Molecular and structural insight into proNGF engagement of p75NTR and sortilin.

PubWeight™: 1.05‹?› | Rank: Top 15%

🔗 View Article (PMC 2847487)

Published in J Mol Biol on December 28, 2009

Authors

Dan Feng1, Taeho Kim, Engin Ozkan, Matthew Light, Risa Torkin, Kenneth K Teng, Barbara L Hempstead, K Christopher Garcia

Author Affiliations

1: Department of Cellular and Molecular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Articles citing this

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. Nat Rev Drug Discov (2013) 1.29

Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal (2011) 1.19

Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nat Commun (2013) 1.10

Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein. J Biol Chem (2011) 0.98

Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity. PLoS One (2011) 0.97

The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase. J Biol Chem (2012) 0.91

Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing. J Biol Chem (2011) 0.86

Brain-Derived Neurotrophic Factor: Three Ligands, Many Actions. Trans Am Clin Climatol Assoc (2015) 0.85

Neurotrophic factor changes in the rat thick skin following chronic constriction injury of the sciatic nerve. Mol Pain (2012) 0.84

Principles of antibody-mediated TNF receptor activation. Cell Death Differ (2015) 0.84

Conformational plasticity of proNGF. PLoS One (2011) 0.83

Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding. J Biol Chem (2010) 0.82

Detection of p75NTR Trimers: Implications for Receptor Stoichiometry and Activation. J Neurosci (2015) 0.81

Structural characterization of the self-association of the death domain of p75(NTR.). PLoS One (2013) 0.80

Ligand-induced dynamics of neurotrophin receptors investigated by single-molecule imaging approaches. Int J Mol Sci (2015) 0.80

Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation. Proc Natl Acad Sci U S A (2013) 0.79

Messenger RNA expression patterns of p75 neurotrophin receptor and tropomyosin-receptor-kinase A following spinal cord injury. J Spinal Cord Med (2013) 0.78

Imbalance of the Nerve Growth Factor and Its Precursor: Implication in Diabetic Retinopathy. J Clin Exp Ophthalmol (2015) 0.77

Structural Basis of p75 Transmembrane Domain Dimerization. J Biol Chem (2016) 0.76

Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor. Front Mol Biosci (2016) 0.75

BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis. Front Pharmacol (2016) 0.75

Trk Receptors and Neurotrophin Cross-Interactions: New Perspectives Toward Manipulating Therapeutic Side-Effects. Front Mol Neurosci (2017) 0.75

Nerve growth factor inhibitor with novel-binding domain demonstrates nanomolar efficacy in both cell-based and cell-free assay systems. Pharmacol Res Perspect (2017) 0.75

Conformational characterization of Nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part. J Biol Chem (2017) 0.75

Articles cited by this

Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01

Phaser crystallographic software. J Appl Crystallogr (2007) 108.34

Structure validation by Calpha geometry: phi,psi and Cbeta deviation. Proteins (2003) 32.38

Version 1.2 of the Crystallography and NMR system. Nat Protoc (2007) 13.01

The nerve growth factor 35 years later. Science (1987) 7.25

Regulation of cell survival by secreted proneurotrophins. Science (2001) 6.32

Automated structure solution with the PHENIX suite. Methods Mol Biol (2008) 5.65

Sortilin is essential for proNGF-induced neuronal cell death. Nature (2004) 5.62

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature (1991) 4.44

ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci (2005) 3.76

Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell (1994) 3.70

Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function. Annu Rev Biochem (2001) 3.64

A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell (2004) 3.38

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature (1991) 3.37

Solution structure of the epithelial cadherin domain responsible for selective cell adhesion. Science (1995) 3.23

Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J Biol Chem (1997) 2.69

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J Biol Chem (1999) 2.55

Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Neuron (2007) 2.54

ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron (2002) 2.53

New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature (1991) 2.47

p75 and Trk: a two-receptor system. Trends Neurosci (1995) 2.39

Structure of nerve growth factor complexed with the shared neurotrophin receptor p75. Science (2004) 2.32

Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding. Eur J Biochem (1994) 2.23

The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Mol Cell Neurosci (2001) 2.15

The O-glycosylated stalk domain is required for apical sorting of neurotrophin receptors in polarized MDCK cells. J Cell Biol (1997) 2.14

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci (2007) 2.10

Functional interactions of neurotrophins and neurotrophin receptors. Annu Rev Neurosci (1995) 2.09

Considerations for the refinement of low-resolution crystal structures. Acta Crystallogr D Biol Crystallogr (2006) 2.02

Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. Proc Natl Acad Sci U S A (2004) 1.98

Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron (2009) 1.96

The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J Cell Biol (1998) 1.90

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature (1999) 1.86

The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor. J Biol Chem (1998) 1.84

Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron (2006) 1.74

The p75 neurotrophin receptor. J Neurobiol (1994) 1.66

Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury. J Neurosci (2007) 1.60

BacMam system for high-level expression of recombinant soluble and membrane glycoproteins for structural studies. Protein Expr Purif (2008) 1.53

Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain. Nat Struct Mol Biol (2009) 1.50

Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF. EMBO J (1991) 1.35

Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families. J Biol Chem (2008) 1.26

The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor. J Biol Chem (2001) 1.25

Processing of the native nerve growth factor precursor to form biologically active nerve growth factor. J Biol Chem (1988) 1.23

The pro-sequence facilitates folding of human nerve growth factor from Escherichia coli inclusion bodies. Eur J Biochem (2001) 1.22

Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. J Neurosci (2008) 1.19

Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature (2008) 1.18

Pro-NGF, sortilin, and p75NTR: potential mediators of injury-induced apoptosis in the mouse dorsal root ganglion. Brain Res (2007) 1.13

Neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain-derived neurotrophic factor. J Neurosci (2000) 1.12

Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system. Eur J Neurosci (2008) 1.12

Construction of a mutated pro-nerve growth factor resistant to degradation and suitable for biophysical and cellular utilization. Proc Natl Acad Sci U S A (2006) 1.08

The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site. Protein Sci (1999) 1.03

Intracellular sortilin expression pattern regulates proNGF-induced naturally occurring cell death during development. Cell Death Differ (2007) 1.01

High affinity not in the vicinity? Neuron (2007) 1.00

Intrinsic structural disorder of mouse proNGF. Proteins (2009) 0.96

Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody. J Mol Biol (2008) 0.94

Zone mapping of the binding domain of the rat low affinity nerve growth factor receptor by the introduction of novel N-glycosylation sites. J Biol Chem (1995) 0.94

Enhanced protein expressions of sortilin and p75NTR in retina of rat following elevated intraocular pressure-induced retinal ischemia. Neurosci Lett (2007) 0.93

Structural and functional properties of mouse proNGF. Biochem Soc Trans (2006) 0.89

Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75NTR. J Biol Chem (2005) 0.85

The pro-peptide of proNGF: structure formation and intramolecular association with NGF. Protein Sci (2007) 0.84

The neurotrophin receptor p75 binds neurotrophin-3 on sympathetic neurons with high affinity and specificity. J Neurosci (1997) 0.81

Articles by these authors

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science (2006) 5.89

Sortilin is essential for proNGF-induced neuronal cell death. Nature (2004) 5.62

Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science (2004) 4.74

Structural basis of Wnt recognition by Frizzled. Science (2012) 4.31

ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci (2005) 3.76

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell (2008) 3.72

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science (2013) 3.59

Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci (2004) 3.47

Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell (2009) 3.46

Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (2013) 3.25

How a single T cell receptor recognizes both self and foreign MHC. Cell (2007) 3.20

Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci (2005) 3.17

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science (2003) 2.87

Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'. Nat Immunol (2007) 2.78

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science (2005) 2.64

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol Cell (2003) 2.61

Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Neuron (2007) 2.54

ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron (2002) 2.53

Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49

Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature (2002) 2.45

Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. J Neurosci (2005) 2.44

Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron (2007) 2.43

New insights in the biology of BDNF synthesis and release: implications in CNS function. J Neurosci (2009) 2.40

Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell (2011) 2.39

An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks. Cell (2013) 2.36

Neuronal release of proBDNF. Nat Neurosci (2009) 2.36

Structure of nerve growth factor complexed with the shared neurotrophin receptor p75. Science (2004) 2.32

Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. Science (2005) 2.32

Structural biology of shared cytokine receptors. Annu Rev Immunol (2009) 2.27

Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A (2005) 2.27

Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery. Angew Chem Int Ed Engl (2008) 2.21

Antigen recognition determinants of gammadelta T cell receptors. Science (2005) 2.14

Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nat Struct Mol Biol (2005) 2.12

Structure of the measles virus hemagglutinin. Nat Struct Mol Biol (2007) 2.11

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci (2007) 2.10

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature (2012) 2.08

Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron (2003) 2.06

A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron (2005) 2.03

Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity (2005) 2.03

Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions. J Control Release (2011) 1.89

T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Immunity (2011) 1.86

Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure (2010) 1.79

Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons. Cell (2007) 1.77

A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol Cell (2006) 1.75

Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron (2006) 1.74

Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. J Clin Invest (2005) 1.74

Specificity and degeneracy of T cells. Mol Immunol (2004) 1.71

Polyspecificity of T cell and B cell receptor recognition. Semin Immunol (2007) 1.68

Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. Science (2008) 1.67

Deconstructing the form and function of the TCR/CD3 complex. Immunity (2006) 1.64

Control of extracellular cleavage of ProBDNF by high frequency neuronal activity. Proc Natl Acad Sci U S A (2009) 1.64

Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure (2011) 1.63

The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol (2012) 1.63

Structural basis of receptor sharing by interleukin 17 cytokines. Nat Immunol (2009) 1.60

Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. J Neurosci (2008) 1.60

Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB. Chem Biol (2010) 1.60

Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery. J Am Chem Soc (2010) 1.58

Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins. J Neurosci (2006) 1.58

BacMam system for high-level expression of recombinant soluble and membrane glycoproteins for structural studies. Protein Expr Purif (2008) 1.53

The structure of interleukin-2 complexed with its alpha receptor. Science (2005) 1.53

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2. J Exp Med (2013) 1.53

Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au. Immunity (2002) 1.47

Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. J Clin Invest (2014) 1.45

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol (2012) 1.41

Multifunctional mesoporous silica nanocomposite nanoparticles for theranostic applications. Acc Chem Res (2011) 1.41

The p75 neurotrophin receptor is a central regulator of glioma invasion. PLoS Biol (2007) 1.40

Mutations in WNT1 cause different forms of bone fragility. Am J Hum Genet (2013) 1.39

Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Mol Cell (2003) 1.38

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation. Immunol Rev (2012) 1.38

The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex. J Immunol (2002) 1.38

Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily. Nat Struct Biol (2002) 1.37

Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin. Nat Chem Biol (2009) 1.36

A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein. EMBO J (2004) 1.36

Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. Cell (2010) 1.35

Understanding proneurotrophin actions: Recent advances and challenges. Dev Neurobiol (2010) 1.35

A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. Blood (2005) 1.35

Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family. J Mol Biol (2004) 1.34

Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells. J Biol Chem (2004) 1.34

Neuroprotection from stroke in the absence of MHCI or PirB. Neuron (2012) 1.33

A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33

An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells. Nat Immunol (2008) 1.33

Neurotrophins and their receptors stimulate melanoma cell proliferation and migration. J Invest Dermatol (2008) 1.29

Structural insight into pre-B cell receptor function. Science (2007) 1.29

Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions. J Exp Med (2002) 1.25

Evidence for a functional sidedness to the alphabetaTCR. Proc Natl Acad Sci U S A (2010) 1.24

Pro-NGF secreted by astrocytes promotes motor neuron cell death. Mol Cell Neurosci (2006) 1.23

Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal (2011) 1.19

Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. J Neurosci (2008) 1.19

Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag. PLoS One (2009) 1.19