The binding of triclosan to SmeT, the repressor of the multidrug efflux pump SmeDEF, induces antibiotic resistance in Stenotrophomonas maltophilia.

PubWeight™: 1.12‹?› | Rank: Top 10%

🔗 View Article (PMC 3128119)

Published in PLoS Pathog on June 30, 2011

Authors

Alvaro Hernández1, Federico M Ruiz, Antonio Romero, José L Martínez

Author Affiliations

1: Centro Nacional del Biotecnología, CSIC, Cantoblanco, Madrid, Spain.

Articles citing this

The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria. Clin Microbiol Rev (2015) 1.81

Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance. Clin Microbiol Rev (2012) 1.74

Evaluation of reduced susceptibility to quaternary ammonium compounds and bisbiguanides in clinical isolates and laboratory-generated mutants of Staphylococcus aureus. Antimicrob Agents Chemother (2013) 1.20

Whole-genome sequence of Stenotrophomonas maltophilia D457, a clinical isolate and a model strain. J Bacteriol (2012) 1.16

Origin and evolution of antibiotic resistance: the common mechanisms of emergence and spread in water bodies. Front Microbiol (2012) 1.15

The TetR family of regulators. Microbiol Mol Biol Rev (2013) 1.14

RND multidrug efflux pumps: what are they good for? Front Microbiol (2013) 1.11

The intrinsic resistome of bacterial pathogens. Front Microbiol (2013) 1.05

The impact of triclosan on the spread of antibiotic resistance in the environment. Front Microbiol (2015) 1.04

Friends or foes: can we make a distinction between beneficial and harmful strains of the Stenotrophomonas maltophilia complex? Front Microbiol (2015) 0.97

Antibiotic resistance in the opportunistic pathogen Stenotrophomonas maltophilia. Front Microbiol (2015) 0.94

A function of SmeDEF, the major quinolone resistance determinant of Stenotrophomonas maltophilia, is the colonization of plant roots. Appl Environ Microbiol (2014) 0.93

Metabolic compensation of fitness costs associated with overexpression of the multidrug efflux pump MexEF-OprN in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2014) 0.92

Emergence and spread of antibiotic resistance: setting a parameter space. Ups J Med Sci (2014) 0.90

The use of machine learning methodologies to analyse antibiotic and biocide susceptibility in Staphylococcus aureus. PLoS One (2013) 0.89

Analysis of triclosan-selected Salmonella enterica mutants of eight serovars revealed increased aminoglycoside susceptibility and reduced growth rates. PLoS One (2013) 0.84

Infections Caused by Stenotrophomonas maltophilia in Recipients of Hematopoietic Stem Cell Transplantation. Front Oncol (2014) 0.83

Phenotypic Resistance to Antibiotics. Antibiotics (Basel) (2013) 0.80

Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants. Microorganisms (2016) 0.79

Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus. Curr Pharm Des (2015) 0.78

Co-Selection of Resistance to Antibiotics, Biocides and Heavy Metals, and Its Relevance to Foodborne Pathogens. Antibiotics (Basel) (2015) 0.77

Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression. BMC Genomics (2015) 0.76

Importance of sigma factor mutations in increased triclosan resistance in Salmonella Typhimurium. BMC Microbiol (2015) 0.76

Vitamin K3 Induces the Expression of the Stenotrophomonas maltophilia SmeVWX Multidrug Efflux Pump. Antimicrob Agents Chemother (2017) 0.75

Predictive Studies Suggest that the Risk for the Selection of Antibiotic Resistance by Biocides Is Likely Low in Stenotrophomonas maltophilia. PLoS One (2015) 0.75

Functional Insights into the Mode of DNA and Ligand Binding of the TetR Family Regulator TylP from Streptomyces fradiae. J Biol Chem (2017) 0.75

Metabolic Compensation of Fitness Costs Is a General Outcome for Antibiotic-Resistant Pseudomonas aeruginosa Mutants Overexpressing Efflux Pumps. MBio (2017) 0.75

