Published in Biochemistry on January 21, 2003
Insertional assembly of actin filament barbed ends in association with formins produces piconewton forces. Proc Natl Acad Sci U S A (2004) 3.89
Unleashing formins to remodel the actin and microtubule cytoskeletons. Nat Rev Mol Cell Biol (2009) 3.45
The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin. J Cell Biol (2003) 3.40
A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin. Mol Biol Cell (2003) 2.77
The yeast actin cytoskeleton: from cellular function to biochemical mechanism. Microbiol Mol Biol Rev (2006) 2.55
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway. Genetics (2011) 2.47
Actin nucleation and elongation factors: mechanisms and interplay. Curr Opin Cell Biol (2009) 2.27
Review of the mechanism of processive actin filament elongation by formins. Cell Motil Cytoskeleton (2009) 2.12
The regulation of mDia1 by autoinhibition and its release by Rho*GTP. EMBO J (2005) 2.10
Regulatory interactions between two actin nucleators, Spire and Cappuccino. J Cell Biol (2007) 2.08
The role of the FH1 domain and profilin in formin-mediated actin-filament elongation and nucleation. Curr Biol (2007) 2.01
Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1. J Cell Biol (2006) 1.99
The formin mDia2 stabilizes microtubules independently of its actin nucleation activity. J Cell Biol (2008) 1.96
Model of formin-associated actin filament elongation. Mol Cell (2006) 1.92
Stable and dynamic axes of polarity use distinct formin isoforms in budding yeast. Mol Biol Cell (2004) 1.80
Overexpression of an Arabidopsis formin stimulates supernumerary actin cable formation from pollen tube cell membrane. Plant Cell (2003) 1.71
Regulation of the formin for3p by cdc42p and bud6p. Mol Biol Cell (2007) 1.68
An overview of Cdk1-controlled targets and processes. Cell Div (2010) 1.66
Processive capping by formin suggests a force-driven mechanism of actin polymerization. J Cell Biol (2004) 1.62
Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex. Dev Cell (2014) 1.61
Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. J Cell Biol (2010) 1.59
The formin homology 1 domain modulates the actin nucleation and bundling activity of Arabidopsis FORMIN1. Plant Cell (2005) 1.46
Cell polarization and cytokinesis in budding yeast. Genetics (2012) 1.45
The formin DAD domain plays dual roles in autoinhibition and actin nucleation. Curr Biol (2011) 1.39
Structure and function of the interacting domains of Spire and Fmn-family formins. Proc Natl Acad Sci U S A (2011) 1.36
Formins at a glance. J Cell Sci (2013) 1.34
Molecular mechanism of Ena/VASP-mediated actin-filament elongation. EMBO J (2011) 1.30
Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. J Mol Biol (2007) 1.29
Specificity of interactions between mDia isoforms and Rho proteins. J Biol Chem (2008) 1.27
Arabidopsis formin AtFH6 is a plasma membrane-associated protein upregulated in giant cells induced by parasitic nematodes. Plant Cell (2004) 1.21
Mammalian tropomodulins nucleate actin polymerization via their actin monomer binding and filament pointed end-capping activities. J Biol Chem (2010) 1.11
Formin homology 2 domains occur in multiple contexts in angiosperms. BMC Genomics (2004) 1.11
Cloning and functional characterization of a formin-like protein (AtFH8) from Arabidopsis. Plant Physiol (2005) 1.10
DAAM1 is a formin required for centrosome re-orientation during cell migration. PLoS One (2010) 1.09
Energetic requirements for processive elongation of actin filaments by FH1FH2-formins. J Biol Chem (2009) 1.08
Concerted action of two formins in gliding motility and host cell invasion by Toxoplasma gondii. PLoS Pathog (2010) 1.07
Molecular mechanisms of cell-cell spread of intracellular bacterial pathogens. Open Biol (2013) 1.04
Mechanism and cellular function of Bud6 as an actin nucleation-promoting factor. Mol Biol Cell (2011) 1.04
Regulation of polarized growth initiation and termination cycles by the polarisome and Cdc42 regulators. J Cell Biol (2004) 1.04
Z-line formins promote contractile lattice growth and maintenance in striated muscles of C. elegans. J Cell Biol (2012) 1.03
Determinants of Formin Homology 1 (FH1) domain function in actin filament elongation by formins. J Biol Chem (2012) 1.02
Inside view of cell locomotion through single-molecule: fast F-/G-actin cycle and G-actin regulation of polymer restoration. Proc Jpn Acad Ser B Phys Biol Sci (2010) 1.00
The myosin passenger protein Smy1 controls actin cable structure and dynamics by acting as a formin damper. Dev Cell (2011) 0.99
The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis. J Cell Biol (2013) 0.99
Mutations to the formin homology 2 domain of INF2 protein have unexpected effects on actin polymerization and severing. J Biol Chem (2012) 0.99
A Rho-type GTPase, rho-4, is required for septation in Neurospora crassa. Eukaryot Cell (2005) 0.99
Initial polarized bud growth by endocytic recycling in the absence of actin cable-dependent vesicle transport in yeast. Mol Biol Cell (2010) 0.97
Vibrio parahaemolyticus inhibition of Rho family GTPase activation requires a functional chromosome I type III secretion system. Infect Immun (2008) 0.96
