HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.

PubWeight™: 5.28‹?› | Rank: Top 1%

🔗 View Article (PMID 22056990)

Published in Nature on November 06, 2011

Authors

David C Goldstone1, Valerie Ennis-Adeniran, Joseph J Hedden, Harriet C T Groom, Gillian I Rice, Evangelos Christodoulou, Philip A Walker, Geoff Kelly, Lesley F Haire, Melvyn W Yap, Luiz Pedro S de Carvalho, Jonathan P Stoye, Yanick J Crow, Ian A Taylor, Michelle Webb

Author Affiliations

1: Division of Molecular Structure, MRC National Institute for Medical Research, London NW7 1AA, UK.

Articles citing this

(truncated to the top 100)

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat Immunol (2012) 5.71

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells. Nat Med (2012) 4.27

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells. Retrovirology (2012) 2.92

The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Cell Host Microbe (2012) 2.79

Intrinsic antiviral immunity. Nat Immunol (2012) 2.71

The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation. Cell Host Microbe (2013) 2.71

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature. Nat Genet (2012) 2.63

The restriction factors of human immunodeficiency virus. J Biol Chem (2012) 2.36

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction. Nat Med (2014) 2.35

Adaptation to the interferon-induced antiviral state by human and simian immunodeficiency viruses. J Virol (2013) 2.28

Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages. J Biol Chem (2012) 2.25

Interferon-inducible effector mechanisms in cell-autonomous immunity. Nat Rev Immunol (2012) 2.21

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. Blood (2013) 2.18

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons. Retrovirology (2012) 1.96

Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction. J Biol Chem (2013) 1.95

Studies of endogenous retroviruses reveal a continuing evolutionary saga. Nat Rev Microbiol (2012) 1.94

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac. Retrovirology (2012) 1.87

HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1. J Biol Chem (2012) 1.86

Aicardi-Goutières syndrome and the type I interferonopathies. Nat Rev Immunol (2015) 1.82

Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem (2013) 1.76

Animal models for HIV/AIDS research. Nat Rev Microbiol (2012) 1.71

Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1. Virology (2012) 1.68

HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. J Clin Invest (2012) 1.63

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells. Proc Natl Acad Sci U S A (2013) 1.61

Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1. J Virol (2013) 1.58

Mechanism of allosteric activation of SAMHD1 by dGTP. Nat Struct Mol Biol (2013) 1.49

HIV-1 transcription and latency: an update. Retrovirology (2013) 1.49

Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx. Cell Host Microbe (2015) 1.48

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus. J Virol (2012) 1.47

Cyclin L2 is a critical HIV dependency factor in macrophages that controls SAMHD1 abundance. Cell Host Microbe (2014) 1.47

Intrinsic cellular defenses against human immunodeficiency viruses. Immunity (2012) 1.45

Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation. Retrovirology (2015) 1.43

Cellular self-defense: how cell-autonomous immunity protects against pathogens. Science (2013) 1.39

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells. PLoS Pathog (2013) 1.37

SAMHD1-dependent retroviral control and escape in mice. EMBO J (2013) 1.36

Innate immune sensing of HIV-1 by dendritic cells. Cell Host Microbe (2012) 1.35

p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway. Proc Natl Acad Sci U S A (2013) 1.31

Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Rep (2013) 1.28

The enemy within: endogenous retroelements and autoimmune disease. Nat Immunol (2014) 1.27

Restriction of diverse retroviruses by SAMHD1. Retrovirology (2013) 1.23

GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state. Proc Natl Acad Sci U S A (2014) 1.21

SAMHD1 prevents autoimmunity by maintaining genome stability. Ann Rheum Dis (2014) 1.20

Intracellular nucleotide levels and the control of retroviral infections. Virology (2012) 1.19

Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1. J Virol (2014) 1.19

SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells. J Virol (2012) 1.18

Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1. Cell Rep (2013) 1.18

Structural basis of lentiviral subversion of a cellular protein degradation pathway. Nature (2013) 1.16

Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection. Retrovirology (2013) 1.16

