Published in Cancer Res on August 01, 1991
p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways. PLoS Biol (2004) 1.44
LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer. Oncogene (2003) 1.23
Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability. Br J Cancer (1993) 1.19
The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. J Cell Biol (1993) 1.18
Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis. Oncogene (2012) 1.11
Epithelial carcinogenesis in the mouse: correlating the genetics and the biology. Philos Trans R Soc Lond B Biol Sci (1998) 1.03
The second intron of the K-ras gene contains regulatory elements associated with mouse lung tumor susceptibility. Proc Natl Acad Sci U S A (1994) 1.00
Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer. Mol Cancer Res (2011) 0.96
Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression. Genes Dev (2013) 0.94
Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis. Leukemia (2016) 0.87
Alterations in the expression of uvomorulin and Na+,K(+)-adenosine triphosphatase during mouse skin tumor progression. Am J Pathol (1992) 0.87
Defects in transforming growth factor-beta signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes. Proc Natl Acad Sci U S A (1999) 0.83
Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition. Oncogene (2013) 0.82
The complexities of TGF-β action during mammary and squamous cell carcinogenesis. Curr Pharm Biotechnol (2011) 0.81
The pluripotency factor NANOG promotes the formation of squamous cell carcinomas. Sci Rep (2015) 0.81
Modeling cutaneous squamous carcinoma development in the mouse. Cold Spring Harb Perspect Med (2014) 0.78
Therapy of murine squamous cell carcinomas with 2-difluoromethylornithine. J Carcinog (2004) 0.76
Dermal fibroblasts tumor suppression of ras-transformed keratinocytes is associated with induction of squamous cell differentiation. Am J Pathol (1994) 0.75
TGF-beta signaling in tumor suppression and cancer progression. Nat Genet (2001) 11.64
Guidelines for the welfare and use of animals in cancer research. Br J Cancer (2010) 6.97
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature (1986) 6.14
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci U S A (1996) 4.39
Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature (1984) 4.28
TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell (1996) 3.73
The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res (1994) 3.28
Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene. Nature (1983) 3.09
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell (1993) 2.62
p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat Genet (1994) 2.61
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res (1999) 2.56
Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter. Cell (1990) 2.34
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell (1990) 2.16
Localized production of TGF-beta mRNA in tumour promoter-stimulated mouse epidermis. Nature (1988) 1.99
Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Cell Growth Differ (1998) 1.98
UKCCCR guidelines for the welfare of animals in experimental neoplasia. Lab Anim (1988) 1.95
Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J Biol Chem (1998) 1.94
Transformation of human breast epithelial cells by c-Ha-ras oncogene. Mol Carcinog (1991) 1.87
v-ras genes from Harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis. Cell (1986) 1.76
High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas. Proc Natl Acad Sci U S A (1995) 1.76
The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted. Curr Biol (1998) 1.69
Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. Proc Natl Acad Sci U S A (1993) 1.66
Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound. Science (1981) 1.63
Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. Am J Pathol (1997) 1.63
Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types. Nat Genet (1994) 1.63
Analysis of the HMGI nuclear proteins in mouse neoplastic cells induced by different procedures. Exp Cell Res (1989) 1.61
Improving information to Italian cancer patients: results of a randomized study. Ann Oncol (2004) 1.60
Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. Proc Natl Acad Sci U S A (2001) 1.60
Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. Mol Cell Biol (1998) 1.56
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines. Mol Carcinog (2001) 1.56
The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas. Hum Pathol (1995) 1.56
The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. Nat Genet (1999) 1.56
TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest. Genes Dev (2000) 1.56
Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression. Proc Natl Acad Sci U S A (1990) 1.56
Genetic events and the role of TGF beta in epithelial tumour progression. J Pathol (1999) 1.52
Studies on mechanism of action of anti-tumor-promoting agents: their specificity in two-stage promotion. Proc Natl Acad Sci U S A (1980) 1.47
The p53 response to ionising radiation in adult and developing murine tissues. Oncogene (1996) 1.46
Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice. Genes Dev (1995) 1.43
Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice. Cancer Res (1995) 1.42
Distinct genetic loci control development of benign and malignant skin tumours in mice. Nat Genet (1995) 1.41
Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes. Oncogene (1992) 1.41
T-cell lymphoma lines derived from rat thymomas induced by Moloney murine leukemia virus: phenotypic diversity and its implications. J Virol (1990) 1.39
Frequent loss of heterozygosity in human primary squamous cell and colon carcinomas at 7q31.1: evidence for a broad range tumor suppressor gene. Cancer Res (1995) 1.36
