A pre-mRNA-associating factor links endogenous siRNAs to chromatin regulation.

PubWeight™: 1.42‹?› | Rank: Top 5%

🔗 View Article (PMC 3161925)

Published in PLoS Genet on August 25, 2011

Authors

Kirk B Burkhart1, Shouhong Guang, Bethany A Buckley, Lily Wong, Aaron F Bochner, Scott Kennedy

Author Affiliations

1: Laboratory of Genetics, University of Wisconsin Madison, Madison, Wisconsin, United States of America.

Articles citing this

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond. Nat Rev Genet (2013) 3.17

Transgenerational epigenetic inheritance: myths and mechanisms. Cell (2014) 2.88

A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality. Nature (2012) 2.04

PIWI-interacting RNAs: from generation to transgenerational epigenetics. Nat Rev Genet (2013) 1.92

RNA-mediated epigenetic regulation of gene expression. Nat Rev Genet (2015) 1.90

Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2011) 1.75

Long noncoding RNAs in C. elegans. Genome Res (2012) 1.69

A Tetrahymena Piwi bound to mature tRNA 3' fragments activates the exonuclease Xrn2 for RNA processing in the nucleus. Mol Cell (2012) 1.65

Extremely stable Piwi-induced gene silencing in Caenorhabditis elegans. EMBO J (2012) 1.41

CHH islands: de novo DNA methylation in near-gene chromatin regulation in maize. Genome Res (2012) 1.36

Mmi1 RNA surveillance machinery directs RNAi complex RITS to specific meiotic genes in fission yeast. EMBO J (2012) 1.31

Small non-coding RNAs mount a silent revolution in gene expression. Curr Opin Cell Biol (2012) 1.00

Effects of ADARs on small RNA processing pathways in C. elegans. Genome Res (2012) 0.97

Endogenous nuclear RNAi mediates behavioral adaptation to odor. Cell (2013) 0.97

RNAi pathways contribute to developmental history-dependent phenotypic plasticity in C. elegans. RNA (2013) 0.92

Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders. Front Genet (2012) 0.89

siRNAs from an X-linked satellite repeat promote X-chromosome recognition in Drosophila melanogaster. Proc Natl Acad Sci U S A (2014) 0.88

The nuclear argonaute NRDE-3 contributes to transitive RNAi in Caenorhabditis elegans. Genetics (2013) 0.86

Chromatin-associated ncRNA activities. Chromosome Res (2013) 0.86

Small RNAs in plants: recent development and application for crop improvement. Front Plant Sci (2015) 0.85

Tertiary siRNAs mediate paramutation in C. elegans. PLoS Genet (2015) 0.85

A nuclear perspective on RNAi pathways in metazoans. Biochim Biophys Acta (2013) 0.85

RNA interference: concept to reality in crop improvement. Planta (2014) 0.84

Regulation of mammalian transcription and splicing by Nuclear RNAi. Nucleic Acids Res (2015) 0.83

Complex coding of endogenous siRNA, transcriptional silencing and H3K9 methylation on native targets of germline nuclear RNAi in C. elegans. BMC Genomics (2014) 0.83

C. elegans epigenetic regulation in development and aging. Brief Funct Genomics (2013) 0.83

Homeland security in the C. elegans germ line: insights into the biogenesis and function of piRNAs. Epigenetics (2013) 0.83

The RNA-induced transcriptional silencing complex targets chromatin exclusively via interacting with nascent transcripts. Genes Dev (2016) 0.82

Regulation of histone methylation by noncoding RNAs. Biochim Biophys Acta (2014) 0.81

Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev (2013) 0.81

Nuclear RNAi contributes to the silencing of off-target genes and repetitive sequences in Caenorhabditis elegans. Genetics (2014) 0.80

A transgenerational role of the germline nuclear RNAi pathway in repressing heat stress-induced transcriptional activation in C. elegans. Epigenetics Chromatin (2016) 0.79

Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2015) 0.79

Nematode endogenous small RNA pathways. Worm (2014) 0.78

Transgenerational functions of small RNA pathways in controlling gene expression in C. elegans. Epigenetics (2013) 0.78

Endogenous RNAi and adaptation to environment in C. elegans. Worm (2012) 0.77

Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways. Elife (2016) 0.77

From early lessons to new frontiers: the worm as a treasure trove of small RNA biology. Front Genet (2014) 0.77

Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegans. Epigenetics Chromatin (2017) 0.75

The Influence of Genotype and Environment on Small RNA Profiles in Grapevine Berry. Front Plant Sci (2016) 0.75

Small RNA library cloning procedure for deep sequencing of specific endogenous siRNA classes in Caenorhabditis elegans. Methods Mol Biol (2014) 0.75

Stable Heritable Germline Silencing Directs Somatic Silencing at an Endogenous Locus. Mol Cell (2017) 0.75

A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress. Elife (2017) 0.75

MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality. Dev Cell (2017) 0.75

The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription. Dev Cell (2017) 0.75

Identification and Characterization of Caenorhabditis elegans RNAi Inheritance Machinery. Genetics (2017) 0.75

Articles cited by this

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 26.58

Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science (2001) 13.55

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15

A distinct small RNA pathway silences selfish genetic elements in the germline. Science (2006) 11.63

Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene (2001) 11.09

RNAi-mediated targeting of heterochromatin by the RITS complex. Science (2004) 8.73

Heterochromatin revisited. Nat Rev Genet (2007) 8.70

Pre-mRNA processing reaches back to transcription and ahead to translation. Cell (2009) 7.45

Small interfering RNA-induced transcriptional gene silencing in human cells. Science (2004) 7.29

Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell (2006) 7.14

Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39

Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science (2004) 6.35

The many faces of histone lysine methylation. Curr Opin Cell Biol (2002) 6.01

Small RNAs in transcriptional gene silencing and genome defence. Nature (2009) 5.98

A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature (2004) 5.57

Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. Nat Chem Biol (2007) 5.05

Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells. Nat Struct Mol Biol (2006) 4.93

Small dsRNAs induce transcriptional activation in human cells. Proc Natl Acad Sci U S A (2006) 4.90

Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell (2009) 4.39

RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nat Genet (2004) 4.23

An Argonaute transports siRNAs from the cytoplasm to the nucleus. Science (2008) 3.86

An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster. Nature (2007) 3.86

Rapid single nucleotide polymorphism mapping in C. elegans. BMC Genomics (2005) 3.57

Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes Dev (2007) 3.46

Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. Nat Struct Mol Biol (2006) 3.46

The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA (2005) 3.14

The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins. Genetics (1994) 3.09

Dicer-independent primal RNAs trigger RNAi and heterochromatin formation. Cell (2010) 2.99

RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production. Proc Natl Acad Sci U S A (2004) 2.88

Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin. Nat Struct Mol Biol (2008) 2.87

Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription. Nature (2010) 2.74

In vitro analyses of the production and activity of secondary small interfering RNAs in C. elegans. EMBO J (2007) 2.57

Distinct phases of siRNA synthesis in an endogenous RNAi pathway in C. elegans soma. Mol Cell (2010) 2.57

RNAi-dependent formation of heterochromatin and its diverse functions. Curr Opin Genet Dev (2010) 2.54

Homologous gene targeting in Caenorhabditis elegans by biolistic transformation. Nucleic Acids Res (2004) 2.06

Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity. Cell (2010) 1.82

Meiotic crossover number and distribution are regulated by a dosage compensation protein that resembles a condensin subunit. Genes Dev (2008) 1.76

HP1 recruitment in the absence of argonaute proteins in Drosophila. PLoS Genet (2010) 1.53

Requirement for the ERI/DICER complex in endogenous RNA interference and sperm development in Caenorhabditis elegans. Genetics (2009) 1.52

EGO-1, a putative RNA-dependent RNA polymerase, is required for heterochromatin assembly on unpaired dna during C. elegans meiosis. Curr Biol (2005) 1.38

RNA interference can target pre-mRNA: consequences for gene expression in a Caenorhabditis elegans operon. Genetics (1999) 1.37

Regulation of heterochromatin assembly on unpaired chromosomes during Caenorhabditis elegans meiosis by components of a small RNA-mediated pathway. PLoS Genet (2009) 1.28

Small RNA-mediated epigenetic modifications in plants. Curr Opin Plant Biol (2010) 1.13

lir-2, lir-1 and lin-26 encode a new class of zinc-finger proteins and are organized in two overlapping operons both in Caenorhabditis elegans and in Caenorhabditis briggsae. Genetics (1999) 0.93

Articles by these authors

DAF-16 target genes that control C. elegans life-span and metabolism. Science (2003) 4.57

Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell (2006) 4.50

Functional genomic analysis of RNA interference in C. elegans. Science (2005) 4.36

An Argonaute transports siRNAs from the cytoplasm to the nucleus. Science (2008) 3.86

Systematic analysis of genes required for synapse structure and function. Nature (2005) 3.67

Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature (2005) 2.98

Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription. Nature (2010) 2.74

Distinct phases of siRNA synthesis in an endogenous RNAi pathway in C. elegans soma. Mol Cell (2010) 2.57

Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint. Nat Genet (2012) 2.07

A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality. Nature (2012) 2.04

Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2011) 1.75

Requirement for the ERI/DICER complex in endogenous RNA interference and sperm development in Caenorhabditis elegans. Genetics (2009) 1.52

Dicer's helicase domain is required for accumulation of some, but not all, C. elegans endogenous siRNAs. RNA (2010) 1.26

Novel venom proteins produced by differential domain-expression strategies in beaded lizards and gila monsters (genus Heloderma). Mol Biol Evol (2009) 1.08

Stability and apoptotic activity of recombinant human cytochrome c. Biochem Biophys Res Commun (2003) 1.06

Ligand regulates epidermal growth factor receptor kinase specificity: activation increases preference for GAB1 and SHC versus autophosphorylation sites. J Biol Chem (2004) 1.05

Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism. J Biol Chem (2007) 1.02

Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. Mol Cell Biol (2005) 1.02

Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209. J Antibiot (Tokyo) (2010) 1.00

Endogenous nuclear RNAi mediates behavioral adaptation to odor. Cell (2013) 0.97

The effects of methotrexate on Drosophila development, female fecundity, and gene expression. Toxicol Sci (2005) 0.92

EGFR kinase possesses a broad specificity for ErbB phosphorylation sites, and ligand increases catalytic-centre activity without affecting substrate binding affinity. Biochem J (2005) 0.89

Functional and structural diversification of the Anguimorpha lizard venom system. Mol Cell Proteomics (2010) 0.87

Predicting consideration of cosmetic surgery in a college population: a continuum of body image disturbance and the importance of coping strategies. Body Image (2011) 0.87

Conformational analysis of chirally deuterated tunicamycin as an active site probe of UDP-N-acetylhexosamine:polyprenol-P N-acetylhexosamine-1-P translocases. Biochemistry (2004) 0.82

Practices and provisions for parents sleeping overnight with a hospitalized child. J Pediatr Psychol (2007) 0.82

Small RNAs, RNAi and the inheritance of gene silencing in Caenorhabditis elegans. J Genet Genomics (2013) 0.82

Evaluation of applied biosystems MicroSEQ real-time PCR system for detection of Salmonella spp. in food. J AOAC Int (2011) 0.81

Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility. J Biol Chem (2013) 0.81

Nuclear RNAi contributes to the silencing of off-target genes and repetitive sequences in Caenorhabditis elegans. Genetics (2014) 0.80

High-resolution MRS in the presence of field inhomogeneity via intermolecular double-quantum coherences on a 3-T whole-body scanner. Magn Reson Med (2010) 0.80

Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase. J Biol Chem (2010) 0.79

Susceptibility to aplastic anemia is associated with HLA-DRB1*1501 in an aboriginal population in Sabah, Malaysia. Hum Immunol (2011) 0.78

Optimization of blood oxygenation level-dependent sensitivity in magnetic resonance imaging using intermolecular double-quantum coherence. J Magn Reson Imaging (2002) 0.77

Non-coding RNAs mediate the rearrangements of genomic DNA in ciliates. Sci China Life Sci (2013) 0.77

Evaluation of butyrate-induced production of a mannose-6-phosphorylated therapeutic enzyme using parallel bioreactors. Biotechnol Appl Biochem (2014) 0.76

Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants. J Biol Chem (2013) 0.75

HbA2 levels in β-thalassaemia carriers with the Filipino β0-deletion: are the levels higher than what is found with non-deletional forms of β0-thalassaemia? Pathology (2013) 0.75

Sleep, sleepiness, and fatigue outcomes for parents of critically ill children. Pediatr Crit Care Med (2014) 0.75

Introducing medical students to radiology as paid emergency department triage assistants. J Am Coll Radiol (2011) 0.75

Factors influencing sleep for parents of critically ill hospitalised children: a qualitative analysis. Intensive Crit Care Nurs (2010) 0.75