How SAMHD1 changes our view of viral restriction. Trends Immunol (2011) 1.15

HIV-1 and interferons: who's interfering with whom? Nat Rev Microbiol (2015) 1.14

Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons. Sci Rep (2012) 1.12

Aicardi-Goutières syndrome: a model disease for systemic autoimmunity. Clin Exp Immunol (2014) 1.10

The biased nucleotide composition of the HIV genome: a constant factor in a highly variable virus. Retrovirology (2012) 1.10

Restricting HIV the SAMHD1 way: through nucleotide starvation. Nat Rev Microbiol (2012) 1.10

SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication. J Virol (2013) 1.09

GTP is the primary activator of the anti-HIV restriction factor SAMHD1. J Biol Chem (2013) 1.09

HIV accessory proteins versus host restriction factors. Curr Opin Virol (2013) 1.08

Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1. PLoS Pathog (2013) 1.08

Mutations in CECR1 associated with a neutrophil signature in peripheral blood. Pediatr Rheumatol Online J (2014) 1.07

Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor. PLoS One (2012) 1.07

Endogenous retroelements and autoimmune disease. Curr Opin Immunol (2012) 1.06

Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase. Curr Opin Virol (2012) 1.06

Structural basis of cellular dNTP regulation by SAMHD1. Proc Natl Acad Sci U S A (2014) 1.06

Host restriction factors in retroviral infection: promises in virus-host interaction. Retrovirology (2012) 1.05

A role for microRNA-155 modulation in the anti-HIV-1 effects of Toll-like receptor 3 stimulation in macrophages. PLoS Pathog (2012) 1.05

Innate immune recognition of HIV-1. Immunity (2012) 1.05

Promoter methylation regulates SAMHD1 gene expression in human CD4+ T cells. J Biol Chem (2013) 1.05

Restrictions to HIV-1 replication in resting CD4+ T lymphocytes. Cell Res (2013) 1.04

Downregulation of SAMHD1 expression correlates with promoter DNA methylation in Sézary syndrome patients. J Invest Dermatol (2013) 1.02

Identification and characterization of naturally occurring splice variants of SAMHD1. Retrovirology (2012) 1.02

Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers. PLoS Pathog (2015) 1.02

Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels. J Biol Chem (2013) 1.02

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development. Immunity (2015) 1.01

HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation. J Biol Chem (2013) 1.01

SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity. Nucleic Acids Res (2015) 1.01

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS. Retrovirology (2014) 0.99

CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain. J Biol Chem (2015) 0.99

Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells. Immunity (2014) 0.99

Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates. J Biol Chem (2014) 0.97

A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1. Antimicrob Agents Chemother (2014) 0.97

Endogenous retroviruses and the development of cancer. J Immunol (2014) 0.97

Polymorphisms of the SAMHD1 gene are not associated with the infection and natural control of HIV type 1 in Europeans and African-Americans. AIDS Res Hum Retroviruses (2012) 0.96

Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation. PLoS One (2013) 0.96

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. Elife (2015) 0.96

Deoxyribonucleotide metabolism, mutagenesis and cancer. Nat Rev Cancer (2015) 0.96

Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein. Gene Ther (2012) 0.95

Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines. Viruses (2013) 0.95

HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx. AIDS Res Hum Retroviruses (2013) 0.94

Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply. Retrovirology (2013) 0.94

SAMHD1 specifically restricts retroviruses through its RNase activity. Retrovirology (2015) 0.94

PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1. Cell (2015) 0.94

The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection. Virology (2013) 0.93

Vpx is critical for SIVmne infection of pigtail macaques. Retrovirology (2012) 0.93

Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic Approaches. Front Immunol (2013) 0.92

Type I interferons as ambiguous modulators of chronic inflammation in the central nervous system. Front Immunol (2012) 0.92

Inhibition of CUL4A Neddylation causes a reversible block to SAMHD1-mediated restriction of HIV-1. J Virol (2013) 0.92

SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx Protein. Front Microbiol (2012) 0.92

dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages. Retrovirology (2014) 0.92

