Published in Proc Natl Acad Sci U S A on September 07, 2011
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A "sliding scale rule" for selectivity among NO, CO, and O₂ by heme protein sensors. Biochemistry (2011) 0.95
Folding helical proteins in explicit solvent using dihedral-biased tempering. Proc Natl Acad Sci U S A (2012) 0.89
How do heme-protein sensors exclude oxygen? Lessons learned from cytochrome c', Nostoc puntiforme heme nitric oxide/oxygen-binding domain, and soluble guanylyl cyclase. Antioxid Redox Signal (2012) 0.89
NO* binds human cystathionine β-synthase quickly and tightly. J Biol Chem (2014) 0.81
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Ultrahigh resolution structures of nitrophorin 4: heme distortion in ferrous CO and NO complexes. Biochemistry (2005) 1.25
Resonance Raman studies of cytochrome c' support the binding of NO and CO to opposite sides of the heme: implications for ligand discrimination in heme-based sensors. Biochemistry (2001) 1.19
Is the CO adduct of myoglobin bent, and does it matter? Acc Chem Res (2001) 1.18
Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis. Structure (2009) 1.15
Visualizing breathing motion of internal cavities in concert with ligand migration in myoglobin. Proc Natl Acad Sci U S A (2009) 1.10
Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions. Biochemistry (2006) 1.08
Measurement of rate constants for reactions of O2, CO, and NO with hemoglobin. Methods Mol Med (2003) 1.01
Accessibility of the distal heme face, rather than Fe-His bond strength, determines the heme-nitrosyl coordination number of cytochromes c': evidence from spectroscopic studies. Biochemistry (2005) 1.00
Ligand migration and binding in the dimeric hemoglobin of Scapharca inaequivalvis. Biochemistry (2007) 1.00
Activation parameters for heme-NO binding in alcaligenes xylosoxidans cytochrome c': the putative dinitrosyl intermediate forms via a dissociative mechanism. J Am Chem Soc (2009) 0.98
Modulation of NO binding to cytochrome c' by distal and proximal haem pocket residues. J Biol Inorg Chem (2008) 0.89
Experimentally restrained molecular dynamics simulations for characterizing the open states of cytochrome P450cam. Biochemistry (2011) 0.85
X-ray structure of nitric oxide reductase (cytochrome P450nor) at atomic resolution. Acta Crystallogr D Biol Crystallogr (2001) 0.79
Atomic description of an enzyme reaction dominated by proton tunneling. Science (2006) 2.84
Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS. Nat Struct Biol (2003) 2.26
Determinants of Indian physicians' satisfaction & dissatisfaction from their job. Indian J Med Res (2014) 2.09
Assessment of owner willingness to treat or manage diseases of dogs and cats as a guide to shelter animal adoptability. J Am Vet Med Assoc (2013) 1.98
Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2007) 1.92
Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants. Proc Natl Acad Sci U S A (2004) 1.76
The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis. J Mol Biol (2003) 1.68
Good vibrations in enzyme-catalysed reactions. Nat Chem (2012) 1.62
A family of nanoporous materials based on an amino acid backbone. Angew Chem Int Ed Engl (2006) 1.51
Combined NIRS and IVUS imaging detects vulnerable plaque using a single catheter system: a head-to-head comparison with OCT. EuroIntervention (2014) 1.44
Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation. J Cell Sci (2003) 1.40
Dynamics driving function: new insights from electron transferring flavoproteins and partner complexes. FEBS J (2007) 1.38
What's in a covalent bond? On the role and formation of covalently bound flavin cofactors. FEBS J (2009) 1.35
Six- to five-coordinate heme-nitrosyl conversion in cytochrome c' and its relevance to guanylate cyclase. Biochemistry (2002) 1.34
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. Proc Natl Acad Sci U S A (2012) 1.34
Biotransformation of explosives by the old yellow enzyme family of flavoproteins. Appl Environ Microbiol (2004) 1.31
Atomic resolution structures of resting-state, substrate- and product-complexed Cu-nitrite reductase provide insight into catalytic mechanism. Proc Natl Acad Sci U S A (2005) 1.28
A new conceptual framework for enzyme catalysis. Hydrogen tunnelling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes. Eur J Biochem (2002) 1.26
Transmission and epidemiology of zoonotic protozoal diseases of companion animals. Clin Microbiol Rev (2013) 1.23
Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase. EMBO J (2003) 1.22
Variable metallation of human superoxide dismutase: atomic resolution crystal structures of Cu-Zn, Zn-Zn and as-isolated wild-type enzymes. J Mol Biol (2005) 1.21
Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis. J Biol Chem (2008) 1.20
Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase. J Biol Chem (2008) 1.19
Extensive conformational sampling in a ternary electron transfer complex. Nat Struct Biol (2003) 1.17
Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction. J Am Chem Soc (2009) 1.17
The pH dependence of kinetic isotope effects in monoamine oxidase A indicates stabilization of the neutral amine in the enzyme-substrate complex. FEBS J (2008) 1.17
Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator. Mol Microbiol (2008) 1.16
Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions. J Am Chem Soc (2010) 1.16
Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects. Proc Natl Acad Sci U S A (2007) 1.16
Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems. Philos Trans R Soc Lond B Biol Sci (2006) 1.15
Conformational changes in an ultrafast light-driven enzyme determine catalytic activity. Nature (2008) 1.14
ElectroShape: fast molecular similarity calculations incorporating shape, chirality and electrostatics. J Comput Aided Mol Des (2010) 1.14
Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function. J Immunol (2013) 1.14
Crystallography with online optical and X-ray absorption spectroscopies demonstrates an ordered mechanism in copper nitrite reductase. J Mol Biol (2008) 1.13
Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase. Chembiochem (2013) 1.12
Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase. J Am Chem Soc (2008) 1.11
Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg. Protein Sci (2005) 1.11
Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex. J Biol Chem (2004) 1.10
Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A. Arch Biochem Biophys (2009) 1.09
Nature of the energy landscape for gated electron transfer in a dynamic redox protein. J Am Chem Soc (2010) 1.08
Alpha-secondary isotope effects as probes of "tunneling-ready" configurations in enzymatic H-tunneling: insight from environmentally coupled tunneling models. J Am Chem Soc (2006) 1.08
Conformational and thermodynamic control of electron transfer in neuronal nitric oxide synthase. Biochemistry (2007) 1.07
Electrical circuitry in biology: emerging principles from protein structure. Curr Opin Struct Biol (2004) 1.07
Kinetic and thermodynamic characterization of the common polymorphic variants of human methionine synthase reductase. Biochemistry (2004) 1.06
Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance(). Medchemcomm (2012) 1.05
Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos (2012) 1.04
Disseminated Leishmania infantum infection in two sibling foxhounds due to possible vertical transmission. Can Vet J (2008) 1.04
Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding. Biochemistry (2002) 1.03
Insight into catalysis of nitrous oxide reductase from high-resolution structures of resting and inhibitor-bound enzyme from Achromobacter cycloclastes. J Mol Biol (2006) 1.02
Immunologic indicators of clinical progression during canine Leishmania infantum infection. Clin Vaccine Immunol (2009) 1.02
H-tunneling in the multiple H-transfers of the catalytic cycle of morphinone reductase and in the reductive half-reaction of the homologous pentaerythritol tetranitrate reductase. J Biol Chem (2003) 1.02
Hydrogen tunneling in quinoproteins. Arch Biochem Biophys (2004) 1.02
Magnetic field effect studies indicate reduced geminate recombination of the radical pair in substrate-bound adenosylcobalamin-dependent ethanolamine ammonia lyase. J Am Chem Soc (2007) 1.02
The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease. J Mol Med (Berl) (2013) 1.02
Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues. Eur J Biochem (2003) 1.01
A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs. Curr Top Med Chem (2006) 1.01
Atomic resolution structures of native copper nitrite reductase from Alcaligenes xylosoxidans and the active site mutant Asp92Glu. J Mol Biol (2003) 1.01
Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication. J Med Chem (2011) 1.01
The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase. FEBS Lett (2005) 1.00
Accessibility of the distal heme face, rather than Fe-His bond strength, determines the heme-nitrosyl coordination number of cytochromes c': evidence from spectroscopic studies. Biochemistry (2005) 1.00
Lys300 plays a major role in the catalytic mechanism of maize polyamine oxidase. Biochemistry (2005) 1.00
Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu-Zn superoxide dismutase. Proc Natl Acad Sci U S A (2007) 1.00
Fast protein motions are coupled to enzyme H-transfer reactions. J Am Chem Soc (2013) 1.00
Active site structures and the redox properties of blue copper proteins: atomic resolution structure of azurin II and electronic structure calculations of azurin, plastocyanin and stellacyanin. Dalton Trans (2006) 0.99
Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo. J Med Chem (2006) 0.99
Crystal structure of bacterial morphinone reductase and properties of the C191A mutant enzyme. J Biol Chem (2002) 0.98
Activation parameters for heme-NO binding in alcaligenes xylosoxidans cytochrome c': the putative dinitrosyl intermediate forms via a dissociative mechanism. J Am Chem Soc (2009) 0.98
Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms. J Am Chem Soc (2007) 0.98
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity. J Med Chem (2010) 0.98
Validation of isolated metabolites from drug metabolism studies as analytical standards by quantitative NMR. Drug Metab Dispos (2010) 0.97
Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation. Adv Synth Catal (2009) 0.97
Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite(s) involvement. Drug Metab Dispos (2012) 0.96
Molecular basis for nitric oxide dynamics and affinity with Alcaligenes xylosoxidans cytochrome c. J Biol Chem (2006) 0.96
The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding. J Mol Biol (2009) 0.96
Updated structure of Drosophila cryptochrome. Nature (2013) 0.95
Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: consistency of simulation and theory with experiment. J Phys Chem B (2007) 0.95
Mechanistic aspects of the covalent flavoprotein dimethylglycine oxidase of Arthrobacter globiformis studied by stopped-flow spectrophotometry. Biochemistry (2002) 0.95
Biocatalysis with thermostable enzymes: structure and properties of a thermophilic 'ene'-reductase related to old yellow enzyme. Chembiochem (2010) 0.95
A stable tyrosyl radical in monoamine oxidase A. J Biol Chem (2004) 0.94
Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible. Drug Metab Dispos (2004) 0.94
Incorporation of hydrostatic pressure into models of hydrogen tunneling highlights a role for pressure-modulated promoting vibrations. Biochemistry (2008) 0.94
Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation. Biochemistry (2007) 0.94
Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA. Biochem J (2003) 0.94
Barrier compression enhances an enzymatic hydrogen-transfer reaction. Angew Chem Int Ed Engl (2009) 0.94
Structural basis of kynurenine 3-monooxygenase inhibition. Nature (2013) 0.94
Coupled motions direct electrons along human microsomal P450 Chains. PLoS Biol (2011) 0.94
Genomic analysis reveals widespread occurrence of new classes of copper nitrite reductases. J Biol Inorg Chem (2007) 0.94
Inter-flavin electron transfer in cytochrome P450 reductase - effects of solvent and pH identify hidden complexity in mechanism. FEBS J (2008) 0.93