Published in Am J Physiol Cell Physiol on July 25, 2007
The cell biology of taste. J Cell Biol (2010) 2.78
P2X7 receptor-Pannexin1 complex: pharmacology and signaling. Am J Physiol Cell Physiol (2008) 2.49
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. Proc Natl Acad Sci U S A (2008) 2.01
Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol (2009) 1.89
A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP. Am J Physiol Cell Physiol (2008) 1.86
Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes. Am J Physiol Heart Circ Physiol (2010) 1.81
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science (2014) 1.77
Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia. J Biol Chem (2011) 1.76
Lens gap junctions in growth, differentiation, and homeostasis. Physiol Rev (2010) 1.70
Gap junctions. Compr Physiol (2012) 1.59
Pannexins in ischemia-induced neurodegeneration. Proc Natl Acad Sci U S A (2011) 1.55
Vesicular and conductive mechanisms of nucleotide release. Purinergic Signal (2012) 1.49
Connexins, pannexins, innexins: novel roles of "hemi-channels". Pflugers Arch (2008) 1.45
Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other. J Biol Chem (2010) 1.39
Paracrine signaling through plasma membrane hemichannels. Biochim Biophys Acta (2012) 1.28
SCAM analysis of Panx1 suggests a peculiar pore structure. J Gen Physiol (2010) 1.25
Pannexin: from discovery to bedside in 11±4 years? Brain Res (2012) 1.24
Connexins in vascular physiology and pathology. Antioxid Redox Signal (2009) 1.22
Voltage dependence of ATP secretion in mammalian taste cells. J Gen Physiol (2008) 1.19
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res Cardiol (2012) 1.17
Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors. J Physiol (2012) 1.17
Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity. J Neurosci (2011) 1.15
Both sides now: multiple interactions of ATP with pannexin-1 hemichannels. Focus on "A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP". Am J Physiol Cell Physiol (2009) 1.06
Homeostasis of extracellular ATP in human erythrocytes. J Biol Chem (2011) 1.04
Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front Pharmacol (2013) 1.02
Differentiating connexin hemichannels and pannexin channels in cellular ATP release. FEBS Lett (2014) 1.01
Two non-vesicular ATP release pathways in the mouse erythrocyte membrane. FEBS Lett (2011) 1.00
Connexin 43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury. Pflugers Arch (2010) 0.99
Biological and biophysical properties of vascular connexin channels. Int Rev Cell Mol Biol (2009) 0.98
Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation. Basic Res Cardiol (2012) 0.97
Cardiac to cancer: connecting connexins to clinical opportunity. FEBS Lett (2014) 0.96
Manipulating connexin communication channels: use of peptidomimetics and the translational outputs. J Membr Biol (2012) 0.95
Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype. J Biol Chem (2012) 0.94
The bizarre pharmacology of the ATP release channel pannexin1. Neuropharmacology (2013) 0.93
Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity. Purinergic Signal (2011) 0.93
Stimulated efflux of amino acids and glutathione from cultured hippocampal slices by omission of extracellular calcium: likely involvement of connexin hemichannels. J Biol Chem (2008) 0.93
Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation. J Biol Chem (2013) 0.92
ATP release through pannexon channels. Philos Trans R Soc Lond B Biol Sci (2015) 0.92
Gap junctions and blood-tissue barriers. Adv Exp Med Biol (2012) 0.92
Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases. Front Cell Neurosci (2014) 0.91
Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacol Rev (2014) 0.90
Intracellular cysteine 346 is essentially involved in regulating Panx1 channel activity. J Biol Chem (2010) 0.89
The effects of age on lens transport. Invest Ophthalmol Vis Sci (2013) 0.89
Extracellular K⁺ and astrocyte signaling via connexin and pannexin channels. Neurochem Res (2012) 0.84
Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal (2013) 0.84
Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. Invest Ophthalmol Vis Sci (2011) 0.84
Pannexin1 channel proteins in the zebrafish retina have shared and unique properties. PLoS One (2013) 0.83
Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes. Cell Death Differ (2016) 0.82
Replacement of a single cysteine in the fourth transmembrane region of zebrafish pannexin 1 alters hemichannel gating behavior. Exp Brain Res (2009) 0.82
High glucose alters Cx43 expression and gap junction intercellular communication in retinal Müller cells: promotes Müller cell and pericyte apoptosis. Invest Ophthalmol Vis Sci (2014) 0.82
Pannexin channels and ischaemia. J Physiol (2014) 0.81
Blockade of gap junction hemichannel protects secondary spinal cord injury from activated microglia-mediated glutamate exitoneurotoxicity. J Neurotrauma (2014) 0.79
Antibodies targeting extracellular domain of connexins for studies of hemichannels. Neuropharmacology (2013) 0.79
Emerging concepts regarding pannexin 1 in the vasculature. Biochem Soc Trans (2015) 0.78
Connexin hemichannel and pannexin channel electrophysiology: how do they differ? FEBS Lett (2014) 0.77
Mechanosensitive unpaired innexin channels in C. elegans touch neurons. Am J Physiol Cell Physiol (2014) 0.77
Interactions of Pannexin1 channels with purinergic and NMDA receptor channels. Biochim Biophys Acta (2017) 0.75
Nucleoside-Diphosphate-Kinase of P. gingivalis is Secreted from Epithelial Cells In the Absence of a Leader Sequence Through a Pannexin-1 Interactome. Sci Rep (2016) 0.75
A new perspective of mechanosensitive pannexin-1 channels in cancer metastasis: clues for the treatment of other stress-induced diseases. Acta Biochim Biophys Sin (Shanghai) (2016) 0.75
Gap Junction Blockers: An Overview of their Effects on Induced Seizures in Animal Models. Curr Neuropharmacol (2016) 0.75
Pannexin- and Connexin-Mediated Intercellular Communication in Platelet Function. Int J Mol Sci (2017) 0.75
Large Pore Ion and Metabolite-Permeable Channel Regulation of Postnatal Ventricular Zone Neural Stem and Progenitor Cells: Interplay between Aquaporins, Connexins, and Pannexins? Stem Cells Int (2012) 0.75
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol Rev (2017) 0.75
Up-regulation of gap junction in peripheral blood T lymphocytes contributes to the inflammatory response in essential hypertension. PLoS One (2017) 0.75
Connexin Hemichannels in Astrocytes: An Assessment of Controversies Regarding Their Functional Characteristics. Neurochem Res (2017) 0.75
Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett (2004) 4.73
Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci U S A (2006) 4.03
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett (2005) 3.89
Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett (2007) 3.19
The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem (2009) 2.90
Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol (2008) 2.79
Pannexin 1: the molecular substrate of astrocyte "hemichannels". J Neurosci (2009) 2.48
Pannexin: to gap or not to gap, is that a question? IUBMB Life (2006) 2.05
Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane. J Biol Chem (2007) 2.05
Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice. J Cereb Blood Flow Metab (2008) 1.99
A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci (2008) 1.93
Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. Endocrinology (2008) 1.91
Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol (2009) 1.89
Connexin and pannexin mediated cell-cell communication. Neuron Glia Biol (2007) 1.86
A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP. Am J Physiol Cell Physiol (2008) 1.86
Pannexin channels are not gap junction hemichannels. Channels (Austin) (2011) 1.84
Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. J Cereb Blood Flow Metab (2009) 1.69
Beta-catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem (2008) 1.60
Connexins are mechanosensitive. Am J Physiol Cell Physiol (2004) 1.46
Involvement of the inflammasome in abnormal semen quality of men with spinal cord injury. Fertil Steril (2012) 1.43
Function of the voltage gate of gap junction channels: selective exclusion of molecules. Proc Natl Acad Sci U S A (2002) 1.40
Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other. J Biol Chem (2010) 1.39
Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain. J Neurosci (2011) 1.27
SCAM analysis of Panx1 suggests a peculiar pore structure. J Gen Physiol (2010) 1.25
Pannexin: from discovery to bedside in 11±4 years? Brain Res (2012) 1.24
