Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system.

PubWeight™: 8.42‹?› | Rank: Top 0.1%

🔗 View Article (PMC 2169385)

Published in Cell on October 05, 2007

Authors

Wendy S Garrett1, Graham M Lord, Shivesh Punit, Geanncarlo Lugo-Villarino, Sarkis K Mazmanian, Susumu Ito, Jonathan N Glickman, Laurie H Glimcher

Author Affiliations

1: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

Articles citing this

(truncated to the top 100)

The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol (2009) 13.87

Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science (2010) 12.54

Metagenomic biomarker discovery and explanation. Genome Biol (2011) 11.29

Interactions between the microbiota and the immune system. Science (2012) 10.45

Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci U S A (2010) 9.57

The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science (2013) 8.53

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol (2009) 8.32

Genetics and pathogenesis of inflammatory bowel disease. Nature (2011) 7.79

Inflammatory bowel disease. Annu Rev Immunol (2010) 7.10

Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol (2009) 6.10

Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A (2011) 5.44

Microbes in gastrointestinal health and disease. Gastroenterology (2008) 4.65

Homeostasis and inflammation in the intestine. Cell (2010) 4.60

Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe (2010) 4.54

Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol (2013) 4.34

The keystone-pathogen hypothesis. Nat Rev Microbiol (2012) 4.18

Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe (2008) 4.14

The microbiome in infectious disease and inflammation. Annu Rev Immunol (2012) 3.76

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A (2011) 3.55

Role of the microbiota in immunity and inflammation. Cell (2014) 3.43

Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe (2013) 3.21

A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells. Nature (2013) 3.07

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest (2013) 2.96

Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest (2011) 2.93

Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology (2011) 2.90

Microbiota-mediated colonization resistance against intestinal pathogens. Nat Rev Immunol (2013) 2.89

Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol (2010) 2.85

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol (2013) 2.82

T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol (2010) 2.68

Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. J Exp Med (2012) 2.62

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature (2009) 2.59

Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nat Rev Immunol (2010) 2.58

Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci Transl Med (2013) 2.47

Role of the commensal microbiota in normal and pathogenic host immune responses. Cell Host Microbe (2011) 2.46

The immune system and the gut microbiota: friends or foes? Nat Rev Immunol (2010) 2.38

Predominant role of host genetics in controlling the composition of gut microbiota. PLoS One (2008) 2.33

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation. J Exp Med (2014) 2.33

Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis. Infect Immun (2011) 2.24

The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models. Nat Rev Microbiol (2010) 2.22

Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. Nat Med (2012) 2.20

Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A (2010) 2.10

Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease. Nutrients (2012) 2.10

Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest (2011) 2.09

Intestinal commensal microbes as immune modulators. Cell Host Microbe (2012) 2.07

Microbes, microbiota, and colon cancer. Cell Host Microbe (2014) 2.06

Antibiotic exposure and IBD development among children: a population-based cohort study. Pediatrics (2012) 2.04

Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria. Nat Rev Immunol (2010) 2.02

Metagenomics and personalized medicine. Cell (2011) 2.00

The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells. Immunity (2012) 1.97

Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell (2009) 1.95

Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus. Immunity (2014) 1.94

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A (2009) 1.86

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury. Immunity (2015) 1.80

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence. Gut (2015) 1.80

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation. Immunity (2015) 1.79

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol (2011) 1.77

Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression. PLoS One (2011) 1.74

Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease. Immunity (2012) 1.73

Host-bacterial symbiosis in health and disease. Adv Immunol (2010) 1.73

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway. Nat Immunol (2013) 1.70

T-bet: a bridge between innate and adaptive immunity. Nat Rev Immunol (2013) 1.70

Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet. Cell Metab (2013) 1.68

Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection. Cell Host Microbe (2015) 1.66

Distinct requirements for T-bet in gut innate lymphoid cells. J Exp Med (2012) 1.61

Inflammation and colorectal cancer: colitis-associated neoplasia. Semin Immunopathol (2012) 1.61

Comparison of the immunomodulatory properties of three probiotic strains of Lactobacilli using complex culture systems: prediction for in vivo efficacy. PLoS One (2009) 1.60

The dynamics of gut-associated microbial communities during inflammation. EMBO Rep (2013) 1.59

GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58

Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One (2012) 1.58

Modulation of immune homeostasis by commensal bacteria. Curr Opin Microbiol (2011) 1.57

The intestinal microbiota in health and disease: the influence of microbial products on immune cell homeostasis. Curr Opin Gastroenterol (2009) 1.57

Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function. J Immunol (2010) 1.53

