Published in Nat Rev Cancer on June 09, 2011
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TGFβ signalling in context. Nat Rev Mol Cell Biol (2012) 8.08
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet (2012) 6.65
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature (2012) 5.23
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Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes. Nat Genet (2014) 2.91
BET domain co-regulators in obesity, inflammation and cancer. Nat Rev Cancer (2012) 2.80
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Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers. Nat Genet (2013) 2.15
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev (2013) 2.07
The spectrum of SWI/SNF mutations, ubiquitous in human cancers. PLoS One (2013) 2.00
Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules. Genome Res (2012) 1.95
RNA biomarkers associated with metastatic progression in prostate cancer: a multi-institutional high-throughput analysis of SChLAP1. Lancet Oncol (2014) 1.88
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol (2014) 1.87
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Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria. Am J Med Genet A (2013) 1.72
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers. Proc Natl Acad Sci U S A (2014) 1.71
Molecular genetics of clear-cell renal cell carcinoma. J Clin Oncol (2014) 1.65
Global Decrease of Histone H3K27 Acetylation in ZEB1-Induced Epithelial to Mesenchymal Transition in Lung Cancer Cells. Cancers (Basel) (2013) 1.65
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Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer. Nat Rev Genet (2013) 1.53
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nat Genet (2012) 1.51
Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability. Am J Hum Genet (2012) 1.51
An integrative genomics approach for identifying novel functional consequences of PBRM1 truncated mutations in clear cell renal cell carcinoma (ccRCC). BMC Genomics (2016) 1.46
Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. Nat Rev Cancer (2012) 1.45
Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma. PLoS One (2016) 1.44
A chemical probe toolbox for dissecting the cancer epigenome. Nat Rev Cancer (2017) 1.40
Neat1 is a p53-inducible lincRNA essential for transformation suppression. Genes Dev (2017) 1.39
Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in antiapoptotic and chromatin-remodeling genes. Blood (2012) 1.38
Advances in targeted therapies for hepatocellular carcinoma in the genomic era. Nat Rev Clin Oncol (2015) 1.33
Emerging signaling pathways in hepatocellular carcinoma. Liver Cancer (2012) 1.32
Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation. Mol Cell Biol (2014) 1.28
ISWI and CHD chromatin remodelers bind promoters but act in gene bodies. PLoS Genet (2013) 1.25
The emerging roles of ARID1A in tumor suppression. Cancer Biol Ther (2014) 1.21
Vulnerabilities of mutant SWI/SNF complexes in cancer. Cancer Cell (2014) 1.20
Cancer epigenetics drug discovery and development: the challenge of hitting the mark. J Clin Invest (2014) 1.20
Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. Genes Dev (2015) 1.17
A rationale to target the SWI/SNF complex for cancer therapy. Trends Genet (2014) 1.17
ARID1A mutations and PI3K/AKT pathway alterations in endometriosis and endometriosis-associated ovarian carcinomas. Int J Mol Sci (2013) 1.14
Decreased expression of the ARID1A gene is associated with poor prognosis in primary gastric cancer. PLoS One (2012) 1.12
Specific glycosylation of membrane proteins in epithelial ovarian cancer cell lines: glycan structures reflect gene expression and DNA methylation status. Mol Cell Proteomics (2014) 1.11
SWI/SNF complex in disorder: SWItching from malignancies to intellectual disability. Epigenetics (2012) 1.10
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nat Med (2015) 1.10
Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth. Cancer Genet (2014) 1.10
ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression. Genes Dev (2012) 1.10
Functional DNA demethylation is accompanied by chromatin accessibility. Nucleic Acids Res (2013) 1.09
PBRM1 and BAP1 as novel targets for renal cell carcinoma. Cancer J (2013) 1.07
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ARID1A expression loss in gastric cancer: pathway-dependent roles with and without Epstein-Barr virus infection and microsatellite instability. Virchows Arch (2012) 1.06
Long noncoding RNAs in cancer: from function to translation. Trends Cancer (2015) 1.06
Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart. Circ Res (2012) 1.06
Chromatin as an oxygen sensor and active player in the hypoxia response. Cell Signal (2011) 1.05
miR-320c regulates gemcitabine-resistance in pancreatic cancer via SMARCC1. Br J Cancer (2013) 1.05
ARID1A loss correlates with mismatch repair deficiency and intact p53 expression in high-grade endometrial carcinomas. Mod Pathol (2013) 1.04
Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition. Oncotarget (2014) 1.03
Epigenetic changes in pediatric solid tumors: promising new targets. Clin Cancer Res (2012) 1.03
SWI/SNF chromatin remodeling complexes and cancer. Am J Med Genet C Semin Med Genet (2014) 1.03
Caught in the act: covalent cross-linking captures activator-coactivator interactions in vivo. ACS Chem Biol (2011) 1.02
Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair. Proc Natl Acad Sci U S A (2013) 1.02
New perspectives on molecular targeted therapy in ovarian clear cell carcinoma. Br J Cancer (2013) 1.02
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids. Nat Commun (2014) 1.02
