Published in Hum Mol Genet on August 25, 2011
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Insights into the genetic basis of type 2 diabetes. J Diabetes Investig (2013) 0.90
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Genetic determinants of long-term changes in blood lipid concentrations: 10-year follow-up of the GLACIER study. PLoS Genet (2014) 0.83
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Pharmacogenomic variants have larger effect sizes than genetic variants associated with other dichotomous complex traits. Pharmacogenomics J (2015) 0.81
Sparse Modeling Reveals miRNA Signatures for Diagnostics of Inflammatory Bowel Disease. PLoS One (2015) 0.81
Common low-penetrance risk variants associated with breast cancer in Polish women. BMC Cancer (2013) 0.81
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Genetic architectures of seropositive and seronegative rheumatic diseases. Nat Rev Rheumatol (2015) 0.79
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Multi-locus genetic risk score predicts risk for Crohn's disease in Slovenian population. World J Gastroenterol (2016) 0.77
A comparison of genomic profiles of complex diseases under different models. BMC Med Genomics (2016) 0.77
Incremental value of rare genetic variants for the prediction of multifactorial diseases. Genome Med (2013) 0.77
Combining genetic and nongenetic biomarkers to realize the promise of pharmacogenomics for inflammatory diseases. Pharmacogenomics (2014) 0.77
Annotation of genes having candidate somatic mutations in acute myeloid leukemia with whole-exome sequencing using concept lattice analysis. Genomics Inform (2013) 0.76
Improving accuracy of genomic prediction by genetic architecture based priors in a Bayesian model. BMC Genet (2015) 0.76
Genetic risk prediction for CKD: a journey of a thousand miles. Am J Kidney Dis (2012) 0.75
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy. Nat Commun (2017) 0.75
Risk Prediction Using Genome-Wide Association Studies on Type 2 Diabetes. Genomics Inform (2016) 0.75
A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients. BMC Med Genomics (2017) 0.75
Prediction of Quantitative Traits Using Common Genetic Variants: Application to Body Mass Index. Genomics Inform (2016) 0.75
Exploiting population samples to enhance genome-wide association studies of disease. Genetics (2014) 0.75
Prediction of complex human diseases from pathway-focused candidate markers by joint estimation of marker effects: case of chronic fatigue syndrome. Hum Genomics (2015) 0.75
Assessing Heavy Metal and PCB Exposure from Tap Water by Measuring Levels in Plasma from Sporadic Breast Cancer Patients, a Pilot Study. Int J Environ Res Public Health (2015) 0.75
Everything in moderation, even hype: learning from vaccine controversies to strike a balance with CRISPR. J Med Ethics (2017) 0.75
Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects. Am J Respir Cell Mol Biol (2017) 0.75
Accumulation of minor alleles and risk prediction in schizophrenia. Sci Rep (2017) 0.75
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Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet (2008) 12.51
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90
Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med (2008) 9.83
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet (2011) 9.10
Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. Genet Med (2011) 9.03
Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet (2011) 8.95
Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med (2008) 8.70
Carrier testing for severe childhood recessive diseases by next-generation sequencing. Sci Transl Med (2011) 8.20
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet (2010) 7.62
Meta-analysis of BRCA1 and BRCA2 penetrance. J Clin Oncol (2007) 7.46
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet (2008) 6.97
Effect of direct-to-consumer genomewide profiling to assess disease risk. N Engl J Med (2011) 6.90
Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada. J Natl Cancer Inst (2006) 6.73
Disclosure of APOE genotype for risk of Alzheimer's disease. N Engl J Med (2009) 6.43
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet (2011) 6.20
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet (2009) 6.04
Performance of common genetic variants in breast-cancer risk models. N Engl J Med (2010) 5.79
Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet (2009) 4.79
Predicting the 30-year risk of cardiovascular disease: the framingham heart study. Circulation (2009) 4.62
The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genet (2010) 4.58
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet (2009) 4.38
Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases. Anglian Breast Cancer Study Group. Br J Cancer (2000) 4.37
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet (2010) 3.86
Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet (2009) 3.64
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci U S A (2009) 3.49
Effects of communicating DNA-based disease risk estimates on risk-reducing behaviours. Cochrane Database Syst Rev (2010) 3.25
A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genet (2011) 3.16