The functionally distinct fission yeast formins have specific actin-assembly properties. Mol Biol Cell (2011) 0.95
Characterization of the biochemical properties and biological function of the formin homology domains of Drosophila DAAM. J Biol Chem (2010) 0.95
G1/S cyclin-dependent kinase regulates small GTPase Rho1p through phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae. Mol Biol Cell (2008) 0.93
Diaphanous-related formin 2 and profilin I are required for gastrulation cell movements. PLoS One (2008) 0.93
Formins in development: orchestrating body plan origami. Biochim Biophys Acta (2008) 0.91
Actin polymerization upon processive capping by formin: a model for slowing and acceleration. Biophys J (2006) 0.91
Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6. Proc Natl Acad Sci U S A (2012) 0.90
RhoA-mediated FMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindle formation in mouse oocyte meiosis. Cell Cycle (2015) 0.89
Control of polarized assembly of actin filaments in cell motility. Cell Mol Life Sci (2015) 0.88
The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility. J Cell Biol (2013) 0.88
Phosphorylation of Lte1 by Cdk prevents polarized growth during mitotic arrest in S. cerevisiae. J Cell Biol (2010) 0.88
There is more than one way to model an elephant. Experiment-driven modeling of the actin cytoskeleton. Biophys J (2013) 0.86
The lasso segment is required for functional dimerization of the Plasmodium formin 1 FH2 domain. PLoS One (2012) 0.81
ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization. Science (2015) 0.81
Coordination of the filament stabilizing versus destabilizing activities of cofilin through its secondary binding site on actin. Cytoskeleton (Hoboken) (2014) 0.79
A mathematical model of actin filament turnover for fitting FRAP data. Eur Biophys J (2009) 0.78
Movement in Colorado: the Keystone Symposium on Cell Migration and Invasion. Breckenridge, CO: January 18-23, 2003. J Cell Biol (2003) 0.78
The final cut: cell polarity meets cytokinesis at the bud neck in S. cerevisiae. Cell Mol Life Sci (2016) 0.76
mDia1 and formins: screw cap of the actin filament. Biophysics (Nagoya-shi) (2012) 0.75
INF2- and FHOD-related formins promote ovulation in the somatic gonad of C. elegans. Cytoskeleton (Hoboken) (2016) 0.75
Structural and Biochemical Basis for the Inhibitory Effect of Liprin-α3 on Mouse Diaphanous 1 (mDia1) Function. J Biol Chem (2015) 0.75
Regulation of actin catch-slip bonds with a RhoA-formin module. Sci Rep (2016) 0.75
Actin polymerization is stimulated by actin cross-linking protein palladin. Biochem J (2015) 0.75
Mechanisms of Yersinia YopO kinase substrate specificity. Sci Rep (2017) 0.75
Global mapping of the yeast genetic interaction network. Science (2004) 21.34
The genetic landscape of a cell. Science (2010) 16.52
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell (2005) 10.41
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules. Science (2001) 7.08
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59
Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell (2006) 6.42
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol (2003) 5.60
Role of formins in actin assembly: nucleation and barbed-end association. Science (2002) 5.47
Exploration of essential gene functions via titratable promoter alleles. Cell (2004) 5.21
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell (2005) 4.95
Synthetic genetic array analysis in Saccharomyces cerevisiae. Methods Mol Biol (2006) 4.45
A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell (2003) 4.04
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
Identification of a bacterial type III effector family with G protein mimicry functions. Cell (2006) 3.47
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A (2002) 3.46
Combining biological networks to predict genetic interactions. Proc Natl Acad Sci U S A (2004) 3.18
A specificity map for the PDZ domain family. PLoS Biol (2008) 3.16
The synthetic genetic interaction spectrum of essential genes. Nat Genet (2005) 3.06
Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells. PLoS Biol (2007) 3.01
eSGA: E. coli synthetic genetic array analysis. Nat Methods (2008) 3.01
Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast. Nat Cell Biol (2002) 2.95
Genotype to phenotype: a complex problem. Science (2010) 2.92
Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol Microbiol (2003) 2.84
Formin leaky cap allows elongation in the presence of tight capping proteins. Curr Biol (2003) 2.69
Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. J Biol (2005) 2.68
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat Methods (2010) 2.67
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol (2009) 2.63
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. Nat Genet (2007) 2.58
Functional genomics and proteomics: charting a multidimensional map of the yeast cell. Trends Cell Biol (2003) 2.46
Systematic mapping of genetic interaction networks. Annu Rev Genet (2009) 2.43
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol (2012) 2.40
Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A (2006) 2.39
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J (2005) 2.34
Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell (2004) 2.34
