Published in J Appl Physiol (1985) on September 08, 2011
Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma. PLoS One (2013) 0.84
Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs. J Gerontol A Biol Sci Med Sci (2015) 0.81
Secreted phosphoprotein 1 is a determinant of lung function development in mice. Am J Respir Cell Mol Biol (2014) 0.76
Mammalian Target of Rapamycin: A Target for (Lung) Diseases and Aging. Ann Am Thorac Soc (2016) 0.75
Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell (2006) 18.36
mTOR signaling at a glance. J Cell Sci (2009) 8.66
Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med (2011) 6.74
Asthma control during the year after bronchial thermoplasty. N Engl J Med (2007) 4.79
A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med (1998) 4.52
The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity (2010) 2.85
Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med (2001) 2.34
Bronchoalveolar lavage findings suggest two different forms of childhood asthma. Clin Exp Allergy (1997) 2.17
Sirolimus-associated pulmonary toxicity. Transplantation (2004) 2.15
Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol (1990) 2.14
Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol (2000) 2.12
Rapamycin in transplantation: a review of the evidence. Kidney Int (2001) 1.97
Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. Am J Respir Crit Care Med (2007) 1.93
Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood. Am J Physiol Lung Cell Mol Physiol (2004) 1.84
Clinical phenotypes of asthma. Curr Opin Pulm Med (2004) 1.73
The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur Respir J (2006) 1.62
Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. Thorax (2004) 1.57
Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2003) 1.53
EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 1.51
Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway. Am J Respir Crit Care Med (1998) 1.48
Molecular pathogenesis of lymphangioleiomyomatosis: lessons learned from orphans. Am J Respir Cell Mol Biol (2006) 1.47
Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J (2008) 1.44
PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects. Cell Cycle (2009) 1.38
Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap. Am J Respir Cell Mol Biol (2009) 1.38
Activating mutations of TOR (target of rapamycin). Genes Cells (2011) 1.31
Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2007) 1.29
The use of the internal perimeter to compare airway size and to calculate smooth muscle shortening. Am Rev Respir Dis (1988) 1.27
Epithelial stress and structural remodelling in childhood asthma. Thorax (2005) 1.27
Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2009) 1.24
Airway remodeling in asthma: therapeutic implications of mechanisms. Physiology (Bethesda) (2005) 1.19
Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation. Am J Physiol (1999) 1.18
mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia. FASEB J (2011) 1.14
Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiol (2010) 1.12
The synergistic interactions of allergic lung inflammation and intratracheal cationic protein. Am J Respir Crit Care Med (2007) 1.10
In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. Am J Respir Crit Care Med (2002) 1.07
Dose-dependent lung remodeling in transgenic mice expressing transforming growth factor-alpha. Am J Physiol Lung Cell Mol Physiol (2001) 1.03
Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol (2009) 1.00
Postnatal lung function and morphology in transgenic mice expressing transforming growth factor-alpha. Am J Pathol (1997) 0.96
Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis. Am J Physiol Lung Cell Mol Physiol (2007) 0.94
Effects of corticosteroids on structural cells in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc (2004) 0.93
Reversal of lung lesions in transgenic transforming growth factor alpha mice by expression of mutant epidermal growth factor receptor. Am J Respir Cell Mol Biol (1996) 0.93
Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alpha. Am J Physiol Lung Cell Mol Physiol (2003) 0.91
Phenotype-specific treatment of difficult asthma in children. Paediatr Respir Rev (2004) 0.90
Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats. Immunology (2003) 0.89
Noninflammatory mechanisms of airway hyper-responsiveness in bronchial asthma: an overview. Ther Adv Respir Dis (2009) 0.85
Sirolimus-related pulmonary toxicity mimicking 'asthma like' symptoms. World J Gastroenterol (2007) 0.85
Anti-T cell strategies in asthma. Inflamm Res (1999) 0.83
Molecular basis of different outcomes for drug-eluting stents that release sirolimus or tacrolimus. Curr Opin Drug Discov Devel (2010) 0.81
Diagnosis and treatment of refractory asthma. Eur Rev Med Pharmacol Sci (2008) 0.79
Asthma refractory to glucocorticoids: the role of newer immunosuppressants. Am J Respir Med (2002) 0.77
Five-year clinical follow-up after sirolimus-eluting stent implantation for the treatment of coronary in-stent restenosis. Coron Artery Dis (2011) 0.76
Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A (2002) 5.54
Pulmonary alveolar proteinosis. N Engl J Med (2003) 4.93
ABCA3 gene mutations in newborns with fatal surfactant deficiency. N Engl J Med (2004) 4.64
Conditional gene expression in the respiratory epithelium of the mouse. Transgenic Res (2002) 4.01
Transcriptional control of lung morphogenesis. Physiol Rev (2007) 3.58
beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem (2003) 3.37
A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet (2008) 3.37
Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway. Nat Immunol (2004) 2.86
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol (2005) 2.73
Diesel exhaust particle induction of IL-17A contributes to severe asthma. J Allergy Clin Immunol (2013) 2.62
ABCA3 mutations associated with pediatric interstitial lung disease. Am J Respir Crit Care Med (2005) 2.52
Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development (2007) 2.40
Foxa2 regulates alveolarization and goblet cell hyperplasia. Development (2004) 2.35
Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene. J Mol Med (Berl) (2002) 2.34
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest (2009) 2.28
Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am J Respir Cell Mol Biol (2005) 2.28
Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense. Annu Rev Physiol (2002) 2.23
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem (2005) 2.15
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J Clin Invest (2006) 2.15
Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell (2009) 2.14
The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung. J Clin Invest (2002) 2.13
Transdifferentiation of ciliated cells during repair of the respiratory epithelium. Am J Respir Cell Mol Biol (2005) 2.12
Bone marrow-derived stromal cells are invasive and hyperproliferative and alter transforming growth factor-α-induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2014) 2.12
Chemokines in asthma: cooperative interaction between chemokines and IL-13. J Allergy Clin Immunol (2003) 2.06
SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol (2003) 2.00
TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem (2004) 1.98
SPDEF regulates goblet cell hyperplasia in the airway epithelium. J Clin Invest (2007) 1.96
Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis. Thorax (2011) 1.93
Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol (2005) 1.93
Deletion of Forkhead Box M1 transcription factor from respiratory epithelial cells inhibits pulmonary tumorigenesis. PLoS One (2009) 1.93
Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. J Exp Med (2008) 1.88
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest (2007) 1.86
Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation. Am J Respir Crit Care Med (2011) 1.84
GM-CSF in the lung protects against lethal influenza infection. Am J Respir Crit Care Med (2011) 1.83
Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. Am J Respir Cell Mol Biol (2005) 1.83
GATA6 regulates differentiation of distal lung epithelium. Development (2002) 1.82
Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infection. Am J Respir Crit Care Med (2003) 1.81
Genetic disorders of surfactant dysfunction. Pediatr Dev Pathol (2009) 1.77
Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. Am J Pathol (2005) 1.76
Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn (2004) 1.75
Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues. Gene Expr Patterns (2004) 1.75
TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. J Biol Chem (2003) 1.75
Mutations in the surfactant protein C gene associated with interstitial lung disease. Chest (2002) 1.74
Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol (2010) 1.74
Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells. PLoS One (2009) 1.69
R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development (2008) 1.66
C/EBPalpha is required for lung maturation at birth. Development (2006) 1.65
Pneumonitis and emphysema in sp-C gene targeted mice. J Biol Chem (2003) 1.62
Human GM-CSF autoantibodies and reproduction of pulmonary alveolar proteinosis. N Engl J Med (2009) 1.58
Foxa2 is required for transition to air breathing at birth. Proc Natl Acad Sci U S A (2004) 1.57
Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2003) 1.53
EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 1.51
Stat-3 is required for pulmonary homeostasis during hyperoxia. J Clin Invest (2004) 1.51
Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol (2007) 1.51
Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol (2008) 1.49
Surfactant protein-d enhances phagocytosis and pulmonary clearance of respiratory syncytial virus. Am J Respir Cell Mol Biol (2004) 1.47
Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas. PLoS One (2008) 1.46
In defense of the lung: surfactant protein A and surfactant protein D. Curr Opin Pharmacol (2006) 1.44
Retracted Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice. Am J Respir Cell Mol Biol (2010) 1.44
Transcriptional programs controlling perinatal lung maturation. PLoS One (2012) 1.41
Normal lung development and function after Sox9 inactivation in the respiratory epithelium. Genesis (2005) 1.39
Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap. Am J Respir Cell Mol Biol (2009) 1.38
IL-1beta disrupts postnatal lung morphogenesis in the mouse. Am J Respir Cell Mol Biol (2006) 1.38
Surfactant composition and function in patients with ABCA3 mutations. Pediatr Res (2006) 1.37
Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. Dev Biol (2009) 1.36
Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung. J Clin Invest (2012) 1.36
Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development (2008) 1.35
GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol (2008) 1.34
Sox17 influences the differentiation of respiratory epithelial cells. Dev Biol (2006) 1.33
Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest (2006) 1.33
Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol (2003) 1.33
Forkhead Box m1 transcription factor is required for perinatal lung function. Proc Natl Acad Sci U S A (2008) 1.32
Conditional control of gene expression in the respiratory epithelium: A cautionary note. Am J Respir Cell Mol Biol (2006) 1.32
A common mutation in the surfactant protein C gene associated with lung disease. J Pediatr (2005) 1.31
Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus. Am J Physiol Lung Cell Mol Physiol (2003) 1.31
GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS. Am J Respir Cell Mol Biol (2006) 1.31
Midkine is regulated by hypoxia and causes pulmonary vascular remodeling. J Biol Chem (2004) 1.30
Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2007) 1.29
Sox2 activates cell proliferation and differentiation in the respiratory epithelium. Am J Respir Cell Mol Biol (2010) 1.29
Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies. Expert Opin Ther Targets (2010) 1.29
GATA-6 is required for maturation of the lung in late gestation. Am J Physiol Lung Cell Mol Physiol (2002) 1.26
Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2009) 1.24
Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J (2013) 1.23
Bronchoalveolar lavage fluid surfactant protein-A and surfactant protein-D are inversely related to inflammation in early cystic fibrosis. Am J Respir Crit Care Med (2003) 1.22
Vascular changes after intra-amniotic endotoxin in preterm lamb lungs. Am J Physiol Lung Cell Mol Physiol (2004) 1.22
Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. Am J Physiol Lung Cell Mol Physiol (2003) 1.22
Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med (2010) 1.21