Published in Proc Natl Acad Sci U S A on September 17, 2004
Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev (2005) 14.71
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proc Natl Acad Sci U S A (2004) 7.30
Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. Antimicrob Agents Chemother (2008) 7.06
Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions. PLoS Pathog (2010) 3.15
Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility. Proc Natl Acad Sci U S A (2006) 3.07
Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer. BMC Biol (2009) 2.94
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients. J Bacteriol (2008) 2.71
Bordetella pertussis, the causative agent of whooping cough, evolved from a distinct, human-associated lineage of B. bronchiseptica. PLoS Pathog (2005) 2.71
Genetic tools for select-agent-compliant manipulation of Burkholderia pseudomallei. Appl Environ Microbiol (2007) 2.40
Genomic patterns of pathogen evolution revealed by comparison of Burkholderia pseudomallei, the causative agent of melioidosis, to avirulent Burkholderia thailandensis. BMC Microbiol (2006) 2.35
Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies. BMC Genomics (2005) 2.34
Management of accidental laboratory exposure to Burkholderia pseudomallei and B. mallei. Emerg Infect Dis (2008) 2.24
Virulent Burkholderia species mimic host actin polymerases to drive actin-based motility. Cell (2015) 2.20
Multilocus sequence typing scheme that provides both species and strain differentiation for the Burkholderia cepacia complex. J Clin Microbiol (2005) 2.17
Genome sequence of Lactobacillus helveticus, an organism distinguished by selective gene loss and insertion sequence element expansion. J Bacteriol (2007) 2.15
Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens. PLoS Pathog (2009) 1.87
A horizontal gene transfer event defines two distinct groups within Burkholderia pseudomallei that have dissimilar geographic distributions. J Bacteriol (2007) 1.82
Genomic islands from five strains of Burkholderia pseudomallei. BMC Genomics (2008) 1.82
Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant. J Bacteriol (2005) 1.71
Environmental factors that affect the survival and persistence of Burkholderia pseudomallei. Appl Environ Microbiol (2006) 1.71
A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence. PLoS Pathog (2010) 1.65
Sensitive and specific molecular detection of Burkholderia pseudomallei, the causative agent of melioidosis, in the soil of tropical northern Australia. Appl Environ Microbiol (2007) 1.62
Genetic diversity and microevolution of Burkholderia pseudomallei in the environment. PLoS Negl Trop Dis (2008) 1.58
Tandem repeat regions within the Burkholderia pseudomallei genome and their application for high resolution genotyping. BMC Microbiol (2007) 1.54
The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. Antimicrob Agents Chemother (2010) 1.50
Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family. BMC Biol (2010) 1.49
Ab initio genotype-phenotype association reveals intrinsic modularity in genetic networks. Mol Syst Biol (2006) 1.49
Significant gene order and expression differences in Bordetella pertussis despite limited gene content variation. J Bacteriol (2006) 1.48
Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola. PLoS Genet (2009) 1.48
Simple sequence repeats in prokaryotic genomes. Proc Natl Acad Sci U S A (2007) 1.45
Burkholderia mallei cluster 1 type VI secretion mutants exhibit growth and actin polymerization defects in RAW 264.7 murine macrophages. Infect Immun (2009) 1.45
Present and future therapeutic strategies for melioidosis and glanders. Expert Rev Anti Infect Ther (2010) 1.45
Evolution of Burkholderia pseudomallei in recurrent melioidosis. PLoS One (2012) 1.43
The early stage of bacterial genome-reductive evolution in the host. PLoS Pathog (2010) 1.35
Within-host evolution of Burkholderia pseudomallei in four cases of acute melioidosis. PLoS Pathog (2010) 1.33
Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis. J Bacteriol (2009) 1.33
ParABS systems of the four replicons of Burkholderia cenocepacia: new chromosome centromeres confer partition specificity. J Bacteriol (2006) 1.33
Genome of the actinomycete plant pathogen Clavibacter michiganensis subsp. sepedonicus suggests recent niche adaptation. J Bacteriol (2008) 1.32
Burkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human Toll-like receptor 4 complexes. Mol Microbiol (2006) 1.31
