Published in J Neurotrauma on September 21, 2011
Antioxidant therapies in traumatic brain and spinal cord injury. Biochim Biophys Acta (2011) 1.48
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors. Inflammopharmacology (2012) 1.06
Nrf2-a therapeutic target for the treatment of neurodegenerative diseases. Free Radic Biol Med (2015) 0.95
Drug delivery systems, CNS protection, and the blood brain barrier. Biomed Res Int (2014) 0.95
Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers. J Neurosci (2014) 0.92
Perspectives on molecular biomarkers of oxidative stress and antioxidant strategies in traumatic brain injury. Biomed Res Int (2014) 0.91
Neuroprotective effects of sulforaphane after contusive spinal cord injury. J Neurotrauma (2012) 0.87
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Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment. PLoS One (2012) 0.86
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Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci (2014) 0.78
Neuroprotective effects of erucin against 6-hydroxydopamine-induced oxidative damage in a dopaminergic-like neuroblastoma cell line. Int J Mol Sci (2012) 0.78
Nrf2 activation in astrocytes contributes to spinal cord ischemic tolerance induced by hyperbaric oxygen preconditioning. J Neurotrauma (2014) 0.77
The multifaceted role of Nrf2 in mitochondrial function. Curr Opin Toxicol (2016) 0.76
2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside Isolated from Polygoni Multiflori Ameliorates the Development of Periodontitis. Mediators Inflamm (2016) 0.75
Neuroprotection by diarylpropionitrile in mice with spinal cord injury. EXCLI J (2014) 0.75
Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons. Pain (2016) 0.75
Activation of the nuclear factor E2-related factor 2/anitioxidant response element alleviates the nitroglycerin-induced hyperalgesia in rats. J Headache Pain (2016) 0.75
Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts. Oncotarget (2017) 0.75
A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma (1995) 13.48
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A (2001) 6.78
Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem (2000) 5.75
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem (1999) 4.77
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci (2001) 4.02
Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. J Neurosci (2003) 3.54
Regulation of glutathione synthesis. Mol Aspects Med (2008) 3.40
Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog (2009) 2.94
An important role of Nrf2-ARE pathway in the cellular defense mechanism. J Biochem Mol Biol (2004) 2.74
Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol Appl Pharmacol (2001) 2.40
Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis. J Neurosci (2008) 2.34
Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem (2001) 2.26
Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochem Pharmacol (2008) 2.21
The transcription factor Nrf2 is a therapeutic target against brain inflammation. J Immunol (2008) 2.03
CatWalk-assisted gait analysis in the assessment of spinal cord injury. J Neurotrauma (2006) 1.98
A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci (2008) 1.93
Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase. Mol Aspects Med (2008) 1.92
Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury. J Neurosci (2007) 1.82
Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radic Biol Med (2007) 1.73
Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. Mol Cancer Ther (2007) 1.68
Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. Stroke (2007) 1.61
Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett (2005) 1.57
Neuroprotective role of haptoglobin after intracerebral hemorrhage. J Neurosci (2009) 1.38
Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival. J Biol Chem (2005) 1.36
Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem Pharmacol (2008) 1.26
Disruption of Nrf2 enhances upregulation of nuclear factor-kappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury. Mediators Inflamm (2009) 1.22
Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells. Oncogene (2003) 1.08
Activation of Nrf2-ARE pathway in brain after traumatic brain injury. Neurosci Lett (2007) 1.07
Role of Nrf2 in protection against traumatic brain injury in mice. J Neurotrauma (2009) 1.04
Apoptotic and anti-apoptotic mechanisms following spinal cord injury. J Neuropathol Exp Neurol (2001) 1.02
Sulforaphane suppresses LPS-induced inflammation in primary rat microglia. Inflamm Res (2009) 1.00
Influence of Nrf2 genotype on pulmonary NF-kappaB activity and inflammatory response after traumatic brain injury. Ann Clin Lab Sci (2008) 0.98
