PubRank

Sheena E Radford

Author PubWeight™ 151.49‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Nucleation of protein fibrillation by nanoparticles. Proc Natl Acad Sci U S A 2007 3.23
2 Pulling geometry defines the mechanical resistance of a beta-sheet protein. Nat Struct Biol 2003 3.21
3 Im7 folding mechanism: misfolding on a path to the native state. Nat Struct Biol 2002 3.15
4 Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly. Proc Natl Acad Sci U S A 2008 2.90
5 Amyloid formation under physiological conditions proceeds via a native-like folding intermediate. Nat Struct Mol Biol 2006 2.82
6 Structural properties of an amyloid precursor of beta(2)-microglobulin. Nat Struct Biol 2002 2.21
7 Optimizing protein stability in vivo. Mol Cell 2009 2.15
8 Fibril fragmentation enhances amyloid cytotoxicity. J Biol Chem 2009 2.13
9 Competing pathways determine fibril morphology in the self-assembly of beta2-microglobulin into amyloid. J Mol Biol 2005 2.10
10 Folding versus aggregation: polypeptide conformations on competing pathways. Arch Biochem Biophys 2007 1.97
11 Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins. Protein Sci 2005 1.91
12 Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism. Mol Cell 2006 1.81
13 A diversity of assembly mechanisms of a generic amyloid fold. Mol Cell 2011 1.80
14 The Yin and Yang of protein folding. FEBS J 2005 1.68
15 Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties. Proc Natl Acad Sci U S A 2002 1.66
16 Intermediates: ubiquitous species on folding energy landscapes? Curr Opin Struct Biol 2007 1.60
17 Direct observation of oligomeric species formed in the early stages of amyloid fibril formation using electrospray ionisation mass spectrometry. J Mol Biol 2006 1.60
18 Mechanically unfolding the small, topologically simple protein L. Biophys J 2005 1.57
19 Structural analysis of the rate-limiting transition states in the folding of Im7 and Im9: similarities and differences in the folding of homologous proteins. J Mol Biol 2003 1.52
20 A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein. PLoS Biol 2013 1.48
21 Amyloid-forming peptides from beta2-microglobulin-Insights into the mechanism of fibril formation in vitro. J Mol Biol 2003 1.44
22 An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms. Nat Struct Mol Biol 2009 1.43
23 Dynamics in the unfolded state of beta2-microglobulin studied by NMR. J Mol Biol 2004 1.41
24 Mechanically unfolding proteins: the effect of unfolding history and the supramolecular scaffold. Protein Sci 2002 1.39
25 Conformational conversion during amyloid formation at atomic resolution. Mol Cell 2011 1.39
26 Hierarchical assembly of beta2-microglobulin amyloid in vitro revealed by atomic force microscopy. J Mol Biol 2003 1.39
27 Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction. J Am Chem Soc 2008 1.38
28 The transition state for folding of an outer membrane protein. Proc Natl Acad Sci U S A 2010 1.37
29 The effect of core destabilization on the mechanical resistance of I27. Biophys J 2002 1.36
30 A systematic study of the effect of physiological factors on beta2-microglobulin amyloid formation at neutral pH. Biochemistry 2006 1.33
31 pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases. J Am Chem Soc 2003 1.32
32 The yeast prion Ure2p retains its native alpha-helical conformation upon assembly into protein fibrils in vitro. EMBO J 2002 1.31
33 Determination of an ensemble of structures representing the intermediate state of the bacterial immunity protein Im7. Proc Natl Acad Sci U S A 2005 1.31
34 Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies. J Am Chem Soc 2010 1.30
35 Elongated oligomers in beta2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry. Proc Natl Acad Sci U S A 2010 1.29
36 Trapping the on-pathway folding intermediate of Im7 at equilibrium. J Mol Biol 2004 1.29
37 A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation. J Mol Biol 2003 1.28
