89

Promotion of parallel DNA quadruplexes by a yeast telomere binding protein: a circular dichroism study. Proc Natl Acad Sci U S A (1994) 1.83

Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation. Nucleic Acids Res (2007) 1.72

Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer. FEBS J (2009) 1.67

Engineering the quadruplex fold: nucleoside conformation determines both folding topology and molecularity in guanine quadruplexes. J Am Chem Soc (2006) 1.49

G-rich oligonucleotide inhibits the binding of a nuclear protein to the Ki-ras promoter and strongly reduces cell growth in human carcinoma pancreatic cells. Biochemistry (2004) 1.47

Structural insights into G-quadruplexes: towards new anticancer drugs. Future Med Chem (2010) 1.44

A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc (2009) 1.40

Human telomeric DNA forms parallel-stranded intramolecular G-quadruplex in K+ solution under molecular crowding condition. J Am Chem Soc (2007) 1.40

Antiproliferative activity of G-quartet-forming oligonucleotides with backbone and sugar modifications. Biochemistry (2002) 1.36

Energetics and kinetics of a conformational switch in G-quadruplex DNA. J Phys Chem B (2009) 1.29

The use of high-performance liquid chromatography for the determination of size and molecular weight of proteins: a caution and a list of membrane proteins suitable as standards. Anal Biochem (1986) 1.28

Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol (2003) 1.23

Ion selective folding of loop domains in a potent anti-HIV oligonucleotide. Biochemistry (1997) 1.23

Geometric formalism for DNA quadruplex folding. Chemistry (2007) 1.21

Hydration is a major determinant of the G-quadruplex stability and conformation of the human telomere 3' sequence of d(AG3(TTAG3)3). J Am Chem Soc (2010) 1.19

Drug discovery: Predicting promiscuity. Nature (2009) 1.16

G-quadruplexes induce apoptosis in tumor cells. Cancer Res (2006) 1.14

Characterization of a K+-induced conformational switch in a human telomeric DNA oligonucleotide using 2-aminopurine fluorescence. Biochemistry (2010) 1.10

Intramolecular G-quartet motifs confer nuclease resistance to a potent anti-HIV oligonucleotide. J Biol Chem (1996) 1.08

Effects of an 8-bromodeoxyguanosine incorporation on the parallel quadruplex structure [d(TGGGT)]4. Org Biomol Chem (2004) 1.03

6-Thioguanine alters the structure and stability of duplex DNA and inhibits quadruplex DNA formation. Nucleic Acids Res (1999) 1.02

Divalent transition metal cations counteract potassium-induced quadruplex assembly of oligo(dG) sequences. Nucleic Acids Res (1997) 1.01

Four-stranded DNA: cancer, gene regulation and drug development. Philos Trans A Math Phys Eng Sci (2007) 1.01

Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence. Nucleic Acids Res (2010) 1.01

Disparity between Stokes radii of dextrans and proteins as determined by retention volume in gel permeation chromatography. Anal Chem (1983) 1.01

Site-specific probing of oxidative reactivity and telomerase function using 7,8-dihydro-8-oxoguanine in telomeric DNA. J Am Chem Soc (2002) 0.99

Rational drug design of G-quartet DNA as anti-cancer agents. Curr Pharm Des (2005) 0.96

Effect of O6-methylguanine on the stability of G-quadruplex DNA. J Am Chem Soc (2008) 0.94

Theoretical study of the guanine --> 6-thioguanine substitution in duplexes, triplexes, and tetraplexes. J Am Chem Soc (2004) 0.89

Human telomere quadruplex: refolding and selection of individual conformers via RNA/DNA chimeric editing. Biochemistry (2007) 0.89

8-methyl-2'-deoxyguanosine incorporation into parallel DNA quadruplex structures. Nucleic Acids Res (2005) 0.88

Effects of 8-methyl-2'-deoxyadenosine incorporation into quadruplex forming oligodeoxyribonucleotides. Bioorg Med Chem (2005) 0.86

Role of locked nucleic acid modified complementary strand in quadruplex/Watson-Crick duplex equilibrium. J Phys Chem B (2007) 0.85