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46

MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36

Inference of macromolecular assemblies from crystalline state. J Mol Biol (2007) 44.95

The integration of macromolecular diffraction data. Acta Crystallogr D Biol Crystallogr (2005) 19.21

CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues. Nucleic Acids Res (2006) 9.19

The TetR family of transcriptional repressors. Microbiol Mol Biol Rev (2005) 6.02

The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants. Genome Biol (2008) 3.85

Structural mechanisms of QacR induction and multidrug recognition. Science (2001) 3.10

The versatility and adaptation of bacteria from the genus Stenotrophomonas. Nat Rev Microbiol (2009) 3.00

Regulation of bacterial drug export systems. Microbiol Mol Biol Rev (2002) 3.00

Stenotrophomonas maltophilia: an emerging opportunist human pathogen. Lancet Infect Dis (2009) 2.61

Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR. EMBO J (2002) 2.53

The rhizosphere as a reservoir for opportunistic human pathogenic bacteria. Environ Microbiol (2005) 2.42

Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ. Antimicrob Agents Chemother (2001) 2.27

Overexpression of marA, soxS, or acrAB produces resistance to triclosan in laboratory and clinical strains of Escherichia coli. FEMS Microbiol Lett (1998) 2.24

Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2000) 2.17

Multiple antibiotic resistance in Stenotrophomonas maltophilia. Antimicrob Agents Chemother (1997) 2.13

Triclosan: applications and safety. Am J Infect Control (1996) 2.11

Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1997) 2.06

Crystal structure of the transcription activator BmrR bound to DNA and a drug. Nature (2001) 1.90

Antibacterial household products: cause for concern. Emerg Infect Dis (2001) 1.85

Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems. FEMS Microbiol Rev (2009) 1.79

Consumer antibacterial soaps: effective or just risky? Clin Infect Dis (2007) 1.70

Expanding the model: anisotropic displacement parameters in protein structure refinement. Acta Crystallogr D Biol Crystallogr (1999) 1.69

Paradigm lost, paradigm found: the re-emergence of hormesis as a fundamental dose response model in the toxicological sciences. Environ Pollut (2005) 1.62

SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2002) 1.60

Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants. BMC Microbiol (2008) 1.59

Crystal structures of multidrug binding protein TtgR in complex with antibiotics and plant antimicrobials. J Mol Biol (2007) 1.55

Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistance. J Mol Biol (2004) 1.54

Triclosan: a review of effectiveness and safety in health care settings. Am J Infect Control (2000) 1.54

Expression of multidrug efflux pump SmeDEF by clinical isolates of Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2001) 1.53

SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2001) 1.45

Crystal structure of a gamma-butyrolactone autoregulator receptor protein in Streptomyces coelicolor A3(2). J Mol Biol (2004) 1.44

Triclosan and antimicrobial resistance in bacteria: an overview. Microb Drug Resist (2006) 1.43

Emergence of multidrug-resistant mutants is increased under antibiotic selective pressure in Pseudomonas aeruginosa. Microbiology (1999) 1.38

Antibacterial cleaning and hygiene products as an emerging risk factor for antibiotic resistance in the community. Lancet Infect Dis (2003) 1.37

Attributable mortality of Stenotrophomonas maltophilia infections: a systematic review of the literature. Future Microbiol (2009) 1.34

Cloning and characterization of SmeT, a repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF. Antimicrob Agents Chemother (2002) 1.34

Antibiotic-dependent induction of Pseudomonas putida DOT-T1E TtgABC efflux pump is mediated by the drug binding repressor TtgR. Antimicrob Agents Chemother (2003) 1.34

Crystal structure of the transcriptional regulator CmeR from Campylobacter jejuni. J Mol Biol (2007) 1.28

Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2006) 1.22

SmeDEF-mediated antimicrobial drug resistance in Stenotrophomonas maltophilia clinical isolates having defined phylogenetic relationships. J Antimicrob Chemother (2006) 1.22

Stenotrophomonas maltophilia drug resistance. Future Microbiol (2009) 1.22

Crystal structure of the transcriptional regulator AcrR from Escherichia coli. J Mol Biol (2007) 1.21