38 A generic mechanism of beta2-microglobulin amyloid assembly at neutral pH involving a specific proline switch. J Mol Biol 2009 1.26
39 The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints. Nat Struct Mol Biol 2009 1.26
40 Direct three-dimensional visualization of membrane disruption by amyloid fibrils. Proc Natl Acad Sci U S A 2012 1.24
41 Switching two-state to three-state kinetics in the helical protein Im9 via the optimisation of stabilising non-native interactions by design. J Mol Biol 2004 1.23
42 Fibril growth kinetics reveal a region of beta2-microglobulin important for nucleation and elongation of aggregation. J Mol Biol 2008 1.23
43 Monitoring copopulated conformational states during protein folding events using electrospray ionization-ion mobility spectrometry-mass spectrometry. J Am Soc Mass Spectrom 2007 1.22
44 Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils. J Mol Biol 2009 1.21
45 Intermolecular alignment in β2-microglobulin amyloid fibrils. J Am Chem Soc 2010 1.18
46 NMR analysis of the conformational properties of the trapped on-pathway folding intermediate of the bacterial immunity protein Im7. J Mol Biol 2006 1.17
47 Tuning the elastic modulus of hydrated collagen fibrils. Biophys J 2009 1.17
48 Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling. J Biol Chem 2010 1.17
49 Microsecond folding dynamics of the F13W G29A mutant of the B domain of staphylococcal protein A by laser-induced temperature jump. Proc Natl Acad Sci U S A 2004 1.16
50 A common beta-sheet architecture underlies in vitro and in vivo beta2-microglobulin amyloid fibrils. J Biol Chem 2008 1.14
51 Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry. Proc Natl Acad Sci U S A 2008 1.14
52 Glimpses of the molecular mechanisms of beta2-microglobulin fibril formation in vitro: aggregation on a complex energy landscape. FEBS Lett 2009 1.13
53 The N-terminal helix is a post-assembly clamp in the bacterial outer membrane protein PagP. J Mol Biol 2007 1.13
54 Urea-induced unfolding of the immunity protein Im9 monitored by spFRET. Biophys J 2006 1.11
55 Viscoelastic measurements of single molecules on a millisecond time scale by magnetically driven oscillation of an atomic force microscope cantilever. Langmuir 2005 1.10
56 Mechanical resistance of proteins explained using simple molecular models. Biophys J 2005 1.10
57 The oligomeric state and arrangement of the active bacterial translocon. J Biol Chem 2010 1.09
58 Understanding the complex mechanisms of β2-microglobulin amyloid assembly. FEBS J 2011 1.09
59 Investigation into the role of macrophages in the formation and degradation of beta2-microglobulin amyloid fibrils. J Biol Chem 2007 1.09
60 Fibril fragmentation in amyloid assembly and cytotoxicity: when size matters. Prion 2010 1.06
61 Ion mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors. J Am Chem Soc 2013 1.06
62 Equilibrium hydrogen exchange reveals extensive hydrogen bonded secondary structure in the on-pathway intermediate of Im7. J Mol Biol 2004 1.05
63 Competition between intramolecular and intermolecular interactions in an amyloid-forming protein. J Mol Biol 2009 1.02
64 Viscoelastic study of the mechanical unfolding of a protein by AFM. Biophys J 2006 1.01
65 Ligand binding to distinct states diverts aggregation of an amyloid-forming protein. Nat Chem Biol 2011 1.01
66 N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer. Protein Sci 2012 1.01
67 Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation. Proc Natl Acad Sci U S A 2010 1.00
68 Separation of beta2-microglobulin conformers by high-field asymmetric waveform ion mobility spectrometry (FAIMS) coupled to electrospray ionisation mass spectrometry. Rapid Commun Mass Spectrom 2004 0.99
69 Investigating the structural properties of amyloid-like fibrils formed in vitro from beta2-microglobulin using limited proteolysis and electrospray ionisation mass spectrometry. Rapid Commun Mass Spectrom 2006 0.99
70 Beta edge strands in protein structure prediction and aggregation. Protein Sci 2003 0.98