Brucella microti: the genome sequence of an emerging pathogen. BMC Genomics (2009) 1.31
Burkholderia pseudomallei, B. thailandensis, and B. ambifaria produce 4-hydroxy-2-alkylquinoline analogues with a methyl group at the 3 position that is required for quorum-sensing regulation. J Bacteriol (2008) 1.27
Comparative genomics and an insect model rapidly identify novel virulence genes of Burkholderia mallei. J Bacteriol (2008) 1.27
Continuing evolution of Burkholderia mallei through genome reduction and large-scale rearrangements. Genome Biol Evol (2010) 1.24
Prevalence and sequence diversity of a factor required for actin-based motility in natural populations of Burkholderia species. J Clin Microbiol (2008) 1.18
Genome degeneration and adaptation in a nascent stage of symbiosis. Genome Biol Evol (2014) 1.18
Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis. BMC Microbiol (2007) 1.16
Complete genome sequences for 59 burkholderia isolates, both pathogenic and near neighbor. Genome Announc (2015) 1.14
Antimicrobial drug-selection markers for Burkholderia pseudomallei and B. mallei. Emerg Infect Dis (2008) 1.14
Diversity of 16S-23S rDNA internal transcribed spacer (ITS) reveals phylogenetic relationships in Burkholderia pseudomallei and its near-neighbors. PLoS One (2011) 1.13
Specialized metabolites from the microbiome in health and disease. Cell Metab (2014) 1.12
BurkDiff: a real-time PCR allelic discrimination assay for Burkholderia pseudomallei and B. mallei. PLoS One (2010) 1.11
Strategies toward vaccines against Burkholderia mallei and Burkholderia pseudomallei. Expert Rev Vaccines (2008) 1.09
Glyphosate resistance as a novel select-agent-compliant, non-antibiotic-selectable marker in chromosomal mutagenesis of the essential genes asd and dapB of Burkholderia pseudomallei. Appl Environ Microbiol (2009) 1.09
Development of Burkholderia mallei and pseudomallei vaccines. Front Cell Infect Microbiol (2013) 1.08
Role of phages in the pathogenesis of Burkholderia, or 'Where are the toxin genes in Burkholderia phages?'. Curr Opin Microbiol (2007) 1.08
In vivo Himar1 transposon mutagenesis of Burkholderia pseudomallei. Appl Environ Microbiol (2008) 1.08
iNOS activity is critical for the clearance of Burkholderia mallei from infected RAW 264.7 murine macrophages. Cell Microbiol (2007) 1.07
The Burkholderia mallei BmaR3-BmaI3 quorum-sensing system produces and responds to N-3-hydroxy-octanoyl homoserine lactone. J Bacteriol (2008) 1.06
Octanoyl-homoserine lactone is the cognate signal for Burkholderia mallei BmaR1-BmaI1 quorum sensing. J Bacteriol (2007) 1.05
Burkholderia mallei tssM encodes a putative deubiquitinase that is secreted and expressed inside infected RAW 264.7 murine macrophages. Infect Immun (2009) 1.03
Genetic and phenotypic diversity in Burkholderia: contributions by prophage and phage-like elements. BMC Microbiol (2010) 1.02
Defining pathogenic bacterial species in the genomic era. Front Microbiol (2011) 1.02
ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei. BMC Genomics (2007) 1.00
Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens. J Am Chem Soc (2012) 0.98
Involvement of quinolinate phosphoribosyl transferase in promotion of potato growth by a Burkholderia strain. Appl Environ Microbiol (2006) 0.98
Global analysis of the Burkholderia thailandensis quorum sensing-controlled regulon. J Bacteriol (2014) 0.97
Genome sequence alterations detected upon passage of Burkholderia mallei ATCC 23344 in culture and in mammalian hosts. BMC Genomics (2006) 0.95
Identification of Burkholderia mallei and Burkholderia pseudomallei adhesins for human respiratory epithelial cells. BMC Microbiol (2010) 0.95
Evaluation of surrogate animal models of melioidosis. Front Microbiol (2010) 0.95
Ribosome-inactivating proteins: potent poisons and molecular tools. Virulence (2013) 0.94
Burkholderia pseudomallei isolates from Sarawak, Malaysian Borneo, are predominantly susceptible to aminoglycosides and macrolides. Antimicrob Agents Chemother (2013) 0.92
Genomic perspectives on the evolution and spread of bacterial pathogens. Proc Biol Sci (2015) 0.92
Antibodies from patients with melioidosis recognize Burkholderia mallei but not Burkholderia thailandensis antigens in the indirect hemagglutination assay. J Clin Microbiol (2005) 0.92
Efflux pump-mediated drug resistance in Burkholderia. Front Microbiol (2015) 0.91
