Published in FEBS Lett on November 26, 1990
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J (2001) 9.40
Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits. Proc Natl Acad Sci U S A (2002) 2.01
Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Cancer Lett (2013) 1.74
Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus. J Clin Invest (2005) 1.52
Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity. J Immunol (2009) 1.15
The protein-phosphatome of the human malaria parasite Plasmodium falciparum. BMC Genomics (2008) 1.08
Active-site mutations impairing the catalytic function of the catalytic subunit of human protein phosphatase 2A permit baculovirus-mediated overexpression in insect cells. Biochem J (2001) 1.02
Molecular cloning and developmental expression of the catalytic and 65-kDa regulatory subunits of protein phosphatase 2A in Drosophila. Mol Biol Cell (1992) 0.98
A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres. Biochem J (2000) 0.96
Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans. Development (2010) 0.94
A novel protein phosphatase 2A (PP2A) is involved in the transformation of human protozoan parasite Trypanosoma cruzi. Biochem J (2003) 0.93
Whole genome sequencing identifies a deletion in protein phosphatase 2A that affects its stability and localization in Chlamydomonas reinhardtii. PLoS Genet (2013) 0.89
The Interplay between PP2A and microRNAs in Leukemia. Front Oncol (2015) 0.79
A serine/threonine-protein phosphatase PP2A catalytic subunit is essential for asexual development and plant infection in Magnaporthe oryzae. Curr Genet (2012) 0.77
The broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance. BBA Clin (2016) 0.77
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1. EMBO J (1997) 4.05
Protein phosphatases come of age. J Biol Chem (1989) 3.77
dunce, a mutant of Drosophila deficient in learning. Proc Natl Acad Sci U S A (1976) 3.74
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. EMBO J (1996) 3.51
Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism. EMBO J (1994) 3.11
One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis. Cell (1990) 2.91
Identification of the Ca2+-dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase. FEBS Lett (1978) 2.86
Memory extinction, learning anew, and learning the new: dissociations in the molecular machinery of learning in cortex. Science (2001) 2.34
The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. Biochem J (1993) 2.23
Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes. EMBO J (1990) 2.15
Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme. Eur J Biochem (1993) 2.06
A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. EMBO J (1994) 1.98
Taste memory: the role of protein synthesis in gustatory cortex. Behav Neural Biol (1993) 1.89
High efficiency site-specific genetic engineering of the mosquito genome. Insect Mol Biol (2006) 1.87
Protein serine/threonine phosphatases; an expanding family. FEBS Lett (1990) 1.86
HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: response to both initial and salvage therapy. AIDS (1999) 1.86
Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate. J Mol Biol (1995) 1.84
Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex. J Biol Chem (1985) 1.81
PPX, a novel protein serine/threonine phosphatase localized to centrosomes. EMBO J (1993) 1.80
Isolation and sequence analysis of a cDNA clone encoding a type-1 protein phosphatase catalytic subunit: homology with protein phosphatase 2A. FEBS Lett (1987) 1.72
Conservation analysis and structure prediction of the protein serine/threonine phosphatases. Sequence similarity with diadenosine tetraphosphatase from Escherichia coli suggests homology to the protein phosphatases. Eur J Biochem (1994) 1.65
NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1. Biochem J (2000) 1.65
Complementation of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string. EMBO J (1990) 1.64
NMDA receptor and the tyrosine phosphorylation of its 2B subunit in taste learning in the rat insular cortex. J Neurosci (1997) 1.61
cAMP response element-binding protein in the amygdala is required for long- but not short-term conditioned taste aversion memory. J Neurosci (1997) 1.61
The Drosophila mus101 gene, which links DNA repair, replication and condensation of heterochromatin in mitosis, encodes a protein with seven BRCA1 C-terminus domains. Genetics (2000) 1.58
Memory phases in Drosophila. Nature (1976) 1.55
Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53. FEBS Lett (1995) 1.49
Activation of protein phosphatase 5 by limited proteolysis or the binding of polyunsaturated fatty acids to the TPR domain. FEBS Lett (1997) 1.46
Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat. J Neurosci (1998) 1.44
The role of calmodulin in the structure and regulation of phosphorylase kinase from rabbit skeletal muscle. Eur J Biochem (1979) 1.37
Isolation and sequence analysis of a cDNA clone encoding the entire catalytic subunit of a type-2A protein phosphatase. FEBS Lett (1987) 1.35
Amino acid sequence and expression of the hepatic glycogen-binding (GL)-subunit of protein phosphatase-1. FEBS Lett (1995) 1.35
Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. Biochim Biophys Acta (1992) 1.35
Transient expression of c-Fos in rat amygdala during training is required for encoding conditioned taste aversion memory. Learn Mem (1999) 1.32
Long-term potentiation increases tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo. Proc Natl Acad Sci U S A (1996) 1.31
Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos. J Cell Sci (1996) 1.29
Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos. J Cell Sci (1998) 1.28
Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. FEBS Lett (1998) 1.28
Vectors for the expression of tagged proteins in Drosophila. Biotechniques (2001) 1.27
