Conformational plasticity of proNGF.

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Precursor and mature NGF live tracking: one versus many at a time in the axons. Sci Rep (2016) 0.78

An Optimized Procedure for the Site-Directed Labeling of NGF and proNGF for Imaging Purposes. Front Mol Biosci (2017) 0.75

Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor. Front Mol Biosci (2016) 0.75

Conformational characterization of Nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part. J Biol Chem (2017) 0.75

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Sortilin is essential for proNGF-induced neuronal cell death. Nature (2004) 5.62

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Structure of nerve growth factor complexed with the shared neurotrophin receptor p75. Science (2004) 2.32

The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Mol Cell Neurosci (2001) 2.15

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The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor. J Neurochem (2004) 1.34

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The pro-sequence facilitates folding of human nerve growth factor from Escherichia coli inclusion bodies. Eur J Biochem (2001) 1.22

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Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites. J Mol Biol (1994) 1.03

Isotopically labeled expression in E. coli, purification, and refolding of the full ectodomain of the influenza virus membrane fusion protein. Protein Expr Purif (2008) 0.98

Intrinsic structural disorder of mouse proNGF. Proteins (2009) 0.96

Kinetics of conformational changes of fibronectin adsorbed onto model surfaces. Colloids Surf B Biointerfaces (2007) 0.95

Fate of prions in soil: trapped conformation of full-length ovine prion protein induced by adsorption on clays. Biochim Biophys Acta (2005) 0.95

Pro-sequence assisted folding and disulfide bond formation of human nerve growth factor. J Mol Biol (2001) 0.94

Structural and functional properties of mouse proNGF. Biochem Soc Trans (2006) 0.89

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The mature part of proNGF induces the structure of its pro-peptide. FEBS Lett (2004) 0.85

The pro-peptide of proNGF: structure formation and intramolecular association with NGF. Protein Sci (2007) 0.84

Processing of nerve growth factor: the role of basic amino acid clusters in the pro-region. Biochem Biophys Res Commun (2006) 0.78

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EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat Struct Mol Biol (2008) 5.32

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature (2011) 5.28

Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature (2003) 4.00

Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol (2006) 3.88

Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28. Nat Genet (2010) 2.66

Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50

Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6. EMBO J (2005) 2.30

Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. Nat Struct Mol Biol (2004) 2.29

Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS. Nat Struct Mol Biol (2009) 2.08

Key features of the interaction between Pcf11 CID and RNA polymerase II CTD. Nat Struct Mol Biol (2005) 2.07

Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. J Mol Biol (2003) 1.99

Solution structure of polyglutamine tracts in GST-polyglutamine fusion proteins. FEBS Lett (2002) 1.78

From Alzheimer to Huntington: why is a structural understanding so difficult? EMBO J (2003) 1.68

The pathogenesis of Friedreich ataxia and the structure and function of frataxin. J Neurol (2009) 1.68

Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction. J Neurosci (2008) 1.67

The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition. Proc Natl Acad Sci U S A (2005) 1.62

Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly. Nat Commun (2010) 1.56

Solution structure of the bacterial frataxin ortholog, CyaY: mapping the iron binding sites. Structure (2004) 1.55

G-quartet-dependent recognition between the FMRP RGG box and RNA. RNA (2003) 1.54

Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. J Neurosci (2004) 1.51

The structure of the C-terminal KH domains of KSRP reveals a noncanonical motif important for mRNA degradation. Structure (2007) 1.49

The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction. Structure (2006) 1.45

The structure of Lethocerus troponin C: insights into the mechanism of stretch activation in muscles. Structure (2007) 1.45

Iron binding and oxidation kinetics in frataxin CyaY of Escherichia coli. J Mol Biol (2004) 1.42

Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element. Structure (2003) 1.41

Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3. J Mol Biol (2004) 1.41

Polyglutamine is not all: the functional role of the AXH domain in the ataxin-1 protein. J Mol Biol (2005) 1.36

Structural and biochemical characterization of a fluorogenic rhodamine-labeled malarial protease substrate. Biochemistry (2002) 1.36

Crystal structure of wild-type chaperonin GroEL. J Mol Biol (2005) 1.35

Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri. PLoS One (2008) 1.33

Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif. J Biol Chem (2005) 1.32

Annual fishes of the genus Nothobranchius as a model system for aging research. Aging Cell (2005) 1.31

Pathogenic and non-pathogenic polyglutamine tracts have similar structural properties: towards a length-dependent toxicity gradient. J Mol Biol (2007) 1.31

SCA3: neurological features, pathogenesis and animal models. Cerebellum (2008) 1.31

Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc Natl Acad Sci U S A (2005) 1.29

Temperature affects longevity and age-related locomotor and cognitive decay in the short-lived fish Nothobranchius furzeri. Aging Cell (2006) 1.29

Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease. J Biol Chem (2011) 1.26

Acidic residues of yeast frataxin have an essential role in Fe-S cluster assembly. EMBO Rep (2006) 1.24

The respiratory syncytial virus M2-1 protein forms tetramers and interacts with RNA and P in a competitive manner. J Virol (2009) 1.20