Disruption of Nrf2 enhances the upregulation of nuclear factor-kappaB activity, tumor necrosis factor-α, and matrix metalloproteinase-9 after spinal cord injury in mice. Mediators Inflamm (2010) 0.94
E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer disease patients. J Biol Chem (2011) 0.91
Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione. Mol Pharmacol (2010) 0.90
Chitosan prevents oxidative stress-induced amyloid beta formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-kappaB. Mol Cell Biochem (2009) 0.90
Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation. J Neurosci Res (2010) 0.90
Dual mechanisms of NF-kappaB inhibition in carnosol-treated endothelial cells. Toxicol Appl Pharmacol (2010) 0.88
Neuroprotective effects of bone morphogenetic protein 7 (BMP7) treatment after spinal cord injury. Neurosci Lett (2009) 0.84
The neuroprotective potential of phase II enzyme inducer on motor neuron survival in traumatic spinal cord injury in vitro. Cell Mol Neurobiol (2007) 0.83
Neuroprotective effects of the drug GVT (monosodium luminol) are mediated by the stabilization of Nrf2 in astrocytes. Neurochem Int (2010) 0.81
Heme oxygenase-1 expression after spinal cord injury: the induction in activated neutrophils. J Neurotrauma (2002) 0.81
The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem (2009) 2.90
The role of Nrf2 in migration and invasion of human glioma cell U251. World Neurosurg (2011) 2.76
Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice. J Cereb Blood Flow Metab (2008) 1.99
A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci (2008) 1.93
Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. J Cereb Blood Flow Metab (2009) 1.69
Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am J Physiol Cell Physiol (2007) 1.60
Involvement of the inflammasome in abnormal semen quality of men with spinal cord injury. Fertil Steril (2012) 1.43
Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain. J Neurosci (2011) 1.27
Pannexin: from discovery to bedside in 11±4 years? Brain Res (2012) 1.24
Disruption of Nrf2 enhances upregulation of nuclear factor-kappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury. Mediators Inflamm (2009) 1.22
Alterations in blood-brain barrier permeability to large and small molecules and leukocyte accumulation after traumatic brain injury: effects of post-traumatic hypothermia. J Neurotrauma (2009) 1.18
Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage. Eur J Neurosci (2006) 1.11
P2X4 receptors influence inflammasome activation after spinal cord injury. J Neurosci (2012) 1.05
Human astrocytes express a novel NLRP2 inflammasome. Glia (2013) 1.05
Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4/NF-κB pathway after traumatic brain injury in the rat. Mediators Inflamm (2011) 1.04
Role of Nrf2 in protection against traumatic brain injury in mice. J Neurotrauma (2009) 1.04
Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. J Neurosci (2004) 1.02
Hyperintense vessels on FLAIR: a useful non-invasive method for assessing intracerebral collaterals. Eur J Radiol (2010) 1.00
Effects of therapeutic hypothermia on inflammasome signaling after traumatic brain injury. J Cereb Blood Flow Metab (2012) 0.99
Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats. BMC Neurosci (2011) 0.98
Increased intestinal inflammatory response and gut barrier dysfunction in Nrf2-deficient mice after traumatic brain injury. Cytokine (2008) 0.98
Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome: clinical article. J Neurosurg (2012) 0.95
Monoubiquitination and cellular distribution of XIAP in neurons after traumatic brain injury. J Cereb Blood Flow Metab (2003) 0.94
Disruption of Nrf2 enhances the upregulation of nuclear factor-kappaB activity, tumor necrosis factor-α, and matrix metalloproteinase-9 after spinal cord injury in mice. Mediators Inflamm (2010) 0.94
Inhibition of cathepsin S produces neuroprotective effects after traumatic brain injury in mice. Mediators Inflamm (2013) 0.92
Oligodendrocyte vulnerability following traumatic brain injury in rats. Neurosci Lett (2011) 0.91
Evaluation of angiographic changes of the anterior choroidal and posterior communicating arteries for predicting cerebrovascular lesions in adult moyamoya disease. J Clin Neurosci (2011) 0.91
Nrf2 is required to maintain the self-renewal of glioma stem cells. BMC Cancer (2013) 0.90
Astrogliosis involves activation of retinoic acid-inducible gene-like signaling in the innate immune response after spinal cord injury. Glia (2011) 0.90
