Published in Proc Natl Acad Sci U S A on August 05, 2011
Genome evolution in filamentous plant pathogens: why bigger can be better. Nat Rev Microbiol (2012) 1.93
How do filamentous pathogens deliver effector proteins into plant cells? PLoS Biol (2014) 1.40
The role of effectors of biotrophic and hemibiotrophic fungi in infection. Cell Microbiol (2011) 1.33
Genome-wide association mapping of quantitative resistance to sudden death syndrome in soybean. BMC Genomics (2014) 1.26
Ubiquitination during plant immune signaling. Plant Physiol (2012) 1.21
Sequence divergent RXLR effectors share a structural fold conserved across plant pathogenic oomycete species. PLoS Pathog (2012) 1.09
Host-targeting protein 1 (SpHtp1) from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate-dependent manner. Proc Natl Acad Sci U S A (2012) 1.09
Patterns of plant subcellular responses to successful oomycete infections reveal differences in host cell reprogramming and endocytic trafficking. Cell Microbiol (2012) 1.03
From pathogen genomes to host plant processes: the power of plant parasitic oomycetes. Genome Biol (2013) 0.97
WRKY Transcription Factors Phosphorylated by MAPK Regulate a Plant Immune NADPH Oxidase in Nicotiana benthamiana. Plant Cell (2015) 0.97
The RxLR Motif of the Host Targeting Effector AVR3a of Phytophthora infestans Is Cleaved Before Secretion. Plant Cell (2017) 0.96
RNA-Seq of early-infected poplar leaves by the rust pathogen Melampsora larici-populina uncovers PtSultr3;5, a fungal-induced host sulfate transporter. PLoS One (2012) 0.95
On the front line: structural insights into plant-pathogen interactions. Nat Rev Microbiol (2013) 0.95
Structural and functional studies of a phosphatidic acid-binding antifungal plant defensin MtDef4: identification of an RGFRRR motif governing fungal cell entry. PLoS One (2013) 0.95
Relocalization of late blight resistance protein R3a to endosomal compartments is associated with effector recognition and required for the immune response. Plant Cell (2012) 0.93
Structures of the flax-rust effector AvrM reveal insights into the molecular basis of plant-cell entry and effector-triggered immunity. Proc Natl Acad Sci U S A (2013) 0.93
Retracted Pathogen virulence of Phytophthora infestans: from gene to functional genomics. Physiol Mol Biol Plants (2013) 0.92
Avirulence protein 3a (AVR3a) from the potato pathogen Phytophthora infestans forms homodimers through its predicted translocation region and does not specifically bind phospholipids. J Biol Chem (2012) 0.90
Computational prediction and molecular characterization of an oomycete effector and the cognate Arabidopsis resistance gene. PLoS Genet (2012) 0.88
Rust secreted protein Ps87 is conserved in diverse fungal pathogens and contains a RXLR-like motif sufficient for translocation into plant cells. PLoS One (2011) 0.88
Structure Analysis Uncovers a Highly Diverse but Structurally Conserved Effector Family in Phytopathogenic Fungi. PLoS Pathog (2015) 0.88
Human β-defensin 3 contains an oncolytic motif that binds PI(4,5)P2 to mediate tumour cell permeabilisation. Oncotarget (2016) 0.86
Effector-triggered post-translational modifications and their role in suppression of plant immunity. Front Plant Sci (2012) 0.86
Phosphite-induced changes of the transcriptome and secretome in Solanum tuberosum leading to resistance against Phytophthora infestans. BMC Plant Biol (2014) 0.85
Showdown at the RXLR motif: Serious differences of opinion in how effector proteins from filamentous eukaryotic pathogens enter plant cells. Proc Natl Acad Sci U S A (2011) 0.85
Intrinsic disorder in pathogen effectors: protein flexibility as an evolutionary hallmark in a molecular arms race. Plant Cell (2013) 0.85
Phytophthora infestans RXLR-WY Effector AVR3a Associates with Dynamin-Related Protein 2 Required for Endocytosis of the Plant Pattern Recognition Receptor FLS2. PLoS One (2015) 0.84
Poplar root exudates contain compounds that induce the expression of MiSSP7 in Laccaria bicolor. Plant Signal Behav (2012) 0.84
Computational Prediction of Effector Proteins in Fungi: Opportunities and Challenges. Front Plant Sci (2016) 0.83
Structural elucidation and functional characterization of the Hyaloperonospora arabidopsidis effector protein ATR13. PLoS Pathog (2011) 0.82
Oomycete interactions with plants: infection strategies and resistance principles. Microbiol Mol Biol Rev (2015) 0.81
Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding. Nat Commun (2016) 0.80
Genome analysis and avirulence gene cloning using a high-density RADseq linkage map of the flax rust fungus, Melampsora lini. BMC Genomics (2016) 0.78
Silencing of DS2 aminoacylase-like genes confirms basal resistance to Phytophthora infestans in Nicotiana benthamiana. Plant Signal Behav (2014) 0.78