Cloning and characterisation of the abundant cytoplasmic 7S RNA from mouse cells. Nucleic Acids Res (1982) 1.36
Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res (1994) 1.33
Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice. Oncogene (1991) 1.32
Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer (2000) 1.32
Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors. Cancer Res (1995) 1.32
Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells. J Natl Cancer Inst (2000) 1.31
Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. Cancer Res (2001) 1.29
Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines. Am J Pathol (1991) 1.29
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells. Proc Natl Acad Sci U S A (2001) 1.26
Proliferative potential and K-ras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union. Cancer (1998) 1.25
An allelotype of squamous carcinoma of the head and neck using microsatellite markers. Cancer Res (1994) 1.25
E2F-1: a proliferative marker of breast neoplasia. Cancer Epidemiol Biomarkers Prev (2000) 1.20
Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy. Proc Natl Acad Sci U S A (1987) 1.19
Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells. Cancer Res (1989) 1.19
The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. J Cell Biol (1993) 1.18
Epistatic interactions between skin tumor modifier loci in interspecific (spretus/musculus) backcross mice. Cancer Res (2001) 1.15
Immunohistochemical analysis of p53 expression in human pancreatic carcinomas. Arch Pathol Lab Med (1994) 1.13
Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene. Proc Natl Acad Sci U S A (1993) 1.13
Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis. Oncogene (2012) 1.11
Induction of dark keratinocytes by 12-O-tetradecanoylphorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency. Carcinogenesis (1980) 1.08
Transforming ras oncogenes and multistage carcinogenesis. Br J Cancer (1985) 1.07
Studies on the mechanisms involved in multistage carcinogenesis in mouse skin. J Cell Biochem (1982) 1.07
Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo. Carcinogenesis (1991) 1.07
Development of vascular endothelial growth factor receptor (VEGFR) kinase inhibitors as anti-angiogenic agents in cancer therapy. Curr Med Chem (2004) 1.06
High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model. Oncogene (2000) 1.06
Aneuploidy, an early event in mouse skin tumor development. Carcinogenesis (1986) 1.06
Immunohistochemistry of cyclin D1 in human breast cancer. Am J Clin Pathol (1994) 1.06
Dermoscopic diagnosis by a trained clinician vs. a clinician with minimal dermoscopy training vs. computer-aided diagnosis of 341 pigmented skin lesions: a comparative study. Br J Dermatol (2002) 1.05
The proprotein convertases furin and PACE4 play a significant role in tumor progression. Mol Carcinog (2000) 1.05
Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior. Int J Cancer (1999) 1.05
Markers of proliferation in normal and leukoplakic oral epithelia. Oral Oncol (2000) 1.04
Integration of positive and negative growth signals during ras pathway activation in vivo. Curr Opin Genet Dev (2000) 1.04
Epithelial carcinogenesis in the mouse: correlating the genetics and the biology. Philos Trans R Soc Lond B Biol Sci (1998) 1.03
Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma. Oncogene (2011) 1.03
Hyperpigmentation and melanocytic hyperplasia in transgenic mice expressing the human T24 Ha-ras gene regulated by a mouse tyrosinase promoter. Mol Carcinog (1995) 1.03
A direct cytogenetic technique for mouse skin carcinomas and papillomas. Cancer Genet Cytogenet (1986) 1.03
Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma. J Clin Invest (1997) 1.03
Alterations of the p53 tumor suppressor gene during mouse skin tumor progression. Cancer Res (1991) 1.02
Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide. Cancer Res (1986) 1.01
A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression. Mol Carcinog (1994) 1.01
The synthesis of specific proteins in adult mouse epidermis during phases of proliferation and differentiation induced by the tumor promoter TPA, and in basal and differentiating layers of neonatal mouse epidermis. J Invest Dermatol (1976) 1.00
A subset of skin tumor modifier loci determines survival time of tumor-bearing mice. Proc Natl Acad Sci U S A (1999) 1.00
Potentiation of diffuse lung damage by oxygen: determining variables. Am Rev Respir Dis (1981) 1.00
Antisense cyclin D1 induces apoptosis and tumor shrinkage in human squamous carcinomas. Cancer Res (1999) 1.00
Subpopulations of primary adult murine epidermal basal cells sedimented on density gradients. Cell Tissue Kinet (1990) 1.00
Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations. Cancer Res (1992) 1.00
Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Cell Death Differ (2012) 0.99
Building 'validated' mouse models of human cancer. Curr Opin Cell Biol (2001) 0.99
Potentiation of butylated hydroxytoluene-induced acute lung damage by oxygen. Cell kinetics and collagen metabolism. Am Rev Respir Dis (1983) 0.99
Immunocytochemical demonstration of p21 ras family oncogene product in normal mucosa and in premalignant and malignant tumours of the colorectum. Br J Cancer (1985) 0.99
Altered epidermal cell growth control in vivo by inducible expression of transforming growth factor beta 1 in the skin of transgenic mice. Cell Growth Differ (1996) 0.99
K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients. Cancer Lett (1997) 0.98
Nick translation of mammalian DNA. Biochim Biophys Acta (1979) 0.98