Published in Front Microbiol on February 11, 2011
Global fluoroquinolone resistance epidemiology and implictions for clinical use. Interdiscip Perspect Infect Dis (2012) 1.55
Origin and evolution of antibiotic resistance: the common mechanisms of emergence and spread in water bodies. Front Microbiol (2012) 1.15
Distribution of quinolones, sulfonamides, tetracyclines in aquatic environment and antibiotic resistance in indochina. Front Microbiol (2012) 1.15
Plasmid-mediated quinolone resistance. Microbiol Spectr (2014) 1.13
RND multidrug efflux pumps: what are they good for? Front Microbiol (2013) 1.11
Contribution of phenotypic heterogeneity to adaptive antibiotic resistance. Proc Natl Acad Sci U S A (2013) 1.07
Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus. BMC Microbiol (2011) 1.04
Plasmid-mediated quinolone resistance genes and antibiotic residues in wastewater and soil adjacent to swine feedlots: potential transfer to agricultural lands. Environ Health Perspect (2012) 0.96
Multidrug Efflux Pumps in Staphylococcus aureus: an Update. Open Microbiol J (2013) 0.95
A function of SmeDEF, the major quinolone resistance determinant of Stenotrophomonas maltophilia, is the colonization of plant roots. Appl Environ Microbiol (2014) 0.93
Emergence and spread of antibiotic resistance: setting a parameter space. Ups J Med Sci (2014) 0.90
Presence of multi-drug resistant pathogenic Escherichia coli in the San Pedro River located in the State of Aguascalientes, Mexico. Front Microbiol (2013) 0.87
Characterizations of clinical isolates of clostridium difficile by toxin genotypes and by susceptibility to 12 antimicrobial agents, including fidaxomicin (OPT-80) and rifaximin: a multicenter study in Taiwan. Antimicrob Agents Chemother (2012) 0.86
Antibiotic resistance determinants in a Pseudomonas putida strain isolated from a hospital. PLoS One (2014) 0.84
MLST genotypes and antibiotic resistance of Campylobacter spp. isolated from poultry in Grenada. Biomed Res Int (2013) 0.82
Emergence and Diversity of Salmonella enterica Serovar Indiana Isolates with Concurrent Resistance to Ciprofloxacin and Cefotaxime from Patients and Food-Producing Animals in China. Antimicrob Agents Chemother (2016) 0.81
Differential epigenetic compatibility of qnr antibiotic resistance determinants with the chromosome of Escherichia coli. PLoS One (2012) 0.78
Multidrug Efflux Pumps at the Crossroad between Antibiotic Resistance and Bacterial Virulence. Front Microbiol (2016) 0.78
Prevalence of Salmonella Isolates from Chicken and Pig Slaughterhouses and Emergence of Ciprofloxacin and Cefotaxime Co-Resistant S. enterica Serovar Indiana in Henan, China. PLoS One (2015) 0.77
The inactivation of RNase G reduces the Stenotrophomonas maltophilia susceptibility to quinolones by triggering the heat shock response. Front Microbiol (2015) 0.76
Low-Concentration Ciprofloxacin Selects Plasmid-Mediated Quinolone Resistance Encoding Genes and Affects Bacterial Taxa in Soil Containing Manure. Front Microbiol (2016) 0.75
Predicting antibiotic resistance, not just for quinolones. Front Microbiol (2011) 0.75
Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus. BMC Microbiol (2015) 0.75
The Soil as a Source of Microorganisms Antagonistic to Disease-Producing Bacteria. J Bacteriol (1940) 12.56
Quinolone resistance from a transferable plasmid. Lancet (1998) 11.28
DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev (1997) 9.69
Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones. Mol Microbiol (1994) 7.89
Inactivation of antibiotics and the dissemination of resistance genes. Science (1994) 7.89
Mechanism of plasmid-mediated quinolone resistance. Proc Natl Acad Sci U S A (2002) 7.76
Sampling the antibiotic resistome. Science (2006) 7.27
Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat Med (2005) 7.15
Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China. Antimicrob Agents Chemother (2003) 6.26
Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15. Emerg Infect Dis (2008) 6.21
qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob Agents Chemother (2006) 5.50
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc Natl Acad Sci U S A (1973) 5.20