8-Amino guanine accelerates tetramolecular G-quadruplex formation. Chem Commun (Camb) (2008) 0.85

Quadruplex structure of polyriboinosinic acid: dependence on alkali metal ion concentration, pH and temperature. J Phys Chem B (2008) 0.84

A new class of DNA quadruplexes formed by oligodeoxyribonucleotides containing a 3'-3' or 5'-5' inversion of polarity site. Chem Commun (Camb) (2005) 0.84

The use of gel chromatography for the determination of sizes and relative molecular masses of proteins. Interpretation of calibration curves in terms of gel-pore-size distribution. Biochem J (1987) 0.84

Structural transition of d(G4T4G4) from antiparallel to parallel G-quartet induced by divalent cations. Nucleic Acids Res Suppl (2001) 0.82

Inhibition of human immunodeficiency virus type 1 activity in vitro by a new self-stabilized oligonucleotide with guanosine-thymidine quadruplex motifs. J Virol (2002) 0.81

Sedimentation velocity ultracentrifugation analysis for hydrodynamic characterization of G-quadruplex structures. Methods Mol Biol (2010) 0.77

Articles by these authors

Stability and kinetics of G-quadruplex structures. Nucleic Acids Res (2008) 2.75

Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal. Nucleic Acids Res (2005) 2.57

Biophysical and biological properties of quadruplex oligodeoxyribonucleotides. Nucleic Acids Res (2003) 2.34

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer. Exp Mol Pathol (2009) 2.25

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther (2008) 1.89

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions. Proc Natl Acad Sci U S A (2003) 1.54

A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res (2008) 1.49

beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. J Biol Chem (2004) 1.39

Antiproliferative activity of G-quartet-forming oligonucleotides with backbone and sugar modifications. Biochemistry (2002) 1.36

Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1. Immunity (2008) 1.27

The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor. J Immunol (2009) 1.25

Tiny telomere DNA. Nucleic Acids Res (2002) 1.20

Hydration is a major determinant of the G-quadruplex stability and conformation of the human telomere 3' sequence of d(AG3(TTAG3)3). J Am Chem Soc (2010) 1.19

Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol Cancer Ther (2013) 1.19

Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation. J Transl Med (2012) 1.13

Characterization of a K+-induced conformational switch in a human telomeric DNA oligonucleotide using 2-aminopurine fluorescence. Biochemistry (2010) 1.10

Aldose reductase-catalyzed reduction of aldehyde phospholipids. J Biol Chem (2004) 1.10

Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2. Curr Drug Metab (2008) 1.09

Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists. Org Biomol Chem (2003) 1.08

The tail of the telomere. J Am Chem Soc (2008) 1.07

Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis. J Biol Chem (2003) 1.04

Ribosomal proteins Rps0 and Rps21 of Saccharomyces cerevisiae have overlapping functions in the maturation of the 3' end of 18S rRNA. Nucleic Acids Res (2003) 1.02

Structure and stability of higher-order human telomeric quadruplexes. J Am Chem Soc (2011) 1.02

Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence. Nucleic Acids Res (2010) 1.01

Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. J Biol Chem (2005) 1.01

The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications. Nucleic Acids Res (2003) 0.99

Molecular docking of intercalators and groove-binders to nucleic acids using Autodock and Surflex. J Chem Inf Model (2008) 0.98

Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries. Angew Chem Int Ed Engl (2003) 0.97

Potent inhibitors of LXXLL-based protein-protein interactions. Chembiochem (2005) 0.97

Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection. Nucleic Acids Res (2013) 0.97

Effect of O6-methylguanine on the stability of G-quadruplex DNA. J Am Chem Soc (2008) 0.94

Structure-function analyses of single nucleotide polymorphisms in human N-acetyltransferase 1. Drug Metab Rev (2008) 0.92

Restricted variable residues in the C-terminal segment of HIV-1 V3 loop regulate the molecular anatomy of CCR5 utilization. J Mol Biol (2005) 0.91

Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org Biomol Chem (2003) 0.90

Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities. J Med Chem (2007) 0.90

Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis. Mol Cell Biol (2014) 0.88

An integrated molecular dynamics (MD) and experimental study of higher order human telomeric quadruplexes. Biopolymers (2010) 0.88