Habituation and dishabituation of a cleaning reflex in normal and mutant Drosophila. J Neurosci (1989) 1.26
Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1. FEBS Lett (1996) 1.26
PPP1R6, a novel member of the family of glycogen-targetting subunits of protein phosphatase 1. FEBS Lett (1997) 1.26
Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2. Biochim Biophys Acta (1993) 1.25
Restricted variation in the glycolytic enzymes of human brain and erythrocytes. Nat New Biol (1973) 1.25
Identification of protein-phosphatase-1-binding domains on the glycogen and myofibrillar targetting subunits. Eur J Biochem (1996) 1.25
The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1. FEBS Lett (1995) 1.24
Protein phosphatase 1 can modulate alternative 5' splice site selection in a HeLa splicing extract. FEBS Lett (1994) 1.23
Purification by affinity chromatography of acetylcholinesterase from electric organ tissue of the electric eel subsequent to tryptic treatment. Biochim Biophys Acta (1972) 1.22
Molecular cloning and primary structure of a protein phosphatase 2C isoform. FEBS Lett (1992) 1.21
Cloning and chromosomal localization of Drosophila cDNA encoding the catalytic subunit of protein phosphatase 1 alpha. High conservation between mammalian and insect sequences. Eur J Biochem (1989) 1.21
Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M. FEBS Lett (1994) 1.20
Nucleotide sequences from messenger RNA transcribed from the operator-proximal portion of the tryptophan operon of Escherichia coli. J Mol Biol (1973) 1.20
Drosophila contains three genes that encode distinct isoforms of protein phosphatase 1. Eur J Biochem (1990) 1.18
Protein phosphatase 1 activity in Drosophila mutants with abnormalities in mitosis and chromosome condensation. FEBS Lett (1990) 1.17
The role of identified neurotransmitter systems in the response of insular cortex to unfamiliar taste: activation of ERK1-2 and formation of a memory trace. J Neurosci (2000) 1.16
Further evidence that inhibitor-2 acts like a chaperone to fold PP1 into its native conformation. FEBS Lett (1996) 1.15
Identification of the separate domains in the hepatic glycogen-targeting subunit of protein phosphatase 1 that interact with phosphorylase a, glycogen and protein phosphatase 1. Biochem J (1998) 1.14
Identification by molecular cloning of two cDNA sequences from the plant Brassica napus which are very similar to mammalian protein phosphatases-1 and -2A. FEBS Lett (1990) 1.12
Germ cells colonized by endosymbiotic bacteria. Nature (1999) 1.12
Protein phosphatase 1beta is required for the maintenance of muscle attachments. Curr Biol (2000) 1.09
The molecular basis of skeletal muscle phosphorylase kinase deficiency. Eur J Biochem (1976) 1.09
Identification of the regions on the M110 subunit of protein phosphatase 1M that interact with the M21 subunit and with myosin. Eur J Biochem (1997) 1.09
Transient impairment of cholinergic function in the rat insular cortex disrupts the encoding of taste in conditioned taste aversion. Behav Brain Res (1996) 1.09
Nuclear localization of protein phosphatase 5 is dependent on the carboxy-terminal region. FEBS Lett (2001) 1.07
Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster. J Cell Sci (1995) 1.06
A second catalytic subunit of type-2A protein phosphatase from rabbit skeletal muscle. FEBS Lett (1987) 1.06
Electrophoretic methods for differentiating glycolytic enzymes of mouse and human origin. In Vitro (1974) 1.05
Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex. Nucleic Acids Res (2000) 1.05
Identification of a novel protein phosphatase catalytic subunit by cDNA cloning. FEBS Lett (1988) 1.05
Molecular structures of acetylcholinesterase from electric organ tissue of the electric eel. Proc Natl Acad Sci U S A (1973) 1.04
Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB). Biochim Biophys Acta (1994) 1.04
Purification by affinity chromatography of the molecular forms of acetylcholinesterase present in fresh electric-organ tissue of electric eel. Proc Natl Acad Sci U S A (1972) 1.03
Modulation of protein tyrosine phosphorylation in rat insular cortex after conditioned taste aversion training. Proc Natl Acad Sci U S A (1995) 1.01
Aminergic receptors in Drosophila melanogaster: responsiveness of adenylate cyclase to putative neurotransmitters. J Neurochem (1982) 1.01
A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. Hum Mol Genet (1995) 1.00
Adenylate cyclase in the Drosophila memory mutant rutabaga displays an altered Ca2+ sensitivity. Neurosci Lett (1984) 1.00
Differential modulation of brain immediate early genes by intraperitoneal LiCl. Neuroreport (1995) 1.00
Molecular cloning and chromosomal localization of a novel Drosophila protein phosphatase. FEBS Lett (1989) 0.99
Purification and properties of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa. J Biol Chem (1970) 0.99
Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases. FEBS Lett (1992) 0.98
Cloning of the fourth functional gene for protein phosphatase 1 in Drosophila melanogaster from its chromosomal location. Eur J Biochem (1993) 0.98
Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM. Diabetes (1994) 0.98
Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13. Genomics (1990) 0.97
Both isoforms of protein phosphatase Z are essential for the maintenance of cell size and integrity in Saccharomyces cerevisiae in response to osmotic stress. Eur J Biochem (1993) 0.97
A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres. Biochem J (2000) 0.96
Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes. Biochim Biophys Acta (1991) 0.96
Human malic enzyme: high-frequency polymorphism of the mitochondrial form. Biochem Genet (1972) 0.96
A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. Diabetes (1998) 0.96