Multidrug-resistance efflux pumps - not just for resistance. Nat Rev Microbiol (2006) 5.18
Cross-resistance to fluoroquinolones in multiple-antibiotic-resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes in addition to OmpF reduction. Antimicrob Agents Chemother (1989) 5.09
Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin. Antimicrob Agents Chemother (1994) 4.87
Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev (2006) 4.77
Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b. Antimicrob Agents Chemother (2005) 4.74
Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae. J Antimicrob Chemother (2005) 4.65
Plasmid-mediated quinolone resistance: a multifaceted threat. Clin Microbiol Rev (2009) 4.43
The antibiotic resistome: the nexus of chemical and genetic diversity. Nat Rev Microbiol (2007) 4.14
Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase. Antimicrob Agents Chemother (2005) 4.03
Mechanisms of resistance to quinolones. Clin Infect Dis (2005) 4.02
Antibiotic resistance caused by gram-negative multidrug efflux pumps. Clin Infect Dis (1998) 3.85
Antibiotics and antibiotic resistance genes in natural environments. Science (2008) 3.77
Heavy use of prophylactic antibiotics in aquaculture: a growing problem for human and animal health and for the environment. Environ Microbiol (2006) 3.43
New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Antimicrob Agents Chemother (2007) 3.33
Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments. Int J Antimicrob Agents (2005) 3.29
Mutation frequencies and antibiotic resistance. Antimicrob Agents Chemother (2000) 3.27
Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria. Antimicrob Agents Chemother (2000) 3.22
Origin of plasmid-mediated quinolone resistance determinant QnrA. Antimicrob Agents Chemother (2005) 3.18
Mechanism of quinolone inhibition of DNA gyrase. Appearance of unique norfloxacin binding sites in enzyme-DNA complexes. J Biol Chem (1989) 3.00
qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. Antimicrob Agents Chemother (2008) 3.00
Regulation of bacterial drug export systems. Microbiol Mol Biol Rev (2002) 3.00
Antibiotics and antibiotic resistance in water environments. Curr Opin Biotechnol (2008) 2.96
In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM. Antimicrob Agents Chemother (1999) 2.90
Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria. FASEB J (1998) 2.53
New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Antimicrob Agents Chemother (2009) 2.32
Predicting antibiotic resistance. Nat Rev Microbiol (2007) 2.28
Vibrionaceae as a possible source of Qnr-like quinolone resistance determinants. J Antimicrob Chemother (2005) 2.17
Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2000) 2.17
Multiple antibiotic resistance in Stenotrophomonas maltophilia. Antimicrob Agents Chemother (1997) 2.13
Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrob Agents Chemother (2000) 2.07
Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp. Emerg Infect Dis (2008) 2.05
Plasmid-encoded multidrug efflux pump conferring resistance to olaquindox in Escherichia coli. Antimicrob Agents Chemother (2004) 2.03
Intrinsic resistance of Mycobacterium smegmatis to fluoroquinolones may be influenced by new pentapeptide protein MfpA. Antimicrob Agents Chemother (2001) 2.02
Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli. J Bacteriol (2008) 2.01
The mechanism of inhibition of topoisomerase IV by quinolone antibacterials. J Biol Chem (1998) 1.96
Mechanisms of fluoroquinolone resistance: an update 1994-1998. Drugs (1999) 1.91
Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria. J Antimicrob Chemother (2007) 1.85
A global view of antibiotic resistance. FEMS Microbiol Rev (2008) 1.83
The neglected intrinsic resistome of bacterial pathogens. PLoS One (2008) 1.82
Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems. FEMS Microbiol Rev (2009) 1.79
Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. Antimicrob Agents Chemother (2007) 1.78
Plasmid-mediated 4-quinolone resistance: a real or apparent absence? Antimicrob Agents Chemother (1990) 1.75
The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibition. J Mol Biol (2001) 1.74