Differential regulation of L1 and L2 beta-lactamase expression in Stenotrophomonas maltophilia. J Antimicrob Chemother (2002) 1.19

Does microbial resistance or adaptation to biocides create a hazard in infection prevention and control? J Hosp Infect (2010) 1.19

Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2008) 1.18

The biocide triclosan selects Stenotrophomonas maltophilia mutants that overproduce the SmeDEF multidrug efflux pump. Antimicrob Agents Chemother (2005) 1.17

Induction of L1 and L2 beta-lactamase production in Stenotrophomonas maltophilia is dependent on an AmpR-type regulator. Antimicrob Agents Chemother (2008) 1.14

Overexpression of the multidrug efflux pump SmeDEF impairs Stenotrophomonas maltophilia physiology. J Antimicrob Chemother (2004) 1.14

Polymorphic mutation frequencies of clinical and environmental Stenotrophomonas maltophilia populations. Appl Environ Microbiol (2010) 1.14

Stenotrophomonas maltophilia bacteremia in adults: four years' experience in a medical center in northern Taiwan. J Microbiol Immunol Infect (2004) 1.13

SmQnr contributes to intrinsic resistance to quinolones in Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2009) 1.09

Emerging pathogens in cystic fibrosis: ten years of follow-up in a cohort of patients. Eur J Clin Microbiol Infect Dis (2008) 1.07

Inactivation of the Pseudomonas putida cytochrome o ubiquinol oxidase leads to a significant change in the transcriptome and to increased expression of the CIO and cbb3-1 terminal oxidases. Environ Microbiol (2006) 1.06

Regulatory regions of smeDEF in Stenotrophomonas maltophilia strains expressing different amounts of the multidrug efflux pump SmeDEF. Antimicrob Agents Chemother (2004) 1.05

Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA. J Mol Biol (2008) 1.05

Differential selection of multidrug efflux mutants by trovafloxacin and ciprofloxacin in an experimental model of Pseudomonas aeruginosa acute pneumonia in rats. Antimicrob Agents Chemother (2001) 1.05

Multidrug-binding transcription factor QacR binds the bivalent aromatic diamidines DB75 and DB359 in multiple positions. J Am Chem Soc (2007) 1.04

Antimicrobial mortar surfaces for the improvement of hygienic conditions. J Appl Microbiol (2010) 1.04

Persistence and variability of Stenotrophomonas maltophilia in cystic fibrosis patients, Madrid, 1991-1998. Emerg Infect Dis (2001) 1.04

Structural and functional analysis of SmeT, the repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF. J Biol Chem (2009) 1.03

Active efflux, a common mechanism for biocide and antibiotic resistance. Symp Ser Soc Appl Microbiol (2002) 1.01

Contribution of integrons, and SmeABC and SmeDEF efflux pumps to multidrug resistance in clinical isolates of Stenotrophomonas maltophilia. J Antimicrob Chemother (2004) 1.01

Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. Antimicrob Agents Chemother (2009) 1.00

Slow-tight-binding inhibition of enoyl-acyl carrier protein reductase from Plasmodium falciparum by triclosan. Biochem J (2004) 0.98

Clinical significance of overexpression of multiple RND-family efflux pumps in Bacteroides fragilis isolates. J Antimicrob Chemother (2006) 0.97

Exposure of Escherichia coli and Salmonella enterica serovar Typhimurium to triclosan induces a species-specific response, including drug detoxification. J Antimicrob Chemother (2009) 0.97

A molecular biological protocol to distinguish potentially human pathogenic Stenotrophomonas maltophilia from plant-associated Stenotrophomonas rhizophila. Environ Microbiol (2005) 0.97

Clinical impact of the over-expression of efflux pump in nonfermentative Gram-negative bacilli, development of efflux pump inhibitors. Curr Drug Targets (2008) 0.96

Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in Staphylococcus epidermidis. Nucleic Acids Res (2008) 0.96