Genetic ablation of Nrf2 enhances susceptibility to acute lung injury after traumatic brain injury in mice. Exp Biol Med (Maywood) (2009) 0.90
A novel protein complex in membrane rafts linking the NR2B glutamate receptor and autophagy is disrupted following traumatic brain injury. J Neurotrauma (2009) 0.90
Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1α. Int J Cancer (2014) 0.88
Effects of tert-butylhydroquinone on intestinal inflammatory response and apoptosis following traumatic brain injury in mice. Mediators Inflamm (2011) 0.88
Caspase-1 level is higher in the scalp in androgenetic alopecia. Dermatol Surg (2012) 0.88
Transcription factor Nrf2 protects the spinal cord from inflammation produced by spinal cord injury. J Surg Res (2011) 0.88
Protective effect of tert-butylhydroquinone on cerebral inflammatory response following traumatic brain injury in mice. Injury (2011) 0.87
Therapeutic strategies targeting caspase inhibition following spinal cord injury in rats. Exp Neurol (2002) 0.87
The absence of Nrf2 enhances NF-κB-dependent inflammation following scratch injury in mouse primary cultured astrocytes. Mediators Inflamm (2012) 0.86
Effects of finasteride on apoptosis and regulation of the human hair cycle. J Cutan Med Surg (2002) 0.86
FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway. Tumour Biol (2014) 0.86
FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury. J Neurotrauma (2007) 0.85
Isoflurane/nitrous oxide anesthesia induces increases in NMDA receptor subunit NR2B protein expression in the aged rat brain. Brain Res (2011) 0.85
Neuroprotective effects of bone morphogenetic protein 7 (BMP7) treatment after spinal cord injury. Neurosci Lett (2009) 0.84
Peripheral ophthalmic artery aneurysm. Neurosurg Rev (2010) 0.84
Depletion of Nrf2 enhances inflammation induced by oxyhemoglobin in cultured mice astrocytes. Neurochem Res (2011) 0.84
Mincle signaling in the innate immune response after traumatic brain injury. J Neurotrauma (2014) 0.83
Correlation of Nrf2 and HIF-1α in glioblastoma and their relationships to clinicopathologic features and survival. Neurol Res (2013) 0.83
In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations. Hybridoma (Larchmt) (2011) 0.82
Deep tissue injury in development of pressure ulcers: a decrease of inflammasome activation and changes in human skin morphology in response to aging and mechanical load. PLoS One (2013) 0.82
Erythropoietin prevents secondary brain injury induced by cortical lesion in mice: possible involvement of Nrf2 signaling pathway. Ann Clin Lab Sci (2011) 0.82
Necrostatin-1 ameliorates intracerebral hemorrhage-induced brain injury in mice through inhibiting RIP1/RIP3 pathway. Neurochem Res (2015) 0.81
Neuroendocrine and cardiac metabolic dysfunction and NLRP3 inflammasome activation in adipose tissue and pancreas following chronic spinal cord injury in the mouse. ASN Neuro (2013) 0.81
Protective effects of erythropoietin in traumatic spinal cord injury by inducing the Nrf2 signaling pathway activation. J Trauma Acute Care Surg (2014) 0.81
The involvement of Nrf2-ARE pathway in regulation of apoptosis in human glioblastoma cell U251. Neurol Res (2012) 0.81
RIG-1 receptor expression in the pathology of Alzheimer's disease. J Neuroinflammation (2014) 0.80
Tert-butylhydroquinone protects the spinal cord against inflammatory response produced by spinal cord injury. Ann Clin Lab Sci (2014) 0.79
Inhibitors of apoptosis proteins in injury and disease. IUBMB Life (2002) 0.79
Erythropoietin administration modulates pulmonary Nrf2 signaling pathway after traumatic brain injury in mice. J Trauma (2011) 0.78
Intracranial meningeal melanocytoma associated with nevus of Ota. J Clin Neurosci (2011) 0.78
Anti-inflammatory effects of curcumin in experimental spinal cord injury in rats. Inflamm Res (2014) 0.77
Sex differences in XIAP cleavage after traumatic brain injury in the rat. Neurosci Lett (2009) 0.77
Inhibition of Rac1 Signaling Downregulates Inflammasome Activation and Attenuates Lung Injury in Neonatal Rats Exposed to Hyperoxia. Neonatology (2016) 0.76
5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-methyl-D-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization. J Biol Chem (2012) 0.75
Lentivirus-Mediated Knockdown of TCTN1 Inhibits Glioma Cell Proliferation. Appl Biochem Biotechnol (2015) 0.75
Huge Frontal-Temporal Lobe Arachnoid Cyst Presenting as an Weariness Migraine. J Craniofac Surg (2016) 0.75
Management of acute hydrocephalus due to pregnancy with ventriculoperitoneal shunt. Arch Gynecol Obstet (2013) 0.75
Chryseobacterium indologenes catheter-related meningitis in an elderly patient after intracranial aneurysm clipping surgery. Neurol Sci (2013) 0.75