Astragalus polysaccharides attenuate postburn sepsis via inhibiting negative immunoregulation of CD4+ CD25(high) T cells.

PubWeight™: 0.96‹?› | Rank: Top 15%

🔗 View Article (PMC 3115936)

Published in PLoS One on June 15, 2011

Authors

Qing-yang Liu1, Yong-ming Yao, Yan Yu, Ning Dong, Zhi-yong Sheng

Author Affiliations

1: Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, People's Republic of China. llqq2003yy@yahoo.com.cn

Articles citing this

Effects of Astragalus polysaccharide on immune responses of porcine PBMC stimulated with PRRSV or CSFV. PLoS One (2012) 0.99

Astragalus polysaccharide suppresses doxorubicin-induced cardiotoxicity by regulating the PI3k/Akt and p38MAPK pathways. Oxid Med Cell Longev (2014) 0.96

The significance and regulatory mechanisms of innate immune cells in the development of sepsis. J Interferon Cytokine Res (2013) 0.84

Neuropilin-1(high)CD4(+)CD25(+) Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis. Mediators Inflamm (2016) 0.84

Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. Sci Rep (2015) 0.82

Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis. Mediators Inflamm (2015) 0.78

Metallothionein ameliorates burn sepsis partly via activation of Akt signaling pathway in mice: a randomized animal study. World J Emerg Surg (2015) 0.77

A comparative study on inhibition of total astragalus saponins and astragaloside IV on TNFR1-mediated signaling pathways in arterial endothelial cells. PLoS One (2014) 0.76

Tuftsin prevents the negative immunoregulation of neuropilin-1highCD4+CD25+regulatory T cells and improves survival rate in septic mice. Oncotarget (2016) 0.75

Characterization of the Physiological Response following In Vivo Administration of Astragalus membranaceus. Evid Based Complement Alternat Med (2016) 0.75

The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression. Mediators Inflamm (2017) 0.75

Effects of astragalus polysaccharide on the adhesion-related immune response of endothelial cells stimulated with CSFV in vitro. PeerJ (2017) 0.75

Articles cited by this

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol (2004) 17.40

Natural regulatory T cells in infectious disease. Nat Immunol (2005) 6.49

Interleukin-10 and related cytokines and receptors. Annu Rev Immunol (2004) 5.41

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol (2004) 4.59

IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage. J Clin Invest (2004) 3.69

Regulatory T cells: friend or foe in immunity to infection? Nat Rev Immunol (2004) 3.61

Natural regulatory T cells: mechanisms of suppression. Trends Mol Med (2007) 3.37

Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol (2004) 2.62

A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem Biophys Res Commun (2004) 1.99

The regulatory T cell family: distinct subsets and their interrelations. J Immunol (2003) 1.92

CD4+CD25+ regulatory T cells control innate immune reactivity after injury. J Immunol (2005) 1.89

Chemical analysis of Radix Astragali (Huangqi) in China: a comparison with its adulterants and seasonal variations. J Agric Food Chem (2002) 1.77

The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis. Shock (2007) 1.71

Regulatory T cells. Curr Opin Pharmacol (2004) 1.52

Role of regulatory T cells in human diseases. J Allergy Clin Immunol (2005) 1.52

Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft. Carcinogenesis (2006) 1.32

In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus. J Ethnopharmacol (2007) 1.28

CD4+ regulatory T cells: mechanisms of induction and effector function. Autoimmun Rev (2005) 1.27

Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient. Int Immunol (2006) 1.19

The source of early IFN-gamma that plays a role in Th1 priming. J Immunol (2001) 1.13

The role of high mobility group box-1 protein in severe sepsis. Curr Opin Infect Dis (2006) 1.11

Sepsis and the dendritic cell. Shock (2003) 1.02

Astragalus polysaccharides regulate T cell-mediated immunity via CD11c(high)CD45RB(low) DCs in vitro. J Ethnopharmacol (2010) 1.00

Burn injury induces a change in T cell homeostasis affecting preferentially CD4+ T cells. J Leukoc Biol (2004) 0.99

Burn injury induces an early activation response by lymph node CD4+ T cells. Shock (2006) 0.97

Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming. J Ethnopharmacol (2008) 0.94

In vivo dynamical interactions between CD4 Tregs, CD8 Tregs and CD4+ CD25- cells in mice. PLoS One (2009) 0.87

Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activation. J Diabetes Complications (2009) 0.87

Naturally existing CD11c(low)CD45RB(high) dendritic cells protect mice from acute severe inflammatory response induced by thermal injury. Immunobiology (2010) 0.85

Factors that regulate naturally occurring T regulatory cell-mediated suppression. J Allergy Clin Immunol (2005) 0.83

Regulatory T-cells and autoimmunity. J Surg Res (2005) 0.79

Nonruminant nutrition symposium on natural phytobiotics for health of young animals and poultry: mechanisms and application. J Anim Sci (2007) 0.78

Articles by these authors

Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA (2012) 4.67

Structural flexibility in the Burkholderia mallei genome. Proc Natl Acad Sci U S A (2004) 4.13

