Published in J Biol Chem on October 17, 2007
Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog (2008) 3.81
The life of lipid droplets. Biochim Biophys Acta (2008) 2.75
Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles. J Virol (2008) 2.74
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies. Nat Med (2013) 2.63
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. J Lipid Res (2009) 2.55
Dengue virus capsid protein usurps lipid droplets for viral particle formation. PLoS Pathog (2009) 2.52
Hepatitis C virus hijacks host lipid metabolism. Trends Endocrinol Metab (2009) 2.05
Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog (2009) 1.94
Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles. J Virol (2008) 1.70
The ins and outs of hepatitis C virus entry and assembly. Nat Rev Microbiol (2013) 1.69
Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly. PLoS Pathog (2010) 1.67
Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesis. Nat Rev Microbiol (2008) 1.60
Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations. PLoS Pathog (2009) 1.56
Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation. PLoS Pathog (2009) 1.52
Hepatitis C virus: assembly and release of virus particles. J Biol Chem (2010) 1.42
A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly. PLoS Pathog (2011) 1.41
Trafficking of hepatitis C virus core protein during virus particle assembly. PLoS Pathog (2011) 1.32
Inhibition of cellular autophagy deranges dengue virion maturation. J Virol (2012) 1.32
Secretion of hepatitis C virus envelope glycoproteins depends on assembly of apolipoprotein B positive lipoproteins. PLoS One (2009) 1.31
Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein. J Gen Virol (2009) 1.30
Unique ties between hepatitis C virus replication and intracellular lipids. Trends Endocrinol Metab (2011) 1.27
Cell culture-adaptive mutations promote viral protein-protein interactions and morphogenesis of infectious hepatitis C virus. J Virol (2012) 1.24
Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. PLoS Pathog (2013) 1.23
Multifaceted roles for lipids in viral infection. Trends Microbiol (2011) 1.22
hepatitis c Virus p7 is critical for capsid assembly and envelopment. PLoS Pathog (2013) 1.20
The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake. J Lipid Res (2012) 1.16
Virion assembly and release. Curr Top Microbiol Immunol (2013) 1.15
Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A. J Biol Chem (2011) 1.13
Hepatitis C virus budding at lipid droplet-associated ER membrane visualized by 3D electron microscopy. Histochem Cell Biol (2008) 1.12
Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease. Viruses (2013) 1.12
Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice. J Biol Chem (2009) 1.10
Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets. PLoS Pathog (2013) 1.10
The ESCRT system is required for hepatitis C virus production. PLoS One (2011) 1.08
Role of lipids in virus replication. Cold Spring Harb Perspect Biol (2011) 1.08
Mouse models for the study of HCV infection and virus-host interactions. J Hepatol (2008) 1.05
Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium ion dependent and is mediated by LD surface proteins. J Virol (2011) 1.04
Characterization of hepatitis C RNA-containing particles from human liver by density and size. J Gen Virol (2008) 1.03
Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells. Proc Natl Acad Sci U S A (2010) 1.03
A novel inhibitor of dengue virus replication that targets the capsid protein. Antimicrob Agents Chemother (2012) 1.02
Naturally occurring hepatitis C virus subgenomic deletion mutants replicate efficiently in Huh-7 cells and are trans-packaged in vitro to generate infectious defective particles. J Virol (2009) 1.01
Internal initiation stimulates production of p8 minicore, a member of a newly discovered family of hepatitis C virus core protein isoforms. J Virol (2009) 1.01
Characterization of hepatitis C virus core protein multimerization and membrane envelopment: revelation of a cascade of core-membrane interactions. J Virol (2009) 1.01
Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins. J Virol (2014) 0.99
Dengue virus- and hepatitis C virus-induced replication and assembly compartments: the enemy inside--caught in the web. J Virol (2014) 0.99
Palmitoylation of hepatitis C virus core protein is important for virion production. J Biol Chem (2009) 0.98
Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents. PLoS Pathog (2012) 0.98
Role for ADP ribosylation factor 1 in the regulation of hepatitis C virus replication. J Virol (2010) 0.97
Role for TBC1D20 and Rab1 in hepatitis C virus replication via interaction with lipid droplet-bound nonstructural protein 5A. J Virol (2012) 0.97