Laboratory diagnosis of melioidosis: past, present and future. Exp Biol Med (Maywood) (2015) 0.90
Protective antigens against glanders identified by expression library immunization. Front Microbiol (2011) 0.90
Bactobolin resistance is conferred by mutations in the L2 ribosomal protein. MBio (2012) 0.90
Insertion sequence content reflects genome plasticity in strains of the root nodule actinobacterium Frankia. BMC Genomics (2009) 0.90
Mechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia mallei. Biochemistry (2010) 0.90
Use of a safe, reproducible, and rapid aerosol delivery method to study infection by Burkholderia pseudomallei and Burkholderia mallei in mice. PLoS One (2013) 0.89
Novel Burkholderia mallei virulence factors linked to specific host-pathogen protein interactions. Mol Cell Proteomics (2013) 0.88
Characterization of clinically-attenuated Burkholderia mallei by whole genome sequencing: candidate strain for exclusion from Select Agent lists. PLoS One (2008) 0.87
Burkholderia mallei and Burkholderia pseudomallei cluster 1 type VI secretion system gene expression is negatively regulated by iron and zinc. PLoS One (2013) 0.87
Multiplex qPCR for reliable detection and differentiation of Burkholderia mallei and Burkholderia pseudomallei. BMC Infect Dis (2013) 0.87
The complete genome of Burkholderia phenoliruptrix strain BR3459a, a symbiont of Mimosa flocculosa: highlighting the coexistence of symbiotic and pathogenic genes. BMC Genomics (2014) 0.86
Virulence of Burkholderia mallei quorum-sensing mutants. Infect Immun (2013) 0.86
Melioidosis: molecular aspects of pathogenesis. Expert Rev Anti Infect Ther (2014) 0.85
Systematic overestimation of gene gain through false diagnosis of gene absence. Genome Biol (2007) 0.85
Stretches of alternating pyrimidine/purines and purines are respectively linked with pathogenicity and growth temperature in prokaryotes. BMC Genomics (2009) 0.84
Proteomic analysis of the Burkholderia pseudomallei type II secretome reveals hydrolytic enzymes, novel proteins, and the deubiquitinase TssM. Infect Immun (2014) 0.84
Mining host-pathogen protein interactions to characterize Burkholderia mallei infectivity mechanisms. PLoS Comput Biol (2015) 0.84
Characterization and inference of gene gain/loss along burkholderia evolutionary history. Evol Bioinform Online (2011) 0.83
In planta gene expression analysis of Xanthomonas oryzae pathovar oryzae, African strain MAI1. BMC Microbiol (2010) 0.83
Isolation and characterization of Burkholderia rinojensis sp. nov., a non-Burkholderia cepacia complex soil bacterium with insecticidal and miticidal activities. Appl Environ Microbiol (2013) 0.83
Phenotypic Characterization of a Novel Virulence-Factor Deletion Strain of Burkholderia mallei That Provides Partial Protection against Inhalational Glanders in Mice. Front Cell Infect Microbiol (2016) 0.82
Diversity of the parB and repA genes of the Burkholderia cepacia complex and their utility for rapid identification of Burkholderia cenocepacia. BMC Microbiol (2008) 0.82
Use of the common marmoset to study Burkholderia mallei infection. PLoS One (2015) 0.82
A gold nanoparticle-linked glycoconjugate vaccine against Burkholderia mallei. Nanomedicine (2014) 0.82
Whole-genome assemblies of 56 burkholderia species. Genome Announc (2014) 0.81
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science (1995) 68.34
The Pfam protein families database. Nucleic Acids Res (2000) 42.28
TIGRFAMs: a protein family resource for the functional identification of proteins. Nucleic Acids Res (2001) 20.84
Microbial gene identification using interpolated Markov models. Nucleic Acids Res (1998) 20.26
Functions of the gene products of Escherichia coli. Microbiol Rev (1993) 15.51
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proc Natl Acad Sci U S A (2004) 7.30
Complete genome sequence of Caulobacter crescentus. Proc Natl Acad Sci U S A (2001) 5.58
Glanders in a military research microbiologist. N Engl J Med (2001) 4.77
Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei. Antimicrob Agents Chemother (1999) 4.29
Biological warfare. A historical perspective. JAMA (1997) 4.10
Global dinucleotide signatures and analysis of genomic heterogeneity. Curr Opin Microbiol (1998) 3.09
A comparative study of Pseudomonas pseudomallei and Bacillus mallei. J Gen Microbiol (1966) 2.97
New technologies to assess genotype-phenotype relationships. Nat Rev Genet (2003) 2.91