Elucidating the Role of Effectors in Plant-Fungal Interactions: Progress and Challenges. Front Microbiol (2016) 0.78
Eukaryotic virulence determinants utilize phosphoinositides at the ER and host cell surface. Trends Microbiol (2013) 0.77
At the Frontier; RXLR Effectors Crossing the Phytophthora-Host Interface. Front Plant Sci (2011) 0.77
Bioinformatics Analysis Reveals Abundant Short Alpha-Helices as a Common Structural Feature of Oomycete RxLR Effector Proteins. PLoS One (2015) 0.76
Functional analysis of Hyaloperonospora arabidopsidis RXLR effectors. PLoS One (2014) 0.76
The Pectin Methylesterase Gene Complement of Phytophthora sojae: Structural and Functional Analyses, and the Evolutionary Relationships with Its Oomycete Homologs. PLoS One (2015) 0.76
Crystallization and preliminary X-ray analysis of the RXLR-type effector RXLR3 from the oomycete pathogen Hyaloperonospora arabidopsidis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
Structural Basis of Host Autophagy-related Protein 8 (ATG8) Binding by the Irish Potato Famine Pathogen Effector Protein PexRD54. J Biol Chem (2016) 0.75
Photosynthate Regulation of the Root System Architecture Mediated by the Heterotrimeric G Protein Complex in Arabidopsis. Front Plant Sci (2016) 0.75
Uptake of the Fusarium Effector Avr2 by Tomato Is Not a Cell Autonomous Event. Front Plant Sci (2016) 0.75
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature (2009) 6.44
A translocation signal for delivery of oomycete effector proteins into host plant cells. Nature (2007) 5.60
A catalogue of the effector secretome of plant pathogenic oomycetes. Annu Rev Phytopathol (2006) 3.86
Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis. Science (2001) 3.67
An ancestral oomycete locus contains late blight avirulence gene Avr3a, encoding a protein that is recognized in the host cytoplasm. Proc Natl Acad Sci U S A (2005) 3.06
RXLR-mediated entry of Phytophthora sojae effector Avr1b into soybean cells does not require pathogen-encoded machinery. Plant Cell (2008) 2.72
External lipid PI3P mediates entry of eukaryotic pathogen effectors into plant and animal host cells. Cell (2010) 2.40
Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1. Proc Natl Acad Sci U S A (2010) 2.07
The U-box protein CMPG1 is required for efficient activation of defense mechanisms triggered by multiple resistance genes in tobacco and tomato. Plant Cell (2006) 1.81
Oomycete RXLR effectors: delivery, functional redundancy and durable disease resistance. Curr Opin Plant Biol (2008) 1.45
Visualization of PtdIns3P dynamics in living plant cells. Plant J (2006) 1.44
The Arabidopsis Phosphatidylinositol Phosphate 5-Kinase PIP5K3 is a key regulator of root hair tip growth. Plant Cell (2008) 1.41
Recent developments in effector biology of filamentous plant pathogens. Cell Microbiol (2010) 1.39
Type B phosphatidylinositol-4-phosphate 5-kinases mediate Arabidopsis and Nicotiana tabacum pollen tube growth by regulating apical pectin secretion. Plant Cell (2008) 1.36
Structures of Phytophthora RXLR effector proteins: a conserved but adaptable fold underpins functional diversity. J Biol Chem (2011) 1.34
The type B phosphatidylinositol-4-phosphate 5-kinase 3 is essential for root hair formation in Arabidopsis thaliana. Plant Cell (2008) 1.34
PIP5K9, an Arabidopsis phosphatidylinositol monophosphate kinase, interacts with a cytosolic invertase to negatively regulate sugar-mediated root growth. Plant Cell (2007) 1.34
CMPG1-dependent cell death follows perception of diverse pathogen elicitors at the host plasma membrane and is suppressed by Phytophthora infestans RXLR effector AVR3a. New Phytol (2011) 1.26
Imaging phosphatidylinositol 4-phosphate dynamics in living plant cells. Plant J (2008) 1.25
Phosphoinositides regulate clathrin-dependent endocytosis at the tip of pollen tubes in Arabidopsis and tobacco. Plant Cell (2010) 1.20
Distinct amino acids of the Phytophthora infestans effector AVR3a condition activation of R3a hypersensitivity and suppression of cell death. Mol Plant Microbe Interact (2009) 1.07
Oomycete genomics: new insights and future directions. FEMS Microbiol Lett (2007) 1.04
AtPIP5K1, an Arabidopsis thaliana phosphatidylinositol phosphate kinase, synthesizes PtdIns(3,4)P(2) and PtdIns(4,5)P(2) in vitro and is inhibited by phosphorylation. Biochem J (2001) 0.99
Lipid binding activities of flax rust AvrM and AvrL567 effectors. Plant Signal Behav (2010) 0.97
Breaking the code of DNA binding specificity of TAL-type III effectors. Science (2009) 22.33
Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest (2007) 8.71
Sequence-based species delimitation for the DNA taxonomy of undescribed insects. Syst Biol (2006) 7.36
TAL effectors: finding plant genes for disease and defense. Curr Opin Plant Biol (2010) 7.13
Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis. Science (2006) 6.74
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature (2009) 6.44
Inhibition of shoot branching by new terpenoid plant hormones. Nature (2008) 5.89
The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Science (2002) 4.54
CERK1, a LysM receptor kinase, is essential for chitin elicitor signaling in Arabidopsis. Proc Natl Acad Sci U S A (2007) 4.34
Detection of functional haematopoietic stem cell niche using real-time imaging. Nature (2008) 4.06
Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer (2006) 3.34
Promoter elements of rice susceptibility genes are bound and activated by specific TAL effectors from the bacterial blight pathogen, Xanthomonas oryzae pv. oryzae. New Phytol (2010) 3.27
Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease. Nat Biotechnol (2013) 3.20
An ancestral oomycete locus contains late blight avirulence gene Avr3a, encoding a protein that is recognized in the host cytoplasm. Proc Natl Acad Sci U S A (2005) 3.06
Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res (2006) 2.95
Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses. Nat Genet (2012) 2.92
The main auxin biosynthesis pathway in Arabidopsis. Proc Natl Acad Sci U S A (2011) 2.87
MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest (2010) 2.87
Genome sequence of foxtail millet (Setaria italica) provides insights into grass evolution and biofuel potential. Nat Biotechnol (2012) 2.82
Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation. J Am Chem Soc (2004) 2.79
Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants. Proc Natl Acad Sci U S A (2002) 2.76
HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis. Proc Natl Acad Sci U S A (2003) 2.75
Emerging concepts in effector biology of plant-associated organisms. Mol Plant Microbe Interact (2009) 2.75
Genome sequencing reveals agronomically important loci in rice using MutMap. Nat Biotechnol (2012) 2.69
AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. Cell (2005) 2.68
Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein. EMBO J (2003) 2.67
Adaptive evolution has targeted the C-terminal domain of the RXLR effectors of plant pathogenic oomycetes. Plant Cell (2007) 2.66
From Guard to Decoy: a new model for perception of plant pathogen effectors. Plant Cell (2008) 2.62
Genome evolution following host jumps in the Irish potato famine pathogen lineage. Science (2010) 2.62
EST mining and functional expression assays identify extracellular effector proteins from the plant pathogen Phytophthora. Genome Res (2003) 2.57
Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes. Nature (2012) 2.57
Differential recognition of highly divergent downy mildew avirulence gene alleles by RPP1 resistance genes from two Arabidopsis lines. Plant Cell (2005) 2.53
Large-scale phosphorylation mapping reveals the extent of tyrosine phosphorylation in Arabidopsis. Mol Syst Biol (2008) 2.49
Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange. Nat Struct Mol Biol (2012) 2.37
Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire. Genome Biol (2010) 2.36
Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis. Plant Cell (2009) 2.32
microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res (2009) 2.32
The Irish potato famine pathogen Phytophthora infestans translocates the CRN8 kinase into host plant cells. PLoS Pathog (2012) 2.31
Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. Cancer Discov (2013) 2.29
RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed. Plant Cell (2002) 2.29
Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population. Sci Transl Med (2009) 2.25
Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. Nature (2013) 2.22
Effector genomics accelerates discovery and functional profiling of potato disease resistance and phytophthora infestans avirulence genes. PLoS One (2008) 2.21
Uncovering growth-suppressive MicroRNAs in lung cancer. Clin Cancer Res (2009) 2.19
Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome. Hum Mol Genet (2002) 2.16
MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis. J Biol Chem (2006) 2.11
The malarial host-targeting signal is conserved in the Irish potato famine pathogen. PLoS Pathog (2006) 2.10
Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1. Proc Natl Acad Sci U S A (2010) 2.07
Association genetics reveals three novel avirulence genes from the rice blast fungal pathogen Magnaporthe oryzae. Plant Cell (2009) 2.03
A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction. J Virol (2009) 2.03
Generating daily high spatial land surface temperatures by combining ASTER and MODIS land surface temperature products for environmental process monitoring. Environ Sci Process Impacts (2015) 2.03