Experimental inflammatory bowel disease: insights into the host-microbiota dialog. Immunity (2011) 1.53

Intestinal microbial diversity during early-life colonization shapes long-term IgE levels. Cell Host Microbe (2013) 1.51

Cd1d-dependent regulation of bacterial colonization in the intestine of mice. J Clin Invest (2009) 1.49

Investigating the biological and clinical significance of human dysbioses. Trends Microbiol (2011) 1.48

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease. Sci Transl Med (2015) 1.46

Conducting a microbiome study. Cell (2014) 1.46

'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution. Nat Rev Microbiol (2013) 1.45

Host lysozyme-mediated lysis of Lactococcus lactis facilitates delivery of colitis-attenuating superoxide dismutase to inflamed colons. Proc Natl Acad Sci U S A (2015) 1.44

Mammalian gut immunity. Biomed J (2014) 1.43

Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis. ISME J (2012) 1.43

Increased gap density predicts weakness of the epithelial barrier in vivo by confocal laser endomicroscopy in indomethacin-induced enteropathy. Dig Dis Sci (2014) 1.41

Pathobionts of the gastrointestinal microbiota and inflammatory disease. Curr Opin Immunol (2011) 1.39

Inflammatory bowel disease as a model for translating the microbiome. Immunity (2014) 1.39

Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission. ISME J (2014) 1.38

Role of the endothelium in inflammatory bowel diseases. World J Gastroenterol (2011) 1.35

The role of microbiome in central nervous system disorders. Brain Behav Immun (2013) 1.34

Regulation of innate and adaptive immunity by the commensal microbiota. Curr Opin Immunol (2011) 1.34

Patterns and scales in gastrointestinal microbial ecology. Gastroenterology (2009) 1.33

Host genetic variation impacts microbiome composition across human body sites. Genome Biol (2015) 1.32

The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes (2012) 1.32

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease. Mucosal Immunol (2011) 1.30

Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol (2014) 1.28

Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism. J Exp Med (2013) 1.27

Crohn's disease: NOD2, autophagy and ER stress converge. Gut (2011) 1.27

Crohn disease: a current perspective on genetics, autophagy and immunity. Autophagy (2011) 1.26

Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A (2013) 1.23

Microbiota-mediated inflammation and antimicrobial defense in the intestine. Annu Rev Immunol (2015) 1.23

Articles cited by this

Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A (2005) 33.66

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32

Host-bacterial mutualism in the human intestine. Science (2005) 26.39

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med (1992) 22.13

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med (1994) 21.52

Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell (2006) 18.83

Commensal host-bacterial relationships in the gut. Science (2001) 14.82

The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol (2003) 8.28

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol (2005) 7.44

Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature (2007) 7.17

The fundamental basis of inflammatory bowel disease. J Clin Invest (2007) 6.84

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol (2005) 6.77

Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc Natl Acad Sci U S A (2004) 5.93

Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature (2007) 4.68

Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J Exp Med (2006) 4.53

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med (2002) 4.47

Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol (2006) 4.04

Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 3.98

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest (2004) 3.90

Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science (2002) 3.58

Mucosal dendritic cells. Annu Rev Immunol (2007) 3.26

Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol (2004) 2.38

Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria. Immunology (2005) 1.89

Role of the innate immune system and host-commensal mutualism. Curr Top Microbiol Immunol (2006) 1.65

What immunologists should know about bacterial communities of the human bowel. Semin Immunol (2006) 1.65

Inflammatory bowel disease and the apical junctional complex. Ann N Y Acad Sci (2006) 1.59

Trawling for treasure: tales of T-bet. Nat Immunol (2007) 1.57

Regional specialization of the mucosal immune system. Intraepithelial lymphocytes of the large intestine have a different phenotype and function than those of the small intestine. J Immunol (1993) 1.39

Different cytokine response of primary colonic epithelial cells to commensal bacteria. World J Gastroenterol (2005) 1.29

Mechanisms of intestinal epithelial cell injury and colitis in interleukin 2 (IL2)-deficient mice. Cell Immunol (1998) 1.29

Dendritic cells: the commanders-in-chief of mucosal immune defenses. Curr Opin Gastroenterol (2006) 1.27

Differential activation of cytokine secretion in primary human colonic fibroblast/myofibroblast cultures. Scand J Gastroenterol (2001) 1.24

Remission-inducing effect of anti-TNF monoclonal antibody in TNBS colitis: mechanisms beyond neutralization? Inflamm Bowel Dis (2007) 1.21

