Calcium Sparks in the Heart: Dynamics and Regulation.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27212876)

Published in Res Rep Biol on October 16, 2015

Authors

Tuan M Hoang-Trong1, Aman Ullah1, M Saleet Jafri2

Author Affiliations

1: Department of Molecular Neuroscience, Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030.
2: Department of Molecular Neuroscience, Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030; Biomedical Engineering and Technology, University of Maryland, Baltimore, MD 20201.

Articles cited by this

(truncated to the top 100)

The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol (2000) 19.46

Cardiac excitation-contraction coupling. Nature (2002) 18.48

Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science (1993) 17.63

Calcium signaling. Cell (2007) 11.09

Relaxation of arterial smooth muscle by calcium sparks. Science (1995) 10.27

Theory of excitation-contraction coupling in cardiac muscle. Biophys J (1992) 8.57

Ryanodine receptor adaptation: control mechanism of Ca(2+)-induced Ca2+ release in heart. Science (1993) 7.48

Neuronal calcium signaling. Neuron (1998) 7.03

The control of calcium release in heart muscle. Science (1995) 6.05

Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation (2001) 5.68

Calcium sparks and [Ca2+]i waves in cardiac myocytes. Am J Physiol (1996) 5.18

Two mechanisms of quantized calcium release in skeletal muscle. Nature (1996) 4.95

Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes. Am J Physiol (1995) 4.15

Regulation of the cardiac ryanodine receptor channel by luminal Ca2+ involves luminal Ca2+ sensing sites. Biophys J (1998) 3.69

T-tubule remodeling during transition from hypertrophy to heart failure. Circ Res (2010) 3.57

Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane. J Biol Chem (1997) 3.50

Submicroscopic calcium signals as fundamental events of excitation--contraction coupling in guinea-pig cardiac myocytes. J Physiol (1996) 3.45

Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques. Circ Res (1999) 3.42

A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. Am J Hum Genet (2001) 3.38

Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release. Biophys J (2002) 3.38

Relation between the sarcolemmal Ca2+ current and Ca2+ sparks and local control theories for cardiac excitation-contraction coupling. Circ Res (1996) 3.30

Calcium fluxes involved in control of cardiac myocyte contraction. Circ Res (2000) 3.28

X-ROS signaling: rapid mechano-chemo transduction in heart. Science (2011) 3.20

Deaths: final data for 2009. Natl Vital Stat Rep (2011) 3.18

Local control models of cardiac excitation-contraction coupling. A possible role for allosteric interactions between ryanodine receptors. J Gen Physiol (1999) 3.14

Local, stochastic release of Ca2+ in voltage-clamped rat heart cells: visualization with confocal microscopy. J Physiol (1994) 3.12

Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation. Science (1995) 3.05

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass. J Mol Cell Cardiol (2009) 2.98

Luminal Ca2+ controls termination and refractory behavior of Ca2+-induced Ca2+ release in cardiac myocytes. Circ Res (2002) 2.89

Coupled gating between cardiac calcium release channels (ryanodine receptors). Circ Res (2001) 2.71

Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation (2012) 2.58

Ca2+ blinks: rapid nanoscopic store calcium signaling. Proc Natl Acad Sci U S A (2005) 2.56

T-tubule function in mammalian cardiac myocytes. Circ Res (2003) 2.44

Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Biophys J (1998) 2.41

Recent advances in the molecular pathophysiology of atrial fibrillation. J Clin Invest (2011) 2.38

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes. Proc Natl Acad Sci U S A (2009) 2.29

An estimate of the calcium content of the sarcoplasmic reticulum in rat ventricular myocytes. Pflugers Arch (1993) 2.22

Sterological measurements of cardiac ultrastructures implicated in excitation-contraction coupling. Proc Natl Acad Sci U S A (1971) 2.22

A study of the T system in rat heart. J Cell Biol (1970) 2.20

Ca2+ sparks and Ca2+ waves in saponin-permeabilized rat ventricular myocytes. J Physiol (1999) 2.15

Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion. Circ Res (2008) 2.12

Ca2+ 'sparks' and waves in intact ventricular muscle resolved by confocal imaging. Circ Res (1997) 2.04

Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes. Biophys J (2006) 2.03

CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation. Circ Res (2010) 2.02

Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes. J Physiol (2010) 2.01

Atrial fibrillation is associated with increased spontaneous calcium release from the sarcoplasmic reticulum in human atrial myocytes. Circulation (2004) 1.97

Regulation of sarcoplasmic reticulum calcium release by luminal calcium in cardiac muscle. Front Biosci (2002) 1.84

Quarky calcium release in the heart. Circ Res (2010) 1.75

Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. Circulation (2013) 1.69

Termination of Ca2+ release during Ca2+ sparks in rat ventricular myocytes. J Physiol (1998) 1.68

Locations of calmodulin and FK506-binding protein on the three-dimensional architecture of the skeletal muscle ryanodine receptor. J Biol Chem (1997) 1.66

Sarcoplasmic reticulum calsequestrins: structural and functional properties. Mol Cell Biochem (1994) 1.66

Calcium sparks in intact skeletal muscle fibers of the frog. J Gen Physiol (2001) 1.65

Cardiac intracellular calcium release channels: role in heart failure. Circ Res (2000) 1.62

