Published in Nat Rev Mol Cell Biol on September 11, 2008
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer (2010) 6.27
Integrative epigenomic mapping defines four main chromatin states in Arabidopsis. EMBO J (2011) 3.16
Unlimited multistability in multisite phosphorylation systems. Nature (2009) 2.57
p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54
High throughput characterization of combinatorial histone codes. Mol Cell Proteomics (2009) 2.52
Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code. Proc Natl Acad Sci U S A (2010) 2.47
The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer (2009) 2.13
The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. Mol Cell (2010) 2.06
Operating on chromatin, a colorful language where context matters. J Mol Biol (2011) 2.00
Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway. Cell Signal (2010) 1.99
Influence of combinatorial histone modifications on antibody and effector protein recognition. Curr Biol (2010) 1.93
Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding. Wiley Interdiscip Rev Syst Biol Med (2012) 1.81
Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). Nucl Recept Signal (2009) 1.80
RNA templating the epigenome: long noncoding RNAs as molecular scaffolds. Epigenetics (2011) 1.75
Finding one's way in proteomics: a protein species nomenclature. Chem Cent J (2009) 1.75
The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon. EMBO Rep (2009) 1.69
A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. Genes Dev (2009) 1.49
The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Res (2009) 1.46
Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA. Oncogene (2013) 1.44
Epigenetic regulation of the neural transcriptome: the meaning of the marks. Nat Neurosci (2010) 1.44
Vitamin A and retinoid signaling: genomic and nongenomic effects. J Lipid Res (2013) 1.43
Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat Cell Biol (2011) 1.40
Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization. Genes Dev (2012) 1.38
Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB. Mol Cell Biol (2010) 1.36
A statistical framework for modeling gene expression using chromatin features and application to modENCODE datasets. Genome Biol (2011) 1.36
Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth. EMBO J (2011) 1.33
Surf the post-translational modification network of p53 regulation. Int J Biol Sci (2012) 1.25
Proteoglycomics: recent progress and future challenges. OMICS (2010) 1.25
The fission yeast HIRA histone chaperone is required for promoter silencing and the suppression of cryptic antisense transcripts. Mol Cell Biol (2009) 1.25
Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell (2012) 1.23
Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code. EMBO J (2010) 1.22
Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription. PLoS Genet (2012) 1.21
EZH2: not EZHY (easy) to deal. Mol Cancer Res (2014) 1.20
Epigenetic regulatory mechanisms in vertebrate eye development and disease. Heredity (Edinb) (2010) 1.16
Alcohol-induced protein hyperacetylation: mechanisms and consequences. World J Gastroenterol (2009) 1.15
Targeting Huntington's disease through histone deacetylases. Clin Epigenetics (2011) 1.13
Peptide microarrays to interrogate the "histone code". Methods Enzymol (2012) 1.13
Application of Celluspots peptide arrays for the analysis of the binding specificity of epigenetic reading domains to modified histone tails. BMC Biochem (2011) 1.13
Epigenetic mechanisms facilitating oligodendrocyte development, maturation, and aging. Glia (2009) 1.09
Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3. Mol Cell Biol (2011) 1.08
Interrogating the function of metazoan histones using engineered gene clusters. Dev Cell (2015) 1.07
Cardiac deletion of Smyd2 is dispensable for mouse heart development. PLoS One (2010) 1.06
The structural and functional signatures of proteins that undergo multiple events of post-translational modification. Protein Sci (2014) 1.05
Lysine-specific modifications of p53: a matter of life and death? Oncotarget (2013) 1.03
Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling. PLoS One (2012) 1.03
Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns. Mol Cell Proteomics (2011) 1.03
Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. J Mol Biol (2010) 1.03
Chromatin dynamics associated with HIV-1 Tat-activated transcription. Biochim Biophys Acta (2009) 1.01
Haspin: a newly discovered regulator of mitotic chromosome behavior. Chromosoma (2009) 1.00
p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation. PLoS One (2011) 1.00
Deciphering post-translational modification codes. FEBS Lett (2013) 0.99
Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9. J Biol Chem (2010) 0.97
The dynamics of individual nucleosomes controls the chromatin condensation pathway: direct atomic force microscopy visualization of variant chromatin. Biophys J (2009) 0.96
Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function. PLoS One (2010) 0.94
Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association. J Biol Chem (2009) 0.93
Posttranslational modifications of the retinoblastoma tumor suppressor protein as determinants of function. Genes Cancer (2012) 0.93
RIP140 in thyroid hormone-repression and chromatin remodeling of Crabp1 gene during adipocyte differentiation. Nucleic Acids Res (2009) 0.92
Proteome-wide survey of phosphorylation patterns affected by nuclear DNA polymorphisms in Arabidopsis thaliana. BMC Genomics (2010) 0.92
Natural single-nucleosome epi-polymorphisms in yeast. PLoS Genet (2010) 0.91
It takes two to tango: Ubiquitin and SUMO in the DNA damage response. Front Genet (2013) 0.90