Gene expression analysis of plant host-pathogen interactions by SuperSAGE. Proc Natl Acad Sci U S A (2003) 2.02
RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens. Plant J (2009) 2.02
Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens. Plant Cell (2002) 1.99
RAR1 positively controls steady state levels of barley MLA resistance proteins and enables sufficient MLA6 accumulation for effective resistance. Plant Cell (2004) 1.98
Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa. Structure (2009) 1.96
Expression of a Phytophthora sojae necrosis-inducing protein occurs during transition from biotrophy to necrotrophy. Plant J (2002) 1.96
Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma. Blood (2011) 1.95
Understanding and exploiting late blight resistance in the age of effectors. Annu Rev Phytopathol (2011) 1.93
Large-scale comparative phosphoproteomics identifies conserved phosphorylation sites in plants. Plant Physiol (2010) 1.93
Genome evolution in filamentous plant pathogens: why bigger can be better. Nat Rev Microbiol (2012) 1.93
Comparative genomic and transcriptomic analyses reveal the hemibiotrophic stage shift of Colletotrichum fungi. New Phytol (2012) 1.93
Role of SGT1 in resistance protein accumulation in plant immunity. EMBO J (2006) 1.92
Trafficking arms: oomycete effectors enter host plant cells. Trends Microbiol (2005) 1.88
Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol (2010) 1.88
QTL-seq: rapid mapping of quantitative trait loci in rice by whole genome resequencing of DNA from two bulked populations. Plant J (2013) 1.85
The rise and fall of the Phytophthora infestans lineage that triggered the Irish potato famine. Elife (2013) 1.84
The U-box protein CMPG1 is required for efficient activation of defense mechanisms triggered by multiple resistance genes in tobacco and tomato. Plant Cell (2006) 1.81
Comparative genome analysis provides insights into the evolution and adaptation of Pseudomonas syringae pv. aesculi on Aesculus hippocastanum. PLoS One (2010) 1.80
Ancient class of translocated oomycete effectors targets the host nucleus. Proc Natl Acad Sci U S A (2010) 1.79
Effector specialization in a lineage of the Irish potato famine pathogen. Science (2014) 1.78
Delayed correlation of mRNA and protein expression in rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to rapamycin. Mol Cell Proteomics (2009) 1.76
Genome analyses of an aggressive and invasive lineage of the Irish potato famine pathogen. PLoS Pathog (2012) 1.75
Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. J Mol Biol (2008) 1.75
Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger. Science (2012) 1.74
A Kazal-like extracellular serine protease inhibitor from Phytophthora infestans targets the tomato pathogenesis-related protease P69B. J Biol Chem (2004) 1.74
Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. Cell Rep (2013) 1.74
Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling. FASEB J (2011) 1.74
Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell (2010) 1.73
RACK1 functions in rice innate immunity by interacting with the Rac1 immune complex. Plant Cell (2008) 1.70
A Phytophthora infestans cystatin-like protein targets a novel tomato papain-like apoplastic protease. Plant Physiol (2006) 1.67
Recognition specificity and RAR1/SGT1 dependence in barley Mla disease resistance genes to the powdery mildew fungus. Plant Cell (2003) 1.67
Fungal effector protein AVR2 targets diversifying defense-related cys proteases of tomato. Plant Cell (2008) 1.64
A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses. J Infect Dis (2008) 1.63
Analysis of the Pythium ultimum transcriptome using Sanger and Pyrosequencing approaches. BMC Genomics (2008) 1.62
Oomycetes, effectors, and all that jazz. Curr Opin Plant Biol (2012) 1.62
The diverse roles of ubiquitin and the 26S proteasome in the life of plants. Nat Rev Genet (2003) 1.61
Mutations in PDLIM3 and MYOZ1 encoding myocyte Z line proteins are infrequently found in idiopathic dilated cardiomyopathy. Mol Genet Metab (2007) 1.60
Genome sequencing and mapping reveal loss of heterozygosity as a mechanism for rapid adaptation in the vegetable pathogen Phytophthora capsici. Mol Plant Microbe Interact (2012) 1.59
Phytophthora infestans effector AVRblb2 prevents secretion of a plant immune protease at the haustorial interface. Proc Natl Acad Sci U S A (2011) 1.58
In planta expression screens of Phytophthora infestans RXLR effectors reveal diverse phenotypes, including activation of the Solanum bulbocastanum disease resistance protein Rpi-blb2. Plant Cell (2009) 1.57
Multidimensional protein identification technology (MudPIT) analysis of ubiquitinated proteins in plants. Mol Cell Proteomics (2007) 1.57
ERG oncogene modulates prostaglandin signaling in prostate cancer cells. Cancer Biol Ther (2011) 1.56