Published in Pain on June 01, 2016
The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (1997) 30.59
Tumor necrosis factor signaling. Cell Death Differ (2003) 8.48
Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase. New Biol (1990) 5.90
A decade of CDK5. Nat Rev Mol Cell Biol (2001) 5.24
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med (2010) 4.23
Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci Lett (2004) 2.97
Immune and inflammatory mechanisms in neuropathic pain. Brain Res Rev (2006) 2.59
Central mechanisms of pathological pain. Nat Med (2010) 2.37
Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase. J Cell Sci (2003) 2.21
ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. Nat Cell Biol (2001) 2.11
Expression of CCR2 by endothelial cells : implications for MCP-1 mediated wound injury repair and In vivo inflammatory activation of endothelium. Arterioscler Thromb Vasc Biol (1999) 1.80
Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia. Genesis (2004) 1.75
TNF-alpha and neuropathic pain--a review. J Neuroinflammation (2010) 1.68
Chemokines: integrators of pain and inflammation. Nat Rev Drug Discov (2005) 1.68
Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels. J Neurosci (2009) 1.61
Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivity. Pain (2005) 1.53
Tumor necrosis factor. Cancer Lett (2012) 1.41
Contribution of the activation of satellite glia in sensory ganglia to pathological pain. Neurosci Biobehav Rev (2009) 1.36
Cyclin-dependent kinase 5 activity regulates pain signaling. Proc Natl Acad Sci U S A (2006) 1.34
Importance of glial activation in neuropathic pain. Eur J Pharmacol (2013) 1.31
Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci U S A (2006) 1.31
Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35. J Biol Chem (2008) 1.30
The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation. Mol Cell Neurosci (2007) 1.27
Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proc Natl Acad Sci U S A (2005) 1.21
Peripheral and central mechanisms of orofacial inflammatory pain. Int Rev Neurobiol (2011) 1.11
Cdk5: a new player in pain signaling. Cell Cycle (2006) 1.10
Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. Pain (2010) 1.09
Inactivation of TNF-α ameliorates diabetic neuropathy in mice. Am J Physiol Endocrinol Metab (2011) 1.08
Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Lab Invest (2010) 1.08
Tumor necrosis factor alpha enhances the sensitivity of rat trigeminal neurons to capsaicin. Neuroscience (2008) 1.07
Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1. Hum Mol Genet (2007) 1.03
Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia. Pain (2006) 1.03
Activation of the nuclear factor E2-related factor 2/antioxidant response element pathway is neuroprotective after spinal cord injury. J Neurotrauma (2011) 0.98
Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance. J Neurosci (2009) 0.97
TNF-alpha increases expression of IL-6 and ICAM-1 genes through activation of NF-kappaB in osteoblast-like ROS17/2.8 cells. J Bone Miner Res (1998) 0.96
Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B. J Neurosci (2012) 0.96
Cyclin-dependent kinase 5 activator p35 over-expression and amyloid beta synergism increase apoptosis in cultured neuronal cells. Neuroscience (2009) 0.96
Cdk5 activity in the brain - multiple paths of regulation. J Cell Sci (2014) 0.95
Tumor necrosis factor receptor 1 induces interleukin-6 upregulation through NF-kappaB in a rat neuropathic pain model. Eur J Pain (2008) 0.94
TNFα levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine. PLoS One (2013) 0.93
Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun (2015) 0.93
Resveratrol inhibits Cdk5 activity through regulation of p35 expression. Mol Pain (2011) 0.92
Transforming growth factor-β1 regulates Cdk5 activity in primary sensory neurons. J Biol Chem (2012) 0.91
Molecular Roles of Cdk5 in Pain Signaling. Drug Discov Today Ther Strateg (2009) 0.90
Use of the Operant Orofacial Pain Assessment Device (OPAD) to measure changes in nociceptive behavior. J Vis Exp (2013) 0.89
The Cdk5 kinase downregulates ATP-gated ionotropic P2X3 receptor function via serine phosphorylation. Cell Mol Neurobiol (2009) 0.89
TNF-alpha and phosphorylation of ERK in DRG and spinal cord: insights into mechanisms of sciatica. Spine (Phila Pa 1976) (2006) 0.88
Cdk5 regulates multiple cellular events in neural development, function and disease. Dev Growth Differ (2014) 0.86
Orofacial pain. Pain (2011) 0.84
TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells. Mol Pain (2013) 0.83
Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia. Mol Pain (2013) 0.83
ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity. PLoS One (2014) 0.83
Mitogen-activated protein kinase pathways are involved in the upregulation of calcitonin gene-related peptide of rat trigeminal ganglion after organ culture. J Mol Neurosci (2012) 0.83
Tumour necrosis factor α enhances CCL2 and ICAM-1 expression in peripheral nerve microvascular endoneurial endothelial cells. ASN Neuro (2013) 0.82
