Metagenomic biomarker discovery and explanation.

PubWeight™: 11.29‹?› | Rank: Top 0.1%

🔗 View Article (PMC 3218848)

Published in Genome Biol on June 24, 2011

Authors

Nicola Segata1, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower

Author Affiliations

1: Department of Biostatistics, 677 Huntington Avenue, Harvard School of Public Health, Boston, MA 02115, USA.

Articles citing this

(truncated to the top 100)

Diet rapidly and reproducibly alters the human gut microbiome. Nature (2013) 11.04

Metabolic reconstruction for metagenomic data and its application to the human microbiome. PLoS Comput Biol (2012) 6.27

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res (2011) 5.97

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol (2012) 5.66

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife (2013) 5.49

The placenta harbors a unique microbiome. Sci Transl Med (2014) 5.10

Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biol (2012) 4.68

Differential abundance analysis for microbial marker-gene surveys. Nat Methods (2013) 4.49

Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell (2014) 4.25

Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci Transl Med (2013) 4.15

Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell (2014) 3.70

Experimental and analytical tools for studying the human microbiome. Nat Rev Genet (2011) 3.30

Xenobiotics shape the physiology and gene expression of the active human gut microbiome. Cell (2013) 3.26

Diet dominates host genotype in shaping the murine gut microbiota. Cell Host Microbe (2014) 3.08

Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy. Hepatology (2015) 2.91

The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation. ISME J (2013) 2.90

Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome. Aliment Pharmacol Ther (2015) 2.87

Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer. PLoS One (2012) 2.77

Oligotyping: Differentiating between closely related microbial taxa using 16S rRNA gene data. Methods Ecol Evol (2013) 2.46

Microbial biogeography of wine grapes is conditioned by cultivar, vintage, and climate. Proc Natl Acad Sci U S A (2013) 2.44

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nat Med (2016) 2.40

Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol (2015) 2.26

The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome (2014) 2.24

Ecological modeling from time-series inference: insight into dynamics and stability of intestinal microbiota. PLoS Comput Biol (2013) 2.16

The human gut microbiome as a screening tool for colorectal cancer. Cancer Prev Res (Phila) (2014) 2.08

The microbiome of uncontacted Amerindians. Sci Adv (2015) 2.04

The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. Blood (2014) 2.04

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity. Nature (2014) 2.03

A metagenomic approach to characterization of the vaginal microbiome signature in pregnancy. PLoS One (2012) 1.98

Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation. Am J Physiol Gastrointest Liver Physiol (2012) 1.98

The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe (2011) 1.97

Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis. Nat Commun (2016) 1.84

Computational meta'omics for microbial community studies. Mol Syst Biol (2013) 1.84

Intestinal dysbiosis and depletion of butyrogenic bacteria in Clostridium difficile infection and nosocomial diarrhea. J Clin Microbiol (2013) 1.79

Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness. Nature (2014) 1.78

Functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis. Genome Med (2015) 1.77

Helminth infection promotes colonization resistance via type 2 immunity. Science (2016) 1.72

Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior. Elife (2016) 1.69

Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children. EBioMedicine (2015) 1.68

The human microbiome: our second genome. Annu Rev Genomics Hum Genet (2012) 1.64

Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth. Nat Cell Biol (2015) 1.63

Gut microbial community structure and complications after kidney transplantation: a pilot study. Transplantation (2014) 1.60

Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants. Microbiome (2013) 1.58

Oligotyping analysis of the human oral microbiome. Proc Natl Acad Sci U S A (2014) 1.56

Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery. Nat Med (2017) 1.55

Transmission of atherosclerosis susceptibility with gut microbial transplantation. J Biol Chem (2014) 1.53

Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon. PLoS Pathog (2012) 1.52

Assessing bacterial populations in the lung by replicate analysis of samples from the upper and lower respiratory tracts. PLoS One (2012) 1.51

Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice. Proc Natl Acad Sci U S A (2016) 1.50

