Calcium signaling in cardiac myocytes.

Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories. J Mol Cell Cardiol (2015) 2.20

Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes. Proc Natl Acad Sci U S A (2015) 1.16

The contributions of cardiac myosin binding protein C and troponin I phosphorylation to β-adrenergic enhancement of in vivo cardiac function. J Physiol (2016) 1.08

The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth. Br J Pharmacol (2013) 1.00

Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1. J Mol Cell Cardiol (2013) 0.87

Regulation of metabolism in individual mitochondria during excitation-contraction coupling. J Mol Cell Cardiol (2014) 0.86

Caffeine exposure alters cardiac gene expression in embryonic cardiomyocytes. Am J Physiol Regul Integr Comp Physiol (2014) 0.80

Extracellular sodium dependence of the conduction velocity-calcium relationship: evidence of ephaptic self-attenuation. Am J Physiol Heart Circ Physiol (2016) 0.78

The human subject: an integrative animal model for 21(st) century heart failure research. Am J Transl Res (2015) 0.77

Multi-Material Tissue Engineering Scaffold with Hierarchical Pore Architecture. Adv Funct Mater (2016) 0.75

The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+-binding but not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor. J Biol Chem (2016) 0.75

Calcium Sparks in the Heart: Dynamics and Regulation. Res Rep Biol (2015) 0.75

Muscarinic Stimulation Facilitates Sarcoplasmic Reticulum Ca Release by Modulating Ryanodine Receptor 2 Phosphorylation Through Protein Kinase G and Ca/Calmodulin-Dependent Protein Kinase II. Hypertension (2016) 0.75

Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient. Sci Rep (2017) 0.75

Metabolic carbonyl reduction of anthracyclines - role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents. Invest New Drugs (2017) 0.75

microRNA and thyroid hormone signaling in cardiac and skeletal muscle. Cell Biosci (2017) 0.75

Cardiac inositol 1,4,5-trisphosphate receptors. Biochim Biophys Acta (2016) 0.75

PM2.5 exposure in utero contributes to neonatal cardiac dysfunction in mice. Environ Pollut (2017) 0.75

Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med (1990) 17.52

Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol (1983) 10.99

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell (2000) 10.25

Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol (2000) 9.88

Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature (1985) 9.68

The influence of calcium on sodium efflux in squid axons. J Physiol (1969) 9.43

The dependence of calcium efflux from cardiac muscle on temperature and external ion composition. J Physiol (1968) 8.13

A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart. J Physiol (1883) 8.09

Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle. J Cell Biol (1988) 6.30

Involvement of dihydropyridine receptors in excitation-contraction coupling in skeletal muscle. Nature (1987) 6.29

Calcium cycling and signaling in cardiac myocytes. Annu Rev Physiol (2008) 6.19

Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature (1999) 5.36

Calmodulin is the Ca2+ sensor for Ca2+ -dependent inactivation of L-type calcium channels. Neuron (1999) 5.32

Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science (1997) 4.81

Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium. J Physiol (1985) 4.69

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell (2003) 4.68

Sinoatrial nodal cell ryanodine receptor and Na(+)-Ca(2+) exchanger: molecular partners in pacemaker regulation. Circ Res (2001) 4.42

Sequence motifs for calmodulin recognition. FASEB J (1997) 4.38

Pacemaker mechanisms in cardiac tissue. Annu Rev Physiol (1993) 4.34

Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res (2004) 4.11

Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms. J Physiol (1994) 3.85

Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells. Nature (2001) 3.79

Calcium sparks. Physiol Rev (2008) 3.64

Rapid calcium release from cardiac sarcoplasmic reticulum vesicles is dependent on Ca2+ and is modulated by Mg2+, adenine nucleotide, and calmodulin. J Biol Chem (1987) 3.56

How does adrenaline accelerate the heart? Nature (1979) 3.54

Reduction in density of transverse tubules and L-type Ca(2+) channels in canine tachycardia-induced heart failure. Cardiovasc Res (2001) 3.39

The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium (2003) 3.38

The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes. Science (1990) 3.16

Reconstitution of troponin activity from three protein components. J Biol Chem (1971) 3.13

Reduced synchrony of Ca2+ release with loss of T-tubules-a comparison to Ca2+ release in human failing cardiomyocytes. Cardiovasc Res (2004) 3.10

Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity. J Biol Chem (1991) 3.10

Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps. J Biol Chem (1992) 3.09

Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation. Science (1995) 3.05

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell (2005) 3.01

What keeps us ticking: a funny current, a calcium clock, or both? J Mol Cell Cardiol (2009) 2.99

Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger. Science (1990) 2.95

Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels. Nature (2001) 2.95

Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C. Circ Res (2000) 2.76

Calsequestrin determines the functional size and stability of cardiac intracellular calcium stores: Mechanism for hereditary arrhythmia. Proc Natl Acad Sci U S A (2003) 2.72

Regulation and deregulation of cardiac Na(+)-Ca2+ exchange in giant excised sarcolemmal membrane patches. Nature (1990) 2.68

The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation. Cardiovasc Res (1998) 2.57

Excitation-contraction coupling of isolated cardiac fibers with disrupted or closed sarcolemmas. Calcium-dependent cyclic and tonic contractions. Circ Res (1972) 2.55

CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. J Cell Biol (2005) 2.47

The sarcoplasmic reticulum Ca2+ channel/ryanodine receptor: modulation by endogenous effectors, drugs and disease states. Pharmacol Rev (1997) 2.46

Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol (2010) 2.46

T-tubule function in mammalian cardiac myocytes. Circ Res (2003) 2.44

Ca2+-induced inhibition of the cardiac Ca2+ channel depends on calmodulin. Proc Natl Acad Sci U S A (1999) 2.32

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Phospholamban inhibitory function is activated by depolymerization. J Biol Chem (1997) 2.26

Abnormal intrastore calcium signaling in chronic heart failure. Proc Natl Acad Sci U S A (2005) 2.20

Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers. J Cell Biol (2001) 2.16

Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains. J Biol Chem (1986) 2.09

Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes. Biophys J (2006) 2.03

Intracellular Ca2+ release contributes to automaticity in cat atrial pacemaker cells. J Physiol (2000) 2.00

Abnormal interactions of calsequestrin with the ryanodine receptor calcium release channel complex linked to exercise-induced sudden cardiac death. Circ Res (2006) 1.99

Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase. Am J Physiol (1994) 1.98

Structural and functional characterization of the purified cardiac ryanodine receptor-Ca2+ release channel complex. J Biol Chem (1989) 1.97

Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A (2009) 1.95

Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel. Cell (2008) 1.95

Macromolecular complexes regulating cardiac ryanodine receptor function. J Mol Cell Cardiol (2004) 1.93

Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation. J Gen Physiol (1992) 1.92

Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells. Nature (1986) 1.86

Biology of the troponin complex in cardiac myocytes. Prog Cardiovasc Dis (2005) 1.83

Ca2+-sensitive inactivation of L-type Ca2+ channels depends on multiple cytoplasmic amino acid sequences of the alpha1C subunit. Proc Natl Acad Sci U S A (1998) 1.81

The stimulation of calcium transport in cardiac sarcoplasmic reticulum by adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1974) 1.81

Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation. Circ Res (2004) 1.80

Sarcomeric proteins and inherited cardiomyopathies. Cardiovasc Res (2007) 1.75

Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol (2009) 1.72

Abnormal calcium signaling and sudden cardiac death associated with mutation of calsequestrin. Circ Res (2004) 1.71

Intermolecular failure of L-type Ca2+ channel and ryanodine receptor signaling in hypertrophy. PLoS Biol (2007) 1.70

Heart failure after myocardial infarction: altered excitation-contraction coupling. Circulation (2001) 1.69

Phosphorylation of the calcium antagonist receptor of the voltage-sensitive calcium channel by cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1985) 1.67

Locations of calmodulin and FK506-binding protein on the three-dimensional architecture of the skeletal muscle ryanodine receptor. J Biol Chem (1997) 1.66

Sarcoplasmic reticulum calsequestrins: structural and functional properties. Mol Cell Biochem (1994) 1.66

Beta-adrenergic receptor signaling in the heart: role of CaMKII. J Mol Cell Cardiol (2009) 1.65

Selective binding of FKBP12.6 by the cardiac ryanodine receptor. J Biol Chem (1996) 1.64