Studies on Certain Biological Characteristics of Malleomyces mallei and Malleomyces pseudomallei: I. Morphology, Cultivation, Viability, and Isolation from Contaminated Specimens. J Bacteriol (1948) 2.71
Identification of a Burkholderia mallei polysaccharide gene cluster by subtractive hybridization and demonstration that the encoded capsule is an essential virulence determinant. Microb Pathog (2001) 2.52
Studies on Certain Biological Characteristics of Malleomyces mallei and Malleomyces pseudomallei: II. Virulence and Infectivity for Animals. J Bacteriol (1948) 1.78
Computer analysis of nucleic acid sequences. Methods Enzymol (1988) 1.63
Type III secretion: a virulence factor delivery system essential for the pathogenicity of Burkholderia mallei. Infect Immun (2004) 1.55
Molecular characterization, nucleotide sequence, and expression of the fliO, fliP, fliQ, and fliR genes of Escherichia coli. J Bacteriol (1994) 1.51
Molecular genetic analysis and regulation of aflatoxin biosynthesis. Appl Microbiol Biotechnol (2003) 1.49
Characterization of experimental equine glanders. Microbes Infect (2003) 1.37
Molecular characterization of genetic loci required for secretion of exoproducts in Burkholderia pseudomallei. J Bacteriol (1999) 1.29
Nucleotide sequence of the virG locus of the Agrobacterium tumefaciens plasmid pTiC58. Mol Microbiol (1987) 1.29
[Glanders outbreak in lions in the Istanbul zoological garden]. Berl Munch Tierarztl Wochenschr (1986) 1.27
Use of RNA and genomic DNA references for inferred comparisons in DNA microarray analyses. Biotechniques (2002) 1.19
The great glanders epizootic, 1861-1866: a Civil War legacy. Agric Hist (1995) 1.15
Diversity of the human intestinal microbial flora. Science (2005) 49.64
Environmental genome shotgun sequencing of the Sargasso Sea. Science (2004) 45.23
Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89
The minimum information about a genome sequence (MIGS) specification. Nat Biotechnol (2008) 31.04
Metagenomic analysis of the human distal gut microbiome. Science (2006) 29.76
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36
Toward an online repository of Standard Operating Procedures (SOPs) for (meta)genomic annotation. OMICS (2008) 18.69
InterPro, progress and status in 2005. Nucleic Acids Res (2005) 17.53
Evolution and classification of the CRISPR-Cas systems. Nat Rev Microbiol (2011) 17.11
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome". Proc Natl Acad Sci U S A (2005) 14.59
The TIGRFAMs database of protein families. Nucleic Acids Res (2003) 13.59
Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution. Nature (2005) 11.99
A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes. PLoS Comput Biol (2005) 11.82
The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48
Improving the Arabidopsis genome annotation using maximal transcript alignment assemblies. Nucleic Acids Res (2003) 11.03
Functional metagenomic profiling of nine biomes. Nature (2008) 11.00
Big data: The future of biocuration. Nature (2008) 10.81
The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria. Nature (2003) 10.38
Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis. Science (2002) 9.83
Genome sequence of Aedes aegypti, a major arbovirus vector. Science (2007) 9.19
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature (2002) 8.92
TIGRFAMs and Genome Properties: tools for the assignment of molecular function and biological process in prokaryotic genomes. Nucleic Acids Res (2006) 8.89
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature (2005) 8.55
A catalog of reference genomes from the human microbiome. Science (2010) 8.10
Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc Natl Acad Sci U S A (2006) 7.99
Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements. PLoS Biol (2004) 7.95
Molecular analysis of the bacterial microbiota in the human stomach. Proc Natl Acad Sci U S A (2006) 7.77
Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus. Science (2003) 7.73
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science (2005) 7.61
Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications. Nat Biotechnol (2011) 7.53
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proc Natl Acad Sci U S A (2004) 7.30
A Sanger/pyrosequencing hybrid approach for the generation of high-quality draft assemblies of marine microbial genomes. Proc Natl Acad Sci U S A (2006) 7.17
Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis. Nat Biotechnol (2002) 6.96