Comparison of the levels of bacterial diversity in freshwater, intertidal wetland, and marine sediments by using millions of illumina tags. Appl Environ Microbiol (2012) 1.50

Intestinal microbiota, microbial translocation, and systemic inflammation in chronic HIV infection. J Infect Dis (2014) 1.47

Pretreatment gut microbiome predicts chemotherapy-related bloodstream infection. Genome Med (2016) 1.47

Compact graphical representation of phylogenetic data and metadata with GraPhlAn. PeerJ (2015) 1.47

The first microbial environment of infants born by C-section: the operating room microbes. Microbiome (2015) 1.46

Toward an efficient method of identifying core genes for evolutionary and functional microbial phylogenies. PLoS One (2011) 1.45

The microenvironment of injured murine gut elicits a local pro-restitutive microbiota. Nat Microbiol (2016) 1.44

Cheese rind communities provide tractable systems for in situ and in vitro studies of microbial diversity. Cell (2014) 1.42

Longitudinal Survey of Microbiota in Hospitalized Preterm Very-Low-Birth-Weight Infants. J Pediatr Gastroenterol Nutr (2016) 1.42

Sequencing and beyond: integrating molecular 'omics' for microbial community profiling. Nat Rev Microbiol (2015) 1.41

Changes in bacterial community composition of Escherichia coli O157:H7 super-shedder cattle occur in the lower intestine. PLoS One (2017) 1.40

Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota. Nat Microbiol (2016) 1.40

High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model. Nat Commun (2014) 1.40

Microbiome data distinguish patients with Clostridium difficile infection and non-C. difficile-associated diarrhea from healthy controls. MBio (2014) 1.40

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. Nat Med (2017) 1.40

The Microbiome of Ehrlichia-Infected and Uninfected Lone Star Ticks (Amblyomma americanum). PLoS One (2016) 1.39

Calcium Reduces Liver Injury in Mice on a High-Fat Diet: Alterations in Microbial and Bile Acid Profiles. PLoS One (2016) 1.39

Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission. ISME J (2014) 1.38

The nasopharyngeal microbiota of beef cattle before and after transport to a feedlot. BMC Microbiol (2017) 1.37

Structural modulation of gut microbiota in life-long calorie-restricted mice. Nat Commun (2013) 1.36

Helminth colonization is associated with increased diversity of the gut microbiota. PLoS Negl Trop Dis (2014) 1.35

Severity-related changes of bronchial microbiome in chronic obstructive pulmonary disease. J Clin Microbiol (2014) 1.35

Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. Nat Commun (2015) 1.32

Using high throughput sequencing to explore the biodiversity in oral bacterial communities. Mol Oral Microbiol (2012) 1.30

IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue. Mucosal Immunol (2013) 1.29

Gut microbiome and dietary patterns in different Saudi populations and monkeys. Sci Rep (2016) 1.29

A single genus in the gut microbiome reflects host preference and specificity. ISME J (2014) 1.28

An introduction to the analysis of shotgun metagenomic data. Front Plant Sci (2014) 1.27

Host-specificity among abundant and rare taxa in the sponge microbiome. ISME J (2014) 1.26

Antibiotics, birth mode, and diet shape microbiome maturation during early life. Sci Transl Med (2016) 1.23

Microbiota-mediated inflammation and antimicrobial defense in the intestine. Annu Rev Immunol (2015) 1.23

Differences in vaginal microbiome in African American women versus women of European ancestry. Microbiology (2014) 1.20

Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome. Diabetes (2015) 1.19

Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease. Biol Blood Marrow Transplant (2015) 1.19

Metagenomic Sequencing with Strain-Level Resolution Implicates Uropathogenic E. coli in Necrotizing Enterocolitis and Mortality in Preterm Infants. Cell Rep (2016) 1.19

Gut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome. Gut Microbes (2014) 1.19

Bacterial community development in experimental gingivitis. PLoS One (2013) 1.19

Ecological succession and stochastic variation in the assembly of Arabidopsis thaliana phyllosphere communities. MBio (2014) 1.14