ATP signaling is deficient in cultured Pannexin1-null mouse astrocytes. Glia (2012) 1.22
Trafficking dynamics of glycosylated pannexin 1 proteins. Cell Commun Adhes (2008) 1.20
Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage. Eur J Neurosci (2006) 1.11
The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials. FEBS J (2009) 1.07
Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism. PLoS One (2012) 1.05
P2X4 receptors influence inflammasome activation after spinal cord injury. J Neurosci (2012) 1.05
Innexins form two types of channels. FEBS Lett (2007) 1.05
Human astrocytes express a novel NLRP2 inflammasome. Glia (2013) 1.05
Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. J Neurosci (2004) 1.02
The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1. J Gen Physiol (2013) 1.01
Conductance of connexin hemichannels segregates with the first transmembrane segment. Biophys J (2005) 1.00
Two non-vesicular ATP release pathways in the mouse erythrocyte membrane. FEBS Lett (2011) 1.00
Effects of therapeutic hypothermia on inflammasome signaling after traumatic brain injury. J Cereb Blood Flow Metab (2012) 0.99
Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats. BMC Neurosci (2011) 0.98
Activation of the nuclear factor E2-related factor 2/antioxidant response element pathway is neuroprotective after spinal cord injury. J Neurotrauma (2011) 0.98
Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome: clinical article. J Neurosurg (2012) 0.95
Neuroglial ATP release through innexin channels controls microglial cell movement to a nerve injury. J Gen Physiol (2010) 0.95
Monoubiquitination and cellular distribution of XIAP in neurons after traumatic brain injury. J Cereb Blood Flow Metab (2003) 0.94
Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity. Purinergic Signal (2011) 0.93
A novel protein complex in membrane rafts linking the NR2B glutamate receptor and autophagy is disrupted following traumatic brain injury. J Neurotrauma (2009) 0.90
Astrogliosis involves activation of retinoic acid-inducible gene-like signaling in the innate immune response after spinal cord injury. Glia (2011) 0.90
Caspase-1 level is higher in the scalp in androgenetic alopecia. Dermatol Surg (2012) 0.88
Cosegregation of permeability and single-channel conductance in chimeric connexins. Biophys J (2005) 0.88
Therapeutic strategies targeting caspase inhibition following spinal cord injury in rats. Exp Neurol (2002) 0.87
Effects of finasteride on apoptosis and regulation of the human hair cycle. J Cutan Med Surg (2002) 0.86
FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury. J Neurotrauma (2007) 0.85
Accessibility of cx46 hemichannels for uncharged molecules and its modulation by voltage. Biophys J (2004) 0.84
Gender and estradiol as major factors in the expression and dimerization of nNOSα in rats with experimental diabetic gastroparesis. Dig Dis Sci (2012) 0.84
Neuroprotective effects of bone morphogenetic protein 7 (BMP7) treatment after spinal cord injury. Neurosci Lett (2009) 0.84
Deep tissue injury in development of pressure ulcers: a decrease of inflammasome activation and changes in human skin morphology in response to aging and mechanical load. PLoS One (2013) 0.82
In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations. Hybridoma (Larchmt) (2011) 0.82
Neuroendocrine and cardiac metabolic dysfunction and NLRP3 inflammasome activation in adipose tissue and pancreas following chronic spinal cord injury in the mouse. ASN Neuro (2013) 0.81
RIG-1 receptor expression in the pathology of Alzheimer's disease. J Neuroinflammation (2014) 0.80
Arachidonic acid closes innexin/pannexin channels and thereby inhibits microglia cell movement to a nerve injury. Dev Neurobiol (2013) 0.80
Inhibitors of apoptosis proteins in injury and disease. IUBMB Life (2002) 0.79
Assessing a potential role of host Pannexin 1 during Chlamydia trachomatis infection. PLoS One (2013) 0.78
Sex differences in XIAP cleavage after traumatic brain injury in the rat. Neurosci Lett (2009) 0.77
Inhibition of Rac1 Signaling Downregulates Inflammasome Activation and Attenuates Lung Injury in Neonatal Rats Exposed to Hyperoxia. Neonatology (2016) 0.76
5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-methyl-D-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization. J Biol Chem (2012) 0.75