Triclosan-tolerant bacteria: changes in susceptibility to antibiotics. J Hosp Infect (2009) 0.94

Stenotrophomonas maltophilia endocarditis. Scand J Infect Dis (2002) 0.93

Optimization of the palindromic order of the TtgR operator enhances binding cooperativity. J Mol Biol (2007) 0.92

Evaluation of the antibacterial effect of a triclosan-containing floor used in the food industry. J Food Prot (2006) 0.91

Stenotrophomonas maltophilia pneumonia in cancer patients without traditional risk factors for infection, 1997-2004. Eur J Clin Microbiol Infect Dis (2007) 0.89

MD recognition by MDR gene regulators. Curr Opin Struct Biol (2010) 0.84

Antimicrobial effect of four different toothpastes. Scand J Dent Res (1976) 0.76

Articles by these authors

[Preferences for oral anticoagulant treatment in the medium and long term prevention of stroke in non valvular atrial fibrillation]. Rev Neurol (2012) 1.95

A conformational switch between transcriptional repression and replication initiation in the RepA dimerization domain. Nat Struct Biol (2003) 1.83

The neglected intrinsic resistome of bacterial pathogens. PLoS One (2008) 1.82

Proposal and validation of a new functional ambulation classification scale for clinical use. Arch Phys Med Rehabil (2005) 1.79

Antibiotics as signals that trigger specific bacterial responses. Curr Opin Microbiol (2008) 1.73

Fitness of in vitro selected Pseudomonas aeruginosa nalB and nfxB multidrug resistant mutants. J Antimicrob Chemother (2002) 1.65

Crystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of carbapenem hydrolysis. Proc Natl Acad Sci U S A (2007) 1.63

Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants. BMC Microbiol (2008) 1.59

Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding. J Mol Biol (2004) 1.57

From lectin structure to functional glycomics: principles of the sugar code. Trends Biochem Sci (2011) 1.46

Crystal structure of the 14-subunit RNA polymerase I. Nature (2013) 1.40

Characteristics of sudden death in inherited heart disease. Rev Esp Cardiol (2010) 1.39

Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. J Biol Chem (2010) 1.36

Whole-genome sequence of Stenotrophomonas maltophilia D457, a clinical isolate and a model strain. J Bacteriol (2012) 1.16

Immunophenotype and gene expression profiles of cell surface markers of mesenchymal stem cells derived from equine bone marrow and adipose tissue. Vet Immunol Immunopathol (2011) 1.16

Quinolone resistance: much more than predicted. Front Microbiol (2011) 1.14

Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase. J Am Chem Soc (2010) 1.12

RND multidrug efflux pumps: what are they good for? Front Microbiol (2013) 1.11

Structure-function studies of arginine at position 276 in CTX-M beta-lactamases. J Antimicrob Chemother (2008) 1.10

SmQnr contributes to intrinsic resistance to quinolones in Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2009) 1.09

Variable number of tandem repeats of TNF receptor type 2 promoter as genetic biomarker of susceptibility to develop invasive pulmonary aspergillosis. Hum Immunol (2006) 1.06

Interleukin-10 promoter polymorphism as risk factor to develop invasive pulmonary aspergillosis. Immunol Lett (2007) 1.06

The global regulator Crc modulates metabolism, susceptibility to antibiotics and virulence in Pseudomonas aeruginosa. Environ Microbiol (2010) 1.04

Ligninolytic peroxidase genes in the oyster mushroom genome: heterologous expression, molecular structure, catalytic and stability properties, and lignin-degrading ability. Biotechnol Biofuels (2014) 1.04

Structural and functional analysis of SmeT, the repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF. J Biol Chem (2009) 1.03

Transcriptional regulation of mexR, the repressor of Pseudomonas aeruginosa mexAB-oprM multidrug efflux pump. FEMS Microbiol Lett (2002) 1.02

Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: a homologue of human PSA. J Mol Biol (2002) 1.01

Walking recovery after an acute stroke: assessment with a new functional classification and the Barthel Index. Arch Phys Med Rehabil (2005) 0.99

