Published in J Virol on June 29, 2011
Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature (2016) 1.56
At the centre: influenza A virus ribonucleoproteins. Nat Rev Microbiol (2014) 1.33
Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers. J Virol (2011) 1.28
TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase. PLoS Pathog (2015) 0.98
Biogenesis, assembly, and export of viral messenger ribonucleoproteins in the influenza A virus infected cell. RNA Biol (2013) 0.96
MicroRNA regulation of human protease genes essential for influenza virus replication. PLoS One (2012) 0.96
HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication. J Virol (2012) 0.93
Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication. J Virol (2014) 0.92
Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. Immunity (2016) 0.89
Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses. Semin Immunol (2012) 0.88
Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis. Nat Rev Microbiol (2016) 0.88
Exploration of binary virus-host interactions using an infectious protein complementation assay. Mol Cell Proteomics (2013) 0.86
Moving H5N1 studies into the era of systems biology. Virus Res (2013) 0.84
Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein. Cell Host Microbe (2014) 0.83
Protective efficacy of orally administered, heat-killed Lactobacillus pentosus b240 against influenza A virus. Sci Rep (2013) 0.83
pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA. Elife (2015) 0.81
Crucial role of PA in virus life cycle and host adaptation of influenza A virus. Med Microbiol Immunol (2014) 0.80
Cellular protein HAX1 interacts with the influenza A virus PA polymerase subunit and impedes its nuclear translocation. J Virol (2012) 0.80
DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity. J Virol (2014) 0.79
A novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice. BMC Genomics (2014) 0.78
Generation and Comprehensive Analysis of Host Cell Interactome of the PA Protein of the Highly Pathogenic H5N1 Avian Influenza Virus in Mammalian Cells. Front Microbiol (2017) 0.75
Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction. Nat Commun (2017) 0.75
Pre-mRNA processing factor Prp18 is a stimulatory factor of influenza virus RNA synthesis and possesses the NP chaperone activity. J Virol (2016) 0.75
Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction. Cell Rep (2017) 0.75
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc (2009) 137.99
Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal Chem (2002) 35.30
A statistical model for identifying proteins by tandem mass spectrometry. Anal Chem (2003) 29.58
A novel influenza A virus mitochondrial protein that induces cell death. Nat Med (2001) 9.90
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88
Human host factors required for influenza virus replication. Nature (2010) 5.28
A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. Cell (2009) 4.98
Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Nature (2010) 4.23
Drosophila RNAi screen identifies host genes important for influenza virus replication. Nature (2008) 4.18
Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein. Science (2002) 3.73
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs. J Virol (2002) 3.37
Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus. PLoS Pathog (2008) 3.37
Expression of the zinc-finger antiviral protein inhibits alphavirus replication. J Virol (2003) 3.19
Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat Struct Mol Biol (2007) 3.13
NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein. Virology (1995) 2.74
The NPI-1/NPI-3 (karyopherin alpha) binding site on the influenza a virus nucleoprotein NP is a nonconventional nuclear localization signal. J Virol (1997) 2.51
Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. Science (1996) 2.42
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. J Virol (2010) 2.35
Cellular splicing factor RAF-2p48/NPI-5/BAT1/UAP56 interacts with the influenza virus nucleoprotein and enhances viral RNA synthesis. J Virol (2001) 2.33
Cellular networks involved in the influenza virus life cycle. Cell Host Microbe (2010) 2.23
Identification of cellular interaction partners of the influenza virus ribonucleoprotein complex and polymerase complex using proteomic-based approaches. J Proteome Res (2007) 2.21
Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II. J Virol (2005) 2.19
The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes. J Virol (1993) 2.04
Distinct regions of influenza virus PB1 polymerase subunit recognize vRNA and cRNA templates. EMBO J (1999) 2.00
PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators. J Virol (2001) 1.98
Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex. J Virol (2006) 1.93
Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits. J Virol (2006) 1.93
Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes. J Virol (2007) 1.92
High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses. Proc Natl Acad Sci U S A (2011) 1.85
The amino-terminal one-third of the influenza virus PA protein is responsible for the induction of proteolysis. J Virol (1996) 1.79
The voltage-dependent anion channel: an essential player in apoptosis. Biochimie (2002) 1.75
The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. PLoS Pathog (2010) 1.73
Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation. J Mol Biol (1998) 1.72
On the role of VDAC in apoptosis: fact and fiction. J Bioenerg Biomembr (2005) 1.68
Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome. Nucleic Acids Res (2004) 1.58
Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase. J Virol (2010) 1.46
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses. Nat Immunol (2010) 1.43
Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1. J Biol Chem (2010) 1.43