Environmental and clinical isolates of Pseudomonas aeruginosa show pathogenic and biodegradative properties irrespective of their origin. Environ Microbiol (1999) 1.71
Pentapeptide repeat proteins. Biochemistry (2006) 1.68
Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility. Antimicrob Agents Chemother (2008) 1.67
Plasmids of the same Inc groups in Enterobacteria before and after the medical use of antibiotics. Nature (1984) 1.65
Multidrug efflux pumps and resistance: regulation and evolution. Curr Opin Microbiol (2003) 1.63
Viridans group streptococci are donors in horizontal transfer of topoisomerase IV genes to Streptococcus pneumoniae. Antimicrob Agents Chemother (2003) 1.62
Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants. BMC Microbiol (2008) 1.59
The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis. Mol Med (2002) 1.58
Expression of multidrug efflux pump SmeDEF by clinical isolates of Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2001) 1.53
Horizontal transfer of parC and gyrA in fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother (2000) 1.52
Antibiotic preparations contain DNA: a source of drug resistance genes? Antimicrob Agents Chemother (1993) 1.41
Relative contributions of the AcrAB, MdfA and NorE efflux pumps to quinolone resistance in Escherichia coli. J Antimicrob Chemother (2003) 1.38
Surveillance for plasmid-mediated quinolone resistance determinants in Enterobacteriaceae within the Calgary Health Region, Canada: the emergence of aac(6')-Ib-cr. J Antimicrob Chemother (2008) 1.38
NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus. Antimicrob Agents Chemother (2006) 1.37
Changes in qnr prevalence and fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 to 2005. Antimicrob Agents Chemother (2007) 1.37
Role of a qnr-like gene in the intrinsic resistance of Enterococcus faecalis to fluoroquinolones. Antimicrob Agents Chemother (2007) 1.36
Qnr-like pentapeptide repeat proteins in gram-positive bacteria. J Antimicrob Chemother (2008) 1.36
Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics. Antimicrob Agents Chemother (2010) 1.35
Genetic environment of quinolone resistance gene qnrB2 in a complex sul1-type integron in the newly described Salmonella enterica serovar Keurmassar. Antimicrob Agents Chemother (2006) 1.34
Quinolone generations: natural history or natural selection? J Antimicrob Chemother (2000) 1.32
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1. Antimicrob Agents Chemother (2007) 1.31
Contribution of gentamicin 2'-N-acetyltransferase to the O acetylation of peptidoglycan in Providencia stuartii. J Bacteriol (1995) 1.26
Plasmid-mediated quinolone resistance in Aeromonas allosaccharophila recovered from a Swiss lake. J Antimicrob Chemother (2008) 1.25
Stenotrophomonas maltophilia drug resistance. Future Microbiol (2009) 1.22
Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2008) 1.18
Origins, acquisition and dissemination of antibiotic resistance determinants. Ciba Found Symp (1997) 1.14
Quinolone resistance by mutations in chromosomal gyrase genes. Just the tip of the iceberg? J Antimicrob Chemother (1998) 1.12
SmQnr contributes to intrinsic resistance to quinolones in Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2009) 1.09
Efflux-mediated resistance to fluoroquinolones in gram-positive bacteria and the mycobacteria. Antimicrob Agents Chemother (2000) 1.07
Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 beta-lactamase. Clin Microbiol Infect (2006) 1.07
Preservation of topoisomerase genetic sequences during in vivo and in vitro development of high-level resistance to ciprofloxacin in isogenic Stenotrophomonas maltophilia strains. J Antimicrob Chemother (2005) 1.02
Clinical impact of the over-expression of efflux pump in nonfermentative Gram-negative bacilli, development of efflux pump inhibitors. Curr Drug Targets (2008) 0.96
Mutations in gyrA and parC QRDRs are not relevant for quinolone resistance in epidemiological unrelated Stenotrophomonas maltophilia clinical isolates. Microb Drug Resist (2002) 0.94
In vitro plasmid-encoded resistance to quinolones. FEMS Microbiol Lett (1997) 0.93
Development of resistance to ofloxacin. Drugs (1987) 0.90
The chromosomal 2'-N-acetyltransferase of Providencia stuartii: physiological functions and genetic regulation. Front Biosci (1999) 0.88