Two new crystal forms of the choline-binding domain of the major pneumococcal autolysin: insights into the dynamics of the active homodimer. J Mol Biol (2002) 0.98

Two oxidation sites for low redox potential substrates: a directed mutagenesis, kinetic, and crystallographic study on Pleurotus eryngii versatile peroxidase. J Biol Chem (2012) 0.97

Sperm coating mechanism from the 1.8 A crystal structure of PDC-109-phosphorylcholine complex. Structure (2002) 0.96

Mediterranean diet and bone mineral density in two age groups of women. Int J Food Sci Nutr (2012) 0.94

Sirolimus as part of immunosuppressive therapy for refractory chronic graft-versus-host disease. Biol Blood Marrow Transplant (2007) 0.94

Lack of main K+ uptake systems in Saccharomyces cerevisiae cells affects yeast performance in both potassium-sufficient and potassium-limiting conditions. FEMS Yeast Res (2010) 0.94

Site-directed mutagenesis of the catalytic tryptophan environment in Pleurotus eryngii versatile peroxidase. Biochemistry (2008) 0.94

Effect of transcriptional activators SoxS, RobA, and RamA on expression of multidrug efflux pump AcrAB-TolC in Enterobacter cloacae. Antimicrob Agents Chemother (2012) 0.92

Experimental validation of Haldane's hypothesis on the role of infection as an evolutionary force for Metazoans. Proc Natl Acad Sci U S A (2007) 0.92

Protein radicals in fungal versatile peroxidase: catalytic tryptophan radical in both compound I and compound II and studies on W164Y, W164H, and W164S variants. J Biol Chem (2009) 0.92

Analysis of a novel calcium auxotrophy in Aspergillus nidulans. Fungal Genet Biol (2010) 0.91

Differential interactions within the Caenorhabditis elegans-Pseudomonas aeruginosa pathogenesis model. J Theor Biol (2003) 0.91

Crystal structure of ovocleidin-17, a major protein of the calcified Gallus gallus eggshell: implications in the calcite mineral growth pattern. J Biol Chem (2004) 0.91

Different expression systems for production of recombinant proteins in Saccharomyces cerevisiae. Biotechnol Bioeng (2012) 0.90

Leads for development of new naphthalenesulfonate derivatives with enhanced antiangiogenic activity: crystal structure of acidic fibroblast growth factor in complex with 5-amino-2-naphthalene sulfonate. J Biol Chem (2003) 0.90

Novel structural features in the GMC family of oxidoreductases revealed by the crystal structure of fungal aryl-alcohol oxidase. Acta Crystallogr D Biol Crystallogr (2009) 0.90

Natural single amino acid polymorphism (F19Y) in human galectin-8: detection of structural alterations and increased growth-regulatory activity on tumor cells. FEBS J (2014) 0.89

Recent advances in the potential interconnection between antimicrobial resistance to biocides and antibiotics. Expert Rev Anti Infect Ther (2013) 0.88

Crystallographic, kinetic, and spectroscopic study of the first ligninolytic peroxidase presenting a catalytic tyrosine. J Biol Chem (2011) 0.86

The effect of increasing concentrations of precipitating salts used to crystallize proteins on the structure of the lipidic Q224 cubic phase. Chem Phys Lipids (2004) 0.84

Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors. J Biol Chem (2005) 0.84

Ref2, a regulatory subunit of the yeast protein phosphatase 1, is a novel component of cation homoeostasis. Biochem J (2010) 0.83

Effect of hypoxia on equine mesenchymal stem cells derived from bone marrow and adipose tissue. BMC Vet Res (2012) 0.83

How FMN binds to anabaena apoflavodoxin: a hydrophobic encounter at an open binding site. J Biol Chem (2003) 0.83

Variables associated with contrast-enhanced cardiovascular magnetic resonance in hypertrophic cardiomyopathy: clinical implications. J Card Fail (2008) 0.83

The Inactivation of intrinsic antibiotic resistance determinants widens the mutant selection window for quinolones in Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2012) 0.80