A multiplex cytokine score for the prediction of disease severity in pediatric hematology/oncology patients with septic shock. Cytokine (2013) 0.82
Cdk5 inhibitor roscovitine alleviates neuropathic pain in the dorsal root ganglia by downregulating N-methyl-D-aspartate receptor subunit 2A. Neurol Sci (2014) 0.82
Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia. Exp Neurol (2015) 0.79
Conditional TNF-α Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis. J Dent Res (2015) 0.79
Co-induction of cyclooxygenase-2 [correction of cyclooxyenase-2] and early growth response gene (Egr-1) in spinal cord in a clinical model of persistent inflammation and hyperalgesia. Mol Pain (2011) 0.79
Intrathecal administration of roscovitine prevents remifentanil-induced postoperative hyperalgesia and decreases the phosphorylation of N-methyl-D-aspartate receptor and metabotropic glutamate receptor 5 in spinal cord. Brain Res Bull (2014) 0.79
A system for applying rapid warming or cooling stimuli to cells during patch clamp recording or ion imaging. J Neurosci Methods (2001) 0.79
The Red Nucleus TNF-α Participates in the Initiation and Maintenance of Neuropathic Pain Through Different Signaling Pathways. Neurochem Res (2015) 0.78
Searching for novel Cdk5 substrates in brain by comparative phosphoproteomics of wild type and Cdk5-/- mice. PLoS One (2014) 0.78
Colitogenic role of tumour necrosis factor (TNF) receptors in trinitrobenzene sulphonic acid colitis: TNF-R1 ablation does not affect systemic inflammatory response. Clin Exp Immunol (2011) 0.78
Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain. J Biol Chem (2014) 0.78
Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality. J Neuroinflammation (2014) 0.78
Cdk5 contributes to inflammation-induced thermal hyperalgesia mediated by the p38 MAPK pathway in microglia. Brain Res (2015) 0.77
Epigenetic upregulation of Cdk5 in the dorsal horn contributes to neuropathic pain in rats. Neuroreport (2014) 0.77
A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol (2008) 4.28
Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science (2003) 3.05
Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. J Biol Chem (2003) 3.03
Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts. J Cell Biol (2004) 3.00
The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol (2005) 2.13
Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β. Nat Immunol (2011) 1.94
PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer. Clin Cancer Res (2013) 1.81
Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration. Neuron (2004) 1.70
Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization. Matrix Biol (2009) 1.64
Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons. Cell Cycle (2012) 1.62
Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea. Nat Med (2010) 1.50
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development (2007) 1.40
Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. J Biol Chem (2003) 1.38
Cyclin-dependent kinase 5 activity regulates pain signaling. Proc Natl Acad Sci U S A (2006) 1.34
Going out of the brain: non-nervous system physiological and pathological functions of Cdk5. Cell Signal (2011) 1.33
Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci U S A (2006) 1.31
Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. J Biol Chem (2001) 1.30
Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model. Clin Cancer Res (2012) 1.30
Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35. J Biol Chem (2008) 1.30
Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res (2009) 1.24
Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proc Natl Acad Sci U S A (2005) 1.21
Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability. J Neurochem (2005) 1.20
MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma. Cancer Lett (2013) 1.19
DSPP effects on in vivo bone mineralization. Bone (2008) 1.19
Partial rescue of the amelogenin null dental enamel phenotype. J Biol Chem (2008) 1.19
MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity. Mol Biol Cell (2010) 1.17
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. EMBO J (2012) 1.17
Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors. J Physiol (2007) 1.16
Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development. Mol Cell Biol (2006) 1.16
Spatial expression of Cbfa1/Runx2 isoforms in teeth and characterization of binding sites in the DSPP gene. Connect Tissue Res (2002) 1.15
Transgenic mouse expressing human mutant alpha-galactosidase A in an endogenous enzyme deficient background: a biochemical animal model for studying active-site specific chaperone therapy for Fabry disease. Biochim Biophys Acta (2004) 1.14
Genetically altered mouse models: the good, the bad, and the ugly. Crit Rev Oral Biol Med (2003) 1.14
Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. EMBO J (2002) 1.13
A cool channel in cold transduction. Physiology (Bethesda) (2011) 1.11
Cdk5: a new player in pain signaling. Cell Cycle (2006) 1.10
Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev Biol (2009) 1.09
Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology. Am J Pathol (2004) 1.08
Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Lab Invest (2010) 1.08