Towards an ecological approach to antibiotics and antibiotic resistance genes. Clin Microbiol Infect (2009) 0.83
[Preferences for oral anticoagulant treatment in the medium and long term prevention of stroke in non valvular atrial fibrillation]. Rev Neurol (2012) 1.95
The neglected intrinsic resistome of bacterial pathogens. PLoS One (2008) 1.82
Proposal and validation of a new functional ambulation classification scale for clinical use. Arch Phys Med Rehabil (2005) 1.79
Antibiotics as signals that trigger specific bacterial responses. Curr Opin Microbiol (2008) 1.73
Fitness of in vitro selected Pseudomonas aeruginosa nalB and nfxB multidrug resistant mutants. J Antimicrob Chemother (2002) 1.65
Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants. BMC Microbiol (2008) 1.59
Whole-genome sequence of Stenotrophomonas maltophilia D457, a clinical isolate and a model strain. J Bacteriol (2012) 1.16
The binding of triclosan to SmeT, the repressor of the multidrug efflux pump SmeDEF, induces antibiotic resistance in Stenotrophomonas maltophilia. PLoS Pathog (2011) 1.12
RND multidrug efflux pumps: what are they good for? Front Microbiol (2013) 1.11
SmQnr contributes to intrinsic resistance to quinolones in Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2009) 1.09
The global regulator Crc modulates metabolism, susceptibility to antibiotics and virulence in Pseudomonas aeruginosa. Environ Microbiol (2010) 1.04
Structural and functional analysis of SmeT, the repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF. J Biol Chem (2009) 1.03
Transcriptional regulation of mexR, the repressor of Pseudomonas aeruginosa mexAB-oprM multidrug efflux pump. FEMS Microbiol Lett (2002) 1.02
Walking recovery after an acute stroke: assessment with a new functional classification and the Barthel Index. Arch Phys Med Rehabil (2005) 0.99
Lack of main K+ uptake systems in Saccharomyces cerevisiae cells affects yeast performance in both potassium-sufficient and potassium-limiting conditions. FEMS Yeast Res (2010) 0.94
Experimental validation of Haldane's hypothesis on the role of infection as an evolutionary force for Metazoans. Proc Natl Acad Sci U S A (2007) 0.92
Differential interactions within the Caenorhabditis elegans-Pseudomonas aeruginosa pathogenesis model. J Theor Biol (2003) 0.91
Analysis of a novel calcium auxotrophy in Aspergillus nidulans. Fungal Genet Biol (2010) 0.91
Different expression systems for production of recombinant proteins in Saccharomyces cerevisiae. Biotechnol Bioeng (2012) 0.90
Recent advances in the potential interconnection between antimicrobial resistance to biocides and antibiotics. Expert Rev Anti Infect Ther (2013) 0.88
Differentiation between protective reflexes: cardiac defense and startle. Psychophysiology (2005) 0.86
Ref2, a regulatory subunit of the yeast protein phosphatase 1, is a novel component of cation homoeostasis. Biochem J (2010) 0.83
The DSF quorum sensing system controls the positive influence of Stenotrophomonas maltophilia on plants. PLoS One (2013) 0.82
The Inactivation of intrinsic antibiotic resistance determinants widens the mutant selection window for quinolones in Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2012) 0.80
Correlation of cell growth and heterologous protein production by Saccharomyces cerevisiae. Appl Microbiol Biotechnol (2013) 0.79
The efflux pump inhibitor Phe-Arg-beta-naphthylamide does not abolish the activity of the Stenotrophomonas maltophilia SmeDEF multidrug efflux pump. J Antimicrob Chemother (2003) 0.79
Differential epigenetic compatibility of qnr antibiotic resistance determinants with the chromosome of Escherichia coli. PLoS One (2012) 0.78
Oxidative stress sensitivity in Debaryomyces hansenii. FEMS Yeast Res (2009) 0.77
Are nonlethal targets useful for developing novel antimicrobials? Future Microbiol (2011) 0.76
A new look at cardiac defense: attention or emotion? Span J Psychol (2003) 0.75
[Grampositive pathogen clonal diversification and evolution: new perspectives in the XXI century]. Enferm Infecc Microbiol Clin (2010) 0.75
Identification of Atlantic hake species by a simple PCR-based methodology employing microsatellite loci. J Food Prot (2003) 0.75