Subpopulations of primary adult murine epidermal basal cells sedimented on density gradients.

Enrichment for murine keratinocyte stem cells based on cell surface phenotype. Proc Natl Acad Sci U S A (2000) 3.12

Keratinocyte stem cells: targets for cutaneous carcinogens. J Clin Invest (2000) 1.40

Efficient in vivo targeting of epidermal stem cells by early gestational intraamniotic injection of lentiviral vector driven by the keratin 5 promoter. Mol Ther (2007) 1.12

Isolation of a mesenchymal cell population from murine dermis that contains progenitors of multiple cell lineages. FASEB J (2007) 0.89

Aloe-emodin, an anthraquinone, in vitro inhibits proliferation and induces apoptosis in human colon carcinoma cells. Oncol Lett (2010) 0.88

Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis. Nat Commun (2015) 0.83

Stem cells and tissue-engineered skin. Skin Pharmacol Physiol (2009) 0.83

Keratinocyte stem cells and the targets for nonmelanoma skin cancer. Photochem Photobiol (2012) 0.79

Epithelial cell-targeted transgene expression enables isolation of cyan fluorescent protein (CFP)-expressing prostate stem/progenitor cells. Transgenic Res (2011) 0.79

Cells of origin and tumor-initiating cells for nonmelanoma skin cancers. Cancer Lett (2012) 0.77

The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res (1999) 2.56

Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor. Mol Cell (2000) 2.02

Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion. Proc Natl Acad Sci U S A (1980) 1.94

Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin. J Cell Biol (1991) 1.94

Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J Biol Chem (1998) 1.94

Transformation of human breast epithelial cells by c-Ha-ras oncogene. Mol Carcinog (1991) 1.87

High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas. Proc Natl Acad Sci U S A (1995) 1.76

Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. Proc Natl Acad Sci U S A (1993) 1.66

Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. Am J Pathol (1997) 1.63

Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound. Science (1981) 1.63

Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types. Nat Genet (1994) 1.63

Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. Proc Natl Acad Sci U S A (2001) 1.60

Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. Mol Cell Biol (1998) 1.56

The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. Nat Genet (1999) 1.56

Elevated furin expression in aggressive human head and neck tumors and tumor cell lines. Mol Carcinog (2001) 1.56

The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas. Hum Pathol (1995) 1.56

Comparison of the tumor-initiating activity of 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene in female SENCAR and CS-1 mice. Carcinogenesis (1980) 1.55

Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell cultures. Nature (1976) 1.54

Evidence that the centrally and peripherally located cells in the murine epidermal proliferative unit are two distinct cell populations. J Invest Dermatol (1985) 1.47

Studies on mechanism of action of anti-tumor-promoting agents: their specificity in two-stage promotion. Proc Natl Acad Sci U S A (1980) 1.47

15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells. J Natl Cancer Inst (2000) 1.43

Overview of tumor promotion in animals. Environ Health Perspect (1983) 1.43

Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J (2001) 1.42

Evidence that a slowly cycling subpopulation of adult murine epidermal cells retains carcinogen. Cancer Res (1986) 1.41

Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes. Oncogene (1992) 1.41

T-cell lymphoma lines derived from rat thymomas induced by Moloney murine leukemia virus: phenotypic diversity and its implications. J Virol (1990) 1.39

Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on epidermal ornithine decarboxylase activity, isoproterenol-stimulated levels of cyclic adenosine 3':5'-monophosphate, and induction of mouse skin tumors in vivo. Cancer Res (1979) 1.37

Frequent loss of heterozygosity in human primary squamous cell and colon carcinomas at 7q31.1: evidence for a broad range tumor suppressor gene. Cancer Res (1995) 1.36

Down regulation of specific binding of [20-3H]phorbol 12,13-dibutyrate and phorbol ester-induced differentiation of human promyelocytic leukemia cells. Proc Natl Acad Sci U S A (1981) 1.34

Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res (1994) 1.33

Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer (2000) 1.32

15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. Cancer Res (2000) 1.31

Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells. J Natl Cancer Inst (2000) 1.31

Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines. Am J Pathol (1991) 1.29

Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. Cancer Res (2001) 1.29

Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. Oncogene (2006) 1.26

Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells. Proc Natl Acad Sci U S A (2001) 1.26

Comparison of two-stage epidermal carcinogenesis initiated by 7,12-dimethylbenz(a)anthracene or N-methyl-N'-nitro-N-nitrosoguanidine in newborn and adult SENCAR and BALB/c mice. Cancer Res (1981) 1.26

Specific binding of phorbol ester tumor promoters to intact primary epidermal cells from Sencar mice. Proc Natl Acad Sci U S A (1981) 1.26

Proliferative potential and K-ras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union. Cancer (1998) 1.25

Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues. J Biol Chem (1998) 1.24

Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression. Mol Carcinog (1988) 1.24

Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice. J Natl Cancer Inst (1999) 1.23

Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression. Cancer Res (2001) 1.22

Overexpression of cyclin D1 in mouse skin carcinogenesis. Oncogene (1993) 1.22

E2F-1: a proliferative marker of breast neoplasia. Cancer Epidemiol Biomarkers Prev (2000) 1.20

Marked differences in the skin tumor-initiating activities of the optical enantiomers of the diastereomeric benzo(a)pyrene 7,8-diol-9,10-epoxides. Cancer Res (1979) 1.20

Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy. Proc Natl Acad Sci U S A (1987) 1.19

Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells. Cancer Res (1989) 1.19

The role of epidermal aryl hydrocarbon hydroxylase in the covalent binding of polycyclic hydrocarbon to DNA and its relationship to tumor initiation. Biochem Biophys Res Commun (1976) 1.18

Immunohistochemical analysis of p53 expression in human pancreatic carcinomas. Arch Pathol Lab Med (1994) 1.13

Overexpression of the prostaglandin E2 receptor EP2 results in enhanced skin tumor development. Oncogene (2006) 1.13

Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene. Proc Natl Acad Sci U S A (1993) 1.13

The hamster cheek pouch carcinogenesis model. J Cell Biochem Suppl (1993) 1.12

Epidermal cell proliferation and promoting ability of phorbol esters. J Natl Cancer Inst (1976) 1.11

Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7. Cancer Res (1991) 1.11

Promotion of carcinomas by repeated abrasion in initiated skin of mice. Cancer Res (1981) 1.10

Murine susceptibility to two-stage skin carcinogenesis is influenced by the agent used for promotion. Carcinogenesis (1984) 1.10

Malignant progression of papilloma-derived keratinocytes: differential effects of the ras, neu, and p53 oncogenes. Mol Carcinog (1988) 1.08

Induction of dark keratinocytes by 12-O-tetradecanoylphorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency. Carcinogenesis (1980) 1.08

Dose-response studies on the ability of 7,12-dimethylbenz(alpha)anthracene and benz(alpha)anthracene to initiate skin tumors. J Natl Cancer Inst (1974) 1.08

Comparative tumor-initiating activity of complex mixtures from environmental particulate emissions on SENCAR mouse skin. J Natl Cancer Inst (1982) 1.08

Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model. Proc Natl Acad Sci U S A (2001) 1.08

Chemical carcinogens. A review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox Carcinogen Data Base. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res (1987) 1.07

Studies on the mechanisms involved in multistage carcinogenesis in mouse skin. J Cell Biochem (1982) 1.07

Increased expression of p50-NF-kappaB and constitutive activation of NF-kappaB transcription factors during mouse skin carcinogenesis. Oncogene (1999) 1.07

Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions. Mol Carcinog (1989) 1.06

Aneuploidy, an early event in mouse skin tumor development. Carcinogenesis (1986) 1.06

Inhibition of tumor initiation and promotion by anti-inflammatory agents. J Natl Cancer Inst (1973) 1.06

Immunohistochemistry of cyclin D1 in human breast cancer. Am J Clin Pathol (1994) 1.06

The proprotein convertases furin and PACE4 play a significant role in tumor progression. Mol Carcinog (2000) 1.05

Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior. Int J Cancer (1999) 1.05

Phosphorylation of histones is stimulated by phorbol esters in quiescent Reuber H35 hepatoma cells. J Biol Chem (1986) 1.05

Induction of beta-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-kappaB. J Biol Chem (2001) 1.05

Deletion and mutation analyses of the P16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas. Cancer Res (1996) 1.04

Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator. Cancer Res (1977) 1.04

Markers of proliferation in normal and leukoplakic oral epithelia. Oral Oncol (2000) 1.04

Molecular pathology of primary and metastatic ductal pancreatic lesions: analyses of mutations and expression of the p53, mdm-2, and p21/WAF-1 genes in sporadic and familial lesions. Cancer (1997) 1.04

Separation of epidermal cells by density centrifugation: a new technique for studies on normal and pathological differentiation. J Cutan Pathol (1982) 1.03

Prostaglandin E(2) regulation of cyclooxygenase expression in keratinocytes is mediated via cyclic nucleotide-linked prostaglandin receptors. J Lipid Res (2000) 1.03

A direct cytogenetic technique for mouse skin carcinomas and papillomas. Cancer Genet Cytogenet (1986) 1.03

Comparison of the tumor-initiating activities of benzo(a)pyrene arene oxides and diol-epoxides. Cancer Res (1977) 1.02

Alterations of the p53 tumor suppressor gene during mouse skin tumor progression. Cancer Res (1991) 1.02

Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide. Cancer Res (1986) 1.01

Terminal differentiation-resistant epidermal cells in mice undergoing two-stage carcinogenesis. Cancer Res (1987) 1.01