The LLP risk model: an individual risk prediction model for lung cancer. Br J Cancer (2007) 3.15
From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes. PLoS Genet (2009) 2.99
Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Invest Ophthalmol Vis Sci (2008) 2.91
Frequency of breast cancer attributable to BRCA1 in a population-based series of American women. JAMA (1998) 2.76
Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. JAMA (2011) 2.61
Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet (2010) 2.51
Narrative review: Assessment of C-reactive protein in risk prediction for cardiovascular disease. Ann Intern Med (2006) 2.32
Identification by whole-genome resequencing of gene defect responsible for severe hypercholesterolemia. Hum Mol Genet (2010) 2.19
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. Mol Psychiatry (2009) 2.03
ACOG Practice Bulletin No. 103: Hereditary breast and ovarian cancer syndrome. Obstet Gynecol (2009) 2.02
Risk assessment tools for identifying individuals at risk of developing type 2 diabetes. Epidemiol Rev (2011) 2.01
Multi-locus models of genetic risk of disease. Genome Med (2010) 1.33
Improved risk prediction for Crohn's disease with a multi-locus approach. Hum Mol Genet (2011) 1.28
Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening. Am J Hum Genet (2011) 1.26
Evaluation of polygenic risk scores for predicting breast and prostate cancer risk. Genet Epidemiol (2011) 1.23
Role of molecular genetics in transforming diagnosis of diabetes mellitus. Expert Rev Mol Diagn (2011) 1.02
Genotyping for NOD2 genetic variants and crohn disease: a metaanalysis. Clin Chem (2009) 0.88
Successful implementation of a national HLA-B*5701 genetic testing service in Canada. Tissue Antigens (2009) 0.87
Family-based genetic risk prediction of multifactorial disease. Genome Med (2010) 0.83
[Genetic variants, cardiovascular risk and genome-wide association studies]. Rev Esp Cardiol (2011) 0.78
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Common deletion polymorphisms in the human genome. Nat Genet (2006) 15.66
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
A systematic survey of loss-of-function variants in human protein-coding genes. Science (2012) 12.25
The zebrafish reference genome sequence and its relationship to the human genome. Nature (2013) 8.52
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Multiple common variants for celiac disease influencing immune gene expression. Nat Genet (2010) 6.90
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet (2011) 6.36
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet (2008) 4.96
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms. Am J Hum Genet (2008) 4.28
The UK10K project identifies rare variants in health and disease. Nature (2015) 3.89
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science (2013) 3.33
Haploview: Visualization and analysis of SNP genotype data. Cold Spring Harb Protoc (2009) 2.74
Biases and reconciliation in estimates of linkage disequilibrium in the human genome. Am J Hum Genet (2006) 2.26
Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. Gastroenterology (2008) 2.17
Synthetic associations are unlikely to account for many common disease genome-wide association signals. PLoS Biol (2011) 2.00
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. Nat Genet (2012) 1.85
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature (2013) 1.79
Imputation of low-frequency variants using the HapMap3 benefits from large, diverse reference sets. Eur J Hum Genet (2011) 1.68
Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene. Inflamm Bowel Dis (2007) 1.47
Synthetic associations in the context of genome-wide association scan signals. Hum Mol Genet (2010) 1.36
Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet (2011) 1.30
Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Hum Mol Genet (2009) 1.26
Evoker: a visualization tool for genotype intensity data. Bioinformatics (2010) 1.26
Imputation-based meta-analysis of severe malaria in three African populations. PLoS Genet (2013) 1.25
To what extent do scans of non-synonymous SNPs complement denser genome-wide association studies? Eur J Hum Genet (2008) 1.24
How next-generation sequencing is transforming complex disease genetics. Trends Genet (2012) 1.16
Marker selection for genetic case-control association studies. Nat Protoc (2009) 1.12
Association of PTPN22 haplotypes with Graves' disease. J Clin Endocrinol Metab (2006) 1.05
The intermediate filament protein, vimentin, is a regulator of NOD2 activity. Gut (2012) 0.91
Using genetic prediction from known complex disease Loci to guide the design of next-generation sequencing experiments. PLoS One (2013) 0.88
Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clin Endocrinol (Oxf) (2010) 0.83
Olorin: combining gene flow with exome sequencing in large family studies of complex disease. Bioinformatics (2012) 0.82
Misuse of hierarchical linear models overstates the significance of a reported association between OXTR and prosociality. Proc Natl Acad Sci U S A (2012) 0.78
Characterization of expression quantitative trait loci in the human colon. Inflamm Bowel Dis (2015) 0.78