71 Viscoelastic properties of single polysaccharide molecules determined by analysis of thermally driven oscillations of an atomic force microscope cantilever. Langmuir 2004 0.98
72 Quantifying heterogeneity and conformational dynamics from single molecule FRET of diffusing molecules: recurrence analysis of single particles (RASP). Phys Chem Chem Phys 2011 0.98
73 Structural plasticity and noncovalent substrate binding in the GroEL apical domain. A study using electrospay ionization mass spectrometry and fluorescence binding studies. J Biol Chem 2002 0.98
74 Semisynthesis of a glycosylated Im7 analogue for protein folding studies. J Am Chem Soc 2005 0.97
75 Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics. J Mol Biol 2007 0.97
76 Identification of a mechanical rheostat in the hydrophobic core of protein L. J Mol Biol 2009 0.97
77 Internal friction of single polypeptide chains at high stretch. Faraday Discuss 2008 0.97
78 Amyloid fibril length distribution quantified by atomic force microscopy single-particle image analysis. Protein Eng Des Sel 2009 0.96
79 Co-populated conformational ensembles of beta2-microglobulin uncovered quantitatively by electrospray ionization mass spectrometry. J Biol Chem 2004 0.96
80 The effect of increasing the stability of non-native interactions on the folding landscape of the bacterial immunity protein Im9. J Mol Biol 2007 0.95
81 Thermodynamic description of polymorphism in Q- and N-rich peptide aggregates revealed by atomistic simulation. Biophys J 2009 0.95
82 HDX-ESI-MS reveals enhanced conformational dynamics of the amyloidogenic protein beta(2)-microglobulin upon release from the MHC-1. J Am Soc Mass Spectrom 2008 0.94
83 Role of the N and C-terminal strands of beta 2-microglobulin in amyloid formation at neutral pH. J Mol Biol 2003 0.93
84 Ultraviolet resonance Raman studies reveal the environment of tryptophan and tyrosine residues in the native and partially folded states of the E colicin-binding immunity protein Im7. Biochemistry 2005 0.93
85 Characterisation of the conformational properties of urea-unfolded Im7: implications for the early stages of protein folding. J Mol Biol 2006 0.92
86 The effect of protein complexation on the mechanical stability of Im9. Biophys J 2007 0.92
87 A structural model for apolipoprotein C-II amyloid fibrils: experimental characterization and molecular dynamics simulations. J Mol Biol 2010 0.91
88 Dissecting the effects of periplasmic chaperones on the in vitro folding of the outer membrane protein PagP. J Mol Biol 2013 0.91
89 Secondary structure in the core of amyloid fibrils formed from human β₂m and its truncated variant ΔN6. J Am Chem Soc 2014 0.90
90 Production and characterization of RNA aptamers specific for amyloid fibril epitopes. J Biol Chem 2007 0.90
91 Desolvation and development of specific hydrophobic core packing during Im7 folding. J Mol Biol 2010 0.90
92 Helix stability and hydrophobicity in the folding mechanism of the bacterial immunity protein Im9. Protein Eng Des Sel 2005 0.90
93 Conformational properties of the unfolded state of Im7 in nondenaturing conditions. J Mol Biol 2011 0.89
94 Structure and dynamics of oligomeric intermediates in β2-microglobulin self-assembly. Biophys J 2011 0.88
95 The role of conformational flexibility in β2-microglobulin amyloid fibril formation at neutral pH. Rapid Commun Mass Spectrom 2012 0.88
96 Amphipathic polymers enable the study of functional membrane proteins in the gas phase. Anal Chem 2012 0.88
97 Structural determinants of polymerization reactivity of the P pilus adaptor subunit PapF. Structure 2008 0.88
98 Amyloid under the atomic force microscope. Protein Pept Lett 2006 0.88
99 Comparison of the transition state ensembles for folding of Im7 and Im9 determined using all-atom molecular dynamics simulations with phi value restraints. Proteins 2004 0.87