In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide. Proc Natl Acad Sci U S A (2016) 0.90
Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae. BMC Mol Biol (2009) 0.90
The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status. Mol Cell (2012) 0.89
NEDDylation regulates E2F-1-dependent transcription. EMBO Rep (2012) 0.89
Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation. J Biol Chem (2010) 0.89
The biology of lysine acetylation integrates transcriptional programming and metabolism. Nutr Metab (Lond) (2011) 0.87
Extensive post-translational modification of active and inactivated forms of endogenous p53. Mol Cell Proteomics (2013) 0.86
On your histone mark, SET, methylate! Epigenetics (2013) 0.85
Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proc Natl Acad Sci U S A (2011) 0.84
SUMO chain formation is required for response to replication arrest in S. pombe. PLoS One (2009) 0.83
Antibody screening identifies 78 putative host proteins involved in Cyprinid herpesvirus 3 infection or propagation in common carp, Cyprinus carpio L. J Fish Dis (2013) 0.83
Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression. ASN Neuro (2015) 0.83
Elements of the cellular metabolic structure. Front Mol Biosci (2015) 0.83
Epigenetic dysregulation in cancer. Am J Pathol (2009) 0.82
Epigenetic setting and reprogramming for neural cell fate determination and differentiation. Philos Trans R Soc Lond B Biol Sci (2014) 0.82
Signal transduction: From the atomic age to the post-genomic era. Cold Spring Harb Perspect Biol (2014) 0.82
Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs. Transcription (2012) 0.82
Polycomb repressive complex's evolutionary conserved function: the role of EZH2 status and cellular background. Clin Epigenetics (2016) 0.81
PolyADP-ribosylation is required for pronuclear fusion during postfertilization in mice. PLoS One (2010) 0.80
Cell cycle-dependent acetylation of Rb2/p130 in NIH3T3 cells. Oncogene (2010) 0.80
Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry. J Proteomics (2015) 0.80
Human EHMT2/G9a activates p53 through methylation-independent mechanism. Oncogene (2016) 0.79
Initiation of meiotic homologous recombination: flexibility, impact of histone modifications, and chromatin remodeling. Cold Spring Harb Perspect Biol (2015) 0.79
Analysis of T4SS-induced signaling by H. pylori using quantitative phosphoproteomics. Front Microbiol (2014) 0.79
The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97. Front Mol Biosci (2017) 0.79
In vitro phosphorylation and acetylation of the murine pocket protein Rb2/p130. PLoS One (2012) 0.78
ATP6AP2/(pro)renin receptor contributes to glucose metabolism via stabilizing the pyruvate dehydrogenase E1 β subunit. J Biol Chem (2015) 0.77
Systematic Analysis and Prediction of In Situ Cross Talk of O-GlcNAcylation and Phosphorylation. Biomed Res Int (2015) 0.77
Defining the chromatin landscape in demyelinating disorders. Neurobiol Dis (2009) 0.77
Direct interrogation of the role of H3K9 in metazoan heterochromatin function. Genes Dev (2016) 0.77
Identification of Posttranslational Modifications in Peroxisome Proliferator-Activated Receptor γ Using Mass Spectrometry. PPAR Res (2014) 0.76
Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus. Virol J (2011) 0.76
Flynet: a genomic resource for Drosophila melanogaster transcriptional regulatory networks. Bioinformatics (2009) 0.76
Impact of the adenoviral E4 Orf3 protein on the activity and posttranslational modification of p53. J Virol (2015) 0.76
Partners in crime: The role of tandem modules in gene transcription. Protein Sci (2015) 0.76
The role of O-GlcNAc transferase in regulating the gene transcription of developing and failing hearts. Future Cardiol (2014) 0.75
Mass spectrometric analysis of mono- and multi-phosphopeptides by selective binding with NiZnFe₂O₄ magnetic nanoparticles. Nat Commun (2013) 0.75
Pairwise detection of site-specific receptor phosphorylations using single-molecule blotting. Nat Commun (2016) 0.75
PRMT5-Mediated Methylation of NF-κB p65 at Arg174 Is Required for Endothelial CXCL11 Gene Induction in Response to TNF-α and IFN-γ Costimulation. PLoS One (2016) 0.75
Dichotomy in the Epigenetic Mark Lysine Acetylation is Critical for the Proliferation of Prostate Cancer Cells. Cancers (Basel) (2015) 0.75
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
The Polycomb complex PRC2 and its mark in life. Nature (2011) 11.97
Elongation by RNA polymerase II: the short and long of it. Genes Dev (2004) 9.17
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
A unified theory of gene expression. Cell (2002) 7.61
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41
Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75
Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev (2004) 6.19
Histones: annotating chromatin. Annu Rev Genet (2009) 5.93
FACT facilitates transcription-dependent nucleosome alteration. Science (2003) 5.83
Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (2003) 5.80
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell (2002) 5.59
Histone lysine methylation: a signature for chromatin function. Trends Genet (2003) 5.55
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
The key to development: interpreting the histone code? Curr Opin Genet Dev (2005) 4.96
Molecular signals of epigenetic states. Science (2010) 4.81
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci U S A (2005) 4.57
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20
Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell (2005) 4.04
Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03
Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation. Cell (2003) 3.82