Formins: signaling effectors for assembly and polarization of actin filaments. J Cell Sci (2003) 2.31
Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Nat Rev Genet (2006) 2.30
Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast. Nat Cell Biol (2002) 2.27
Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol (2011) 2.26
Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. Nature (2009) 2.14
Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. EMBO J (2003) 2.03
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc Natl Acad Sci U S A (2008) 2.01
Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p. Nat Cell Biol (2004) 1.94
Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. J Cell Biol (2008) 1.92
Systematic exploration of synergistic drug pairs. Mol Syst Biol (2011) 1.89
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Genes Dev (2011) 1.89
AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion. J Cell Biol (2010) 1.81
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. Mol Cell Biol (2010) 1.81
The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Mol Cell Biol (2006) 1.79
High-resolution genetic mapping with ordered arrays of Saccharomyces cerevisiae deletion mutants. Genetics (2002) 1.78
Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins. PLoS Biol (2009) 1.78
Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell. Nat Biotechnol (2011) 1.77
Mammalian CARMIL inhibits actin filament capping by capping protein. Dev Cell (2005) 1.77
Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway. Mol Biol Cell (2004) 1.76
Synthetic genetic array (SGA) analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Methods Enzymol (2010) 1.73
Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation. Proc Natl Acad Sci U S A (2005) 1.72
Global gene deletion analysis exploring yeast filamentous growth. Science (2012) 1.67
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol (2007) 1.66
The interaction network of the chaperonin CCT. EMBO J (2008) 1.63
An integrated approach to characterize genetic interaction networks in yeast metabolism. Nat Genet (2011) 1.62
A network of multi-tasking proteins at the DNA replication fork preserves genome stability. PLoS Genet (2005) 1.61
Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. EMBO J (2004) 1.59
Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. Genetics (2003) 1.57
Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers. Nat Methods (2008) 1.56
Global map of SUMO function revealed by protein-protein interaction and genetic networks. Mol Cell (2009) 1.55
The origin recognition complex links replication, sister chromatid cohesion and transcriptional silencing in Saccharomyces cerevisiae. Genetics (2004) 1.49
Identifying specificity profiles for peptide recognition modules from phage-displayed peptide libraries. Nat Protoc (2007) 1.49
Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage. Mol Cell Biol (2004) 1.48
Problems with co-funding in Canada. Science (2005) 1.48
An interactional network of genes involved in chitin synthesis in Saccharomyces cerevisiae. BMC Genet (2005) 1.47
The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast. Genome Res (2008) 1.44
DRYGIN: a database of quantitative genetic interaction networks in yeast. Nucleic Acids Res (2009) 1.41
Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Mol Cell Biol (2005) 1.39
Synthetic lethal analysis implicates Ste20p, a p21-activated potein kinase, in polarisome activation. Mol Biol Cell (2003) 1.37
Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. J Cell Biol (2010) 1.36
Bringing order to protein disorder through comparative genomics and genetic interactions. Genome Biol (2011) 1.34
Ybp2 associates with the central kinetochore of Saccharomyces cerevisiae and mediates proper mitotic progression. PLoS One (2008) 1.31
Identification of a novel lysophospholipid acyltransferase in Saccharomyces cerevisiae. J Biol Chem (2007) 1.28
Charting the genetic interaction map of a cell. Curr Opin Biotechnol (2010) 1.28
Genetic dissection of parallel sister-chromatid cohesion pathways. Genetics (2007) 1.26
Putting genetic interactions in context through a global modular decomposition. Genome Res (2011) 1.24
An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer. Cancer Res (2012) 1.23
The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol (2009) 1.22
Shifted Transversal Design smart-pooling for high coverage interactome mapping. Genome Res (2009) 1.22
Genetic interactions reveal the evolutionary trajectories of duplicate genes. Mol Syst Biol (2010) 1.22
The GTPase Arf1p and the ER to Golgi cargo receptor Erv14p cooperate to recruit the golgin Rud3p to the cis-Golgi. J Cell Biol (2004) 1.21
Systems-level antimicrobial drug and drug synergy discovery. Nat Chem Biol (2013) 1.19
Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle. Mol Biol Cell (2007) 1.18
Mechanism of actin filament bundling by fascin. J Biol Chem (2011) 1.18
DNA methylation profiling defines clinically relevant biological subsets of non-small cell lung cancer. Clin Cancer Res (2012) 1.16
Interaction between a Ras and a Rho GTPase couples selection of a growth site to the development of cell polarity in yeast. Mol Biol Cell (2003) 1.16