Genetic analysis of the carboxy-terminal region of the hepatitis C virus core protein. J Virol (2009) 0.97
Lipid metabolism and HCV infection. Viruses (2010) 0.96
Steatosis and insulin resistance in hepatitis C: a way out for the virus? World J Gastroenterol (2009) 0.96
Dimerization-driven interaction of hepatitis C virus core protein with NS3 helicase. J Gen Virol (2010) 0.94
Identification of a functional, CRM-1-dependent nuclear export signal in hepatitis C virus core protein. PLoS One (2011) 0.94
Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies. RNA (2011) 0.94
Amphipathic α-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles. PLoS Pathog (2014) 0.93
How viruses use the endoplasmic reticulum for entry, replication, and assembly. Cold Spring Harb Perspect Biol (2013) 0.93
Coevolution of the hepatitis C virus polyprotein sites in patients on combined pegylated interferon and ribavirin therapy. J Virol (2011) 0.92
Characterization of hepatitis C virus intra- and intergenotypic chimeras reveals a role of the glycoproteins in virus envelopment. J Virol (2013) 0.92
Exploitation of lipid components by viral and host proteins for hepatitis C virus infection. Front Microbiol (2012) 0.92
Hepatitis C virus life cycle and lipid metabolism. Biology (Basel) (2014) 0.91
Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production. J Virol (2011) 0.91
The deubiquitinase activity of the Salmonella pathogenicity island 2 effector, SseL, prevents accumulation of cellular lipid droplets. Infect Immun (2011) 0.90
A host YB-1 ribonucleoprotein complex is hijacked by hepatitis C virus for the control of NS3-dependent particle production. J Virol (2013) 0.90
Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. J Am Chem Soc (2012) 0.89
Virological footprint of CD4+ T-cell responses during chronic hepatitis C virus infection. J Gen Virol (2010) 0.89
Kinetic analysis of the nucleic acid chaperone activity of the hepatitis C virus core protein. Nucleic Acids Res (2010) 0.89
Cholesterol depletion of hepatoma cells impairs hepatitis B virus envelopment by altering the topology of the large envelope protein. J Virol (2011) 0.89
Production of infectious chimeric hepatitis C virus genotype 2b harboring minimal regions of JFH-1. J Virol (2011) 0.87
Morphogenesis of infectious hepatitis C virus particles. Front Microbiol (2012) 0.87
Hepatitis C virus assembly imaging. Viruses (2011) 0.85
Spatiotemporal analysis of hepatitis C virus infection. PLoS Pathog (2015) 0.85
Efficiency of E2-p7 processing modulates production of infectious hepatitis C virus. J Virol (2013) 0.85
HCV core residues critical for infectivity are also involved in core-NS5A complex formation. PLoS One (2014) 0.85
A disulfide-bonded dimer of the core protein of hepatitis C virus is important for virus-like particle production. J Virol (2010) 0.84
Domain 3 of hepatitis C virus core protein is sufficient for intracellular lipid accumulation. J Infect Dis (2009) 0.83
Core as a novel viral target for hepatitis C drugs. Viruses (2010) 0.83
Functional characterization of bovine viral diarrhea virus nonstructural protein 5A by reverse genetic analysis and live cell imaging. J Virol (2013) 0.82
Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus. J Biol Chem (2014) 0.81
Detergent-resistant membrane association of NS2 and E2 during hepatitis C virus replication. J Virol (2015) 0.81
Conserved glycine 33 residue in flexible domain I of hepatitis C virus core protein is critical for virus infectivity. J Virol (2011) 0.81
Structural analysis of hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal peptide peptidase. J Virol (2012) 0.81
The modulation of hepatitis C virus 1a replication by PKR is dependent on NF-kB mediated interferon beta response in Huh7.5.1 cells. Virology (2013) 0.80
Dengue Virus Uses a Non-Canonical Function of the Host GBF1-Arf-COPI System for Capsid Protein Accumulation on Lipid Droplets. Traffic (2015) 0.80
Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses (2016) 0.79
Bidirectional lipid droplet velocities are controlled by differential binding strengths of HCV core DII protein. PLoS One (2013) 0.79
A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins. MBio (2014) 0.79
Hepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagy. World J Gastroenterol (2015) 0.79
Cytoplasmic vacuolization in cell death and survival. Oncotarget (2016) 0.78
Visualization and analysis of hepatitis C virus structural proteins at lipid droplets by super-resolution microscopy. PLoS One (2014) 0.78
Properties and Functions of the Dengue Virus Capsid Protein. Annu Rev Virol (2016) 0.77