The intestinal epithelial barrier: how to distinguish between the microbial flora and pathogens. Semin Immunol (2007) 1.20

Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells. Immunol Lett (2005) 1.20

Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli. Clin Exp Immunol (2005) 1.13

Differential expression of T-bet, a T-box transcription factor required for Th1 T-cell development, in peripheral T-cell lymphomas. Am J Clin Pathol (2003) 1.06

Characterization and distribution of colonic dendritic cells in Crohn's disease. Inflamm Bowel Dis (2004) 1.02

Articles by these authors

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08

The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol (2009) 13.87

XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol (2003) 11.17

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A (2010) 9.81

Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med (2008) 9.20

The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science (2013) 8.53

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol (2003) 7.06

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity (2004) 6.72

T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity (2004) 6.43

Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol (2001) 6.30

Regulation of hepatic lipogenesis by the transcription factor XBP1. Science (2008) 6.02

The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science (2011) 6.01

Microbial exposure during early life has persistent effects on natural killer T cell function. Science (2012) 5.90

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest (2002) 5.83

Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med (2004) 5.13

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2010) 5.10

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet (2008) 5.07

Animals in a bacterial world, a new imperative for the life sciences. Proc Natl Acad Sci U S A (2013) 5.03

Transcriptome sequencing of malignant pleural mesothelioma tumors. Proc Natl Acad Sci U S A (2008) 4.75

Homeostasis and inflammation in the intestine. Cell (2010) 4.60

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol (2010) 4.56

Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe (2010) 4.54

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity (2007) 4.49

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci U S A (2003) 4.47

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science (2006) 4.46

T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol (2002) 4.38

Has the microbiota played a critical role in the evolution of the adaptive immune system? Science (2010) 4.29

The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol (2008) 4.09

High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry. J Biol (2006) 4.04

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med (2009) 3.97

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J (2005) 3.92

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science (2002) 3.91

NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81

Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75

Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol (2006) 3.70

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science (2005) 3.65

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest (2010) 3.41

Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A (2005) 3.32

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res (2004) 3.24

Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci U S A (2003) 3.23

Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe (2013) 3.21

The role of Th1/Th2 polarization in mucosal immunity. Nat Med (2002) 3.19

A critical period for social experience-dependent oligodendrocyte maturation and myelination. Science (2012) 3.17

Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med (2002) 3.16

Critical roles for transcription factor GATA-3 in thymocyte development. Immunity (2003) 3.15

Recent developments in the transcriptional regulation of cytolytic effector cells. Nat Rev Immunol (2004) 3.14

BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell (2009) 3.07

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev (2009) 3.03

T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood (2005) 2.95

Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc Natl Acad Sci U S A (2007) 2.92

Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science (2006) 2.70

T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol (2010) 2.68

T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A (2002) 2.63

Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. Clin Cancer Res (2009) 2.62

Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes (2007) 2.54

A pathobiont of the microbiota balances host colonization and intestinal inflammation. Cell Host Microbe (2010) 2.50

The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol Rev (2011) 2.50

Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. Mol Cell (2009) 2.47

Outer membrane vesicles of a human commensal mediate immune regulation and disease protection. Cell Host Microbe (2012) 2.41

T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci U S A (2003) 2.34

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest (2008) 2.29

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med (2008) 2.26

Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production. Cancer Res (2013) 2.21

Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mol Cell (2004) 2.20

The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol Rev (2003) 2.20

Bacterial colonization factors control specificity and stability of the gut microbiota. Nature (2013) 2.20

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc Natl Acad Sci U S A (2005) 2.19

Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest (2006) 2.16

The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med (2007) 2.12

Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice. Gastroenterology (2012) 2.11

Signaling pathways in Th2 development. Immunol Rev (2004) 2.10

Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A (2010) 2.10

Paneth cells as a site of origin for intestinal inflammation. Nature (2013) 2.09

T-bet in disease. Nat Immunol (2011) 2.09

Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A (2007) 2.02

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest (2010) 1.98

Anchoring of surface proteins to the cell wall of Staphylococcus aureus. III. Lipid II is an in vivo peptidoglycan substrate for sortase-catalyzed surface protein anchoring. J Biol Chem (2002) 1.97

Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron (2012) 1.97

Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses. J Immunol (2011) 1.97

The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells. Immunity (2012) 1.97

Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell (2009) 1.95

The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe (2013) 1.91

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. Cell Metab (2012) 1.90

Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence. Mol Microbiol (2002) 1.89

T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes. J Exp Med (2004) 1.88

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol Cell (2011) 1.87

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A (2009) 1.86