Structural and biochemical analysis of the Rv0805 cyclic nucleotide phosphodiesterase from Mycobacterium tuberculosis. J Mol Biol (2006) 1.20

Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis. Biochemistry (2012) 1.19

Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo. Mol Cell Neurosci (2005) 1.19

Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc Natl Acad Sci U S A (2002) 1.17

Josephin domain of ataxin-3 contains two distinct ubiquitin-binding sites. Biopolymers (2009) 1.17

Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail. FEBS Lett (2003) 1.16

The interplay between PolyQ and protein context delays aggregation by forming a reservoir of protofibrils. PLoS One (2006) 1.15

The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre. J Mol Biol (2004) 1.15

Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding. Nat Struct Mol Biol (2009) 1.14

The factors governing the thermal stability of frataxin orthologues: how to increase a protein's stability. Biochemistry (2004) 1.13

Functional interactions as a survival strategy against abnormal aggregation. FASEB J (2010) 1.13

Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. J Biol Chem (2010) 1.12

Protein stability in nanocages: a novel approach for influencing protein stability by molecular confinement. J Mol Biol (2004) 1.12

An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis. Sci Signal (2009) 1.12

On the molecular basis linking Nerve Growth Factor (NGF) to Alzheimer's disease. Cell Mol Neurobiol (2006) 1.12

Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors. Biochemistry (2006) 1.12

The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain. Proc Natl Acad Sci U S A (2007) 1.12

Clinical and genetic aspects of Bernard-Soulier syndrome: searching for genotype/phenotype correlations. Haematologica (2010) 1.11

Interaction of sweet proteins with their receptor. A conformational study of peptides corresponding to loops of brazzein, monellin and thaumatin. Eur J Biochem (2004) 1.11

Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors. PLoS One (2009) 1.11

Understanding the binding properties of an unusual metal-binding protein--a study of bacterial frataxin. FEBS J (2007) 1.10

Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing. J Biol Chem (2010) 1.09

The oligomerization properties of prion protein are restricted to the H2H3 domain. FASEB J (2010) 1.08

The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies. J Mol Biol (2002) 1.08

Molecular basis of FIR-mediated c-myc transcriptional control. Nat Struct Mol Biol (2010) 1.07

Activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells. J Alzheimers Dis (2008) 1.06

Conformational stability of human frataxin and effect of Friedreich's ataxia-related mutations on protein folding. Biochem J (2006) 1.05

Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies. Mol Cell Neurosci (2002) 1.05

PB1-F2 influenza A virus protein adopts a beta-sheet conformation and forms amyloid fibers in membrane environments. J Biol Chem (2010) 1.04

The structure of the N-terminal region of murine skeletal muscle alpha-dystroglycan discloses a modular architecture. J Biol Chem (2004) 1.03

Bacterial IscU is a well folded and functional single domain protein. Eur J Biochem (2004) 1.02

Of the vulnerability of orphan complex proteins: the case study of the E. coli IscU and IscS proteins. Protein Expr Purif (2010) 1.02

Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein. Nucleic Acids Res (2011) 1.02

Sequence-specific assignment and secondary structure determination of the 195-residue complex formed by the Mycobacterium tuberculosis proteins CFP-10 and ESAT-6. J Biomol NMR (2004) 1.00

MYH9-related disease: five novel mutations expanding the spectrum of causative mutations and confirming genotype/phenotype correlations. Eur J Med Genet (2012) 1.00

Role of dimerization in KH/RNA complexes: the example of Nova KH3. Biochemistry (2002) 1.00

Prion fibrillization is mediated by a native structural element that comprises helices H2 and H3. J Biol Chem (2010) 1.00

Solution structure of ZASP PDZ domain; implications for sarcomere ultrastructure and enigma family redundancy. Structure (2004) 0.99

Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration. Proc Natl Acad Sci U S A (2010) 0.99

Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3. PLoS One (2010) 0.99

A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease. Protein Eng Des Sel (2011) 0.99

82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization. Hum Mol Genet (2003) 0.99

Abeta-dependent Inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE. J Alzheimers Dis (2009) 0.98

Direct in vivo intracellular selection of conformation-sensitive antibody domains targeting Alzheimer's amyloid-beta oligomers. J Mol Biol (2009) 0.98

Cold denaturation of yeast frataxin offers the clue to understand the effect of alcohols on protein stability. J Am Chem Soc (2008) 0.98

Environmental enrichment delays the onset of memory deficits and reduces neuropathological hallmarks in a mouse model of Alzheimer-like neurodegeneration. J Alzheimers Dis (2007) 0.98

Regulating the contraction of insect flight muscle. J Muscle Res Cell Motil (2011) 0.98

Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2013) 0.97

Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity. PLoS One (2011) 0.97

Spectrum of the mutations in Bernard-Soulier syndrome. Hum Mutat (2014) 0.97

The role of interruptions in polyQ in the pathology of SCA1. PLoS Genet (2013) 0.96

Ferredoxin competes with bacterial frataxin in binding to the desulfurase IscS. J Biol Chem (2013) 0.96

The intracellular antibody capture technology: towards the high-throughput selection of functional intracellular antibodies for target validation. Methods (2004) 0.96