Modulation of cardiac ryanodine receptors of swine and rabbit by a phosphorylation-dephosphorylation mechanism. J Physiol (1995) 1.63

Predetermined recruitment of calcium release sites underlies excitation-contraction coupling in rat atrial myocytes. J Physiol (2001) 1.62

The T-tubule system in the specialized and general myocardium of the rat. J Anat (1978) 1.62

Dual regulation of Ca2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx. Proc Natl Acad Sci U S A (1994) 1.61

Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling. J Clin Invest (2006) 1.59

Calmodulin binding and inhibition of cardiac muscle calcium release channel (ryanodine receptor). J Biol Chem (2001) 1.58

What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis? J Mol Cell Cardiol (2008) 1.55

Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes. J Mol Cell Cardiol (2008) 1.50

The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction. J Cell Sci (2004) 1.47

Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy. Proc Natl Acad Sci U S A (2009) 1.44

Structure of the skeletal muscle calcium release channel activated with Ca2+ and AMP-PCP. Biophys J (1999) 1.43

SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure. Circ Arrhythm Electrophysiol (2011) 1.40

Calcium signaling in cardiac ventricular myocytes. Ann N Y Acad Sci (2005) 1.40

Phospholemman inhibition of the cardiac Na+/Ca2+ exchanger. Role of phosphorylation. J Biol Chem (2006) 1.39

Phospholemman modulates Na+/Ca2+ exchange in adult rat cardiac myocytes. Am J Physiol Heart Circ Physiol (2002) 1.36

Retracted Calmodulin kinase and a calmodulin-binding 'IQ' domain facilitate L-type Ca2+ current in rabbit ventricular myocytes by a common mechanism. J Physiol (2001) 1.34

The Ca(v)3.2 T-type Ca(2+) channel is required for pressure overload-induced cardiac hypertrophy in mice. Circ Res (2009) 1.34

Calmodulin kinase is a molecular switch for cardiac excitation-contraction coupling. Proc Natl Acad Sci U S A (2001) 1.34

The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ Res (2010) 1.34

Serine 68 of phospholemman is critical in modulation of contractility, [Ca2+]i transients, and Na+/Ca2+ exchange in adult rat cardiac myocytes. Am J Physiol Heart Circ Physiol (2005) 1.30

Apocalmodulin and Ca2+ calmodulin bind to the same region on the skeletal muscle Ca2+ release channel. Biochemistry (1999) 1.29

Phosphorylation of phospholamban by calcium-activated, phospholipid-dependent protein kinase. Stimulation of cardiac sarcoplasmic reticulum calcium uptake. J Biol Chem (1984) 1.28

Sodium/calcium exchanger (NCX1) macromolecular complex. J Biol Chem (2003) 1.28

Calcium signalling during excitation-contraction coupling in mammalian atrial myocytes. J Cell Sci (2006) 1.28

Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol (2003) 18.97

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol (2008) 9.37

The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity (2007) 4.74

2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release. FASEB J (2002) 3.60

Mitochondria are morphologically and functionally heterogeneous within cells. EMBO J (2002) 2.97

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate. J Cell Biol (2004) 2.87

Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization. Circ Res (2008) 2.16

The role of inositol 1,4,5-trisphosphate receptors in Ca(2+) signalling and the generation of arrhythmias in rat atrial myocytes. J Physiol (2002) 2.05

2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels. Cell Calcium (2003) 1.75

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals. Mol Cell (2008) 1.71

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor. Proc Natl Acad Sci U S A (2009) 1.61

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis. Proc Natl Acad Sci U S A (2008) 1.59

Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins. EMBO J (2003) 1.58

XTRPC1-dependent chemotropic guidance of neuronal growth cones. Nat Neurosci (2005) 1.55

Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes. J Mol Cell Cardiol (2008) 1.50

The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction. J Cell Sci (2004) 1.47

Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy. Proc Natl Acad Sci U S A (2009) 1.44

Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes. Mol Cell (2009) 1.42

Cell signalling: IP3 receptors channel calcium into cell death. Curr Biol (2004) 1.37

Calcium signalling during excitation-contraction coupling in mammalian atrial myocytes. J Cell Sci (2006) 1.28

Mechanisms underlying the neuronal calcium sensor-1-evoked enhancement of exocytosis in PC12 cells. J Biol Chem (2002) 1.28

