PubRank

Lars Rönnstrand

Author PubWeight™ 61.26‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell 2003 3.58
2 Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol Rev 2012 2.13
3 A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML. Blood 2009 1.58
4 The characterization of epithelial and stromal subsets of candidate stem/progenitor cells in the human adult prostate. Eur Urol 2007 1.46
5 p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils. J Exp Med 2004 1.42
6 Protein kinase C expression is deregulated in chronic lymphocytic leukemia. Leuk Lymphoma 2013 1.40
7 Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3. Cell Signal 2009 1.40
8 Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins. J Biol Chem 2004 1.33
9 Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. Biochem J 2006 1.12
10 Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells. Biochem Biophys Res Commun 2008 1.10
11 Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF. Biochem J 2003 1.10
12 Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2. Blood 2006 1.10
13 Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications. Clin Cancer Res 2003 1.09
14 Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol 2004 1.06
15 Phosphorylation of the potyvirus capsid protein by protein kinase CK2 and its relevance for virus infection. Plant Cell 2003 1.06
16 Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration. Arterioscler Thromb Vasc Biol 2002 1.04
17 Src family kinases are involved in the differential signaling from two splice forms of c-Kit. J Biol Chem 2003 1.02
18 Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. Blood 2012 1.00
19 Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. J Biol Chem 2008 0.99
20 Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation. Exp Hematol 2009 0.98
21 Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase. J Biol Chem 2010 0.98
22 Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl. Exp Cell Res 2007 0.97
23 Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin receptor EP4 that is essential for agonist-induced beta-arrestin1 recruitment but differs from the apparent principal phosphorylation site. Biochem J 2004 0.97
24 SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor. Oncogene 2002 0.96
25 SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML. Blood 2012 0.95
26 Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. J Biol Chem 2011 0.95
27 Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3. J Biol Chem 2012 0.94
28 Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation. Blood 2011 0.94
29 Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor. J Biol Chem 2004 0.94
30 SOCS proteins in regulation of receptor tyrosine kinase signaling. Cell Mol Life Sci 2014 0.93
31 FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia. Mol Oncol 2012 0.90
32 A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival. Br J Haematol 2009 0.90
33 Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD. Biochem Biophys Res Commun 2011 0.89
34 Identification of protein tyrosine phosphatases associating with the PDGF receptor. Biochemistry 2003 0.89
35 Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases. Biochim Biophys Acta 2003 0.89
36 C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation. PLoS One 2011 0.88
37 The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit. Biochem J 2003 0.88
38 SOCS6 is a selective suppressor of receptor tyrosine kinase signaling. Tumour Biol 2014 0.88
39 Ezrin is a substrate for Lck in T cells. FEBS Lett 2003 0.88
40 The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling. Cell Signal 2013 0.88
41 The presence or absence of IL-3 during long-term culture of Flt3-ITD and c-Kit-D816V expressing Ba/F3 cells influences signaling outcome. Exp Hematol 2013 0.88
42 Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling. Mol Oncol 2013 0.87
43 Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin. Exp Cell Res 2003 0.87
44 Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. Exp Cell Res 2003 0.86
45 Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling. PLoS One 2012 0.85
46 The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction. J Biol Chem 2009 0.84
47 Src-like-adaptor protein (SLAP) differentially regulates normal and oncogenic c-Kit signaling. J Cell Sci 2013 0.84
48 HIF-2α expression is suppressed in SCLC cells, which survive in moderate and severe hypoxia when HIF-1α is repressed. Am J Pathol 2011 0.83
49 Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia. Med Oncol 2013 0.82
50 Enhanced SOX10 and KIT expression in cutaneous melanoma. Med Oncol 2013 0.82
51 Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor. J Cell Physiol 2006 0.81
52 FLT3 mutations in patients with childhood acute lymphoblastic leukemia (ALL). Med Oncol 2013 0.81
53 Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling. Cell Mol Life Sci 2015 0.81
54 Phosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation. J Biol Chem 2013 0.79
55 3,4-Diarylmaleimides-a novel class of kinase inhibitors-effectively induce apoptosis in FLT3-ITD-dependent cells. Ann Hematol 2011 0.79
56 The basic helix-loop-helix (bHLH) proteins in breast cancer progression. Med Oncol 2013 0.77
57 Keratin 19 expression correlates with poor prognosis in breast cancer. Mol Biol Rep 2014 0.77
58 Differential activity of c-KIT splice forms is controlled by extracellular peptide insert length. Cell Signal 2013 0.77
59 Irreversible pan-ERBB inhibitor canertinib elicits anti-leukaemic effects and induces the regression of FLT3-ITD transformed cells in mice. Br J Haematol 2011 0.77
60 Deregulation of protein phosphatase expression in acute myeloid leukemia. Med Oncol 2013 0.76
61 EGF and dextran-conjugated EGF induces differential phosphorylation of the EGF receptor. Int J Mol Med 2002 0.75
62 Ser-474 is the major target of insulin-mediated phosphorylation of protein kinase B beta in primary rat adipocytes. Cell Signal 2002 0.75
63 Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation. Br J Haematol 2006 0.75