HMGB1 promotes drug resistance in osteosarcoma. Cancer Res (2011) 2.82

AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: report of Task Group 137. Med Phys (2009) 2.62

Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies. BMC Genomics (2005) 2.34

Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog (2008) 2.09

Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency. Int J Cancer (2008) 2.09

Efficacy and safety of intracameral triamcinolone acetonide to control postoperative inflammation after phacotrabeculectomy. J Cataract Refract Surg (2013) 2.00

Contribution of gene loss to the pathogenic evolution of Burkholderia pseudomallei and Burkholderia mallei. Infect Immun (2004) 1.70

A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function. Nat Biotechnol (2010) 1.62

A pilot study to detect high mobility group box 1 and heat shock protein 72 in cerebrospinal fluid of pediatric patients with meningitis. Crit Care Med (2008) 1.62

Polymorphisms of ERCC1 C118T/C8092A and MDR1 C3435T predict outcome of platinum-based chemotherapies in advanced non-small cell lung cancer: a meta-analysis. Arch Med Res (2011) 1.55

In vivo cancer diagnosis with optical spectroscopy and acoustically induced blood stasis using a murine MCa35 model. Med Phys (2006) 1.54

Luffa echinata Roxb. induces human colon cancer cell (HT-29) death by triggering the mitochondrial apoptosis pathway. Molecules (2012) 1.48

Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein. Autophagy (2011) 1.47

PCB association with model phospholipid bilayers. Environ Sci Technol (2008) 1.42

Experimental and clinical observations of 99mTc-MIBI uptake correlate with P-glycoprotein expression in lung cancer. Nucl Med Commun (2007) 1.41

Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus. Eukaryot Cell (2008) 1.41

Vivo motion and force measurement of surgical needle intervention during prostate brachytherapy. Med Phys (2006) 1.36

The early stage of bacterial genome-reductive evolution in the host. PLoS Pathog (2010) 1.35

Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS One (2012) 1.34

Beta-TCP bone graft substitutes in a bilateral rabbit tibial defect model. Biomaterials (2008) 1.29

Towards consensus practices to qualify safety biomarkers for use in early drug development. Nat Biotechnol (2010) 1.25

Single-layered ultrasmall nanoplates of MoS2 embedded in carbon nanofibers with excellent electrochemical performance for lithium and sodium storage. Angew Chem Int Ed Engl (2014) 1.24

Inferences of biogeographical histories within subfamily Hyacinthoideae using S-DIVA and Bayesian binary MCMC analysis implemented in RASP (Reconstruct Ancestral State in Phylogenies). Ann Bot (2011) 1.23

RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule. Cancer Sci (2011) 1.19

Targeting HMGB1-mediated autophagy as a novel therapeutic strategy for osteosarcoma. Autophagy (2012) 1.19

Molecular targeted therapies for cancer: sorafenib mono-therapy and its combination with other therapies (review). Oncol Rep (2012) 1.16

Genetic diversity and geographic differentiation in endangered Ammopiptanthus (Leguminosae) populations in desert regions of northwest China as revealed by ISSR analysis. Ann Bot (2005) 1.13

Direct observation of lithium staging in partially delithiated LiFePO4 at atomic resolution. J Am Chem Soc (2011) 1.12

DAMP-mediated autophagy contributes to drug resistance. Autophagy (2011) 1.10

Prognostic analysis of patients with gastrointestinal stromal tumors: a single unit experience with surgical treatment of primary disease. Chin Med J (Engl) (2010) 1.09

Balancing the costs of carbon gain and water transport: testing a new theoretical framework for plant functional ecology. Ecol Lett (2013) 1.09

Identification of nuclear import mechanisms for the neuronal Cdk5 activator. J Biol Chem (2006) 1.08

Abnormal neural activities in first-episode, treatment-naïve, short-illness-duration, and treatment-response patients with major depressive disorder: a resting-state fMRI study. J Affect Disord (2011) 1.06

Reg4 protects against acinar cell necrosis in experimental pancreatitis. Gut (2010) 1.06

Genetic regulation of endotoxin-induced airway disease. Genomics (2004) 1.06

Genome-wide expression analysis of iron regulation in Burkholderia pseudomallei and Burkholderia mallei using DNA microarrays. FEMS Microbiol Lett (2005) 1.05

A review of Omics research in acupuncture: the relevance and future prospects for understanding the nature of meridians and acupoints. J Ethnopharmacol (2012) 1.04

The limits of log-ratios. BMC Biotechnol (2004) 1.04

Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro. J Pharmacol Exp Ther (2010) 1.04

Self-supported Li4Ti5O12-C nanotube arrays as high-rate and long-life anode materials for flexible Li-ion batteries. Nano Lett (2014) 1.03

Phylogeny and biogeography of Allium (Amaryllidaceae: Allieae) based on nuclear ribosomal internal transcribed spacer and chloroplast rps16 sequences, focusing on the inclusion of species endemic to China. Ann Bot (2010) 1.01

Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures. J Neurosci (2007) 1.00

microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review). Int J Oncol (2011) 1.00