Association of the vaginal microbiota with human papillomavirus infection in a Korean twin cohort. PLoS One (2013) 1.13

Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals. Mucosal Immunol (2014) 1.13

Metagenomics: tools and insights for analyzing next-generation sequencing data derived from biodiversity studies. Bioinform Biol Insights (2015) 1.13

Edge principal components and squash clustering: using the special structure of phylogenetic placement data for sample comparison. PLoS One (2013) 1.12

Altered fecal microbiota composition associated with food allergy in infants. Appl Environ Microbiol (2014) 1.11

Chemokine (C-C Motif) Receptor 2 Mediates Dendritic Cell Recruitment to the Human Colon but Is Not Responsible for Differences Observed in Dendritic Cell Subsets, Phenotype, and Function Between the Proximal and Distal Colon. Cell Mol Gastroenterol Hepatol (2015) 1.10

Towards predictive models of the human gut microbiome. J Mol Biol (2014) 1.09

Illumina sequencing of 16S rRNA tag revealed spatial variations of bacterial communities in a mangrove wetland. Microb Ecol (2013) 1.09

Effect of metformin on metabolic improvement and gut microbiota. Appl Environ Microbiol (2014) 1.08

Microbiota diversity and gene expression dynamics in human oral biofilms. BMC Genomics (2014) 1.07

Study of the viral and microbial communities associated with Crohn's disease: a metagenomic approach. Clin Transl Gastroenterol (2013) 1.06

Analysis of the intestinal lumen microbiota in an animal model of colorectal cancer. PLoS One (2014) 1.05

Functional Characterization of Inflammatory Bowel Disease-Associated Gut Dysbiosis in Gnotobiotic Mice. Cell Mol Gastroenterol Hepatol (2016) 1.05

Articles cited by this

Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science (1999) 83.27

Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol (2009) 77.55

Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol (2007) 60.97

The Ribosomal Database Project: improved alignments and new tools for rRNA analysis. Nucleic Acids Res (2008) 52.43

A core gut microbiome in obese and lean twins. Nature (2008) 52.30

A genomic perspective on protein families. Science (1997) 50.51

UniFrac: a new phylogenetic method for comparing microbial communities. Appl Environ Microbiol (2005) 49.76

An obesity-associated gut microbiome with increased capacity for energy harvest. Nature (2006) 44.35

The COG database: new developments in phylogenetic classification of proteins from complete genomes. Nucleic Acids Res (2001) 43.17

Microbial diversity in the deep sea and the underexplored "rare biosphere". Proc Natl Acad Sci U S A (2006) 42.38

Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences. Genome Biol (2010) 39.63

SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB. Nucleic Acids Res (2007) 35.65

The subsystems approach to genome annotation and its use in the project to annotate 1000 genomes. Nucleic Acids Res (2005) 29.61

The metagenomics RAST server - a public resource for the automatic phylogenetic and functional analysis of metagenomes. BMC Bioinformatics (2008) 29.20

The human microbiome project. Nature (2007) 28.53

Comparative metagenomics of microbial communities. Science (2005) 25.88

MEGAN analysis of metagenomic data. Genome Res (2007) 25.29

Bacterial community variation in human body habitats across space and time. Science (2009) 24.84

The NIH Human Microbiome Project. Genome Res (2009) 24.61

Accuracy and quality of massively parallel DNA pyrosequencing. Genome Biol (2007) 23.64

Community structure and metabolism through reconstruction of microbial genomes from the environment. Nature (2004) 20.20

Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell (2006) 18.83

Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons. Genome Res (2011) 17.21

Galaxy: a web-based genome analysis tool for experimentalists. Curr Protoc Mol Biol (2010) 17.00

Use of proteomic patterns in serum to identify ovarian cancer. Lancet (2002) 16.38

The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med (2009) 16.02

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A (2010) 15.22

Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes. DNA Res (2007) 13.08

Identification of the uncultured bacillus of Whipple's disease. N Engl J Med (1992) 12.33

Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe (2008) 11.97

Functional metagenomic profiling of nine biomes. Nature (2008) 11.00

Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut (2005) 10.95

An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature (2007) 10.92

Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell (2007) 8.42

Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res (2008) 8.17

Statistical methods for detecting differentially abundant features in clinical metagenomic samples. PLoS Comput Biol (2009) 8.06

Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol (2006) 7.75

Intestinal mucosal barrier function in health and disease. Nat Rev Immunol (2009) 7.15

Microbial community profiling for human microbiome projects: Tools, techniques, and challenges. Genome Res (2009) 7.12

Marine microbial diversity: can it be determined? Trends Microbiol (2006) 5.39

Identifying biologically relevant differences between metagenomic communities. Bioinformatics (2010) 4.86

Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes (Lond) (2008) 4.78

Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis (2009) 4.72

Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe (2010) 4.54

Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea. J Clin Gastroenterol (2010) 4.52

A primer on metagenomics. PLoS Comput Biol (2010) 4.40

2020 visions. Nature (2010) 4.36

Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe (2008) 4.14

False discovery rate, sensitivity and sample size for microarray studies. Bioinformatics (2005) 3.83

Substantial alterations of the cutaneous bacterial biota in psoriatic lesions. PLoS One (2008) 3.56

The properties of high-dimensional data spaces: implications for exploring gene and protein expression data. Nat Rev Cancer (2008) 3.43

High-throughput gene mapping in Caenorhabditis elegans. Genome Res (2002) 3.21

The 'rare biosphere': a reality check. Nat Methods (2009) 3.19

ShotgunFunctionalizeR: an R-package for functional comparison of metagenomes. Bioinformatics (2009) 3.17

A high-throughput DNA sequence aligner for microbial ecology studies. PLoS One (2009) 3.07

National Institute of Allergy and Infectious Diseases bioinformatics resource centers: new assets for pathogen informatics. Infect Immun (2007) 3.02

A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J Immunol (1998) 2.74

Diversity of human vaginal bacterial communities and associations with clinically defined bacterial vaginosis. Appl Environ Microbiol (2008) 2.73

Mouse models of inflammatory bowel disease. Adv Drug Deliv Rev (2007) 2.42

Exploring the diversity of the bifidobacterial population in the human intestinal tract. Appl Environ Microbiol (2009) 2.34

Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol (2003) 2.30

Host specificity in marine sponge-associated bacteria, and potential implications for marine microbial diversity. Environ Microbiol (2004) 2.25

Reshaping the gut microbiome with bacterial transplantation and antibiotic intake. Genome Res (2010) 2.21

Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer. Gastroenterology (2009) 2.13

Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A (2010) 2.10

Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era. Gastroenterology (2009) 1.96

Visual and statistical comparison of metagenomes. Bioinformatics (2009) 1.94

METAREP: JCVI metagenomics reports--an open source tool for high-performance comparative metagenomics. Bioinformatics (2010) 1.72

False-positive selection identified by ML-based methods: examples from the Sig1 gene of the diatom Thalassiosira weissflogii and the tax gene of a human T-cell lymphotropic virus. Mol Biol Evol (2004) 1.64

Over-optimism in bioinformatics research. Bioinformatics (2009) 1.64

Mouse models for the study of Crohn's disease. Trends Mol Med (2003) 1.59

Environmental distribution of prokaryotic taxa. BMC Microbiol (2010) 1.54

Multivariate Cutoff Level Analysis (MultiCoLA) of large community data sets. Nucleic Acids Res (2010) 1.49

The clinical value of salivary biomarkers for periodontal disease. Periodontol 2000 (2009) 1.33

Biomarkers for infants at risk for necrotizing enterocolitis: clues to prevention? Pediatr Res (2009) 1.32

Metagenomics: the role of the microbiome in cardiovascular diseases. Curr Opin Lipidol (2006) 1.25

Oral cavity as natural reservoir for intestinal lactobacilli. Syst Appl Microbiol (2005) 1.23

