Published in Science on June 29, 2006
Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol (2009) 19.99
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature (2008) 10.71
Small RNAs as guardians of the genome. Cell (2009) 8.88
Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells. Science (2008) 8.62
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell (2007) 5.26
Endogenous RNA interference provides a somatic defense against Drosophila transposons. Curr Biol (2008) 5.22
The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs. Nature (2008) 5.05
A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev (2007) 4.95
Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of Piwi- interacting RNAs at their 3' ends. Genes Dev (2007) 4.68
Carbodiimide-mediated cross-linking of RNA to nylon membranes improves the detection of siRNA, miRNA and piRNA by northern blot. Nucleic Acids Res (2007) 4.54
Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell (2009) 4.39
On the road to reading the RNA-interference code. Nature (2009) 4.33
Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet (2010) 4.27
A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24
Critical roles for Dicer in the female germline. Genes Dev (2007) 4.23
Transcription and RNA interference in the formation of heterochromatin. Nature (2007) 4.08
Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies. Curr Biol (2008) 4.07
Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs. Proc Natl Acad Sci U S A (2010) 3.92
A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila. Nature (2009) 3.68
Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes Dev (2007) 3.46
Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature (2010) 3.44
Human tRNA-derived small RNAs in the global regulation of RNA silencing. RNA (2010) 3.40
Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster. Nat Struct Mol Biol (2008) 3.40
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Mol Cell (2008) 3.37
Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster. Proc Natl Acad Sci U S A (2007) 3.31
zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline. Dev Cell (2007) 3.29
The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annu Rev Cell Dev Biol (2009) 3.21
Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20
The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell (2009) 3.13
Argonaute proteins: functional insights and emerging roles. Nat Rev Genet (2013) 3.09
Mighty Piwis defend the germline against genome intruders. Cell (2007) 3.06
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature (2009) 3.04
The rise of regulatory RNA. Nat Rev Genet (2014) 3.02
RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries. RNA (2011) 3.00
Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev (2009) 2.95
A novel repeat-associated small interfering RNA-mediated silencing pathway downregulates complementary sense gypsy transcripts in somatic cells of the Drosophila ovary. J Virol (2006) 2.87
Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. J Cereb Blood Flow Metab (2009) 2.87
The Argonaute protein family. Genome Biol (2008) 2.83
MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS One (2008) 2.82
Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development. Genome Biol (2009) 2.81
Patterns of population epigenomic diversity. Nature (2013) 2.70
A broadly conserved pathway generates 3'UTR-directed primary piRNAs. Curr Biol (2009) 2.69
Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line. Genome Res (2009) 2.68
Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol (2008) 2.67
Gene silencing mechanisms mediated by Aubergine piRNA complexes in Drosophila male gonad. RNA (2007) 2.55
An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J (2010) 2.51
The Arabidopsis RNA-directed DNA methylation argonautes functionally diverge based on their expression and interaction with target loci. Plant Cell (2010) 2.51
Bacterial argonaute samples the transcriptome to identify foreign DNA. Mol Cell (2013) 2.47
A cryptic unstable transcript mediates transcriptional trans-silencing of the Ty1 retrotransposon in S. cerevisiae. Genes Dev (2008) 2.44
Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nat Cell Biol (2009) 2.42
The evolution of RNAi as a defence against viruses and transposable elements. Philos Trans R Soc Lond B Biol Sci (2009) 2.35
Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Genes Dev (2013) 2.34
Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila. Genes Dev (2010) 2.33
C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response. PLoS Negl Trop Dis (2010) 2.29
A novel class of bacteria-induced small RNAs in Arabidopsis. Genes Dev (2007) 2.29
Diverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi. Mol Cell (2010) 2.23
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell (2013) 2.23
New CRISPR-Cas systems from uncultivated microbes. Nature (2016) 2.22
Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline. Nucleic Acids Res (2007) 2.22
Vive la différence: biogenesis and evolution of microRNAs in plants and animals. Genome Biol (2011) 2.21
Comparison of dengue virus type 2-specific small RNAs from RNA interference-competent and -incompetent mosquito cells. PLoS Negl Trop Dis (2010) 2.18
Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms. Annu Rev Genet (2011) 2.07
Computational and analytical framework for small RNA profiling by high-throughput sequencing. RNA (2009) 1.97
Piwi-interacting RNAs protect DNA against loss during Oxytricha genome rearrangement. Cell (2012) 1.95
Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines. EMBO J (2009) 1.94
MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Dev Cell (2011) 1.94
PIWI-interacting RNAs: from generation to transgenerational epigenetics. Nat Rev Genet (2013) 1.92
The piRNA pathway: a fly's perspective on the guardian of the genome. Trends Genet (2010) 1.91
Structure and function of Zucchini endoribonuclease in piRNA biogenesis. Nature (2012) 1.90
A major epigenetic programming mechanism guided by piRNAs. Dev Cell (2013) 1.89
The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians. RNA (2008) 1.87
Zili is required for germ cell differentiation and meiosis in zebrafish. EMBO J (2008) 1.87
Drosophila Piwi functions downstream of piRNA production mediating a chromatin-based transposon silencing mechanism in female germ line. Proc Natl Acad Sci U S A (2011) 1.85
Cutoff and aubergine mutations result in retrotransposon upregulation and checkpoint activation in Drosophila. Curr Biol (2007) 1.84
Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila. Genes Dev (2010) 1.84
GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet (2009) 1.83
Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome. Genome Biol (2006) 1.81
Highly complementary target RNAs promote release of guide RNAs from human Argonaute2. Mol Cell (2013) 1.81
RNA granules in germ cells. Cold Spring Harb Perspect Biol (2011) 1.80
A new class of retroviral and satellite encoded small RNAs emanates from mammalian centromeres. Chromosoma (2008) 1.79
Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains. Mol Cell (2011) 1.79
piRNA-mediated nuclear accumulation of retrotransposon transcripts in the Drosophila female germline. Proc Natl Acad Sci U S A (2008) 1.79
Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2. Nat Genet (2009) 1.78
The flamenco locus controls the gypsy and ZAM retroviruses and is required for Drosophila oogenesis. Genetics (2007) 1.77
The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. RNA (2007) 1.77
Knockdown of midgut genes by dsRNA-transgenic plant-mediated RNA interference in the hemipteran insect Nilaparvata lugens. PLoS One (2011) 1.77
2'-O-methylation stabilizes Piwi-associated small RNAs and ensures DNA elimination in Tetrahymena. RNA (2009) 1.76
Editing independent effects of ADARs on the miRNA/siRNA pathways. EMBO J (2009) 1.76
Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines. Genes Dev (2012) 1.75
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A (2009) 1.73
Mosquito RNAi is the major innate immune pathway controlling arbovirus infection and transmission. Future Microbiol (2011) 1.72
How does the royal family of Tudor rule the PIWI-interacting RNA pathway? Genes Dev (2010) 1.71
A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter. PLoS Biol (2007) 1.69
Small RNA guides for de novo DNA methylation in mammalian germ cells. Genes Dev (2008) 1.68
Production of viable gametes without meiosis in maize deficient for an ARGONAUTE protein. Plant Cell (2011) 1.67
In Drosophila melanogaster the COM locus directs the somatic silencing of two retrotransposons through both Piwi-dependent and -independent pathways. PLoS One (2008) 1.67
A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36
Asymmetry in the assembly of the RNAi enzyme complex. Cell (2003) 22.18
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
A biochemical framework for RNA silencing in plants. Genes Dev (2003) 9.95
Perspective: machines for RNAi. Genes Dev (2005) 9.37
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell (2005) 9.35
Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells. Science (2008) 8.62
microPrimer: the biogenesis and function of microRNA. Development (2005) 8.19
Sequence-specific inhibition of small RNA function. PLoS Biol (2004) 7.98
A protein sensor for siRNA asymmetry. Science (2004) 7.77
Kinetic analysis of the RNAi enzyme complex. Nat Struct Mol Biol (2004) 7.26
Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS Biol (2005) 7.23
Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol Cell (2002) 6.43
MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region. EMBO J (2004) 6.27
RNAi: nature abhors a double-strand. Curr Opin Genet Dev (2002) 5.74
The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr Biol (2007) 5.35
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell (2007) 5.26