Comparison of body weight and gene expression in amelogenin null and wild-type mice. Eur J Oral Sci (2006) 1.08
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules. J Biol Chem (2003) 1.07
A novel role of periostin in postnatal tooth formation and mineralization. J Biol Chem (2010) 1.03
A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel. Eur J Oral Sci (2006) 1.03
Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone. J Neurosci (2007) 1.01
Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proc Natl Acad Sci U S A (2004) 1.00
Amelogenin: a potential regulator of cementum-associated genes. J Periodontol (2003) 1.00
TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma. Cell Cycle (2007) 0.99
Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J Exp Med (2010) 0.99
Overview: engineering transgenic constructs and mice. Curr Protoc Cell Biol (2009) 0.98
Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability. J Neurophysiol (2013) 0.98
Abeta1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases. J Cell Sci (2007) 0.97
The leucine-rich amelogenin peptide alters the amelogenin null enamel phenotype. Cells Tissues Organs (2008) 0.97
N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons. J Biol Chem (2012) 0.97
Rescue of the murine amelogenin null phenotype with two amelogenin transgenes. Eur J Oral Sci (2011) 0.97
Dentin sialophosphoprotein and dentin matrix protein-1: Two highly phosphorylated proteins in mineralized tissues. Arch Oral Biol (2012) 0.96
Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration. Am J Pathol (2009) 0.95
The receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice. J Biol Chem (2003) 0.95
Genetic evidence for key roles of decorin and biglycan in dentin mineralization. Matrix Biol (2009) 0.94
Overexpression of transforming growth factor-beta1 in teeth results in detachment of ameloblasts and enamel defects. Eur J Oral Sci (2006) 0.93
Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases. J Neurochem (2008) 0.93
Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1. Biochem Biophys Res Commun (2010) 0.92
Resveratrol inhibits Cdk5 activity through regulation of p35 expression. Mol Pain (2011) 0.92
Rab-mediated trafficking role in neurite formation. J Neurochem (2014) 0.91
Transforming growth factor-β1 regulates Cdk5 activity in primary sensory neurons. J Biol Chem (2012) 0.91
Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma. Apoptosis (2014) 0.91
Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands. Arthritis Rheum (2007) 0.90
Molecular Roles of Cdk5 in Pain Signaling. Drug Discov Today Ther Strateg (2009) 0.90
Shaken, not stirred: collapsing a peptoid monolayer to produce free-floating, stable nanosheets. J Am Chem Soc (2011) 0.90
Large Sample Group Independent Component Analysis of Functional Magnetic Resonance Imaging Using Anatomical Atlas-Based Reduction and Bootstrapped Clustering. Int J Imaging Syst Technol (2011) 0.90
Endocrine expression of the active form of TGF-beta1 in the TGF-beta1 null mice fails to ameliorate lethal phenotype. Cytokine (2002) 0.89
Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes. J Neurosci Res (2011) 0.88
Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain. J Neurosci (2002) 0.88
Generation of gene knockout mice by ES cell microinjection. Curr Protoc Cell Biol (2009) 0.88
Generation of transgenic mice. Curr Protoc Cell Biol (2009) 0.88
Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation. Mol Biol Cell (2010) 0.87
Antibody-mimetic peptoid nanosheets for molecular recognition. ACS Nano (2013) 0.87
Manipulation of mouse embryonic stem cells for knockout mouse production. Curr Protoc Cell Biol (2009) 0.86
Increased globotriaosylceramide levels in a transgenic mouse expressing human alpha1,4-galactosyltransferase and a mouse model for treating Fabry disease. J Biochem (2010) 0.86
Overview: generation of gene knockout mice. Curr Protoc Cell Biol (2009) 0.86
Characteristics and physiological role of hyperpolarization activated currents in mouse cold thermoreceptors. J Physiol (2009) 0.85
The use of animal models to explore amelogenin variants in amelogenesis imperfecta. Cells Tissues Organs (2005) 0.85
Neuron-specific TGF-beta signaling deficiency results in retinal detachment and cataracts in mice. Biochem Biophys Res Commun (2006) 0.85
The MAP1B case: an old MAP that is new again. Dev Neurobiol (2014) 0.85
TGF-ß regulates enamel mineralization and maturation through KLK4 expression. PLoS One (2013) 0.84
A symptomatic Fabry disease mouse model generated by inducing globotriaosylceramide synthesis. Biochem J (2013) 0.84
Targeting of interleukin-13 receptor α2 for treatment of head and neck squamous cell carcinoma induced by conditional deletion of TGF-β and PTEN signaling. J Transl Med (2013) 0.84
TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells. Mol Pain (2013) 0.83
Role of Ih in the firing pattern of mammalian cold thermoreceptor endings. J Neurophysiol (2012) 0.83
Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions. Cell Cycle (2008) 0.83
Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia. Mol Pain (2013) 0.83