Human Cathelicidin Compensates for the Role of Apolipoproteins in Hepatitis C Virus Infectious Particle Formation. J Virol (2016) 0.77
Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity. Biochim Biophys Acta (2013) 0.77
Recombinant adenoviruses expressing steatosis-associated hepatitis C virus genotype 3 core protein produce intracellular lipid accumulation in cultured and primary hepatocytes. Virus Res (2008) 0.77
Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus-induced interferon alpha responses of plasmacytoid dendritic cells. J Virol (2014) 0.77
Phosphatidylserine-specific phospholipase A1 involved in hepatitis C virus assembly through NS2 complex formation. J Virol (2014) 0.77
Hepatitis C virus e2 protein ectodomain is essential for assembly of infectious virions. Int J Hepatol (2010) 0.77
Dynamics of self-assembly of model viral capsids in the presence of a fluctuating membrane. J Phys Chem B (2013) 0.77
Functional characterization of core genes from patients with acute hepatitis C virus infection. J Infect Dis (2010) 0.76
The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion. PLoS One (2015) 0.76
Fluorescence lifetime imaging of alterations to cellular metabolism by domain 2 of the hepatitis C virus core protein. PLoS One (2013) 0.76
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med (2005) 21.56
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature (2005) 17.47
The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol (2007) 8.98
Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc Natl Acad Sci U S A (2006) 6.87
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J Virol (2003) 5.41
Peroxisomes are signaling platforms for antiviral innate immunity. Cell (2010) 5.24
Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. J Virol (2002) 5.21
Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe (2009) 4.54
Viral and cellular determinants of hepatitis C virus RNA replication in cell culture. J Virol (2003) 4.52
Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog (2008) 3.81
Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses. J Virol (2006) 3.75
Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees. Proc Natl Acad Sci U S A (2002) 3.43
Kissing-loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replication. J Virol (2005) 3.21
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe (2011) 3.05
Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions. PLoS Pathog (2007) 2.98
Quantitative analysis of the hepatitis C virus replication complex. J Virol (2005) 2.91
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. J Biol Chem (2004) 2.71
Genetic analysis of sequences in the 3' nontranslated region of hepatitis C virus that are important for RNA replication. J Virol (2002) 2.62
Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology (2002) 2.53
The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response. Hepatology (2010) 2.52
The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner. J Biol Chem (2007) 2.48
The first five seconds in the life of a clathrin-coated pit. Cell (2012) 2.48
The level of CD81 cell surface expression is a key determinant for productive entry of hepatitis C virus into host cells. J Virol (2006) 2.48
Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus. J Gen Virol (2007) 2.41
euHCVdb: the European hepatitis C virus database. Nucleic Acids Res (2006) 2.41
From structure to function: new insights into hepatitis C virus RNA replication. J Biol Chem (2005) 2.37
Assembly of infectious hepatitis C virus particles. Trends Microbiol (2010) 2.36
Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes. J Virol (2007) 2.29
Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81. Hepatology (2007) 2.25
Structural determinants that target the hepatitis C virus core protein to lipid droplets. J Biol Chem (2006) 2.18
Visualization of double-stranded RNA in cells supporting hepatitis C virus RNA replication. J Virol (2007) 2.15
Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B. J Biol Chem (2006) 2.12
Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome. J Biol Chem (2010) 2.05
Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication. PLoS Pathog (2012) 2.04
Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion. Oncogene (2005) 2.02
High density lipoprotein inhibits hepatitis C virus-neutralizing antibodies by stimulating cell entry via activation of the scavenger receptor BI. J Biol Chem (2006) 2.02
The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology (2006) 1.99
A replicon-based bioassay for the measurement of interferons in patients with chronic hepatitis C. J Virol Methods (2003) 1.96
Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog (2009) 1.94
Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner. Traffic (2008) 1.89
The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection. Nat Rev Microbiol (2013) 1.88
Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33. Hepatology (2006) 1.88
Cell culture adaptation of hepatitis C virus and in vivo viability of an adapted variant. J Virol (2007) 1.87
Viral immune modulators perturb the human molecular network by common and unique strategies. Nature (2012) 1.86
Production of infectious hepatitis C virus in primary cultures of human adult hepatocytes. Gastroenterology (2010) 1.85
Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein. J Biol Chem (2003) 1.79
Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly. J Biol Chem (2008) 1.71
Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles. J Virol (2008) 1.70
Next-generation sequencing sheds light on the natural history of hepatitis C infection in patients who fail treatment. Hepatology (2014) 1.70
The hepatitis C virus NS4B protein can trans-complement viral RNA replication and modulates production of infectious virus. J Virol (2008) 1.70
Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol (2004) 1.67
Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly. PLoS Pathog (2010) 1.67
Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles. Hepatology (2010) 1.65
Mouse hepatic cells support assembly of infectious hepatitis C virus particles. Gastroenterology (2011) 1.64
The hepatitis C virus RNA 3'-untranslated region strongly enhances translation directed by the internal ribosome entry site. J Virol (2006) 1.63
Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication. J Biol Chem (2005) 1.63
The domains required to direct core proteins of hepatitis C virus and GB virus-B to lipid droplets share common features with plant oleosin proteins. J Biol Chem (2001) 1.62
Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B. J Biol Chem (2009) 1.61
Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs. J Virol (2004) 1.61
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PLoS One (2010) 1.59
Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol (2011) 1.57
Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations. PLoS Pathog (2009) 1.56
The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment. J Virol (2002) 1.56
Interferon type I gene expression in chronic hepatitis C. Lab Invest (2004) 1.55
Evidence for novel hepaciviruses in rodents. PLoS Pathog (2013) 1.54
Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I). J Biol Chem (2011) 1.54
Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. Hepatology (2012) 1.49
Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus. Hepatology (2007) 1.49
Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development. Pathol Int (2010) 1.49
Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructural protein 5A. J Virol (2005) 1.47
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest (2009) 1.46
Hepatitis C virus and host cell lipids: an intimate connection. RNA Biol (2011) 1.45
Identification of determinants involved in initiation of hepatitis C virus RNA synthesis by using intergenotypic replicase chimeras. J Virol (2007) 1.44
Hepatitis C virus: assembly and release of virus particles. J Biol Chem (2010) 1.42
Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment. J Virol (2013) 1.42
NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes. J Virol (2011) 1.41
Dissecting the interferon-induced inhibition of hepatitis C virus replication by using a novel host cell line. J Virol (2005) 1.41
A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly. PLoS Pathog (2011) 1.41
Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model. Gastroenterology (2008) 1.40
Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A. Hepatology (2009) 1.40
Serum versus intrahepatic HCV RNA and liver histology. Hepatology (2002) 1.39
A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach. PLoS Pathog (2010) 1.38
Role of annexin A2 in the production of infectious hepatitis C virus particles. J Virol (2010) 1.38
Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy. Hepatology (2007) 1.36
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication. J Virol (2004) 1.36
miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells. Cancer Res (2012) 1.33
Secretion of hepatitis C virus envelope glycoproteins depends on assembly of apolipoprotein B positive lipoproteins. PLoS One (2009) 1.31
Architecture and biogenesis of plus-strand RNA virus replication factories. World J Virol (2013) 1.30
Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein. J Gen Virol (2009) 1.30
Hepatitis C virus RNA replication is resistant to tumour necrosis factor-alpha. J Gen Virol (2003) 1.29