PubRank

Shigeo Ohta

Author PubWeight™ 89.61‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007 7.27
2 Mitochondrial genome variation in eastern Asia and the peopling of Japan. Genome Res 2004 3.34
3 FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest 2008 3.25
4 Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun 2007 2.27
5 Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 2008 2.04
6 Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis. Cancer Res 2005 1.90
7 Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett 2008 1.71
8 Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology 2008 1.55
9 Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol 2009 1.54
10 Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett 2009 1.54
11 Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc Natl Acad Sci U S A 2004 1.47
12 Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS. Intern Med 2012 1.46
13 Transduction of the anti-apoptotic PTD-FNK protein improves the efficiency of transplantation of bone marrow mononuclear cells. J Mol Cell Cardiol 2007 1.40
14 Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res 2009 1.31
15 Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol 2011 1.25
16 Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun 2008 1.24
17 Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. J Neurochem 2003 1.19
18 Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity (Silver Spring) 2011 1.17
19 Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1. J Biol Chem 2009 1.15
20 Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci 2009 1.13
21 Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci 2008 1.12
22 Protection against ischemic brain injury by protein therapeutics. Proc Natl Acad Sci U S A 2002 1.11
23 Prognostic significance of the immunohistochemical index of survivin in glioma: a comparative study with the MIB-1 index. J Neurooncol 2005 1.09
24 MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction. J Cell Sci 2005 1.07
25 Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J Nutr Biochem 2009 1.06
26 Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain. Circ Res 2011 1.05
27 Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial. Mov Disord 2013 1.04
28 Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett 2009 1.02
29 Haploinsufficiency of akt1 prolongs the lifespan of mice. PLoS One 2013 1.02
30 Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects. Neurobiol Dis 2010 0.99
31 Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. FEBS Lett 2005 0.95
32 H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc 2012 0.95
33 Prognosis of glioma patients by combined immunostaining for survivin, Ki-67 and epidermal growth factor receptor. J Clin Neurosci 2008 0.94
34 Suppression of endoplasmic reticulum stress-induced caspase activation and cell death by the overexpression of Bcl-xL or Bcl-2. J Biochem 2007 0.92
35 Prevention of chemotherapy-induced alopecia by the anti-death FNK protein. Life Sci 2007 0.91
36 ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes. Alcohol Clin Exp Res 2004 0.91
37 Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide. Med Gas Res 2011 0.90
38 Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females. J Hum Genet 2003 0.89
39 Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density of the femoral neck in elderly Japanese women. J Mol Med (Berl) 2002 0.89
40 Accumulation of somatic mutation in mitochondrial DNA and atherosclerosis in diabetic patients. Ann N Y Acad Sci 2004 0.88
41 Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice. Neurosci Lett 2009 0.88
42 Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis. J Bone Miner Res 2012 0.87
43 Transduction of anti-apoptotic proteins into chondrocytes in cartilage slice culture. Biochem Biophys Res Commun 2004 0.87
44 Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose-induced insulin secretion. J Biol Chem 2011 0.87
45 Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice. Behav Brain Res 2010 0.86
46 Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis. J Neurosci Res 2008 0.85
47 PTD-mediated delivery of anti-cell death proteins/peptides and therapeutic enzymes. Adv Drug Deliv Rev 2007 0.84
48 Anti-apoptotic PTD-FNK protein suppresses lipopolysaccharide-induced acute lung injury in rats. Exp Mol Pathol 2007 0.84
49 Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population. Alcohol Alcohol 2003 0.83
50 Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat. J Neurochem 2008 0.82
51 Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory. Behav Brain Res 2009 0.82
52 Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations. Mitochondrion 2002 0.81
53 Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde. Neurobiol Aging 2007 0.81
54 Mutations in the mitochondrial genome confer resistance of cancer cells to anticancer drugs. Cancer Sci 2009 0.81
55 Association of alcohol dehydrogenase 2*1 allele with liver damage and insulin concentration in the Japanese. J Hum Genet 2005 0.81