The structure of BRMS1 nuclear export signal and SNX6 interacting region reveals a hexamer formed by antiparallel coiled coils. J Mol Biol (2011) 0.80

Correlation of cell growth and heterologous protein production by Saccharomyces cerevisiae. Appl Microbiol Biotechnol (2013) 0.79

The efflux pump inhibitor Phe-Arg-beta-naphthylamide does not abolish the activity of the Stenotrophomonas maltophilia SmeDEF multidrug efflux pump. J Antimicrob Chemother (2003) 0.79

Development of a Novel Fluorescence Assay Based on the Use of the Thrombin-Binding Aptamer for the Detection of O-Alkylguanine-DNA Alkyltransferase Activity. J Nucleic Acids (2010) 0.79

N-domain of human adhesion/growth-regulatory galectin-9: preference for distinct conformers and non-sialylated N-glycans and detection of ligand-induced structural changes in crystal and solution. Int J Biochem Cell Biol (2010) 0.79

Synthesis of the blood circulating C-terminal fragment of insulin-like growth factor (IGF)-binding protein-4 in its native conformation. Crystallization, heparin and IGF binding, and osteogenic activity. J Biol Chem (2005) 0.79

Differential epigenetic compatibility of qnr antibiotic resistance determinants with the chromosome of Escherichia coli. PLoS One (2012) 0.78

Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6). J Mol Biol (2008) 0.78

Homodimeric chicken galectin CG-1B (C-14): Crystal structure and detection of unique redox-dependent shape changes involving inter- and intrasubunit disulfide bridges by gel filtration, ultracentrifugation, site-directed mutagenesis, and peptide mass fingerprinting. J Mol Biol (2008) 0.78

Contribution of mine wastes to atmospheric metal deposition in the surrounding area of an abandoned heavily polluted mining district (Rio Tinto mines, Spain). Sci Total Environ (2013) 0.78

Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors. J Med Chem (2012) 0.77

Fine-tuning of prototype chicken galectins: structure of CG-2 and structure-activity correlations. Acta Crystallogr D Biol Crystallogr (2013) 0.77

BRMS151-98 and BRMS151-84 are crystal oligomeric coiled coils with different oligomerization states, which behave as disordered protein fragments in solution. J Mol Biol (2013) 0.77

Mechanistic studies of the allylic rearrangements of alpha-silyloxy allylic silanes to silyloxy vinylic silanes. J Org Chem (2007) 0.77

Oxidative stress sensitivity in Debaryomyces hansenii. FEMS Yeast Res (2009) 0.77

Domain versatility in plant AB-toxins: evidence for a local, pH-dependent rearrangement in the 2gamma lectin site of the mistletoe lectin by applying ligand derivatives and modelling. FEBS Lett (2008) 0.77

Correction: Crystal Structure of Hcp from Acinetobacter baumannii: A Component of the Type VI Secretion System. PLoS One (2015) 0.76

Expansion under hypoxic conditions enhances the chondrogenic potential of equine bone marrow-derived mesenchymal stem cells. Vet J (2012) 0.76

Gene design, expression, crystallization and preliminary diffraction analysis of two isolectins from the fungus Coprinus cinereus: a model for studying functional diversification of galectins in the same organism and their evolutionary pathways. Acta Crystallogr D Biol Crystallogr (2004) 0.76

Are nonlethal targets useful for developing novel antimicrobials? Future Microbiol (2011) 0.76

Expression, crystallization and preliminary X-ray diffraction studies on the complete choline-binding domain of the major pneumococcal autolysin. Acta Crystallogr D Biol Crystallogr (2002) 0.76

Crystallization and preliminary crystallographic studies of human kallikrein 7, a serine protease of the multigene kallikrein family. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.75

[Grampositive pathogen clonal diversification and evolution: new perspectives in the XXI century]. Enferm Infecc Microbiol Clin (2010) 0.75

Identification of Atlantic hake species by a simple PCR-based methodology employing microsatellite loci. J Food Prot (2003) 0.75