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell (2010) 5.22
RISC assembly defects in the Drosophila RNAi mutant armitage. Cell (2004) 4.88
Sorting of Drosophila small silencing RNAs. Cell (2007) 4.67
Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell (2009) 4.39
Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Nat Genet (2003) 4.25
Modular recognition of RNA by a human pumilio-homology domain. Cell (2002) 4.17
Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies. Curr Biol (2008) 4.07
Target RNA-directed trimming and tailing of small silencing RNAs. Science (2010) 3.98
Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol (2013) 3.80
The RNA-induced silencing complex is a Mg2+-dependent endonuclease. Curr Biol (2004) 3.68
Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS Genet (2006) 3.23
Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. RNA (2009) 3.19
The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell (2009) 3.13
MicroRNA biogenesis: drosha can't cut it without a partner. Curr Biol (2005) 2.85
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res (2010) 2.56
Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region. Hum Mol Genet (2002) 2.55
Why do miRNAs live in the miRNP? Genes Dev (2002) 2.41
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell (2013) 2.23
In vitro analysis of RNA interference in Drosophila melanogaster. Methods (2003) 2.20
Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients. Curr Biol (2009) 2.19
Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline. Genes Dev (2006) 2.09
Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell (2012) 2.07
Structural determinants of miRNAs for RISC loading and slicer-independent unwinding. Nat Struct Mol Biol (2009) 2.01
Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging Cell (2003) 1.88
Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains. Mol Cell (2011) 1.79
Adaptation to P element transposon invasion in Drosophila melanogaster. Cell (2011) 1.76
A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe. Genes Dev (2004) 1.69
Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods (2012) 1.67
The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Curr Biol (2011) 1.66
Recognition of the pre-miRNA structure by Drosophila Dicer-1. Nat Struct Mol Biol (2011) 1.61
Beginning to understand microRNA function. Cell Res (2007) 1.59
Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing. RNA (2011) 1.59
Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Cell (2012) 1.57
A role for microRNAs in the Drosophila circadian clock. Genes Dev (2009) 1.56
UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery. Cell (2012) 1.53
Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells. Nat Protoc (2008) 1.38
Identification of 13 novel human modification guide RNAs. Nucleic Acids Res (2003) 1.38
MicroRNAs: regulating a change of heart. Circulation (2009) 1.37
Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease. Mol Cell (2011) 1.36
MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression. Mol Ther (2010) 1.30
Rethinking the microprocessor. Cell (2006) 1.29
Argonaute proteins. Curr Biol (2011) 1.26
Linking SNPs to CAG repeat length in Huntington's disease patients. Nat Methods (2008) 1.19
Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. RNA (2010) 1.19
Small silencing RNAs. Curr Biol (2007) 1.18
RNA silencing: genomic defence with a slice of pi. Nature (2007) 1.12
A 5'-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation. Silence (2011) 1.08
Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles. Mol Ther (2012) 1.07
Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection. Silence (2012) 1.07
MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis. J Clin Invest (2015) 1.03
Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development. Dev Biol (2010) 1.02
Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates. RNA (2012) 1.00
Regulation of glutamate receptor subunit availability by microRNAs. J Cell Biol (2009) 0.99
Cnidarian microRNAs frequently regulate targets by cleavage. Genome Res (2014) 0.96
Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin. EMBO J (2014) 0.91
Biochemical dissection of RNA silencing in plants. Methods Mol Biol (2004) 0.91
Huntington's disease: silencing a brutal killer. Exp Neurol (2009) 0.89
Small RNA-directed silencing: the fly finds its inner fission yeast? Curr Biol (2013) 0.84
Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain. EMBO J (2014) 0.84
SnapShot: Fly piRNAs, PIWI proteins, and the ping-pong cycle. Cell (2009) 0.81
Defining piRNA primary transcripts. Cell Cycle (2013) 0.80
siRNAs knock down hepatitis. Nat Med (2003) 0.78
SnapShot: mouse piRNAs, PIWI proteins, and the ping-pong cycle. Cell (2009) 0.78
Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides. Cell (2016) 0.75
Nucleus and gene expression. Curr Opin Cell Biol (2009) 0.75