56 [Hydrogen gas and hydrogen water act as a therapeutic and preventive antioxidant with a novel concept]. Nihon Ronen Igakkai Zasshi 2008 0.80
57 Involvement of mitoKATP channel in protective mechanisms of cerebral ischemic tolerance. Brain Res 2008 0.79
58 Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. EMBO J 2003 0.79
59 Mitochondrial DNA alterations in colorectal cancer cell lines. J Nippon Med Sch 2011 0.79
60 Mild hypothermia enhanced the protective effect of protein therapy with transductive anti-death FNK protein using a rat focal transient cerebral ischemia model. Brain Res 2011 0.79
61 Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population. Pancreas 2005 0.79
62 The anti-cell death FNK protein protects cells from death induced by freezing and thawing. Biochem Biophys Res Commun 2005 0.79
63 Influence of alcohol intake and aldehyde dehydrogenase 2 phenotype on peripheral neuropathy of diabetes. Diabetes Care 2003 0.78
64 Imaging mitochondrial redox environment and oxidative stress using a redox-sensitive fluorescent protein. J Nippon Med Sch 2008 0.78
65 N-terminal deletion augments the cell-death-inducing activity of BAX in adenoviral gene delivery to nonsmall cell lung cancers. Oncogene 2003 0.78
66 Transduction of anti-cell death protein FNK protects isolated rat hearts from myocardial infarction induced by ischemia/reperfusion. Life Sci 2007 0.78
67 Regular moderate or intense exercise prevents depression-like behavior without change of hippocampal tryptophan content in chronically tryptophan-deficient and stressed mice. PLoS One 2013 0.78
68 [Initiation, development and potential of hydrogen medicine: Toward therapeutic and preventive applications of molecular hydrogen against a variety of diseases]. Seikagaku 2015 0.77
69 Transduction of anti-cell death protein FNK suppresses graft degeneration after autologous cylindrical osteochondral transplantation. J Histochem Cytochem 2008 0.77
70 Improvement of the post-thaw qualities of Okinawan native Agu pig sperm frozen in an extender supplemented with antiapoptotic PTD-FNK protein. Theriogenology 2012 0.77
71 Protection of hepatic cells from apoptosis induced by ischemia/reperfusion injury by protein therapeutics. Hepatol Res 2007 0.77
72 Preventive effects of Chlorella on skeletal muscle atrophy in muscle-specific mitochondrial aldehyde dehydrogenase 2 activity-deficient mice. BMC Complement Altern Med 2014 0.77
73 A protein derived from the fusion of TAT peptide and FNK, a Bcl-x(L) derivative, prevents cochlear hair cell death from aminoglycoside ototoxicity in vivo. J Neurosci Res 2007 0.77
74 Mitochondrial tRNA(Leu(UUR)) mutation at position 3243 and symptomatic polyneuropathy in type 2 diabetes. Diabetes Care 2003 0.76
75 Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome　- First-in-Human Pilot Study. Circ J 2016 0.76
76 Increased mitochondrial functions in human glioblastoma cells persistently infected with measles virus. Antiviral Res 2013 0.76
77 Detection of urine survivin in 40 patients with bladder cancer. J Nippon Med Sch 2004 0.75
78 Continuous culture of novel mitochondrial cells lacking nuclei. Mitochondrion 2003 0.75
79 Hepatic failure and enhanced oxidative stress in mitochondrial diabetes. Endocr J 2008 0.75
80 Endurance exercise training inhibits activity of plasma GOT and liver caspase-3 of mice [correction of rats] exposed to stress by induction of heat shock protein 70. J Appl Physiol (1985) 2004 0.75
81 [Gene therapy and protein therapy for mitochondrial diseases]. Nihon Rinsho 2002 0.75
82 Biochemistry of mitochondria, life and intervention 2010. Biochim Biophys Acta 2012 0.75
83 Aggregation of mitochondria. J Nippon Med Sch 2005 0.75
84 Multiple tumors in mitochondrial diabetes associated with tRNALeu(UUR) mutation at position 3264. Diabetes Care 2003 0.75
85 Diabetic vasculopathy and alcohol tolerance trait in type 2 diabetes. Diabetes Care 2003 0.75
86 [Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations]. Nihon Rinsho 2002 0.75
87 Green fluorescent protein causes mitochondria to aggregate in the presence of the Bcl-2 family proteins. Biochem Biophys Res Commun 2004 0.75
88 A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene. Biochim Biophys Acta 2009 0.75
89 Expression of Bcl-2 on leukocytes in prostatic fluid from patients with acute and chronic prostatitis. J Infect Chemother 2003 0.75
90 Various morphologies of mitochondria. J Nippon Med Sch 2005 0.75
91 Isolation and sequence analysis of the rat dihydrolipoamide succinyltransferase gene. DNA Seq 2002 0.75
92 Multiple cranial mononeuropathies with acetylcholine receptor antibody in mitochondrial diabetes. Diabetes Care 2003 0.75
93 [Assay of biochemical activity (respiratory complex activity, pyruvate dehydrogenase complex activity etc)for diagnosis of mitochondrial diseases]. Nihon Rinsho 2002 0.75
94 [Protein transduction and protection of cells against apoptosis]. Seikagaku 2004 0.75