Published in Gastroenterology on June 13, 2011
Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Nature (2013) 3.39
The ins and outs of hepatitis C virus entry and assembly. Nat Rev Microbiol (2013) 1.69
Evidence for novel hepaciviruses in rodents. PLoS Pathog (2013) 1.54
Hepatitis C virus host cell entry. Curr Opin Virol (2012) 1.41
Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation. PLoS Pathog (2012) 1.29
Lipids and HCV. Semin Immunopathol (2012) 1.19
Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells. J Virol (2012) 1.18
Virion assembly and release. Curr Top Microbiol Immunol (2013) 1.15
Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice. Cell Res (2014) 1.13
Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease. Viruses (2013) 1.12
Apolipoprotein E codetermines tissue tropism of hepatitis C virus and is crucial for viral cell-to-cell transmission by contributing to a postenvelopment step of assembly. J Virol (2013) 1.09
Human apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding. Hepatology (2012) 1.06
Characterization of hepatitis C virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps. J Biol Chem (2012) 1.03
Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle. PLoS Pathog (2013) 1.02
Hepatitis C virus infection and related liver disease: the quest for the best animal model. Front Microbiol (2013) 0.99
Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins. J Virol (2014) 0.99
Hepatitis C virus-host interactions, replication, and viral assembly. Curr Opin Virol (2012) 0.97
Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines. Virology (2013) 0.93
Barriers of hepatitis C virus interspecies transmission. Virology (2013) 0.92
Host-Targeting Agents to Prevent and Cure Hepatitis C Virus Infection. Viruses (2015) 0.91
Murine models of hepatitis C: what can we look forward to? Antiviral Res (2014) 0.90
Picornavirus morphogenesis. Microbiol Mol Biol Rev (2014) 0.88
Incorporation of hepatitis C virus E1 and E2 glycoproteins: the keystones on a peculiar virion. Viruses (2014) 0.88
Animal models for the study of HCV. Curr Opin Virol (2015) 0.86
In vivo models of hepatitis B and C virus infection. FEBS Lett (2016) 0.85
Hepatitis C virus assembly imaging. Viruses (2011) 0.85
Syndecan 4 is involved in mediating HCV entry through interaction with lipoviral particle-associated apolipoprotein E. PLoS One (2014) 0.85
Study of hepatitis C virus entry in genetically humanized mice. Methods (2012) 0.85
Animal models for the study of hepatitis C virus infection and replication. World J Gastroenterol (2012) 0.82
Visualizing hepatitis C virus infection in humanized mice. J Immunol Methods (2014) 0.82
Identification of HNRNPK as regulator of hepatitis C virus particle production. PLoS Pathog (2015) 0.80
Specific sequence of a Beta turn in human la protein may contribute to species specificity of hepatitis C virus. J Virol (2014) 0.80
Neglected but Important Role of Apolipoprotein E Exchange in Hepatitis C Virus Infection. J Virol (2016) 0.79
A Gaussia luciferase cell-based system to assess the infection of cell culture- and serum-derived hepatitis C virus. PLoS One (2012) 0.78
Model systems for hepatitis C research: the cup half empty? Gastroenterology (2011) 0.78
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war? World J Gastroenterol (2015) 0.78
Extracellular Interactions between Hepatitis C Virus and Secreted Apolipoprotein E. J Virol (2017) 0.77
Exiting from uncharted territory: hepatitis C virus assembles in mouse cell lines. Hepatology (2012) 0.76
Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization. World J Gastroenterol (2014) 0.76
In Silico Design and Experimental Validation of siRNAs Targeting Conserved Regions of Multiple Hepatitis C Virus Genotypes. PLoS One (2016) 0.75
Proteomic approaches to analyzing hepatitis C virus biology. Proteomics (2015) 0.75
Expanding the Host Range of Hepatitis C Virus through Viral Adaptation. MBio (2016) 0.75
Genetic Dissection of the Host Tropism of Human-Tropic Pathogens. Annu Rev Genet (2015) 0.75
GFP-tagged Apolipoprotein E: a useful marker for the study of hepatic lipoprotein egress. Traffic (2016) 0.75
Hepatitis C virus strain-dependent usage of apolipoprotein E modulates assembly efficiency and specific infectivity of secreted virions. J Virol (2017) 0.75
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med (2005) 21.56
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature (2005) 17.47
The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol (2007) 8.98
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc Natl Acad Sci U S A (2006) 6.87
A high-resolution root spatiotemporal map reveals dominant expression patterns. Science (2007) 6.60
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J Virol (2003) 5.41
Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. J Virol (2002) 5.21
Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe (2009) 4.54
Viral and cellular determinants of hepatitis C virus RNA replication in cell culture. J Virol (2003) 4.52
Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog (2008) 3.81
Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses. J Virol (2006) 3.75
Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees. Proc Natl Acad Sci U S A (2002) 3.43
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest (2005) 3.25
Kissing-loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replication. J Virol (2005) 3.21
Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate. Nature (2010) 3.19
The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly. J Biol Chem (2007) 3.11
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe (2011) 3.05
Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions. PLoS Pathog (2007) 2.98
Quantitative analysis of the hepatitis C virus replication complex. J Virol (2005) 2.91
Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem (2008) 2.87
Distribution of major genotypes among methicillin-resistant Staphylococcus aureus clones in Asian countries. J Clin Microbiol (2005) 2.79
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. J Biol Chem (2004) 2.71
Genetic analysis of sequences in the 3' nontranslated region of hepatitis C virus that are important for RNA replication. J Virol (2002) 2.62
Transcriptional profile of the Arabidopsis root quiescent center. Plant Cell (2005) 2.55
Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology (2002) 2.53
The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response. Hepatology (2010) 2.52
The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner. J Biol Chem (2007) 2.48
Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary. Cancer Res (2005) 2.48
The level of CD81 cell surface expression is a key determinant for productive entry of hepatitis C virus into host cells. J Virol (2006) 2.48
euHCVdb: the European hepatitis C virus database. Nucleic Acids Res (2006) 2.41
From structure to function: new insights into hepatitis C virus RNA replication. J Biol Chem (2005) 2.37
Assembly of infectious hepatitis C virus particles. Trends Microbiol (2010) 2.36
Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes. J Virol (2007) 2.29
Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81. Hepatology (2007) 2.25
Identification of essential genes in Streptococcus pneumoniae by allelic replacement mutagenesis. Mol Cells (2005) 2.20
Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B. J Biol Chem (2006) 2.12
Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome. J Biol Chem (2010) 2.05
Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication. PLoS Pathog (2012) 2.04
Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion. Oncogene (2005) 2.02
High density lipoprotein inhibits hepatitis C virus-neutralizing antibodies by stimulating cell entry via activation of the scavenger receptor BI. J Biol Chem (2006) 2.02
The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology (2006) 1.99
A replicon-based bioassay for the measurement of interferons in patients with chronic hepatitis C. J Virol Methods (2003) 1.96
Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog (2009) 1.94
Multiple effects of silymarin on the hepatitis C virus lifecycle. Hepatology (2010) 1.92
The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection. Nat Rev Microbiol (2013) 1.88
Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33. Hepatology (2006) 1.88
Cell culture adaptation of hepatitis C virus and in vivo viability of an adapted variant. J Virol (2007) 1.87
Viral immune modulators perturb the human molecular network by common and unique strategies. Nature (2012) 1.86
Production of infectious hepatitis C virus in primary cultures of human adult hepatocytes. Gastroenterology (2010) 1.85
Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly. J Biol Chem (2008) 1.71
Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles. J Virol (2008) 1.70
Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol (2004) 1.67
Identification of hepatoprotective flavonolignans from silymarin. Proc Natl Acad Sci U S A (2010) 1.67
Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly. PLoS Pathog (2010) 1.67
The hepatitis C virus RNA 3'-untranslated region strongly enhances translation directed by the internal ribosome entry site. J Virol (2006) 1.63
Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication. J Biol Chem (2005) 1.63
A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study. Breast Cancer Res (2012) 1.62
Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B. J Biol Chem (2009) 1.61
Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs. J Virol (2004) 1.61
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PLoS One (2010) 1.59
Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations. PLoS Pathog (2009) 1.56
The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment. J Virol (2002) 1.56
Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium. Hum Mol Genet (2011) 1.55
Interferon type I gene expression in chronic hepatitis C. Lab Invest (2004) 1.55
Minimal lipidation of pre-beta HDL by ABCA1 results in reduced ability to interact with ABCA1. Arterioscler Thromb Vasc Biol (2007) 1.55
Evidence for novel hepaciviruses in rodents. PLoS Pathog (2013) 1.54
Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I). J Biol Chem (2011) 1.54
The AUXIN BINDING PROTEIN 1 is required for differential auxin responses mediating root growth. PLoS One (2009) 1.51
Hypocholesterolemic effect of Nostoc commune var. sphaeroides Kützing, an edible blue-green alga. Eur J Nutr (2009) 1.50
Quantification of transcription factor expression from Arabidopsis images. Bioinformatics (2006) 1.50
Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. Hepatology (2012) 1.49
Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development. Pathol Int (2010) 1.49
Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus. Hepatology (2007) 1.49
Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructural protein 5A. J Virol (2005) 1.47
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest (2009) 1.46
Hepatitis C virus and host cell lipids: an intimate connection. RNA Biol (2011) 1.45
Identification of determinants involved in initiation of hepatitis C virus RNA synthesis by using intergenotypic replicase chimeras. J Virol (2007) 1.44