Published in J Biol Chem on June 24, 2005
Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc Natl Acad Sci U S A (2006) 6.87
Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus. J Virol (2007) 4.28
Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus. J Virol (2006) 3.45
NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assembly. J Virol (2008) 2.62
Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog (2009) 1.94
Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly. J Biol Chem (2008) 1.71
Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly. PLoS Pathog (2010) 1.67
Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation. PLoS Pathog (2009) 1.52
A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication. PLoS Pathog (2015) 1.46
Determinants of the hepatitis C virus nonstructural protein 2 protease domain required for production of infectious virus. J Virol (2009) 1.21
Virion assembly and release. Curr Top Microbiol Immunol (2013) 1.15
Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3. Proc Natl Acad Sci U S A (2009) 1.14
Naturally occurring hepatitis C virus subgenomic deletion mutants replicate efficiently in Huh-7 cells and are trans-packaged in vitro to generate infectious defective particles. J Virol (2009) 1.01
The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein. J Gen Virol (2010) 0.99
Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator. PLoS Pathog (2011) 0.98
HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. PLoS One (2009) 0.92
Genetic and functional characterization of the N-terminal region of the hepatitis C virus NS2 protein. J Virol (2013) 0.90
The Hepatitis C Virus Nonstructural Protein 2 (NS2): An Up-and-Coming Antiviral Drug Target. Viruses (2010) 0.86
Structures of hepatitis C virus nonstructural proteins required for replicase assembly and function. Curr Opin Virol (2013) 0.84
Conformational stability of hepatitis C virus NS3 protease. Biophys J (2010) 0.84
Discovery and characterization of substituted diphenyl heterocyclic compounds as potent and selective inhibitors of hepatitis C virus replication. Antimicrob Agents Chemother (2008) 0.80
NS3 protease from hepatitis C virus: biophysical studies on an intrinsically disordered protein domain. Int J Mol Sci (2013) 0.78
Post-translational modifications of hepatitis C viral proteins and their biological significance. World J Gastroenterol (2013) 0.78
Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease. Antiviral Res (2015) 0.77
Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analyses. PLoS One (2011) 0.76
Identification of a lead like inhibitor of the hepatitis C virus non-structural NS2 autoprotease. Antiviral Res (2015) 0.75
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med (2005) 21.56
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature (2005) 17.47
The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol (2007) 8.98
Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc Natl Acad Sci U S A (2006) 6.87
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J Virol (2003) 5.41
Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. J Virol (2002) 5.21
Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe (2009) 4.54
Viral and cellular determinants of hepatitis C virus RNA replication in cell culture. J Virol (2003) 4.52
Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog (2008) 3.81
Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses. J Virol (2006) 3.75
Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees. Proc Natl Acad Sci U S A (2002) 3.43
Kissing-loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replication. J Virol (2005) 3.21
The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly. J Biol Chem (2007) 3.11
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe (2011) 3.05
Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions. PLoS Pathog (2007) 2.98
Quantitative analysis of the hepatitis C virus replication complex. J Virol (2005) 2.91
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. J Biol Chem (2004) 2.71
Genetic analysis of sequences in the 3' nontranslated region of hepatitis C virus that are important for RNA replication. J Virol (2002) 2.62
Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology (2002) 2.53
The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response. Hepatology (2010) 2.52
The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner. J Biol Chem (2007) 2.48
The level of CD81 cell surface expression is a key determinant for productive entry of hepatitis C virus into host cells. J Virol (2006) 2.48
Continuous-flow cell saver reduces cognitive decline in elderly patients after coronary bypass surgery. Circulation (2007) 2.47
euHCVdb: the European hepatitis C virus database. Nucleic Acids Res (2006) 2.41
From structure to function: new insights into hepatitis C virus RNA replication. J Biol Chem (2005) 2.37
Assembly of infectious hepatitis C virus particles. Trends Microbiol (2010) 2.36
Beyond frequency: who is most bothered by vasomotor symptoms? Menopause (2008) 2.35
Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes. J Virol (2007) 2.29
Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81. Hepatology (2007) 2.25
Intraperitoneal drug delivery for ovarian cancer: why, how, who, what, and when? Oncology (Williston Park) (2011) 2.16
Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B. J Biol Chem (2006) 2.12
Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome. J Biol Chem (2010) 2.05
Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication. PLoS Pathog (2012) 2.04
Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion. Oncogene (2005) 2.02
High density lipoprotein inhibits hepatitis C virus-neutralizing antibodies by stimulating cell entry via activation of the scavenger receptor BI. J Biol Chem (2006) 2.02
The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology (2006) 1.99
A replicon-based bioassay for the measurement of interferons in patients with chronic hepatitis C. J Virol Methods (2003) 1.96
Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog (2009) 1.94
Multiple effects of silymarin on the hepatitis C virus lifecycle. Hepatology (2010) 1.92
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab (2013) 1.91
The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection. Nat Rev Microbiol (2013) 1.88
Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33. Hepatology (2006) 1.88
Cell culture adaptation of hepatitis C virus and in vivo viability of an adapted variant. J Virol (2007) 1.87
Viral immune modulators perturb the human molecular network by common and unique strategies. Nature (2012) 1.86
Production of infectious hepatitis C virus in primary cultures of human adult hepatocytes. Gastroenterology (2010) 1.85
Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly. J Biol Chem (2008) 1.71
Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles. J Virol (2008) 1.70
Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol (2004) 1.67
Identification of hepatoprotective flavonolignans from silymarin. Proc Natl Acad Sci U S A (2010) 1.67
Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly. PLoS Pathog (2010) 1.67
Mouse hepatic cells support assembly of infectious hepatitis C virus particles. Gastroenterology (2011) 1.64
The hepatitis C virus RNA 3'-untranslated region strongly enhances translation directed by the internal ribosome entry site. J Virol (2006) 1.63
Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B. J Biol Chem (2009) 1.61
Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs. J Virol (2004) 1.61
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PLoS One (2010) 1.59
An oxygen-regulated switch in the protein synthesis machinery. Nature (2012) 1.56
Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations. PLoS Pathog (2009) 1.56
The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment. J Virol (2002) 1.56
Interferon type I gene expression in chronic hepatitis C. Lab Invest (2004) 1.55
Evidence for novel hepaciviruses in rodents. PLoS Pathog (2013) 1.54
Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I). J Biol Chem (2011) 1.54
The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner. Mol Cell Biol (2007) 1.54
Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice. Diabetologia (2014) 1.49
Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. Hepatology (2012) 1.49
Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus. Hepatology (2007) 1.49
Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development. Pathol Int (2010) 1.49
Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructural protein 5A. J Virol (2005) 1.47
Hepatitis C therapeutics: current status and emerging strategies. Nat Rev Drug Discov (2002) 1.46
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest (2009) 1.46
Hepatitis C virus and host cell lipids: an intimate connection. RNA Biol (2011) 1.45
Identification of determinants involved in initiation of hepatitis C virus RNA synthesis by using intergenotypic replicase chimeras. J Virol (2007) 1.44
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.43
Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment. J Virol (2013) 1.42
NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes. J Virol (2011) 1.41
Dissecting the interferon-induced inhibition of hepatitis C virus replication by using a novel host cell line. J Virol (2005) 1.41
Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Res (2006) 1.41
A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly. PLoS Pathog (2011) 1.41
Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A. Hepatology (2009) 1.40
Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model. Gastroenterology (2008) 1.40
Serum versus intrahepatic HCV RNA and liver histology. Hepatology (2002) 1.39