L3MBTL1, a histone-methylation-dependent chromatin lock. Cell (2007) 3.70
Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev (2010) 3.49
Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev (2002) 3.37
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell (2012) 3.28
Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo. Science (2003) 3.22
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12
Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell (2005) 3.01
Facultative heterochromatin: is there a distinctive molecular signature? Mol Cell (2007) 2.94
Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol (2008) 2.93
Histone H3 Lys 4 methylation: caught in a bind? Genes Dev (2006) 2.86
Asymmetrically modified nucleosomes. Cell (2012) 2.79
A double take on bivalent promoters. Genes Dev (2013) 2.79
Genomic comparison of the ants Camponotus floridanus and Harpegnathos saltator. Science (2010) 2.78
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev (2007) 2.77
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature (2007) 2.76
The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev (2005) 2.70
G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64
Histone lysine demethylases and their impact on epigenetics. Cell (2006) 2.54
PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev (2005) 2.51
Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50
Genome-wide and caste-specific DNA methylomes of the ants Camponotus floridanus and Harpegnathos saltator. Curr Biol (2012) 2.50
Histone variants meet their match. Nat Rev Mol Cell Biol (2005) 2.47
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol (2009) 2.47
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell (2005) 2.44
Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol Cell Biol (2004) 2.43
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Mol Cell (2010) 2.39
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
Drosophila Paf1 modulates chromatin structure at actively transcribed genes. Mol Cell Biol (2006) 2.16
Chromatin higher-order structures and gene regulation. Curr Opin Genet Dev (2011) 2.08
The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. J Biol Chem (2009) 2.06
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem (2009) 2.02
The constantly changing face of chromatin. Sci Aging Knowledge Environ (2003) 2.02
Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. Proc Natl Acad Sci U S A (2004) 2.01
PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells. Nat Struct Mol Biol (2013) 2.01
Recent highlights of RNA-polymerase-II-mediated transcription. Curr Opin Cell Biol (2004) 1.91
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription. Genes Dev (2012) 1.81
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell (2012) 1.78
Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A (2002) 1.75
Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol (2007) 1.75
The program for processing newly synthesized histones H3.1 and H4. Nat Struct Mol Biol (2010) 1.71
CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53. Genes Dev (2014) 1.62
Functional analysis of the subunits of the chromatin assembly factor RSF. Mol Cell Biol (2003) 1.56
Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Mol Cell (2005) 1.52
MBT domain proteins in development and disease. Semin Cell Dev Biol (2009) 1.49
Functional characterization of core promoter elements: the downstream core element is recognized by TAF1. Mol Cell Biol (2005) 1.46
Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality. Genome Res (2013) 1.45
Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44
A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev (2011) 1.43
The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation. J Biol Chem (2010) 1.41
The mediator coactivator complex: functional and physical roles in transcriptional regulation. J Cell Sci (2003) 1.41
Facts about FACT and transcript elongation through chromatin. Curr Opin Genet Dev (2004) 1.40
Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. Mol Cell Biol (2004) 1.38
ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol Cell Biol (2003) 1.34
L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell (2011) 1.32
Histone chaperone FACT action during transcription through chromatin by RNA polymerase II. Proc Natl Acad Sci U S A (2013) 1.32
Methods and tips for the purification of human histone methyltransferases. Methods (2003) 1.31
Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. J Biol Chem (2009) 1.28
Phylogenetic and transcriptomic analysis of chemosensory receptors in a pair of divergent ant species reveals sex-specific signatures of odor coding. PLoS Genet (2012) 1.27
FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation. Mol Cell Biol (2002) 1.26
The role of PR-Set7 in replication licensing depends on Suv4-20h. Genes Dev (2012) 1.22
Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. Proc Natl Acad Sci U S A (2003) 1.20
Epigenetic inheritance: uncontested? Cell Res (2011) 1.19
Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev (2012) 1.19
Transcription through chromatin: understanding a complex FACT. Biochim Biophys Acta (2004) 1.15
SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol (2012) 1.12
Processing the H3K36me3 signature. Nat Genet (2009) 1.10
Highly compacted chromatin formed in vitro reflects the dynamics of transcription activation in vivo. Mol Cell (2010) 1.08
Beyond histone methyl-lysine binding: how malignant brain tumor (MBT) protein L3MBTL1 impacts chromatin structure. Cell Cycle (2008) 1.08
EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev (2012) 1.07
New chaps in the histone chaperone arena. Genes Dev (2010) 1.06