Published in Nat Genet on July 01, 2003
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev (2003) 17.64
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24
Inhibition of interferon signaling by dengue virus. Proc Natl Acad Sci U S A (2003) 5.05
Small dsRNAs induce transcriptional activation in human cells. Proc Natl Acad Sci U S A (2006) 4.90
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci U S A (2004) 4.85
Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses. Nucleic Acids Res (2004) 3.46
Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc Natl Acad Sci U S A (2005) 3.24
Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA (2004) 3.16
HOXA9 is required for survival in human MLL-rearranged acute leukemias. Blood (2008) 3.12
Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Nat Genet (2005) 2.92
Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis. J Virol (2004) 2.77
hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay. Mol Cell Biol (2006) 2.69
Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo. Mol Ther (2008) 2.66
RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells. Proc Natl Acad Sci U S A (2005) 2.59
Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol (2005) 2.41
Lipid-based systemic delivery of siRNA. Adv Drug Deliv Rev (2009) 2.28
A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model. Blood (2009) 2.25
The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis. PLoS Biol (2009) 2.17
ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells. J Biol Chem (2004) 2.15
DDX3 DEAD-box RNA helicase is required for hepatitis C virus RNA replication. J Virol (2007) 2.12
Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors. Mol Ther (2006) 1.99
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood (2005) 1.99
Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J Biol Chem (2008) 1.93
Vigilance and validation: Keys to success in RNAi screening. ACS Chem Biol (2010) 1.85
An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi. Nucleic Acids Res (2005) 1.83
GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron (2009) 1.83
Modeling oncogene addiction using RNA interference. Proc Natl Acad Sci U S A (2008) 1.79
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nat Neurosci (2009) 1.75
Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs. RNA (2008) 1.70
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res (2004) 1.67
Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells. Proc Natl Acad Sci U S A (2009) 1.66
The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. Blood (2007) 1.60
Progress in microRNA delivery. J Control Release (2013) 1.58
Effects of length and location on the cellular response to double-stranded RNA. Microbiol Mol Biol Rev (2004) 1.57
Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors. BMC Mol Biol (2004) 1.56
Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity. PLoS One (2012) 1.55
Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference. Proc Natl Acad Sci U S A (2004) 1.54
Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS Genet (2006) 1.49
Hepatitis C virus hijacks P-body and stress granule components around lipid droplets. J Virol (2011) 1.47
The apoptotic pathway as a therapeutic target in sepsis. Curr Drug Targets (2007) 1.47
Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting. RNA (2007) 1.46
Computational estimation and experimental verification of off-target silencing during posttranscriptional gene silencing in plants. Plant Physiol (2006) 1.43
MicroRNA: An emerging therapeutic target and intervention tool. Int J Mol Sci (2008) 1.41
Off-target effects of siRNA specific for GFP. BMC Mol Biol (2008) 1.41
Polymeric nanoparticles for siRNA delivery and gene silencing. Int J Pharm (2008) 1.39
Phospholipid scramblase 1 potentiates the antiviral activity of interferon. J Virol (2004) 1.39
Activation of the protein kinase PKR by short double-stranded RNAs with single-stranded tails. RNA (2004) 1.38
DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem (2007) 1.37
T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. Proc Natl Acad Sci U S A (2003) 1.37
Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells. J Virol (2004) 1.37
DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration. J Virol (2005) 1.34
Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? J Clin Invest (2007) 1.34
The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2007) 1.34
Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system. BMC Neurosci (2010) 1.33
Androgen receptor remains critical for cell-cycle progression in androgen-independent CWR22 prostate cancer cells. Am J Pathol (2006) 1.33
Genomic analysis of anti-hepatitis B virus (HBV) activity by small interfering RNA and lamivudine in stable HBV-producing cells. J Virol (2005) 1.32
Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis. Genome Biol (2005) 1.31
RNA viruses and the host microRNA machinery. Nat Rev Microbiol (2013) 1.31
Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5. Mol Cell Biol (2004) 1.31
GW body disassembly triggered by siRNAs independently of their silencing activity. Nucleic Acids Res (2007) 1.29
How golden is silence? Teaching undergraduates the power and limits of RNA interference. CBE Life Sci Educ (2006) 1.27
Role of peripheral corticotropin-releasing factor and urocortin II in intestinal inflammation and motility in terminal ileum. Proc Natl Acad Sci U S A (2005) 1.25
Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference. Hum Genet (2005) 1.22
The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production. Hepatology (2009) 1.21
Delivery systems for the direct application of siRNAs to induce RNA interference (RNAi) in vivo. J Biomed Biotechnol (2006) 1.21
Minimizing off-target effects by using diced siRNAs for RNA interference. J RNAi Gene Silencing (2006) 1.20
Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice. Int J Biol Sci (2007) 1.20
Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing. J Biol Chem (2010) 1.19
Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway. Oncogene (2008) 1.18
Combinatorial RNAi against HIV-1 using extended short hairpin RNAs. Mol Ther (2009) 1.18
RNA interference in biology and disease. Blood (2005) 1.18
Short-term induction and long-term suppression of HPV16 oncogene silencing by RNA interference in cervical cancer cells. Oncogene (2006) 1.18
Down-regulation of p53 by double-stranded RNA modulates the antiviral response. J Virol (2005) 1.17
Ca2+/calmodulin-dependent protein kinase II alpha is required for the initiation and maintenance of opioid-induced hyperalgesia. J Neurosci (2010) 1.16
Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis. J Clin Invest (2007) 1.15
Systemic delivery of siRNA via LCP nanoparticle efficiently inhibits lung metastasis. Mol Ther (2011) 1.15
Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration. Am J Pathol (2010) 1.13
Double-stranded RNA adenosine deaminases enhance expression of human immunodeficiency virus type 1 proteins. J Virol (2008) 1.13
Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons. J Virol (2007) 1.13
Hepatitis C virus infection induces the beta interferon signaling pathway in immortalized human hepatocytes. J Virol (2007) 1.12
Ocular neuroprotection by siRNA targeting caspase-2. Cell Death Dis (2011) 1.12
siRNA Versus miRNA as Therapeutics for Gene Silencing. Mol Ther Nucleic Acids (2015) 1.12
Sequence-non-specific effects of RNA interference triggers and microRNA regulators. Nucleic Acids Res (2009) 1.11
The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression. PLoS One (2010) 1.10
Persistence of bovine viral diarrhea virus is determined by a cellular cofactor of a viral autoprotease. J Virol (2005) 1.10
The chemokine receptor CXCR4 strongly promotes neuroblastoma primary tumour and metastatic growth, but not invasion. PLoS One (2007) 1.09
Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria. J Biol Chem (2008) 1.09
The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription. Retrovirology (2006) 1.09
Optimizing RNA interference for application in mammalian cells. Biochem J (2004) 1.09
The ESCRT system is required for hepatitis C virus production. PLoS One (2011) 1.08
Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells. Nat Struct Mol Biol (2012) 1.08
Modeling CTLA4-linked autoimmunity with RNA interference in mice. Proc Natl Acad Sci U S A (2006) 1.08
Antagonism of host antiviral responses by Kaposi's sarcoma-associated herpesvirus tegument protein ORF45. PLoS One (2010) 1.07
Dicer-independent processing of short hairpin RNAs. Nucleic Acids Res (2013) 1.06
Design of extended short hairpin RNAs for HIV-1 inhibition. Nucleic Acids Res (2007) 1.06
A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAs. J RNAi Gene Silencing (2005) 1.06
A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. Genome Biol (2007) 1.05
Nucleic acid aptamers for target validation and therapeutic applications. J Biomol Tech (2005) 1.05
Identification of molecular apocrine breast tumours by microarray analysis. Oncogene (2005) 5.27
A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat Med (2009) 3.86
SUMO-targeted ubiquitin ligases in genome stability. EMBO J (2007) 2.77
Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses. J Biol Chem (2003) 2.02
TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in breast cancer (EORTC 10994/BIG 1-00): a randomised phase 3 trial. Lancet Oncol (2011) 1.85
Functional analysis of human MLH1 variants using yeast and in vitro mismatch repair assays. Cancer Res (2007) 1.51
p53 Mutation in histologically normal mucosa of the aero-digestive tract is not a marker of increased risk for second primary carcinoma in head and neck cancer patients. Eur Arch Otorhinolaryngol (2008) 1.42
Regulation of p53 stability and function in HCT116 colon cancer cells. J Biol Chem (2003) 1.27
Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations. Breast Cancer Res (2010) 1.14
Targeted radionuclide therapy using a Wnt-targeted replicating adenovirus encoding the Na/I symporter. Clin Cancer Res (2009) 1.04
An oestrogen-dependent model of breast cancer created by transformation of normal human mammary epithelial cells. Breast Cancer Res (2007) 0.94
Predictive signatures for chemotherapy sensitivity in breast cancer: are they ready for use in the clinic? Eur J Cancer (2009) 0.91
Protection from HIV-1 infection of primary CD4 T cells by CCR5 silencing is effective for the full spectrum of CCR5 expression. Antivir Ther (2003) 0.91
Late expression of nitroreductase in an oncolytic adenovirus sensitizes colon cancer cells to the prodrug CB1954. Hum Gene Ther (2005) 0.86
Deletion of chromosomes 13q and 14q is a common feature of tumors with BRCA2 mutations. PLoS One (2012) 0.78
Therapeutic potential of replication-selective oncolytic adenoviruses on cells from familial and sporadic desmoid tumors. Clin Cancer Res (2008) 0.76