Interferon regulatory factor-3 is an in vivo target of DNA-PK. Proc Natl Acad Sci U S A (2002) 1.42
The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks. J Virol (2010) 1.40
De novo replication of the influenza virus RNA genome is regulated by DNA replicative helicase, MCM. EMBO J (2007) 1.38
The use of Random Homozygous Gene Perturbation to identify novel host-oriented targets for influenza. Virology (2009) 1.35
Influenza virus RNA polymerase PA subunit is a novel serine protease with Ser624 at the active site. Genes Cells (2001) 1.35
Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. Nucleic Acids Res (1999) 1.32
Characterization of a mitochondrial-targeting signal in the PB2 protein of influenza viruses. Virology (2005) 1.27
Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cells. Virology (2009) 1.27
Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein. J Virol (2009) 1.26
An influenza virus replicon system in yeast identified Tat-SF1 as a stimulatory host factor for viral RNA synthesis. Proc Natl Acad Sci U S A (2007) 1.21
Differential localization and function of PB1-F2 derived from different strains of influenza A virus. J Virol (2010) 1.17
The hepatitis E virus ORF3 protein modulates epidermal growth factor receptor trafficking, STAT3 translocation, and the acute-phase response. J Virol (2008) 1.15
The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble. J Virol (2010) 1.13
Host factor Ebp1: selective inhibitor of influenza virus transcriptase. Genes Cells (2007) 1.11
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase promotes the generation of defective interfering RNAs. J Virol (2003) 1.08
Highly pathogenic H5N1 avian influenza virus induces extracellular Ca2+ influx, leading to apoptosis in avian cells. J Virol (2010) 1.07
Identification of gemin5 as a novel 7-methylguanosine cap-binding protein. PLoS One (2009) 1.06
hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator. J Mol Biol (2006) 1.05
Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces. Proc Natl Acad Sci U S A (2005) 1.05
The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit. J Gen Virol (2008) 1.05
The transcript release factor PTRF augments ribosomal gene transcription by facilitating reinitiation of RNA polymerase I. Nucleic Acids Res (2001) 1.04
The human papillomavirus type 16 E5 oncoprotein inhibits epidermal growth factor trafficking independently of endosome acidification. J Virol (2010) 1.02
The role of the influenza virus RNA polymerase in host shut-off. Virulence (2010) 0.99
Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication. J Virol (2011) 0.99
Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT. J Virol (2010) 0.96
Determination of carryover and contamination for mass spectrometry-based chromatographic assays. AAPS J (2007) 0.91
The hepatitis C virus non-structural protein NS5A alters the trafficking profile of the epidermal growth factor receptor. Traffic (2008) 0.90
Inhibition of poxvirus spreading by the anti-tumor drug Gefitinib (Iressa). Antiviral Res (2010) 0.85
Transcription by RNA polymerase II in DNA-PK deficient scid mouse cells. Biochim Biophys Acta (2000) 0.78
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature (2007) 10.40
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18
Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature (2006) 6.46
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol (2004) 4.91
Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. Proc Natl Acad Sci U S A (2002) 4.26
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26
Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A (2009) 4.12
Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog (2009) 3.35
Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. J Biol Chem (2004) 3.10
Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc Natl Acad Sci U S A (2002) 2.93
A targeted proteomics-based pipeline for verification of biomarkers in plasma. Nat Biotechnol (2011) 2.91
Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1. J Virol (2007) 2.59
Into the eye of the cytokine storm. Microbiol Mol Biol Rev (2012) 2.58
Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell (2006) 2.54
Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS Pathog (2010) 2.48
Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK. Diabetes (2005) 2.46
Cellular gene expression upon human immunodeficiency virus type 1 infection of CD4(+)-T-cell lines. J Virol (2003) 2.46
Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes. PLoS Pathog (2009) 2.44
The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway. J Virol (2004) 2.37
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nat Biotechnol (2011) 2.37
Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proc Natl Acad Sci U S A (2013) 2.29
Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice. J Virol (2006) 2.24
The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell (2007) 2.20
Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence. J Virol (2006) 2.14
Contribution of protein fractionation to depth of analysis of the serum and plasma proteomes. J Proteome Res (2007) 2.04
Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers. BMC Genomics (2009) 2.02
Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization. PLoS Pathog (2009) 1.99
Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques. Nat Med (2013) 1.98
Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol (2009) 1.94
Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus-mediated liver disease posttransplantation. Hepatology (2012) 1.82
Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates. Proc Natl Acad Sci U S A (2013) 1.81
Hepatitis C virus and liver disease: global transcriptional profiling and identification of potential markers. Hepatology (2003) 1.80
Retrospective motion correction protocol for high-resolution anatomical MRI. Hum Brain Mapp (2006) 1.80
Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling. MBio (2010) 1.79
Integration of clinical data, pathology, and cDNA microarrays in influenza virus-infected pigtailed macaques (Macaca nemestrina). J Virol (2004) 1.77
Compression of next-generation sequencing reads aided by highly efficient de novo assembly. Nucleic Acids Res (2012) 1.76
Reovirus induces and benefits from an integrated cellular stress response. J Virol (2006) 1.74
Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes. PLoS Pathog (2009) 1.73
Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis. Virol J (2006) 1.58
A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice. J Virol (2009) 1.56
Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein. J Virol (2003) 1.56
Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses. Nat Med (2013) 1.55
MicroRNA expression and virulence in pandemic influenza virus-infected mice. J Virol (2010) 1.54
Systems biology and the host response to viral infection. Nat Biotechnol (2007) 1.53
Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7). J Pediatr (2004) 1.49
Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques. J Virol (2010) 1.47
Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. J Virol (2002) 1.44
Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy. Retrovirology (2008) 1.44
A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo. J Virol (2010) 1.44
Modeling host genetic regulation of influenza pathogenesis in the collaborative cross. PLoS Pathog (2013) 1.43
Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins. J Virol (2006) 1.42
Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. MBio (2013) 1.41
HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice. PLoS Pathog (2009) 1.40
Identification of novel tumor markers in hepatitis C virus-associated hepatocellular carcinoma. Cancer Res (2003) 1.40
Lethal dissemination of H5N1 influenza virus is associated with dysregulation of inflammation and lipoxin signaling in a mouse model of infection. J Virol (2010) 1.40
Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients. Gastroenterology (2006) 1.38
Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children. J Pediatr (2004) 1.37
Dynamic host energetics and cytoskeletal proteomes in human immunodeficiency virus type 1-infected human primary CD4 cells: analysis by multiplexed label-free mass spectrometry. J Virol (2009) 1.35
Expression quantitative trait Loci for extreme host response to influenza a in pre-collaborative cross mice. G3 (Bethesda) (2012) 1.35
Classification of HHV-6A and HHV-6B as distinct viruses. Arch Virol (2013) 1.33
Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus. J Virol (2011) 1.30
Proteome analysis of liver cells expressing a full-length hepatitis C virus (HCV) replicon and biopsy specimens of posttransplantation liver from HCV-infected patients. J Virol (2005) 1.29
The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways. J Virol (2009) 1.29
Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis. J Neurosci (2003) 1.28
The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism. J Virol (2006) 1.28
CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. J Immunol (2010) 1.27
To interfere and to anti-interfere: the interplay between hepatitis C virus and interferon. Viral Immunol (2002) 1.26
Amyloid-binding small molecules efficiently block SEVI (semen-derived enhancer of virus infection)- and semen-mediated enhancement of HIV-1 infection. J Biol Chem (2010) 1.26
The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity. Cell Host Microbe (2012) 1.24
Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin. J Mol Biol (2003) 1.24
HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization. PLoS One (2008) 1.23
Virus-host interactions: from systems biology to translational research. Curr Opin Microbiol (2009) 1.23
Plasma proteome profiling of a mouse model of breast cancer identifies a set of up-regulated proteins in common with human breast cancer cells. J Proteome Res (2008) 1.22
PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells. J Virol (2011) 1.22
Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia. J Immunol (2007) 1.22
Functional genomic analysis of herpes simplex virus type 1 counteraction of the host innate response. J Virol (2006) 1.21
Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human. Genome Biol (2005) 1.20
A systems biology approach to infectious disease research: innovating the pathogen-host research paradigm. MBio (2011) 1.18
Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunction. Hepatology (2007) 1.18
HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells. PLoS One (2011) 1.16
Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques. PLoS Pathog (2007) 1.16
High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein. J Virol (2004) 1.16
Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. J Neurosci (2005) 1.16
The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins. J Gen Virol (2003) 1.14
A systems biology approach reveals that tissue tropism to West Nile virus is regulated by antiviral genes and innate immune cellular processes. PLoS Pathog (2013) 1.14
The non-human primate reference transcriptome resource (NHPRTR) for comparative functional genomics. Nucleic Acids Res (2012) 1.13
2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models. BMC Genomics (2012) 1.13
Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients. Hepatology (2012) 1.13
Mechanistic understanding of an altered fidelity simian immunodeficiency virus reverse transcriptase mutation, V148I, identified in a pig-tailed macaque. J Biol Chem (2003) 1.13
Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk? J Neurovirol (2002) 1.11
Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity. J Virol (2014) 1.10
System-based proteomic analysis of the interferon response in human liver cells. Genome Biol (2004) 1.09