Published in DNA Cell Biol on July 20, 2011
Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. ACS Med Chem Lett (2016) 0.75
ATP-citrate lyase links cellular metabolism to histone acetylation. Science (2009) 8.82
Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes. Nature (1984) 8.65
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology (1990) 6.34
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev (1997) 5.66
GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab (2006) 4.50
Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev (1995) 4.07
Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. J Biol Chem (2002) 3.21
Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci U S A (2002) 2.45
MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem (2002) 2.22
Regulation of insulin gene transcription. Diabetologia (2002) 2.19
Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. Mol Cell Biol (1999) 1.75
Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells. J Biol Chem (2003) 1.71
Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc Natl Acad Sci U S A (1993) 1.61
Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription. J Biol Chem (2005) 1.61
Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Proc Natl Acad Sci U S A (1994) 1.56
Glucose regulation of insulin gene expression in pancreatic beta-cells. Biochem J (2008) 1.50
Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes. Diabetes (2008) 1.46
Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression. Mol Cell Biol (1994) 1.41
Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility. Oncogene (2010) 1.41
The insulin gene promoter. A simplified nomenclature. Diabetes (1995) 1.39
Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5. Biochim Biophys Acta (2009) 1.39
Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase. J Biol Chem (2005) 1.38
The insulin gene contains multiple transcriptional elements that respond to glucose. Mol Cell Biol (1994) 1.36
GSK-3-mediated phosphorylation enhances Maf-transforming activity. Mol Cell (2007) 1.31
Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5. J Endocrinol (2010) 1.28
Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1. Mol Endocrinol (2004) 1.25
Control of insulin gene expression by glucose. Biochem J (1992) 1.23
GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. J Biol Chem (2009) 1.23
Glucose regulates insulin gene transcription by hyperacetylation of histone h4. J Biol Chem (2003) 1.20
Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets. Diabetes (2007) 1.17
The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose. J Biol Chem (2004) 1.14
Quantitative analysis of the hormone-induced hyperacetylation of histone H3 associated with the steroidogenic acute regulatory protein gene promoter. J Biol Chem (2001) 1.13
Glucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway. J Biol Chem (2006) 1.07
The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic beta-cells. Mol Endocrinol (2000) 0.94
Insulinoma-associated antigen-1 zinc-finger transcription factor promotes pancreatic duct cell trans-differentiation. Endocrinology (2010) 0.92
Pdx-1 modulates histone H4 acetylation and insulin gene expression in terminally differentiated alpha-TC-1 cells. Pancreas (2007) 0.89
Acetylation of the BETA2 transcription factor by p300-associated factor is important in insulin gene expression. J Biol Chem (2003) 0.88
Transcription of the insulin gene: towards defining the glucose-sensitive cis-element and trans-acting factors. Diabetologia (1994) 0.82
CAT in the HAT: catabolic inhibition by the histone acetyltransferase GCN5. Cell Metab (2006) 0.77
Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcription. RNA (2008) 1.95
Glucose regulation of insulin gene expression in pancreatic beta-cells. Biochem J (2008) 1.50
Repression of transcription by Rgt1 in the absence of glucose requires Std1 and Mth1. Curr Genet (2003) 1.47
Glucose-mediated phosphorylation converts the transcription factor Rgt1 from a repressor to an activator. J Biol Chem (2003) 1.41
Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase. J Biol Chem (2005) 1.38
Role of microRNAs in diabetes. Biochim Biophys Acta (2008) 1.31
Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1. Mol Endocrinol (2004) 1.25
Glucose mediates the translocation of NeuroD1 by O-linked glycosylation. J Biol Chem (2007) 1.25
Glucose regulates insulin gene transcription by hyperacetylation of histone h4. J Biol Chem (2003) 1.20
The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose. J Biol Chem (2004) 1.14
Glucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway. J Biol Chem (2006) 1.07
Analysis of insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes. Methods Mol Med (2003) 0.98
Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain. J Biol Chem (2006) 0.94
The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation. J Biol Chem (2008) 0.94
Ataxin-10 interacts with O-GlcNAc transferase OGT in pancreatic beta cells. Biochem Biophys Res Commun (2005) 0.86
Adenoviral gene transfer into isolated pancreatic islets. Methods Mol Biol (2009) 0.82
Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia. Acta Neuropathol Commun (2014) 0.82
Multiple kinases regulate mafA expression in the pancreatic beta cell line MIN6. Arch Biochem Biophys (2008) 0.81
Adenoviral gene transfer into beta-cell lines. Methods Mol Med (2003) 0.78
Induction of insulin secretion in engineered liver cells by nitric oxide. BMC Physiol (2007) 0.78
Nitric oxide stimulates insulin release in liver cells expressing human insulin. Biochem Biophys Res Commun (2005) 0.75