Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus.

PubWeight™: 1.30‹?› | Rank: Top 10%

🔗 View Article (PMC 3194976)

Published in J Virol on August 24, 2011

Authors

Chengjun Li1, Armand Bankhead, Amie J Eisfeld, Yasuko Hatta, Sophia Jeng, Jean H Chang, Lauri D Aicher, Sean Proll, Amy L Ellis, G Lynn Law, Katrina M Waters, Gabriele Neumann, Michael G Katze, Shannon McWeeney, Yoshihiro Kawaoka

Author Affiliations

1: University of Wisconsin-Madison, School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, 575 Science Drive, Madison, WI 53711, USA.

Articles citing this

Into the eye of the cytokine storm. Microbiol Mol Biol Rev (2012) 2.58

Transcriptomic characterization of the novel avian-origin influenza A (H7N9) virus: specific host response and responses intermediate between avian (H5N1 and H7N7) and human (H3N2) viruses and implications for treatment options. MBio (2014) 1.52

Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. MBio (2013) 1.41

Avian influenza A H5N1 virus: a continuous threat to humans. Emerg Microbes Infect (2012) 1.30

Adding protein context to the human protein-protein interaction network to reveal meaningful interactions. PLoS Comput Biol (2013) 1.10

Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity. J Virol (2014) 1.10

Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells. J Virol (2013) 1.08

Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses. MBio (2014) 1.06

Integrated clinical, pathologic, virologic, and transcriptomic analysis of H5N1 influenza virus-induced viral pneumonia in the rhesus macaque. J Virol (2012) 1.05

Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems. BMC Syst Biol (2011) 0.97

Characterizing and controlling the inflammatory network during influenza A virus infection. Sci Rep (2014) 0.97

A comprehensive map of the influenza A virus replication cycle. BMC Syst Biol (2013) 0.93

Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses. Immunity (2015) 0.92

Identifying proteins controlling key disease signaling pathways. Bioinformatics (2013) 0.90

Response of primary human airway epithelial cells to influenza infection: a quantitative proteomic study. J Proteome Res (2012) 0.89

Deep sequencing of HIV-infected cells: insights into nascent transcription and host-directed therapy. J Virol (2014) 0.89

Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses. Semin Immunol (2012) 0.88

A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses. PLoS One (2013) 0.87

Host Transcriptional Response to Influenza and Other Acute Respiratory Viral Infections--A Prospective Cohort Study. PLoS Pathog (2015) 0.85

Moving H5N1 studies into the era of systems biology. Virus Res (2013) 0.84

A systems framework for vaccine design. Curr Opin Immunol (2013) 0.83

Translational research in infectious disease: current paradigms and challenges ahead. Transl Res (2012) 0.83

H5N1, a wealth of knowledge to improve pandemic preparedness. Virus Res (2013) 0.82

A comprehensive collection of systems biology data characterizing the host response to viral infection. Sci Data (2014) 0.81

Eicosanoids and respiratory viral infection: coordinators of inflammation and potential therapeutic targets. Mediators Inflamm (2012) 0.81

Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic. PLoS One (2013) 0.80

Construction of the influenza A virus infection-induced cell-specific inflammatory regulatory network based on mutual information and optimization. BMC Syst Biol (2013) 0.80

Multiple low-dose challenges in a rhesus macaque AIDS vaccine trial result in an evolving host response that affects protective outcome. Clin Vaccine Immunol (2014) 0.79

Molecular and genetic inflammation networks in major human diseases. Mol Biosyst (2016) 0.79

Bugs in the system. Immunol Rev (2013) 0.78

Prioritizing biological pathways by recognizing context in time-series gene expression data. BMC Bioinformatics (2016) 0.77

Multitask learning of signaling and regulatory networks with application to studying human response to flu. PLoS Comput Biol (2014) 0.77

Mesenchymal stromal cell treatment prevents H9N2 avian influenza virus-induced acute lung injury in mice. Stem Cell Res Ther (2016) 0.76

Integrating Transcriptomic and Proteomic Data Using Predictive Regulatory Network Models of Host Response to Pathogens. PLoS Comput Biol (2016) 0.76

The roles of hemagglutinin Phe-95 in receptor binding and pathogenicity of influenza B virus. Virology (2013) 0.76

Differential proteomic analysis of respiratory samples from patients suffering from influenza. Virusdisease (2016) 0.75

The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus. BMC Syst Biol (2016) 0.75

Selecting the most appropriate time points to profile in high-throughput studies. Elife (2017) 0.75

A meta-analysis of transcriptomic characterization revealed extracellular matrix pathway involved in the H5N1 and H7N9 infections. Oncotarget (2017) 0.75

Articles cited by this

Bioconductor: open software development for computational biology and bioinformatics. Genome Biol (2004) 143.19