Dynamics of calcium sparks and calcium leak in the heart. Biophys J (2011) 1.57

Comparative ultrastructure of Ca2+ release units in skeletal and cardiac muscle. Ann N Y Acad Sci (1998) 1.54

Microtubules underlie dysfunction in duchenne muscular dystrophy. Sci Signal (2012) 1.54

Novel features of the rabbit transverse tubular system revealed by quantitative analysis of three-dimensional reconstructions from confocal images. Biophys J (2008) 1.47

Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction. Circ Res (2012) 1.47

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression. Circ Res (2014) 1.47

Role of the transverse-axial tubule system in generating calcium sparks and calcium transients in rat atrial myocytes. J Physiol (2003) 1.45

The transverse-axial tubular system (TATS) of mouse myocardium: its morphology in the developing and adult animal. Am J Anat (1984) 1.40

Calcium waves driven by "sensitization" wave-fronts. Cardiovasc Res (2007) 1.38

Catecholaminergic polymorphic ventricular tachycardia. Prog Cardiovasc Dis (2008) 1.37

Emerging mechanisms of T-tubule remodelling in heart failure. Cardiovasc Res (2013) 1.35

Evolution of cardiac calcium waves from stochastic calcium sparks. Biophys J (2001) 1.34

Effect of changes in action potential spike configuration, junctional sarcoplasmic reticulum micro-architecture and altered t-tubule structure in human heart failure. J Muscle Res Cell Motil (2006) 1.29

Models of Ca2+ release channel adaptation. Science (1995) 1.22

Understanding calcium waves and sparks in central neurons. Nat Rev Neurosci (2012) 1.18

Ryanodine receptor and calsequestrin in arrhythmogenesis: what we have learnt from genetic diseases and transgenic mice. J Mol Cell Cardiol (2008) 1.17

Calcium concentration and movement in the ventricular cardiac cell during an excitation-contraction cycle. Biophys J (1998) 1.15

Store overload-induced Ca2+ release as a triggering mechanism for CPVT and MH episodes caused by mutations in RYR and CASQ genes. J Physiol (2009) 1.14

Termination of calcium-induced calcium release by induction decay: an emergent property of stochastic channel gating and molecular scale architecture. J Mol Cell Cardiol (2012) 1.10

A thermodynamic model of the cardiac sarcoplasmic/endoplasmic Ca(2+) (SERCA) pump. Biophys J (2009) 1.10

Predicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytes. Biophys J (2010) 1.10

Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia. Proc Natl Acad Sci U S A (2013) 1.09

Transverse tubules are a common feature in large mammalian atrial myocytes including human. Am J Physiol Heart Circ Physiol (2011) 1.08

Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease. Circ Res (2014) 1.06

Ryanodine receptor luminal Ca2+ regulation: swapping calsequestrin and channel isoforms. Biophys J (2009) 1.05

Pernicious attrition and inter-RyR2 CICR current control in cardiac muscle. J Mol Cell Cardiol (2013) 1.03

FKBP12.6 overexpression decreases Ca2+ spark amplitude but enhances [Ca2+]i transient in rat cardiac myocytes. Am J Physiol Heart Circ Physiol (2004) 1.01

Calcium signaling in cardiac myocytes. Cold Spring Harb Perspect Biol (2011) 1.00

Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View. Biomed Res Int (2015) 0.99

Na-Ca exchange and Ca fluxes during contraction and relaxation in mammalian ventricular muscle. Ann N Y Acad Sci (1996) 0.96

Computational modeling and numerical methods for spatiotemporal calcium cycling in ventricular myocytes. Front Physiol (2012) 0.95

Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response. Proc Natl Acad Sci U S A (2013) 0.93

Ca2+ spark termination: inactivation and adaptation may be manifestations of the same mechanism. J Gen Physiol (1999) 0.91

Nuclear calcium signalling. Cell Mol Life Sci (2000) 0.90

Spatial nonuniformity of excitation-contraction coupling causes arrhythmogenic Ca2+ waves in rat cardiac muscle. Circ Res (2005) 0.90

Models of cardiac excitation-contraction coupling in ventricular myocytes. Math Biosci (2010) 0.89

Role of sarcomere mechanics and Ca2+ overload in Ca2+ waves and arrhythmias in rat cardiac muscle. Ann N Y Acad Sci (2006) 0.84

Integrative modeling of the cardiac ventricular myocyte. Wiley Interdiscip Rev Syst Biol Med (2010) 0.84

Flecainide acetate for the treatment of atrial and ventricular arrhythmias. Expert Opin Pharmacother (2013) 0.81

Modeling the cellular basis of altered excitation-contraction coupling in heart failure. Prog Biophys Mol Biol (1998) 0.80

Calcium in the heart: from physiology to disease. Exp Physiol (2014) 0.80

T-tubules and ryanodine receptor microdomains: on the road to translation. Cardiovasc Res (2013) 0.79

Modeling Local X-ROS and Calcium Signaling in the Heart. Biophys J (2015) 0.78

Ca2+ sparks and puffs are generated and interact in rat hippocampal CA1 pyramidal neuron dendrites. J Neurosci (2013) 0.77

Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves. Conf Proc IEEE Eng Med Biol Soc (2011) 0.77