Innate and Adaptive Immunity in Long-Term Non-Progression in HIV Disease. Front Immunol (2013) 0.91

CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression. J Virol (2014) 0.91

Articles cited by this

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol (2009) 11.17

Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature (2011) 9.30

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature (2011) 7.92

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus. Nat Genet (2006) 6.15

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response. Nat Genet (2009) 5.84

Automated structure solution with the PHENIX suite. Methods Mol Biol (2008) 5.65

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature (2010) 5.45

Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection. Nat Genet (2006) 5.26

The HD domain defines a new superfamily of metal-dependent phosphohydrolases. Trends Biochem Sci (1998) 4.11

Macromolecular size-and-shape distributions by sedimentation velocity analytical ultracentrifugation. Biophys J (2006) 4.06

Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition. Anal Biochem (2004) 3.71

SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells. Retrovirology (2007) 3.51

Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection. PLoS Pathog (2008) 3.27

Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. J Biol Chem (2004) 3.10

Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon. J Virol (2005) 2.90

The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection. J Virol (2009) 2.57

Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts. Proc Natl Acad Sci U S A (2002) 2.43

A cellular restriction dictates the permissivity of nondividing monocytes/macrophages to lentivirus and gammaretrovirus infection. Cell Host Microbe (2009) 2.34

Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells. Immunol Lett (2000) 2.33

Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease. Mol Cell Biol (1999) 2.29

Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. J Virol (2006) 2.16

Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophages. J Biol Chem (2010) 1.70

The purification and properties of deoxyguanosine triphosphate triphosphohydrolase from Escherichia coli. J Biol Chem (1988) 1.38

Structure of dNTP-inducible dNTP triphosphohydrolase: insight into broad specificity for dNTPs and triphosphohydrolase-type hydrolysis. Acta Crystallogr D Biol Crystallogr (2007) 1.29

Biochemical characterization of TT1383 from Thermus thermophilus identifies a novel dNTP triphosphohydrolase activity stimulated by dATP and dTTP. J Biochem (2004) 1.27

Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage. J Biol Chem (2008) 1.23

A novel fluorescence-based assay for the rapid detection and quantification of cellular deoxyribonucleoside triphosphates. Nucleic Acids Res (2011) 1.21

Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease. Biochem Soc Trans (2009) 1.10

Articles by these authors

A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science (2011) 7.86

Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature (2006) 7.56

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell (2003) 7.04

The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature (2006) 6.00

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response. Nat Genet (2009) 5.84

Trim5alpha protein restricts both HIV-1 and murine leukemia virus. Proc Natl Acad Sci U S A (2004) 5.31

A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction. Curr Biol (2005) 5.24

TRIM family proteins: retroviral restriction and antiviral defence. Nat Rev Microbiol (2005) 4.89

ASPM is a major determinant of cerebral cortical size. Nat Genet (2002) 4.57

Structure of mammalian AMPK and its regulation by ADP. Nature (2011) 4.27

Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome. Retrovirology (2010) 4.18

A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1. Proc Natl Acad Sci U S A (2004) 4.06

Mutations in the pericentrin (PCNT) gene cause primordial dwarfism. Science (2008) 4.04

Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature (2003) 4.00

Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis (2008) 3.84

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature (2008) 3.79

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol (2004) 3.26

Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature (2007) 3.26

Identification of microcephalin, a protein implicated in determining the size of the human brain. Am J Hum Genet (2002) 3.13

High-resolution structure of a retroviral capsid hexameric amino-terminal domain. Nature (2004) 2.84

Clinical and molecular phenotype of Aicardi-Goutieres syndrome. Am J Hum Genet (2007) 2.81

Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome. Am J Hum Genet (2007) 2.73

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature. Nat Genet (2012) 2.63

Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell-defective apoptosis and hyperproliferation. Arthritis Rheum (2013) 2.60

Degos disease: a C5b-9/interferon-α-mediated endotheliopathy syndrome. Am J Clin Pathol (2011) 2.50

Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50

Approaches to screening for intimate partner violence in health care settings: a randomized trial. JAMA (2006) 2.50