Computational and experimental analyses of mammalian arylamine N-acetyltransferase structure and function. Drug Metab Dispos (2007) 0.87

Targeting the SUMO E2 conjugating enzyme Ubc9 interaction for anti-cancer drug design. Anticancer Agents Med Chem (2009) 0.87

Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds. J Med Chem (2005) 0.87

Alkaline proteinase inhibitor of Pseudomonas aeruginosa: a mutational and molecular dynamics study of the role of N-terminal residues in the inhibition of Pseudomonas alkaline proteinase. J Biol Chem (2003) 0.87

A new bisintercalating anthracycline with picomolar DNA binding affinity. J Med Chem (2005) 0.86

Polymorphism and resolution of oncogene promoter quadruplex-forming sequences. Org Biomol Chem (2011) 0.85

CCR5 interactions with the variable 3 loop of gp120. J Mol Model (2006) 0.84

Energetic basis of molecular recognition in a DNA aptamer. Biophys Chem (2006) 0.84

Structure-based drug design: from nucleic acid to membrane protein targets. Exp Mol Pathol (2009) 0.83

Understanding base-assisted desulfurization using a variety of disulfide-bridged peptides. Biopolymers (2003) 0.83

Not all G-quadruplexes are created equally: an investigation of the structural polymorphism of the c-Myc G-quadruplex-forming sequence and its interaction with the porphyrin TMPyP4. Org Biomol Chem (2012) 0.82

A short domain within Bcl-3 is responsible for its lymphocyte survival activity. Ann N Y Acad Sci (2002) 0.82

Critical role for polar residues in coupling leukotriene B4 binding to signal transduction in BLT1. J Biol Chem (2007) 0.81

Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds. Org Biomol Chem (2005) 0.80

Solution structure of the RBD1,2 domains from human nucleolin. J Biomol NMR (2010) 0.80

Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs. Org Biomol Chem (2006) 0.80

Importance of Sp1 consensus motifs in the MYCN promoter. Surgery (2002) 0.79

Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem (2005) 0.79

Determining the origin of the stabilization of DNA by 5-aminopropynylation of pyrimidines. Biochemistry (2005) 0.79

Calculation of hydrodynamic properties for G-quadruplex nucleic acid structures from in silico bead models. Top Curr Chem (2013) 0.79

An investigation of G-quadruplex structural polymorphism in the human telomere using a combined approach of hydrodynamic bead modeling and molecular dynamics simulation. J Phys Chem B (2014) 0.78

Structural features of the lysosomal hydrolase mannose 6-phosphate uncovering enzyme. Glycoconj J (2005) 0.78

Structural analysis of the DNA target site and its interaction with Mbp1. Org Biomol Chem (2009) 0.78

Prediction of noncovalent Drug/DNA interaction using computational docking models: studies with over 1350 launched drugs. Environ Mol Mutagen (2013) 0.77

A Discovery Funnel for Nucleic Acid Binding Drug Candidates. Drug Dev Res (2011) 0.77

Extraction, purification, and identification of yersiniabactin, the siderophore of Yersinia pestis. Curr Protoc Microbiol (2011) 0.76

Global structure-activity relationship model for nonmutagenic carcinogens using virtual ligand-protein interactions as model descriptors. Carcinogenesis (2012) 0.76

Discovery of novel triple helical DNA intercalators by an integrated virtual and actual screening platform. Nucleic Acids Res (2009) 0.76

Contribution of a single-turn alpha-helix to the conformational stability and activity of the alkaline proteinase inhibitor of Pseudomonas aeruginosa. Biochemistry (2005) 0.75

Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides. Org Biomol Chem (2004) 0.75

Synthesis and evaluation of a triplex-forming oligonucleotide-pyrrolobenzodiazepine conjugate. Bioconjug Chem (2004) 0.75

Development of chemokine receptor CXCR4 antagonists using bio-mimetic strategy. Adv Exp Med Biol (2009) 0.75

Evidence for the contribution of non-covalent steroid interactions between DNA and topoisomerase in the genotoxicity of steroids. Drug Chem Toxicol (2014) 0.75