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res (2002) 76.95

WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics (2008) 18.58

A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol (2005) 17.23

Generation of influenza A viruses entirely from cloned cDNAs. Proc Natl Acad Sci U S A (1999) 14.90

Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med (2006) 14.21

Avian influenza A (H5N1) infection in humans. N Engl J Med (2005) 12.95

Using GOstats to test gene lists for GO term association. Bioinformatics (2006) 12.58

BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis. Bioinformatics (2005) 9.84

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88

Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R. Bioinformatics (2007) 7.72

Scale-free networks in cell biology. J Cell Sci (2005) 6.08

Conservation and evolution of gene coexpression networks in human and chimpanzee brains. Proc Natl Acad Sci U S A (2006) 5.69

H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog (2008) 4.79

Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir Res (2005) 4.41

Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. J Virol (2006) 4.00

The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts. Cell Host Microbe (2007) 3.11

Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines. PLoS Pathog (2010) 3.08

Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade. Nat Cell Biol (2001) 2.93

Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection. Proc Natl Acad Sci U S A (2007) 2.63

Critical role of IL-17RA in immunopathology of influenza infection. J Immunol (2009) 2.51

Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes. PLoS Pathog (2009) 2.44

Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses. PLoS Pathog (2008) 2.38

Toward unraveling the complexity of simple epithelial keratins in human disease. J Clin Invest (2009) 2.34

Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets. J Virol (2008) 2.23

Modeling host responses in ferrets during A/California/07/2009 influenza infection. Virology (2010) 1.93

Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules. J Immunol (2006) 1.89

Innate immune responses to influenza A H5N1: friend or foe? Trends Immunol (2009) 1.89

Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection. J Immunol (2009) 1.86

Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation. J Invest Dermatol (2005) 1.78

Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression. J Virol (2006) 1.75

Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome. Nucleic Acids Res (2004) 1.58

The MCP/eotaxin subfamily of CC chemokines. Cytokine Growth Factor Rev (1999) 1.57

A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice. J Virol (2009) 1.56

IL-17 and IL-22: siblings, not twins. Trends Immunol (2010) 1.56

A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo. J Virol (2010) 1.44

Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation. PLoS One (2010) 1.41

Viral replication and innate host responses in primary human alveolar epithelial cells and alveolar macrophages infected with influenza H5N1 and H1N1 viruses. J Virol (2011) 1.40

Lethal dissemination of H5N1 influenza virus is associated with dysregulation of inflammation and lipoxin signaling in a mouse model of infection. J Virol (2010) 1.40

Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus. J Infect Dis (2010) 1.33

H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cells. J Virol (2008) 1.32

Influenza A virus-induced apoptosis in bronchiolar epithelial (NCI-H292) cells limits pro-inflammatory cytokine release. J Gen Virol (2003) 1.30

A group of type I keratin genes on human chromosome 17: characterization and expression. Mol Cell Biol (1988) 1.27

Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines. Microbes Infect (2006) 1.22

Novel approach to the development of effective H5N1 influenza A virus vaccines: use of M2 cytoplasmic tail mutants. J Virol (2007) 1.20

Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model. Virology (2009) 1.19

The role of the inflammasome in nonmyeloid cells. J Clin Immunol (2010) 1.18

Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling. J Biol Chem (2006) 1.14

Essential impact of NF-kappaB signaling on the H5N1 influenza A virus-induced transcriptome. J Immunol (2009) 1.13

Differential regulation of the OASL and OAS1 genes in response to viral infections. J Interferon Cytokine Res (2009) 1.13

Host immune and apoptotic responses to avian influenza virus H9N2 in human tracheobronchial epithelial cells. Am J Respir Cell Mol Biol (2010) 1.13

Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia. Virology (2009) 1.07

Highly pathogenic H5N1 avian influenza virus induces extracellular Ca2+ influx, leading to apoptosis in avian cells. J Virol (2010) 1.07

Interleukin-28 and interleukin-29: novel regulators of skin biology. J Interferon Cytokine Res (2010) 0.88

Role of monocyte chemotactic protein-3 and -4 in children with virus exacerbation of asthma. Eur Respir J (2008) 0.86

Articles by these authors

Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21

In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature (2009) 14.59

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature (2012) 14.17

Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature (2009) 11.34

Avian flu: influenza virus receptors in the human airway. Nature (2006) 11.28

Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature (2007) 10.40

The BioPAX community standard for pathway data sharing. Nat Biotechnol (2010) 9.19

Resistant influenza A viruses in children treated with oseltamivir: descriptive study. Lancet (2004) 8.62

Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature (2006) 7.56

Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18

Avian flu: isolation of drug-resistant H5N1 virus. Nature (2005) 6.66

Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature (2006) 6.46

Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. Nature (2004) 6.11

Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell (2004) 6.08

PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology (2004) 5.96

Influenza: lessons from past pandemics, warnings from current incidents. Nat Rev Microbiol (2005) 5.28

Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. J Virol (2006) 5.26

Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol (2004) 4.91

Architecture of ribonucleoprotein complexes in influenza A virus particles. Nature (2006) 4.52

Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice. PLoS Pathog (2007) 4.49

Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. Proc Natl Acad Sci U S A (2002) 4.26

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26

Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and Swine origin human influenza a viruses. J Virol (2009) 4.20

Drosophila RNAi screen identifies host genes important for influenza virus replication. Nature (2008) 4.18

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A (2009) 4.12

Inhibition of Lassa and Marburg virus production by tetherin. J Virol (2008) 3.98

Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations. Arch Virol (2010) 3.77

Characterization of H7N9 influenza A viruses isolated from humans. Nature (2013) 3.71

Gain-of-function experiments on H7N9. Science (2013) 3.67

Biological and structural characterization of a host-adapting amino acid in influenza virus. PLoS Pathog (2010) 3.65

Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP. J Virol (2002) 3.62

The potential for respiratory droplet-transmissible A/H5N1 influenza virus to evolve in a mammalian host. Science (2012) 3.50

Selective incorporation of influenza virus RNA segments into virions. Proc Natl Acad Sci U S A (2003) 3.45

Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog (2009) 3.35

MIFlowCyt: the minimum information about a Flow Cytometry Experiment. Cytometry A (2008) 3.33

Host range restriction and pathogenicity in the context of influenza pandemic. Emerg Infect Dis (2006) 3.27

The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell (2013) 3.19

Mapping cellular transcriptosomes in autopsied Alzheimer's disease subjects and relevant animal models. Neurobiol Aging (2005) 3.09

Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors. JAMA (2007) 3.00

Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc Natl Acad Sci U S A (2002) 2.93

The origins of new pandemic viruses: the acquisition of new host ranges by canine parvovirus and influenza A viruses. Annu Rev Microbiol (2005) 2.89

Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res (2002) 2.81

A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. J Virol (2007) 2.80

Characterization of H5N1 influenza A viruses isolated during the 2003-2004 influenza outbreaks in Japan. Virology (2005) 2.77

Lower clinical effectiveness of oseltamivir against influenza B contrasted with influenza A infection in children. Clin Infect Dis (2006) 2.72

Hierarchy among viral RNA (vRNA) segments in their role in vRNA incorporation into influenza A virions. J Virol (2006) 2.70

Exploitation of nucleic acid packaging signals to generate a novel influenza virus-based vector stably expressing two foreign genes. J Virol (2003) 2.67

Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus. J Virol (2004) 2.67

Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host. PLoS Pathog (2009) 2.62

Contributions of two nuclear localization signals of influenza A virus nucleoprotein to viral replication. J Virol (2006) 2.60

Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner. PLoS Pathog (2010) 2.60

Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1. J Virol (2007) 2.59

Into the eye of the cytokine storm. Microbiol Mol Biol Rev (2012) 2.58

Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture. J Virol (2002) 2.58

Human infection with highly pathogenic H5N1 influenza virus. Lancet (2008) 2.57

Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitor. J Clin Microbiol (2005) 2.55

Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell (2006) 2.54

Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS Pathog (2010) 2.48

Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK. Diabetes (2005) 2.46

Cellular gene expression upon human immunodeficiency virus type 1 infection of CD4(+)-T-cell lines. J Virol (2003) 2.46

Importance of both the coding and the segment-specific noncoding regions of the influenza A virus NS segment for its efficient incorporation into virions. J Virol (2005) 2.45

Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes. PLoS Pathog (2009) 2.44

Molecular determinants of Ebola virus virulence in mice. PLoS Pathog (2006) 2.44

Selection of H5N1 influenza virus PB2 during replication in humans. J Virol (2009) 2.42

The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway. J Virol (2004) 2.37

Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nat Biotechnol (2011) 2.37

Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry. J Virol (2004) 2.34

An improved reverse genetics system for influenza A virus generation and its implications for vaccine production. Proc Natl Acad Sci U S A (2005) 2.33

High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood (2005) 2.33

Avian flu: Gain-of-function experiments on H7N9. Nature (2013) 2.32

Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proc Natl Acad Sci U S A (2013) 2.29

High level of genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses. J Virol (2010) 2.29

Tyro3 family-mediated cell entry of Ebola and Marburg viruses. J Virol (2006) 2.24

Pause on avian flu transmission research. Science (2012) 2.24

Differences in cytokine production in human macrophages and in virulence in mice are attributable to the acidic polymerase protein of highly pathogenic influenza A virus subtype H5N1. J Infect Dis (2012) 2.24

Cellular networks involved in the influenza virus life cycle. Cell Host Microbe (2010) 2.23

Gene expression analyzed by high-resolution state array analysis and quantitative proteomics: response of yeast to mating pheromone. Mol Cell Proteomics (2004) 2.22

A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population. Am J Med Genet (2002) 2.21