Published in Nucleic Acid Ther on June 01, 2011
Hyperactive piggyBac transposons for sustained and robust liver-targeted gene therapy. Mol Ther (2014) 0.93
Safety assessment of liver-targeted hydrodynamic gene delivery in dogs. PLoS One (2014) 0.89
An inducible transgenic mouse model for immune mediated hepatitis showing clearance of antigen expressing hepatocytes by CD8+ T cells. PLoS One (2013) 0.82
An adaptable system for improving transposon-based gene expression in vivo via transient transgene repression. FASEB J (2013) 0.80
Fighting against kidney diseases with small interfering RNA: opportunities and challenges. J Transl Med (2015) 0.78
Characterization of Putative Erythroid Regulators of Hepcidin in Mouse Models of Anemia. PLoS One (2017) 0.76
The dynamic impact of hydrodynamic gene transfer on the immune system. Int J Clin Exp Med (2015) 0.75
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature (2001) 25.15
How cells respond to interferons. Annu Rev Biochem (1998) 24.27
Inducible gene targeting in mice. Science (1995) 21.22
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80
Virus interference. I. The interferon. Proc R Soc Lond B Biol Sci (1957) 13.46
Activation of the interferon system by short-interfering RNAs. Nat Cell Biol (2003) 8.63
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther (1999) 8.28
Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. J Gen Virol (2000) 7.00
Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet (2003) 6.49
Type 1 interferons and the virus-host relationship: a lesson in détente . Science (2006) 6.33
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol (2005) 5.99
High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther (1999) 5.17
Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat Biotechnol (2004) 3.85
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature (2005) 2.87
2-5A-dependent RNase molecules dimerize during activation by 2-5A. J Biol Chem (1995) 2.27
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood (2005) 1.99
Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J Mol Biol (2005) 1.93
Cationic liposome-mediated delivery of siRNAs in adult mice. Biochem Biophys Res Commun (2003) 1.87
Activation of the mammalian immune system by siRNAs. Nat Biotechnol (2005) 1.86
Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2004) 1.82
Lack of interferon response in animals to naked siRNAs. Nat Biotechnol (2004) 1.71
Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors. BMC Mol Biol (2004) 1.56
Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem Biophys Res Commun (2005) 1.50
Determinants of interferon-stimulated gene induction by RNAi vectors. Differentiation (2004) 1.45
The 2-5A system in viral infection and apoptosis. Biomed Pharmacother (1998) 1.30
Cellular gene dose and kinetics of gene expression in mouse livers transfected by high-volume tail-vein injection of naked DNA. DNA Cell Biol (2002) 1.05
Mechanism of plasmid delivery by hydrodynamic tail vein injection. II. Morphological studies. J Gene Med (2006) 1.04
Determinants of cytokine induction by small interfering RNA in human peripheral blood mononuclear cells. J Interferon Cytokine Res (2008) 1.03
Hepatic uptake and gene expression mechanisms following intravenous administration of plasmid DNA by conventional and hydrodynamics-based procedures. J Pharmacol Exp Ther (2001) 1.02
Interferon alpha activates NF-kappaB in JAK1-deficient cells through a TYK2-dependent pathway. J Biol Chem (2005) 1.01
The role of endotoxin, TNF-alpha, and IL-6 in inducing the state of growth hormone insensitivity. World J Gastroenterol (2002) 0.99
Protection of renal ischemia injury using combination gene silencing of complement 3 and caspase 3 genes. Transplantation (2006) 0.97
Intrinsic cellular defenses against virus infection by antiviral type I interferon. Yonsei Med J (2009) 0.97
Hydrodynamic gene delivery to the liver: theoretical and practical issues for clinical application. Curr Gene Ther (2009) 0.97
Immune activation by siRNA/liposome complexes in mice is sequence- independent: lack of a role for Toll-like receptor 3 signaling. Mol Cells (2007) 0.93
No induction of anti-viral responses in human cell lines HeLa and MCF-7 when transfecting with siRNA or siLNA. Biochem Biophys Res Commun (2006) 0.93
Adverse effects induced by short hairpin RNA expression in porcine fetal fibroblasts. Biochem Biophys Res Commun (2008) 0.91
Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C. Biochem Biophys Res Commun (2007) 0.86
Can siRNA technology provide the tools for gene therapy of the future? Curr Med Chem (2006) 0.83
Involvement of proteasomes in gene induction by interferon and double-stranded RNA. Cytokine (2001) 0.82
Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, Tween-80 and Tween-20. Eur J Pharm Sci (2011) 1.05
Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice. Am J Physiol Heart Circ Physiol (2010) 0.94
Increased renoprotection with ACE inhibitor plus aldosterone antagonist as compared to monotherapies--the effect on podocytes. Nephrol Dial Transplant (2009) 0.90
Activation of the miR-17 family and miR-21 during murine kidney ischemia-reperfusion injury. Nucleic Acid Ther (2013) 0.86
Post-transcriptional gene-expression regulation by micro RNA (miRNA) network in renal disease. Adv Drug Deliv Rev (2010) 0.85
Characterization and role of SCAI during renal fibrosis and epithelial-to-mesenchymal transition. Am J Pathol (2012) 0.84
[Effects of 1800 MHz GSM-like exposure on the gonadal function and hematological parameters of male mice]. Magy Onkol (2005) 0.82
Proteomic identification of vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy. Kidney Int (2011) 0.81
Role of invariant natural killer T (iNKT) cells in systemic lupus erythematosus. Curr Med Chem (2008) 0.81
[SiRNA technology, the gene therapy of the future?]. Orv Hetil (2008) 0.79
The Rowett rat strain is resistant to renal fibrosis. Nephrol Dial Transplant (2009) 0.76
Mechanisms behind flare of renal lupus during murine pregnancy. Reprod Biomed Online (2008) 0.75
The Effect of Combined Treatment with the (Pro)Renin Receptor Blocker HRP and Quinapril in Type 1 Diabetic Rats. Kidney Blood Press Res (2017) 0.75