An update on nuclear calcium signalling. J Cell Sci (2009) 1.21

Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation. J Neurosci (2003) 1.21

Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes. J Cell Sci (2006) 1.20

Mitochondria are morphologically heterogeneous within cells. J Exp Biol (2003) 1.18

Atrial cardiomyocyte calcium signalling. Biochim Biophys Acta (2011) 1.16

The primary substrate binding site in the b' domain of ERp57 is adapted for endoplasmic reticulum lectin association. J Biol Chem (2004) 1.15

Calcium signalling: more messengers, more channels, more complexity. Curr Biol (2002) 1.15

Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content. Cell Calcium (2008) 1.11

Comparison of the T-tubule system in adult rat ventricular and atrial myocytes, and its role in excitation-contraction coupling and inotropic stimulation. Cell Calcium (2010) 1.11

Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy. J Cell Biol (2012) 1.08

Subcellular calcium dynamics in a whole-cell model of an atrial myocyte. Proc Natl Acad Sci U S A (2012) 1.07

CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+. J Cell Biol (2005) 1.06

Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease. Cell Calcium (2011) 1.01

The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth. Br J Pharmacol (2013) 1.00

The cellular concentration of Bcl-2 determines its pro- or anti-apoptotic effect. Cell Calcium (2008) 0.97

Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1. Cell Calcium (2007) 0.94

Critical role of phospholipase Cgamma1 in the generation of H2O2-evoked [Ca2+]i oscillations in cultured rat cortical astrocytes. J Biol Chem (2006) 0.93

Calcium oscillations. Adv Exp Med Biol (2008) 0.93

Calcium-induced calcium release. Curr Biol (2003) 0.93

Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. Biochem J (2004) 0.90

Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate. J Org Chem (2007) 0.90

Exposure to GSM RF fields does not affect calcium homeostasis in human endothelial cells, rat pheocromocytoma cells or rat hippocampal neurons. PLoS One (2010) 0.87

Why, where, and when do cardiac myocytes express inositol 1,4,5-trisphosphate receptors? Am J Physiol Heart Circ Physiol (2007) 0.87

Inositol 1,4,5-trisphosphate receptors in the heart. Biol Res (2004) 0.87

Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate. Proc Natl Acad Sci U S A (2002) 0.86

Non-immortalized human neural stem (NS) cells as a scalable platform for cellular assays. Neurochem Int (2011) 0.85

Methacholine and PDGF activate store-operated calcium entry in neuronal precursor cells via distinct calcium entry channels. Biol Res (2008) 0.84

Elevated InsP3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes. Channels (Austin) (2010) 0.83

Pacemaking, arrhythmias, inotropy and hypertrophy: the many possible facets of IP3 signalling in cardiac myocytes. J Physiol (2007) 0.82

Glucocorticoid-mediated inhibition of Lck modulates the pattern of T cell receptor-induced calcium signals by down-regulating inositol 1,4,5-trisphosphate receptors. J Biol Chem (2009) 0.82

Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization. Biochem J (2003) 0.81

Alzheimer's disease-associated peptide Aβ42 mobilizes ER Ca(2+) via InsP3R-dependent and -independent mechanisms. Front Mol Neurosci (2013) 0.80

Epigenetics in the heart: the role of histone modifications in cardiac remodelling. Biochem Soc Trans (2013) 0.80

Using calcium imaging as a readout of GPCR activation. Methods Mol Biol (2011) 0.79

Oncogenic K-Ras suppresses IP₃-dependent Ca²⁺ release through remodelling of the isoform composition of IP₃Rs and ER luminal Ca²⁺ levels in colorectal cancer cell lines. J Cell Sci (2014) 0.79

Redoxing calcium from the ER. Cell (2005) 0.78

Interaction between store-operated and arachidonate-activated calcium entry. Cell Calcium (2006) 0.78

Persistence of pro-arrhythmic spatio-temporal calcium patterns in atrial myocytes: a computational study of ping waves. Front Physiol (2012) 0.77

Calcium influx: is Homer the missing link? Curr Biol (2003) 0.77

Dynamic imaging of calcium and STIM1 in the same cell using wide-field and TIRF microscopy. Biotechniques (2008) 0.77

New Ca2+ indicator has freedom to express. Chem Biol (2006) 0.75