Published in Am J Hum Genet on March 03, 2011
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Genome-wide association study identifies five new schizophrenia loci. Nat Genet (2011) 9.07
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet (2012) 5.78
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. PLoS Genet (2011) 5.01
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet (2012) 4.41
Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood. Bioinformatics (2012) 3.97
Power and predictive accuracy of polygenic risk scores. PLoS Genet (2013) 3.72
Improved heritability estimation from genome-wide SNPs. Am J Hum Genet (2012) 3.48
Finding the sources of missing heritability in a yeast cross. Nature (2013) 3.43
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Pitfalls of predicting complex traits from SNPs. Nat Rev Genet (2013) 3.06
A mixed-model approach for genome-wide association studies of correlated traits in structured populations. Nat Genet (2012) 2.69
Common genetic variants, acting additively, are a major source of risk for autism. Mol Autism (2012) 2.67
Genetic contributions to stability and change in intelligence from childhood to old age. Nature (2012) 2.63
Polygenic modeling with bayesian sparse linear mixed models. PLoS Genet (2013) 2.59
Meta-analysis methods for genome-wide association studies and beyond. Nat Rev Genet (2013) 2.58
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet (2014) 2.53
Advantages and pitfalls in the application of mixed-model association methods. Nat Genet (2014) 2.52
The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev (2011) 2.44
Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. PLoS Genet (2013) 2.19
Current status of genome-wide association studies in cancer. Hum Genet (2011) 2.14
Heritability and genetic correlations explained by common SNPs for metabolic syndrome traits. PLoS Genet (2012) 2.11
Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies. Nat Genet (2013) 2.09
Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes. Eur J Hum Genet (2012) 2.01
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Hum Mol Genet (2012) 1.96
Statistical power to detect genetic (co)variance of complex traits using SNP data in unrelated samples. PLoS Genet (2014) 1.92
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav (2014) 1.90
The genetic architecture of economic and political preferences. Proc Natl Acad Sci U S A (2012) 1.89
Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms. Biol Psychiatry (2012) 1.86
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Nat Genet (2013) 1.85
Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nat Genet (2012) 1.81
No genetic influence for childhood behavior problems from DNA analysis. J Am Acad Child Adolesc Psychiatry (2013) 1.79
Heritability in the genome-wide association era. Hum Genet (2012) 1.76
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nat Genet (2016) 1.74
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet (2013) 1.68
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet (2012) 1.68
Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med (2013) 1.67
Genetic risk prediction in complex disease. Hum Mol Genet (2011) 1.65
Large-scale genomics unveils the genetic architecture of psychiatric disorders. Nat Neurosci (2014) 1.64
Measuring missing heritability: inferring the contribution of common variants. Proc Natl Acad Sci U S A (2014) 1.58
Common DNA markers can account for more than half of the genetic influence on cognitive abilities. Psychol Sci (2013) 1.57
Informed conditioning on clinical covariates increases power in case-control association studies. PLoS Genet (2012) 1.57
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet (2015) 1.55
Quantifying missing heritability at known GWAS loci. PLoS Genet (2013) 1.55
Population structure can inflate SNP-based heritability estimates. Am J Hum Genet (2011) 1.54
Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. Transl Psychiatry (2012) 1.52
A genome-wide association study of myasthenia gravis. JAMA Neurol (2015) 1.52
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nat Genet (2015) 1.51
Practitioner review: A critical perspective on gene-environment interaction models--what impact should they have on clinical perceptions and practice? J Child Psychol Psychiatry (2014) 1.51
The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases. PLoS One (2013) 1.51
Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nat Genet (2015) 1.43
Estimation and partition of heritability in human populations using whole-genome analysis methods. Annu Rev Genet (2013) 1.41
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Nat Genet (2014) 1.41
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nat Genet (2014) 1.41
Pleiotropic Mechanisms Indicated for Sex Differences in Autism. PLoS Genet (2016) 1.41
Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model. PLoS Genet (2015) 1.38
Evaluating empirical bounds on complex disease genetic architecture. Nat Genet (2013) 1.37
Identity by descent: variation in meiosis, across genomes, and in populations. Genetics (2013) 1.37
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. Nat Genet (2015) 1.34
Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease. Am J Hum Genet (2013) 1.31
GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation. PLoS Genet (2014) 1.29
Estimating heritability of complex traits from genome-wide association studies using IBS-based Haseman-Elston regression. Front Genet (2014) 1.28
Alzheimer's disease: analyzing the missing heritability. PLoS One (2013) 1.28
Identification of pathways for bipolar disorder: a meta-analysis. JAMA Psychiatry (2014) 1.26
DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities. Behav Genet (2013) 1.26
Germline genetic contributions to risk for esophageal adenocarcinoma, Barrett's esophagus, and gastroesophageal reflux. J Natl Cancer Inst (2013) 1.25
MAGMA: generalized gene-set analysis of GWAS data. PLoS Comput Biol (2015) 1.25
Child development and molecular genetics: 14 years later. Child Dev (2012) 1.23
The future of genomics for developmentalists. Dev Psychopathol (2013) 1.21
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. Am J Hum Genet (2015) 1.21
DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12. Mol Psychiatry (2013) 1.19
Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes. PLoS One (2011) 1.19
The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes. Hum Mol Genet (2012) 1.18
Genetics of type 2 diabetes-pitfalls and possibilities. Genes (Basel) (2015) 1.16
Using summary data from the danish national registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorder. Front Genet (2012) 1.15
Accurate and robust genomic prediction of celiac disease using statistical learning. PLoS Genet (2014) 1.14
Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning. Aging (Albany NY) (2015) 1.14
Epistasis network centrality analysis yields pathway replication across two GWAS cohorts for bipolar disorder. Transl Psychiatry (2012) 1.13
Genetic-based prediction of disease traits: prediction is very difficult, especially about the future. Front Genet (2014) 1.12
Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants. Am J Med Genet B Neuropsychiatr Genet (2013) 1.11
Patterns of methylation heritability in a genome-wide analysis of four brain regions. Nucleic Acids Res (2013) 1.11
Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data. Hum Mol Genet (2014) 1.10
Molecular genetics and subjective well-being. Proc Natl Acad Sci U S A (2013) 1.09
Next Generation Statistical Genetics: Modeling, Penalization, and Optimization in High-Dimensional Data. Annu Rev Stat Appl (2014) 1.08
Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. Am J Hum Genet (2013) 1.07
Linkage-disequilibrium-based binning affects the interpretation of GWASs. Am J Hum Genet (2012) 1.07
Warped linear mixed models for the genetic analysis of transformed phenotypes. Nat Commun (2014) 1.06
Multilocus genetic models of handedness closely resemble single-locus models in explaining family data and are compatible with genome-wide association studies. Ann N Y Acad Sci (2013) 1.05
Developing and evaluating polygenic risk prediction models for stratified disease prevention. Nat Rev Genet (2016) 1.05
A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A. Hum Mol Genet (2013) 1.05
Human fertility, molecular genetics, and natural selection in modern societies. PLoS One (2015) 1.05
Identity-by-descent-based heritability analysis in the Northern Finland Birth Cohort. Hum Genet (2012) 1.05
Six Degrees of Epistasis: Statistical Network Models for GWAS. Front Genet (2012) 1.04
Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. Arthritis Rheum (2012) 1.03
The Fourth Law of Behavior Genetics. Curr Dir Psychol Sci (2015) 1.03
Most common 'sporadic' cancers have a significant germline genetic component. Hum Mol Genet (2014) 1.03
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nat Genet (2016) 1.03
Novel genetic analysis for case-control genome-wide association studies: quantification of power and genomic prediction accuracy. PLoS One (2013) 1.02
Heritability estimates identify a substantial genetic contribution to risk and outcome of intracerebral hemorrhage. Stroke (2013) 1.02
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet (2010) 20.73
Personal genomes: The case of the missing heritability. Nature (2008) 19.56
Heritability in the genomics era--concepts and misconceptions. Nat Rev Genet (2008) 13.42
Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet (2009) 12.96
Genomewide association studies and assessment of the risk of disease. N Engl J Med (2010) 11.51
Accuracy of predicting the genetic risk of disease using a genome-wide approach. PLoS One (2008) 4.96
The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genet (2010) 4.58
Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study. Diabetes (2003) 4.44
Reconciling the analysis of IBD and IBS in complex trait studies. Nat Rev Genet (2010) 3.62
A commentary on 'common SNPs explain a large proportion of the heritability for human height' by Yang et al. (2010). Twin Res Hum Genet (2010) 3.37
Severe mental disorders in offspring with 2 psychiatrically ill parents. Arch Gen Psychiatry (2010) 1.66
A simple and fast two-locus quality control test to detect false positives due to batch effects in genome-wide association studies. Genet Epidemiol (2010) 1.57
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet (2010) 20.73
