Published in Cell Reprogram on June 30, 2011
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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Immunogenicity of induced pluripotent stem cells. Nature (2011) 7.31
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Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med (2006) 6.18
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol (2004) 5.82
Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol (2007) 5.28
Functional profiling of a human cytomegalovirus genome. Proc Natl Acad Sci U S A (2003) 5.21
The sex-specific genetic architecture of quantitative traits in humans. Nat Genet (2006) 4.93
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med (2008) 4.58
Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell (2003) 4.58
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell (2009) 4.47
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci U S A (2009) 4.46
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study. Lancet Oncol (2012) 4.21
Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med (2008) 3.98
p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol (2007) 3.86
Trends in prevalence of HIV, syphilis, hepatitis C, hepatitis B, and sexual risk behavior among men who have sex with men. Results of 3 consecutive respondent-driven sampling surveys in Beijing, 2004 through 2006. J Acquir Immune Defic Syndr (2007) 3.83
Substrate modulus directs neural stem cell behavior. Biophys J (2008) 3.81
Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res (2006) 3.58
Interaction of the Cas6 riboendonuclease with CRISPR RNAs: recognition and cleavage. Structure (2011) 3.58
Sequence polymorphisms cause many false cis eQTLs. PLoS One (2007) 3.54
Single-layer MoS2 phototransistors. ACS Nano (2011) 3.43
From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci U S A (2008) 3.39
Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin Cancer Res (2009) 3.39
A universal method to produce low-work function electrodes for organic electronics. Science (2012) 3.33
The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev (2004) 3.29
Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease. Diabetes Care (2012) 2.84
Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J Neurosci (2004) 2.76
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72
Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res (2010) 2.65
Genetical genomics: spotlight on QTL hotspots. PLoS Genet (2008) 2.63
New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell (2008) 2.61
Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature (2002) 2.60
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Allele-specific targeting of microRNAs to HLA-G and risk of asthma. Am J Hum Genet (2007) 2.58
Modeling desertification change in Minqin County, China. Environ Monit Assess (2005) 2.56
Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells. Kidney Int (2004) 2.55
Structure and function of archaeal box C/D sRNP core proteins. Nat Struct Biol (2003) 2.55
Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity (2012) 2.47
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell (2008) 2.47
Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg (2004) 2.46
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. Nat Immunol (2002) 2.46
A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. Proc Natl Acad Sci U S A (2002) 2.46
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke. J Biol Chem (2005) 2.44
Reference values for continuous glucose monitoring in Chinese subjects. Diabetes Care (2009) 2.41
BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J Cell Biol (2002) 2.40
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects. Am J Physiol Endocrinol Metab (2009) 2.39
Efficient formulation of the stochastic simulation algorithm for chemically reacting systems. J Chem Phys (2004) 2.36
Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry. Proteomics (2005) 2.34
A new class of Solvent-in-Salt electrolyte for high-energy rechargeable metallic lithium batteries. Nat Commun (2013) 2.33
Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res (2006) 2.32
Rejection of unfair offers in the ultimatum game is no evidence of strong reciprocity. Proc Natl Acad Sci U S A (2012) 2.31
How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J (2002) 2.31
Effects of nonalcoholic fatty liver disease on the development of metabolic disorders. J Gastroenterol Hepatol (2007) 2.30
Use of electrochemical DNA biosensors for rapid molecular identification of uropathogens in clinical urine specimens. J Clin Microbiol (2006) 2.27
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol (2003) 2.26
Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest (2008) 2.24
Molecular symmetry in mitochondrial cardiolipins. Chem Phys Lipids (2005) 2.23
Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res (2007) 2.21
Slc26a11, a chloride transporter, localizes with the vacuolar H(+)-ATPase of A-intercalated cells of the kidney. Kidney Int (2011) 2.21
Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature (2016) 2.21
A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone. Nat Protoc (2010) 2.20
The Human Ageing Genomic Resources: online databases and tools for biogerontologists. Aging Cell (2008) 2.19
Modeling disease in human ESCs using an efficient BAC-based homologous recombination system. Cell Stem Cell (2010) 2.19
An oligonucleotide microarray for microRNA expression analysis based on labeling RNA with quantum dot and nanogold probe. Nucleic Acids Res (2005) 2.15
Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J (2006) 2.12
Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients. Proc Natl Acad Sci U S A (2013) 2.09
The Effect of Erythropoietin-Stimulating Agents on Health-Related Quality of Life in Anemia of Chronic Kidney Disease: A Systematic Review and Meta-analysis. Ann Intern Med (2016) 2.09
Molecular basis of box C/D RNA-protein interactions; cocrystal structure of archaeal L7Ae and a box C/D RNA. Structure (2004) 2.08
Oncogenic ERBB3 mutations in human cancers. Cancer Cell (2013) 2.06
Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells. ACS Nano (2010) 2.05
Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses. J Biol Chem (2003) 2.02
Woltjer-Taylor state without Taylor's conjecture: plasma relaxation at all wavelengths. Phys Rev Lett (2012) 1.98
Medium scale integration of molecular logic gates in an automaton. Nano Lett (2006) 1.98
Crystal structures of a ligand-free MthK gating ring: insights into the ligand gating mechanism of K+ channels. Cell (2006) 1.98
Structure of the Cmr2 subunit of the CRISPR-Cas RNA silencing complex. Structure (2012) 1.97
Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinology (2008) 1.97
Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua. Science (2011) 1.96
Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer. J Clin Oncol (2010) 1.95
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med (2013) 1.93
Characterization of RNA in saliva. Clin Chem (2006) 1.93
Expression quantitative trait loci are highly sensitive to cellular differentiation state. PLoS Genet (2009) 1.92
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci U S A (2009) 1.91
Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. J Clin Invest (2005) 1.90
Incidence of second malignancies among patients treated with proton versus photon radiation. Int J Radiat Oncol Biol Phys (2013) 1.89
Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer. Cancer Res (2003) 1.88
Efficacy and antivascular effects of EphA2 reduction with an agonistic antibody in ovarian cancer. J Natl Cancer Inst (2006) 1.87
The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol (2013) 1.87
Health risks of limited-contact water recreation. Environ Health Perspect (2011) 1.86
Automated chemical crystallography. J Am Chem Soc (2010) 1.86
Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore. Nat Struct Mol Biol (2010) 1.86
Bis(2-dimethylamino-1,10-phenanthroline-κN,N')bis-(thio-cyanato-κN)nickel(II) methanol disolvate. Acta Crystallogr Sect E Struct Rep Online (2008) 1.86
Indications that live poultry markets are a major source of human H5N1 influenza virus infection in China. J Virol (2011) 1.85
Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res (2008) 1.85
TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO J (2007) 1.85
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest (2012) 1.85