Comparison of multiple metagenomes using phylogenetic networks based on ecological indices. ISME J (2010) 1.23

Successful treatment of fulminant Clostridium difficile infection with fecal bacteriotherapy. Ann Intern Med (2008) 1.19

Rarity associated with specific ecological niches in the bacterial world: the 'Synergistes' example. Environ Microbiol (2005) 1.17

Inclusion of a priori information in genome-wide association analysis. Genet Epidemiol (2009) 1.06

Exploring the within- and between-class correlation distributions for tumor classification. Proc Natl Acad Sci U S A (2010) 1.03

Development of colonic adenocarcinomas in a mouse model of ulcerative colitis. Inflamm Bowel Dis (1998) 1.00

Survival of Campylobacter jejuni under conditions of atmospheric oxygen tension with the support of Pseudomonas spp. Appl Environ Microbiol (2010) 0.96

[Immunoproliferative small intestinal disease associated with Campylobacter jejuni]. Med Mal Infect (2005) 0.88

Metascardovia criceti Gen. Nov., Sp. Nov., from hamster dental plaque. Microbiol Immunol (2007) 0.85

Specified species in gingival crevicular fluid predict bacterial diversity. PLoS One (2010) 0.85

Articles by these authors

Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons. Genome Res (2011) 17.21

Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies. PLoS One (2011) 12.26

Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nat Biotechnol (2013) 11.05

The human oral microbiome. J Bacteriol (2010) 9.00

The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science (2013) 8.53

Metagenomic microbial community profiling using unique clade-specific marker genes. Nat Methods (2012) 8.37

A catalog of reference genomes from the human microbiome. Science (2010) 8.10

Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications. Nat Biotechnol (2011) 7.53

Metabolic reconstruction for metagenomic data and its application to the human microbiome. PLoS Comput Biol (2012) 6.27

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res (2011) 5.97

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol (2012) 5.66

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife (2013) 5.49

Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing. Nat Methods (2012) 5.41

Microbial co-occurrence relationships in the human microbiome. PLoS Comput Biol (2012) 5.35

Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med (2011) 5.24

Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry. Proc Natl Acad Sci U S A (2007) 5.09

Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biol (2012) 4.68

The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information. Database (Oxford) (2010) 4.66

Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast. Mol Biol Cell (2007) 4.27

Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut (2012) 3.67

Exploring the functional landscape of gene expression: directed search of large microarray compendia. Bioinformatics (2007) 3.59

Resource partitioning and sympatric differentiation among closely related bacterioplankton. Science (2008) 3.46

Sequence-based discovery of Bradyrhizobium enterica in cord colitis syndrome. N Engl J Med (2013) 3.39

Experimental and analytical tools for studying the human microbiome. Nat Rev Genet (2011) 3.30

Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe (2013) 3.21

Finding function: evaluation methods for functional genomic data. BMC Genomics (2006) 3.10

Efficient and robust RNA-seq process for cultured bacteria and complex community transcriptomes. Genome Biol (2012) 3.02

A guide to enterotypes across the human body: meta-analysis of microbial community structures in human microbiome datasets. PLoS Comput Biol (2013) 2.96

Colorectal cancer: a tale of two sides or a continuum? Gut (2012) 2.85

Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas. Clin Cancer Res (2010) 2.79

Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp. nov. and Burkholderia lata sp. nov. Int J Syst Evol Microbiol (2009) 2.61

GOLEM: an interactive graph-based gene-ontology navigation and analysis tool. BMC Bioinformatics (2006) 2.46

Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues. Lab Invest (2009) 2.43

Fecal microbiota transplant for relapsing Clostridium difficile infection using a frozen inoculum from unrelated donors: a randomized, open-label, controlled pilot study. Clin Infect Dis (2014) 2.41

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest (2014) 2.39

PhyloPhlAn is a new method for improved phylogenetic and taxonomic placement of microbes. Nat Commun (2013) 2.28

mRNA transcript quantification in archival samples using multiplexed, color-coded probes. BMC Biotechnol (2011) 2.20