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Heritability in the genomics era--concepts and misconceptions. Nat Rev Genet (2008) 13.42
Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57
Prediction of individual genetic risk to disease from genome-wide association studies. Genome Res (2007) 8.48
A versatile gene-based test for genome-wide association studies. Am J Hum Genet (2010) 8.44
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Data and theory point to mainly additive genetic variance for complex traits. PLoS Genet (2008) 7.15
Recent human effective population size estimated from linkage disequilibrium. Genome Res (2007) 6.79
Sizing up human height variation. Nat Genet (2008) 6.66
A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry (2012) 6.34
DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet (2009) 5.99
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet (2012) 5.78
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet (2012) 5.55
Genomic inflation factors under polygenic inheritance. Eur J Hum Genet (2011) 4.89
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genet (2010) 4.58
Predicting unobserved phenotypes for complex traits from whole-genome SNP data. PLoS Genet (2008) 4.57
Bias, precision and heritability of self-reported and clinically measured height in Australian twins. Hum Genet (2006) 3.84
Novel multilocus measure of linkage disequilibrium to estimate past effective population size. Genome Res (2003) 3.83
Reconciling the analysis of IBD and IBS in complex trait studies. Nat Rev Genet (2010) 3.62
Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk. Hum Mol Genet (2009) 3.53
Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet (2007) 3.47
A commentary on 'common SNPs explain a large proportion of the heritability for human height' by Yang et al. (2010). Twin Res Hum Genet (2010) 3.37
The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond. BMC Geriatr (2007) 3.33
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
QTL Express: mapping quantitative trait loci in simple and complex pedigrees. Bioinformatics (2002) 3.24
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Highly cost-efficient genome-wide association studies using DNA pools and dense SNP arrays. Nucleic Acids Res (2008) 3.08
Pitfalls of predicting complex traits from SNPs. Nat Rev Genet (2013) 3.06
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. Lancet (2011) 3.03
Geographical structure and differential natural selection among North European populations. Genome Res (2009) 3.03
Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet (2003) 3.02
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Genetic contributions to stability and change in intelligence from childhood to old age. Nature (2012) 2.63
Synthetic associations created by rare variants do not explain most GWAS results. PLoS Biol (2011) 2.60
Geographical genomics of human leukocyte gene expression variation in southern Morocco. Nat Genet (2009) 2.38
Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nat Genet (2009) 2.29
Prediction of individual genetic risk of complex disease. Curr Opin Genet Dev (2008) 2.19
Comparing apples and oranges: equating the power of case-control and quantitative trait association studies. Genet Epidemiol (2010) 2.13
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
SNP genotyping on pooled DNAs: comparison of genotyping technologies and a semi automated method for data storage and analysis. Nucleic Acids Res (2002) 2.12
Accuracy of genomic selection using stochastic search variable selection in Australian Holstein Friesian dairy cattle. Genet Res (Camb) (2009) 2.05
Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat Genet (2010) 2.04
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. Am J Hum Genet (2008) 2.01
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Hum Mol Genet (2012) 1.96
The genetic architecture of economic and political preferences. Proc Natl Acad Sci U S A (2012) 1.89
Analysis of pooled DNA samples on high density arrays without prior knowledge of differential hybridization rates. Nucleic Acids Res (2006) 1.88
Classification based upon gene expression data: bias and precision of error rates. Bioinformatics (2007) 1.88
Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data. Genetics (2011) 1.85
Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence. Genome Res (2012) 1.73
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
Narrowing the boundaries of the genetic architecture of schizophrenia. Schizophr Bull (2009) 1.71
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet (2013) 1.68
On Jim Watson's APOE status: genetic information is hard to hide. Eur J Hum Genet (2008) 1.67
Estimation of SNP heritability from dense genotype data. Am J Hum Genet (2013) 1.64
Human population dispersal "Out of Africa" estimated from linkage disequilibrium and allele frequencies of SNPs. Genome Res (2011) 1.64
A better coefficient of determination for genetic profile analysis. Genet Epidemiol (2012) 1.63
High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury. J Appl Physiol (1985) (2003) 1.62
Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent. Genome Res (2011) 1.58