100 Malleability of the folding mechanism of the outer membrane protein PagP: parallel pathways and the effect of membrane elasticity. J Mol Biol 2012 0.87
101 Expanding the repertoire of amyloid polymorphs by co-polymerization of related protein precursors. J Biol Chem 2013 0.87
102 The organization of aromatic side groups in an amyloid fibril probed by solid-state 2H and 19F NMR spectroscopy. J Am Chem Soc 2006 0.87
103 Effect of sequence variation on the mechanical response of amyloid fibrils probed by steered molecular dynamics simulation. Biophys J 2012 0.86
104 Probing dynamics within amyloid fibrils using a novel capping method. Angew Chem Int Ed Engl 2009 0.86
105 Characterization of the response of primary cells relevant to dialysis-related amyloidosis to β2-microglobulin monomer and fibrils. PLoS One 2011 0.86
106 Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils. Biophys J 2013 0.85
107 Amino acid insertion reveals a necessary three-helical intermediate in the folding pathway of the colicin E7 immunity protein Im7. J Mol Biol 2009 0.85
108 Systematic examination of polymorphism in amyloid fibrils by molecular-dynamics simulation. Biophys J 2011 0.85
109 Mutational analysis of the ability of resveratrol to inhibit amyloid formation by islet amyloid polypeptide: critical evaluation of the importance of aromatic-inhibitor and histidine-inhibitor interactions. Biochemistry 2015 0.84
110 Synthesis, characterization and applications of a perdeuterated amphipol. J Membr Biol 2014 0.84
111 Site-specific identification of an aβ fibril-heparin interaction site by using solid-state NMR spectroscopy. Angew Chem Int Ed Engl 2012 0.84
112 Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation. Chem Commun (Camb) 2008 0.83
113 Amphipols outperform dodecylmaltoside micelles in stabilizing membrane protein structure in the gas phase. Anal Chem 2014 0.82
114 Extraction of accurate biomolecular parameters from single-molecule force spectroscopy experiments. ACS Nano 2015 0.82
115 Single-molecule studies of the Im7 folding landscape. J Mol Biol 2010 0.81
116 The role of chaperone-subunit usher domain interactions in the mechanism of bacterial pilus biogenesis revealed by ESI-MS. Mol Cell Proteomics 2012 0.81
117 Second order rate constants of donor-strand exchange reveal individual amino acid residues important in determining the subunit specificity of pilus biogenesis. J Am Soc Mass Spectrom 2011 0.81
118 Phosphorylation as a tool to modulate aggregation propensity and to predict fibril architecture. Chembiochem 2011 0.81
119 Sulfate-induced effects in the on-pathway intermediate of the bacterial immunity protein Im7. Biochemistry 2006 0.80
120 Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry. Analyst 2015 0.79
121 Analysis of amyloid nanostructures using photo-cross-linking: in situ comparison of three widely used photo-cross-linkers. ACS Chem Biol 2014 0.79
122 Conformational dynamics is more important than helical propensity for the folding of the all α-helical protein Im7. Protein Sci 2013 0.78
123 Protein folding and binding: from biology to physics and back again. Curr Opin Struct Biol 2010 0.78
124 Dissecting key residues in folding and stability of the bacterial immunity protein 7. Protein Eng Des Sel 2011 0.78
125 Unfolding dynamics of proteins under applied force. Philos Trans A Math Phys Eng Sci 2003 0.77
126 Covalent cross-linking within supramolecular peptide structures. Anal Chem 2012 0.77
127 Special issue: the molecular and cellular mechanisms of amyloidosis. J Mol Biol 2012 0.76
128 Molecular dynamics simulations of mechanical failure in polymorphic arrangements of amyloid fibrils containing structural defects. Beilstein J Nanotechnol 2013 0.75
129 Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry. Mol Biosyst 2013 0.75
130 Topological dissection of the membrane transport protein Mhp1 derived from cysteine accessibility and mass spectrometry. Anal Chem 2017 0.75
131 Co-translocational misfolding in the ER of living cells. Nat Struct Biol 2003 0.75