Published in J Endocrinol on January 21, 2010
Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond) (2012) 4.04
A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol (2012) 1.62
Genome-wide profiling of H3K56 acetylation and transcription factor binding sites in human adipocytes. PLoS One (2011) 1.34
Oxidative stress and epigenetic regulation in ageing and age-related diseases. Int J Mol Sci (2013) 1.25
Outcome of severe lactic acidosis associated with metformin accumulation. Crit Care (2010) 1.12
Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity. Diabetes Metab Syndr Obes (2013) 1.12
SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Prev Med (2011) 1.10
Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation. J Biol Chem (2011) 1.09
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochem Pharmacol (2012) 1.06
Repurposing metformin: an old drug with new tricks in its binding pockets. Biochem J (2015) 1.03
Genetic, epigenetic, and environmental contributions to neural tube closure. Annu Rev Genet (2014) 0.99
Mitochondrial dysfunction: a basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities. Mediators Inflamm (2013) 0.93
Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. Am J Physiol Endocrinol Metab (2010) 0.93
Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway. Autophagy (2015) 0.93
Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions. Br J Pharmacol (2014) 0.88
Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism. PLoS One (2012) 0.88
Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health. Mol Metab (2016) 0.87
Activation of toll-like receptors and inflammasome complexes in the diabetic cardiomyopathy-associated inflammation. Int J Endocrinol (2014) 0.85
Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging. Oxid Med Cell Longev (2015) 0.84
Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance. Diabetologia (2014) 0.84
Sirtuin biology and relevance to diabetes treatment. Diabetes Manag (Lond) (2012) 0.83
Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction. Oncotarget (2015) 0.83
Metformin increases mitochondrial energy formation in L6 muscle cell cultures. J Biol Chem (2013) 0.81
Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53. Int J Mol Sci (2016) 0.79
Genomic Characterization of Metformin Hepatic Response. PLoS Genet (2016) 0.79
Management of pediatric and adolescent type 2 diabetes. Int J Pediatr (2013) 0.78
Metformin treatment status and abdominal aortic aneurysm disease progression. J Vasc Surg (2016) 0.78
Sirtuins as novel players in the pathogenesis of diabetes mellitus. World J Diabetes (2014) 0.78
Regulation of insulin gene transcription by multiple histone acetyltransferases. DNA Cell Biol (2011) 0.78
Hepatic adaptations to maintain metabolic homeostasis in response to fasting and refeeding in mice. Nutr Metab (Lond) (2016) 0.78
Shizukaol D isolated from Chloranthus japonicas inhibits AMPK-dependent lipid content in hepatic cells by inducing mitochondrial dysfunction. PLoS One (2013) 0.77
Locating the source of hyperglycemia: liver versus muscle. J Diabetes (2012) 0.77
Pharmacologic Means of Extending Lifespan. J Clin Exp Pathol (2012) 0.76
Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons. PLoS One (2016) 0.76
Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury. Sci Rep (2016) 0.75
A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice. Int J Hepatol (2016) 0.75
Impact of metformin on reproductive tissues: an overview from gametogenesis to gestation. Ann Transl Med (2014) 0.75
The Landscape of Histone Modifications in a High-Fat-Diet-Induced Obese (DIO) Mouse Model. Mol Cell Proteomics (2017) 0.75
Risk stratification in uncomplicated type 2 diabetes: prospective evaluation of the combined use of coronary artery calcium imaging and selective myocardial perfusion scintigraphy. Eur Heart J (2006) 2.74
Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. J Am Soc Nephrol (2004) 2.64
Determinants of progression of coronary artery calcification in type 2 diabetes role of glycemic control and inflammatory/vascular calcification markers. J Am Coll Cardiol (2007) 2.29
Ischemic conditioning protects the uremic heart in a rodent model of myocardial infarction. Circulation (2012) 2.12
Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction. Lab Invest (2008) 1.49
Increased volume of epicardial fat is an independent risk factor for accelerated progression of sub-clinical coronary atherosclerosis. Atherosclerosis (2011) 1.48
Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the β-common receptor. Kidney Int (2013) 1.37
The relationship between plasma osteoprotegerin levels and coronary artery calcification in uncomplicated type 2 diabetic subjects. J Am Coll Cardiol (2006) 1.32
Osteoprotegerin as a predictor of coronary artery disease and cardiovascular mortality and morbidity. J Am Coll Cardiol (2010) 1.25
Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the β-common receptor. Dis Model Mech (2013) 0.92
Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation. Biochem Pharmacol (2012) 0.91
Homocysteine-induced endothelin-1 release is dependent on hyperglycaemia and reactive oxygen species production in bovine aortic endothelial cells. J Vasc Res (2006) 0.90
Regulation of vascular endothelial function by procyanidin-rich foods and beverages. J Agric Food Chem (2010) 0.90
Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism. J Endocrinol (2011) 0.89
Comparison of the relation between renal impairment, angiographic coronary artery disease, and long-term mortality in women versus men. Am J Cardiol (2006) 0.88
A role for increased mRNA stability in the induction of endothelin-1 synthesis by lipopolysaccharide. Biochem Pharmacol (2003) 0.88
Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase. Life Sci (2009) 0.87
A possible explanation for anemia in patients treated with mycophenolic acid. Transplantation (2011) 0.80
A novel mechanism for regulating hepatic glycogen synthesis involving serotonin and cyclin-dependent kinase-5. Diabetes (2011) 0.79
Drinking your health? It's too early to say. Nature (2003) 0.79
Comparison of red wine extract and polyphenol constituents on endothelin-1 synthesis by cultured endothelial cells. Clin Sci (Lond) (2002) 0.79
The procyanidin-induced pseudo laminar shear stress response: a new concept for the reversal of endothelial dysfunction. Clin Sci (Lond) (2004) 0.78
Albumin stimulates cell growth, l-arginine transport, and metabolism to polyamines in human proximal tubular cells. Kidney Int (2005) 0.78
Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter. Mol Cell Biol (2012) 0.78
Quantitative measurement of mRNA levels by RT-PCR. Studies of ECE-1 isoforms. Methods Mol Biol (2002) 0.77
Inhibitory effect of adrenomedullin on basal and tumour necrosis factor alpha-stimulated endothelin-1 synthesis in bovine aortic endothelial cells is independent of cyclic AMP. Biochem Pharmacol (2002) 0.77
Angiotensin-converting enzyme gene polymorphism and erythropoietin requirement. Perit Dial Int (2003) 0.77
Factor VIIa stimulates endothelin-1 synthesis in TNF-primed endothelial cells by activation of protease-activated receptor 2. Clin Sci (Lond) (2005) 0.77
Red wine, chocolate and vascular health: developing the evidence base. Heart (2008) 0.76
Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia. Proc Natl Acad Sci U S A (2014) 0.75
Ischemic conditioning in solid organ transplantation: is it worth giving your right arm for? Curr Opin Nephrol Hypertens (2017) 0.75