Temporal analysis of the honey bee microbiome reveals four novel viruses and seasonal prevalence of known viruses, Nosema, and Crithidia.

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Published in PLoS One on June 07, 2011

Authors

Charles Runckel1, Michelle L Flenniken, Juan C Engel, J Graham Ruby, Donald Ganem, Raul Andino, Joseph L DeRisi

Author Affiliations

1: Howard Hughes Medical Institute, Bethesda, Maryland, United State of America.

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The poliovirus replication machinery can escape inhibition by an antiviral drug that targets a host cell protein. J Virol (2004) 1.04

Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains. Proc Natl Acad Sci U S A (2013) 1.03

Single-cell analysis uncovers extensive biological noise in poliovirus replication. J Virol (2014) 1.02

Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation. Genome Biol (2014) 1.02