Astragalus polysaccharides regulate T cell-mediated immunity via CD11c(high)CD45RB(low) DCs in vitro. J Ethnopharmacol (2010) 1.00

The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats. Shock (2009) 1.00

The potential effect and mechanism of high-mobility group box 1 protein on regulatory T cell-mediated immunosuppression. J Interferon Cytokine Res (2010) 0.99

Malignant mixed müllerian tumor of the fallopian tube: report of two cases and review of literature. Arch Gynecol Obstet (2009) 0.99

Sodium butyrate prevents lethality of severe sepsis in rats. Shock (2007) 0.98

HMGB1 regulates autophagy through increasing transcriptional activities of JNK and ERK in human myeloid leukemia cells. BMB Rep (2011) 0.98

Dosimetric verification using monte carlo calculations for tissue heterogeneity-corrected conformal treatment plans following RTOG 0813 dosimetric criteria for lung cancer stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys (2012) 0.97

High mobility group box-1 protein regulate immunosuppression of regulatory T cells through toll-like receptor 4. Cytokine (2011) 0.97

Targeting hypoxia-inducible factor-1alpha with Tf-PEI-shRNA complex via transferrin receptor-mediated endocytosis inhibits melanoma growth. Mol Ther (2008) 0.96

Presynaptic defects underlying impaired learning and memory function in lipoprotein lipase-deficient mice. J Neurosci (2009) 0.96

Ligustilide attenuates pain behavior induced by acetic acid or formalin. J Ethnopharmacol (2007) 0.96

The development of a combined mathematical model to forecast the incidence of hepatitis E in Shanghai, China. BMC Infect Dis (2013) 0.96

Resonant X-ray enhancement of the Auger effect in high-Z atoms, molecules, and nanoparticles: potential biomedical applications. J Phys Chem A (2009) 0.95

Up-regulated autophagy by endogenous high mobility group box-1 promotes chemoresistance in leukemia cells. Leuk Lymphoma (2011) 0.95

Genome sequence alterations detected upon passage of Burkholderia mallei ATCC 23344 in culture and in mammalian hosts. BMC Genomics (2006) 0.95

Relationship between high-mobility group box 1 protein release and T-cell suppression in rats after thermal injury. Shock (2008) 0.94

Local signals in stem cell-based bone marrow regeneration. Cell Res (2006) 0.94

Microbial diversity and prevalence of virulent pathogens in biofilms developed in a water reclamation system. Res Microbiol (2003) 0.94

Protective effect of recombinant human IL-1Ra on CCl4-induced acute liver injury in mice. World J Gastroenterol (2010) 0.94

Association of high mobility group box-1 protein levels with sepsis and outcome of severely burned patients. Cytokine (2010) 0.94

Rapid estrogen regulation of DHEA metabolism in the male and female songbird brain. J Neurochem (2007) 0.93

A journey from dental pulp stem cells to a bio-tooth. Stem Cell Rev (2011) 0.93

Relationship between age, skeletal site, and time post-ovariectomy on bone mineral and trabecular microarchitecture in rats. J Orthop Res (2010) 0.93

Nitrogen doped porous carbon fibres as anode materials for sodium ion batteries with excellent rate performance. Nanoscale (2014) 0.93

Penalized spline estimation for functional coefficient regression models. Comput Stat Data Anal (2010) 0.92

Single-incision laparoscopic Roux-en-Y hepaticojejunostomy using conventional instruments for children with choledochal cysts. Surg Endosc (2011) 0.92

Multi-channel robotic system for prostate brachytherapy. Conf Proc IEEE Eng Med Biol Soc (2007) 0.92

S100A11: diverse function and pathology corresponding to different target proteins. Cell Biochem Biophys (2009) 0.92

Screening and analysis of the multiple absorbed bioactive components and metabolites of Dangguibuxue decoction by the metabolic fingerprinting technique and liquid chromatography/diode-array detection mass spectrometry. Rapid Commun Mass Spectrom (2007) 0.91

Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas. J Med Chem (2012) 0.91

Association between regulatory T cell activity and sepsis and outcome of severely burned patients: a prospective, observational study. Crit Care (2010) 0.90

A novel model of bone-metastatic prostate cancer in immunocompetent mice. Prostate (2009) 0.90

Transcriptional divergence of the duplicated oxidative stress-responsive genes in the Arabidopsis genome. Plant J (2005) 0.90

Reliability of EUCLIDIAN: an autonomous robotic system for image-guided prostate brachytherapy. Med Phys (2011) 0.90

Effect of low intensity pulsed ultrasound on healing of an ulna defect filled with a bone graft substitute. J Biomed Mater Res B Appl Biomater (2008) 0.90

Endoplasmic reticulum stress and its regulator XBP-1 contributes to dendritic cell maturation and activation induced by high mobility group box-1 protein. Int J Biochem Cell Biol (2012) 0.89

Citrate versus heparin anticoagulation for continuous renal replacement therapy: an updated meta-analysis of RCTs. Intensive Care Med (2015) 0.89