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. Lancet Neurol (2013) 2.36

Role of APOBEC3 in genetic diversity among endogenous murine leukemia viruses. PLoS Genet (2007) 2.33

Receptor binding by an H7N9 influenza virus from humans. Nature (2013) 2.33

Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6. EMBO J (2005) 2.30

Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. Nat Struct Mol Biol (2004) 2.29

tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. Nat Genet (2008) 2.28

Unreferred chronic kidney disease: a longitudinal study. Am J Kidney Dis (2004) 2.28

Crystal structure and functional analysis of the histone methyltransferase SET7/9. Cell (2002) 2.27

All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction. J Virol (2006) 2.26

The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase. Nucleic Acids Res (2007) 2.19

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. Blood (2013) 2.18

Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. Proc Natl Acad Sci U S A (2012) 2.18

Brown-Vialetto-Van Laere syndrome, a ponto-bulbar palsy with deafness, is caused by mutations in c20orf54. Am J Hum Genet (2010) 2.08

A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell (2009) 2.07

Key features of the interaction between Pcf11 CID and RNA polymerase II CTD. Nat Struct Mol Biol (2005) 2.07

Atypical haemolytic uraemic syndrome associated with a hybrid complement gene. PLoS Med (2006) 2.07

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell (2002) 1.99

Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957. Proc Natl Acad Sci U S A (2009) 1.98

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. J Biol Chem (2005) 1.95

Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature. Nat Genet (2011) 1.84

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate. EMBO Rep (2012) 1.82

Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus. Nat Genet (2012) 1.82

Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol (2011) 1.81

Resurrection of endogenous retroviruses in antibody-deficient mice. Nature (2012) 1.81

Solution structure of polyglutamine tracts in GST-polyglutamine fusion proteins. FEBS Lett (2002) 1.78

ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. Nat Genet (2008) 1.78

Tripartite-motif proteins and innate immune regulation. Curr Opin Immunol (2010) 1.73

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors. Proc Natl Acad Sci U S A (2010) 1.71

Type I interferon-dependent and -independent expression of tripartite motif proteins in immune cells. Eur J Immunol (2008) 1.67

Trim-cyclophilin A fusion proteins can restrict human immunodeficiency virus type 1 infection at two distinct phases in the viral life cycle. J Virol (2006) 1.66

Recognizable phenotypes associated with intracranial calcification. Dev Med Child Neurol (2012) 1.63

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations. Hum Mutat (2012) 1.61

Solution structure of the bacterial frataxin ortholog, CyaY: mapping the iron binding sites. Structure (2004) 1.55

The design of artificial retroviral restriction factors. Virology (2007) 1.51

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations. J Clin Invest (2014) 1.50

The structure of the C-terminal KH domains of KSRP reveals a noncanonical motif important for mRNA degradation. Structure (2007) 1.49

Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. Am J Hum Genet (2009) 1.47

TRIM5 alpha cytoplasmic bodies are highly dynamic structures. Mol Biol Cell (2007) 1.47

Intracerebral large artery disease in Aicardi-Goutières syndrome implicates SAMHD1 in vascular homeostasis. Dev Med Child Neurol (2010) 1.47

Clinical and mutational spectrum of Mowat-Wilson syndrome. Eur J Med Genet (2005) 1.46

The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction. Structure (2006) 1.45

Receptor binding by a ferret-transmissible H5 avian influenza virus. Nature (2013) 1.43

Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element. Structure (2003) 1.41

PCR master mixes harbour murine DNA sequences. Caveat emptor! PLoS One (2011) 1.41

In vitro regulation of budding yeast Bfa1/Bub2 GAP activity by Cdc5. J Biol Chem (2003) 1.40

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies. Acta Crystallogr D Biol Crystallogr (2006) 1.39

Virology. A new virus for old diseases? Science (2009) 1.38

ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase. Cell Metab (2011) 1.37

Structural and biochemical characterization of a fluorogenic rhodamine-labeled malarial protease substrate. Biochemistry (2002) 1.36

SAMHD1-dependent retroviral control and escape in mice. EMBO J (2013) 1.36