The Human Microbiome Project: a community resource for the healthy human microbiome. PLoS Biol (2012) 2.17

The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters. FASEB J (2012) 2.13

Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A (2010) 2.10

A metagenomic approach to characterization of the vaginal microbiome signature in pregnancy. PLoS One (2012) 1.98

The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe (2011) 1.97

Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell (2013) 1.96

Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet (2009) 1.90

Towards a prokaryotic genomic taxonomy. FEMS Microbiol Rev (2005) 1.87

Comparative genomics of enterococci: variation in Enterococcus faecalis, clade structure in E. faecium, and defining characteristics of E. gallinarum and E. casseliflavus. MBio (2012) 1.85

Global assessment of genomic regions required for growth in Mycobacterium tuberculosis. PLoS Pathog (2012) 1.85

Computational meta'omics for microbial community studies. Mol Syst Biol (2013) 1.84

MicroRNA-301 mediates proliferation and invasion in human breast cancer. Cancer Res (2011) 1.75

High-quality draft genome sequences of 28 Enterococcus sp. isolates. J Bacteriol (2010) 1.67

Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease. PLoS One (2012) 1.66

STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers. Clin Cancer Res (2011) 1.62

Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants. Microbiome (2013) 1.58

Biodiversity and functional genomics in the human microbiome. Trends Genet (2012) 1.52

Tannerella forsythia, a periodontal pathogen entering the genomic era. Periodontol 2000 (2006) 1.52

Exploring host-microbiota interactions in animal models and humans. Genes Dev (2013) 1.51

Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. Mol Cancer (2010) 1.50

Predicting cellular growth from gene expression signatures. PLoS Comput Biol (2009) 1.50

Application of multilocus sequence analysis (MLSA) for rapid identification of Enterococcus species based on rpoA and pheS genes. Microbiology (2005) 1.49

Pyramidobacter piscolens gen. nov., sp. nov., a member of the phylum 'Synergistetes' isolated from the human oral cavity. Int J Syst Evol Microbiol (2009) 1.48

Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans. PLoS Comput Biol (2009) 1.48

Toward an efficient method of identifying core genes for evolutionary and functional microbial phylogenies. PLoS One (2011) 1.45

Diversity analysis of dairy and nondairy Lactococcus lactis isolates, using a novel multilocus sequence analysis scheme and (GTG)5-PCR fingerprinting. Appl Environ Microbiol (2007) 1.45

A case study for large-scale human microbiome analysis using JCVI's metagenomics reports (METAREP). PLoS One (2012) 1.44

Chapter 12: Human microbiome analysis. PLoS Comput Biol (2012) 1.44

Conservation of the chitin utilization pathway in the Vibrionaceae. Appl Environ Microbiol (2007) 1.40

curatedOvarianData: clinically annotated data for the ovarian cancer transcriptome. Database (Oxford) (2013) 1.40

Optimized application of penalized regression methods to diverse genomic data. Bioinformatics (2011) 1.37

The interpersonal and intrapersonal diversity of human-associated microbiota in key body sites. J Allergy Clin Immunol (2012) 1.35

The incidence of nirS and nirK and their genetic heterogeneity in cultivated denitrifiers. Environ Microbiol (2006) 1.33

The genome of the versatile nitrogen fixer Azorhizobium caulinodans ORS571. BMC Genomics (2008) 1.32

Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships. Microbiome (2013) 1.32

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. Gut (2012) 1.32

Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development. PLoS Genet (2011) 1.30

Identification of lactobacilli by pheS and rpoA gene sequence analyses. Int J Syst Evol Microbiol (2007) 1.30

Genotype and time of day shape the Populus drought response. Plant J (2009) 1.28

Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A (2013) 1.23

Directing experimental biology: a case study in mitochondrial biogenesis. PLoS Comput Biol (2009) 1.20

Potentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma. Clin Cancer Res (2013) 1.13