Published in Immunity on August 11, 2011
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood (2012) 1.63
Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity (2012) 1.50
The multiple faces of leukocyte interstitial migration. Semin Immunopathol (2014) 1.12
Ultrastructure of protrusive actin filament arrays. Curr Opin Cell Biol (2013) 1.03
Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages. J Biol Chem (2012) 0.90
Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity. EMBO J (2013) 0.89
SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression. Nat Cell Biol (2013) 0.84
Taking the lymphatic route: dendritic cell migration to draining lymph nodes. Semin Immunopathol (2014) 0.82
Dendritic cell migration in health and disease. Nat Rev Immunol (2016) 0.81
The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling. J Cell Biol (2015) 0.80
Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells. J Cell Sci (2014) 0.78
Loss of Gadkin Affects Dendritic Cell Migration In Vitro. PLoS One (2015) 0.76
VE-cadherin complex plasticity: EPS8 and YAP play relay at adherens junctions. Tissue Barriers (2016) 0.75
Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma. Cell Res (2016) 0.75
Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol Cell Biol (1998) 11.07
Reconstitution of actin-based motility of Listeria and Shigella using pure proteins. Nature (1999) 8.61
Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28
Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell (2002) 6.80
Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity (2005) 6.48
Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity (2003) 5.52
Developmental regulation of MHC class II transport in mouse dendritic cells. Nature (1997) 5.17
Force generation by actin polymerization II: the elastic ratchet and tethered filaments. Biophys J (2003) 4.27
The biology of cell locomotion within three-dimensional extracellular matrix. Cell Mol Life Sci (2000) 3.70
Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell (2004) 3.48
Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science (2004) 3.08
Migration of dendritic cell subsets and their precursors. Annu Rev Immunol (2008) 3.04
Capping protein increases the rate of actin-based motility by promoting filament nucleation by the Arp2/3 complex. Cell (2008) 3.00
EPS8 and E3B1 transduce signals from Ras to Rac. Nature (1999) 2.82
The dynamics of actin-based motility depend on surface parameters. Nature (2002) 2.78
Correlative light and electron microscopy of the cytoskeleton of cultured cells. Methods Enzymol (1998) 2.59
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Nature (2000) 2.58
Spatial and temporal relationships between actin-filament nucleation, capping, and disassembly. Curr Biol (2007) 2.44
Eps8 controls actin-based motility by capping the barbed ends of actin filaments. Nat Cell Biol (2004) 2.40
Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front. Nat Cell Biol (2008) 2.22
Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming. Science (2004) 2.20
Adaptive force transmission in amoeboid cell migration. Nat Cell Biol (2009) 2.17
Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration. Blood (2009) 2.09
Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation. Blood (2001) 1.96
Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex. Nat Cell Biol (2006) 1.92
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans. Nat Cell Biol (2004) 1.82
Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). PLoS Biol (2009) 1.78
Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells. J Immunol (1986) 1.67
Self-organization of a propulsive actin network as an evolutionary process. Proc Natl Acad Sci U S A (2001) 1.60
The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed. J Immunol (2005) 1.57
Capping protein terminates but does not initiate chemoattractant-induced actin assembly in Dictyostelium. J Cell Biol (1997) 1.57
Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8. Curr Biol (2011) 1.55
Measuring chemotaxis and chemokinesis: the under-agarose cell migration assay. Sci STKE (2003) 1.50
The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses. J Neurosci (1999) 1.50
Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation. Immunobiology (2009) 1.32
Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells. J Pathol (2004) 1.31
Progress in protrusion: the tell-tale scar. Trends Biochem Sci (1999) 1.28
IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness. Cancer Res (2004) 1.27
Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75. J Immunol (1997) 1.23
The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Mol Biol Cell (2003) 1.21
Role of WASP in cell polarity and podosome dynamics of myeloid cells. Eur J Cell Biol (2010) 1.20
Skin inflammation during contact hypersensitivity is mediated by early recruitment of CD8+ T cytotoxic 1 cells inducing keratinocyte apoptosis. J Immunol (2002) 1.19
Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. Cytogenet Cell Genet (1999) 1.17
Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping. PLoS Biol (2010) 1.15
Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. Blood (2007) 1.15
Expression of Wiskott-Aldrich syndrome protein in dendritic cells regulates synapse formation and activation of naive CD8+ T cells. J Immunol (2008) 1.09
In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure. Genomics (2003) 0.99
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. PLoS One (2010) 0.97
Reconstructing leukocyte migration in 3D extracellular matrix by time-lapse videomicroscopy and computer-assisted tracking. Methods Mol Biol (2004) 0.96
Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells. Blood (2010) 0.93
Infection of dendritic cells with herpes simplex virus type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and migration. Blood (2011) 0.87
Distinct intracellular trafficking of hepatitis C virus in myeloid and plasmacytoid dendritic cells. J Virol (2010) 0.81
Serum TABM produced during anterior chamber-associated immune deviation passively transfers suppression of delayed-type hypersensitivity to primed mice. Int Immunol (1997) 0.81
Influence of dibutyl phthalate on dermal sensitization to fluorescein isothiocyanate. Fundam Appl Toxicol (1996) 0.77
Enterotypes of the human gut microbiome. Nature (2011) 24.36
Role of formins in actin assembly: nucleation and barbed-end association. Science (2002) 5.47
Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity (2007) 4.87
Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol (2005) 4.86
Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J Exp Med (2006) 4.53
Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration. Cell (2008) 4.47
Abi1 is essential for the formation and activation of a WAVE2 signalling complex. Nat Cell Biol (2004) 4.04
Role of fascin in filopodial protrusion. J Cell Biol (2006) 3.52
Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. EMBO J (2004) 3.31
The biology of intestinal immunoglobulin A responses. Immunity (2008) 3.18
Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells. PLoS Biol (2007) 3.01
Formin leaky cap allows elongation in the presence of tight capping proteins. Curr Biol (2003) 2.69
Protein complexes regulating Arp2/3-mediated actin assembly. Curr Opin Cell Biol (2005) 2.63
Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings. J Clin Oncol (2002) 2.57
Formation of filopodia-like bundles in vitro from a dendritic network. J Cell Biol (2003) 2.44
Eps8 controls actin-based motility by capping the barbed ends of actin filaments. Nat Cell Biol (2004) 2.40
Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases. Nature (2004) 2.39
Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity. Sci Transl Med (2010) 2.32
Molecular architecture of synaptic actin cytoskeleton in hippocampal neurons reveals a mechanism of dendritic spine morphogenesis. Mol Biol Cell (2009) 2.23
Inhibition of spleen tyrosine kinase as treatment of postoperative ileus. Gut (2012) 2.20
Regulation of actin dynamics by WASP and WAVE family proteins. Trends Cell Biol (2004) 2.19
Structural organization of the actin cytoskeleton at sites of clathrin-mediated endocytosis. Curr Biol (2011) 2.18
Mechanism of formin-induced nucleation of actin filaments. Biochemistry (2003) 2.18
Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes. Nat Cell Biol (2005) 2.16
Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells. Mol Biol Cell (2008) 2.11
Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J Exp Med (2011) 2.06
Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model. Gut (2012) 2.02
IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. Cell Host Microbe (2009) 2.01
Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse. PLoS Biol (2011) 1.92
Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell (2006) 1.92
Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex. Nat Cell Biol (2006) 1.92
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1. J Cell Biol (2003) 1.91
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans. Nat Cell Biol (2004) 1.82
AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion. J Cell Biol (2010) 1.81
Actin dynamics is essential for myosin-based transport of membrane organelles. Curr Biol (2008) 1.80
Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). PLoS Biol (2009) 1.78
Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo. Nat Commun (2012) 1.78
Cascade pathway of filopodia formation downstream of SCAR. J Cell Sci (2004) 1.76
Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing. J Cell Biol (2006) 1.70
Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation. Nat Cell Biol (2004) 1.69
CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci (2010) 1.68
Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease. Gastroenterology (2008) 1.62
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
Comparison of the immunomodulatory properties of three probiotic strains of Lactobacilli using complex culture systems: prediction for in vivo efficacy. PLoS One (2009) 1.60
Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. J Cell Biol (2002) 1.60
Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8. Curr Biol (2011) 1.55
Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Proc Natl Acad Sci U S A (2012) 1.53
Entry route of Salmonella typhimurium directs the type of induced immune response. Immunity (2007) 1.53
Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different. Blood (2005) 1.50
Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas. Blood (2013) 1.49
Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells. J Cell Sci (2006) 1.45
Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion. PLoS One (2009) 1.41
Lipopolysaccharide or whole bacteria block the conversion of inflammatory monocytes into dendritic cells in vivo. J Exp Med (2003) 1.39
TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells. EMBO J (2010) 1.37
Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. Gastroenterology (2007) 1.29
Cancer immunotherapy based on killing of Salmonella-infected tumor cells. Cancer Res (2005) 1.28
The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia. Dev Neurobiol (2011) 1.27
Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice. J Exp Med (2011) 1.25
Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation. Front Immunol (2012) 1.23
Filopodia initiation: focus on the Arp2/3 complex and formins. Cell Adh Migr (2011) 1.23
The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway. Mol Biol Cell (2008) 1.23
Mucosal dendritic cells in immunity and inflammation. Nat Immunol (2004) 1.22
The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Mol Biol Cell (2003) 1.21
Eps8 in the midst of GTPases. Int J Biochem Cell Biol (2002) 1.20
Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization. J Clin Invest (2014) 1.20
The impact of probiotics and prebiotics on the immune system. Nat Rev Immunol (2012) 1.19
Mechanism of actin filament bundling by fascin. J Biol Chem (2011) 1.18
The yin and yang of intestinal epithelial cells in controlling dendritic cell function. J Exp Med (2007) 1.16
The adhesion molecule NCAM promotes ovarian cancer progression via FGFR signalling. EMBO Mol Med (2011) 1.16
Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping. PLoS Biol (2010) 1.15
Divalent cation-induced cluster formation by polyphosphoinositides in model membranes. J Am Chem Soc (2012) 1.14
Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. PLoS Genet (2009) 1.14
Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development (2009) 1.14
Neutrophil chemotaxis by pathogen-associated molecular patterns--formylated peptides are crucial but not the sole neutrophil attractants produced by Staphylococcus aureus. Cell Microbiol (2006) 1.14
Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments. J Cell Biol (2014) 1.13