Selective inhibitors of protein methyltransferases. J Med Chem (2014) 1.01
ANGUSTIFOLIA3 binds to SWI/SNF chromatin remodeling complexes to regulate transcription during Arabidopsis leaf development. Plant Cell (2014) 1.01
Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes. Nat Commun (2014) 1.00
The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer. EMBO Mol Med (2012) 1.00
The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies. Cancer Res (2015) 0.99
Multifaceted role of EZH2 in breast and prostate tumorigenesis: epigenetics and beyond. Epigenetics (2013) 0.99
Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators. Gastroenterology (2013) 0.98
Driver mutations of cancer epigenomes. Protein Cell (2014) 0.98
Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines. Nucleic Acids Res (2014) 0.98
Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. J Biol Chem (2013) 0.98
Tissue-specific SMARCA4 binding at active and repressed regulatory elements during embryogenesis. Genome Res (2014) 0.97
Essential role of ARID2 protein-containing SWI/SNF complex in tissue-specific gene expression. J Biol Chem (2011) 0.97
Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes Dev (2015) 0.96
Long non-coding RNAs and their implications in cancer epigenetics. Biosci Rep (2013) 0.95
Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-κB RelA/p50 heterodimer. J Biol Chem (2012) 0.95
ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors. Cancer Discov (2015) 0.95
Targeting EZH2 and PRC2 dependence as novel anticancer therapy. Exp Hematol (2015) 0.95
Molecular homology and difference between spontaneous canine mammary cancer and human breast cancer. Cancer Res (2014) 0.95
The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine. Development (2013) 0.94
SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies. Proc Natl Acad Sci U S A (2015) 0.94
Aberrant BAF57 signaling facilitates prometastatic phenotypes. Clin Cancer Res (2013) 0.94
Exome sequencing unravels unexpected differential diagnoses in individuals with the tentative diagnosis of Coffin-Siris and Nicolaides-Baraitser syndromes. Hum Genet (2015) 0.94
Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes. Nucleic Acids Res (2013) 0.93
ARID1B, a member of the human SWI/SNF chromatin remodeling complex, exhibits tumour-suppressor activities in pancreatic cancer cell lines. Br J Cancer (2013) 0.93
BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization. Cancer Res (2014) 0.93
Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression. Cell Cycle (2016) 0.93
Role of nucleosome remodeling in neurodevelopmental and intellectual disability disorders. Front Behav Neurosci (2015) 0.93
The role of the double bromodomain-containing BET genes during mammalian spermatogenesis. Curr Top Dev Biol (2013) 0.92
Nuclear shape changes are induced by knockdown of the SWI/SNF ATPase BRG1 and are independent of cytoskeletal connections. PLoS One (2013) 0.92
Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes. PLoS Genet (2015) 0.92
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell (2010) 2.80
Metagene projection for cross-platform, cross-species characterization of global transcriptional states. Proc Natl Acad Sci U S A (2007) 2.60
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. J Clin Invest (2012) 2.42
Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation. Proc Natl Acad Sci U S A (2005) 1.96
Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex. Cancer Res (2009) 1.82
ARID1A mutations in cancer: another epigenetic tumor suppressor? Cancer Discov (2012) 1.81
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway. Nat Med (2010) 1.77
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers. Proc Natl Acad Sci U S A (2014) 1.71
Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters. Proc Natl Acad Sci U S A (2013) 1.60
The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors. Cancer Res (2002) 1.51
SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity. Mol Biol Cell (2009) 1.41
Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability. Mol Cell Biol (2008) 1.36
Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation. Mol Cell Biol (2014) 1.28
Epigenetics and cancer without genomic instability. Cell Cycle (2009) 1.14
TCR-dependent transformation of mature memory phenotype T cells in mice. J Clin Invest (2011) 1.13
Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights. Clin Cancer Res (2013) 1.07
Epigenetics and cancer: altered chromatin remodeling via Snf5 loss leads to aberrant cell cycle regulation. Cell Cycle (2006) 1.06
The SWI/SNF tumor suppressor complex: Regulation of promoter nucleosomes and beyond. Nucleus (2013) 0.88
Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors. Cell Cycle (2012) 0.88
Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors. Pediatr Blood Cancer (2012) 0.87
Tumor-specific cooperation of retinoblastoma protein family and Snf5 inactivation. Cancer Res (2007) 0.87
Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors. PLoS One (2013) 0.86
Linking the SWI/SNF complex to prostate cancer. Nat Genet (2013) 0.81
Inactivation of SNF5 cooperates with p53 loss to accelerate tumor formation in Snf5(+/-);p53(+/-) mice. Mol Carcinog (2009) 0.81
Rhabdoid tumors: an initial clue to the role of chromatin remodeling in cancer. Brain Pathol (2013) 0.81
CHD7 in charge of neurogenesis. Cell Stem Cell (2013) 0.76
Cancer-fighting Smurf. Nat Med (2012) 0.75
Establishment and characterization of MRT cell lines from genetically engineered mouse models and the influence of genetic background on their development. Int J Cancer (2012) 0.75
Erratum: PGBD5 promotes site-specific oncogenic mutations in human tumors. Nat Genet (2017) 0.75